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New theropod remains and implications for megaraptorid diversity in the Winton Formation (lower Upper Cretaceous), Queensland, Australia.

White MA, Bell PR, Poropat SF, Pentland AH, Rigby SL, Cook AG, Sloan T, Elliott DA.

R Soc Open Sci. 2020 Jan 15;7(1):191462. doi: 10.1098/rsos.191462. eCollection 2020 Jan.


LIM kinase 2 (LIMK2) may play an essential role in platelet function.

Antonipillai J, Mittelstaedt K, Rigby S, Bassler N, Bernard O.

Exp Cell Res. 2020 Mar 1;388(1):111822. doi: 10.1016/j.yexcr.2020.111822. Epub 2020 Jan 9.


Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.

Yildirim F, Ng CW, Kappes V, Ehrenberger T, Rigby SK, Stivanello V, Gipson TA, Soltis AR, Vanhoutte P, Caboche J, Housman DE, Fraenkel E.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24840-24851. doi: 10.1073/pnas.1908113116. Epub 2019 Nov 19.


Pharmacological inhibition of LIM kinase pathway impairs platelets functionality and facilitates thrombolysis.

Antonipillai J, Rigby S, Bassler N, Peter K, Bernard O.

Exp Cell Res. 2019 Sep 15;382(2):111458. doi: 10.1016/j.yexcr.2019.06.003. Epub 2019 Jun 8.


The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry.

Marshall SA, Payne KAP, Fisher K, White MD, Ní Cheallaigh A, Balaikaite A, Rigby SEJ, Leys D.

Nat Commun. 2019 May 29;10(1):2357. doi: 10.1038/s41467-019-10220-1.


Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD.

Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC.

Am J Kidney Dis. 2019 Sep;74(3):328-337. doi: 10.1053/j.ajkd.2019.03.417. Epub 2019 May 14.


Heterologous production, reconstitution and EPR spectroscopic analysis of prFMN dependent enzymes.

Marshall SA, Payne KAP, Fisher K, Gahloth D, Bailey SS, Balaikaite A, Saaret A, Gostimskaya I, Aleku G, Huang H, Rigby SEJ, Procter D, Leys D.

Methods Enzymol. 2019;620:489-508. doi: 10.1016/bs.mie.2019.03.022. Epub 2019 Apr 11.


Investigating the referral of patients with non-urgent conditions to a regional Australian emergency department: a study protocol.

Unwin M, Crisp E, Rigby S, Kinsman L.

BMC Health Serv Res. 2018 Aug 20;18(1):647. doi: 10.1186/s12913-018-3411-4.


Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila.

Baker GJ, Girvan HM, Matthews S, McLean KJ, Golovanova M, Waltham TN, Rigby SEJ, Nelson DR, Blankley RT, Munro AW.

ACS Omega. 2017 Aug 31;2(8):4705-4724. doi: 10.1021/acsomega.7b00450. Epub 2017 Aug 18.


Empathy and face processing in adults with and without autism spectrum disorder.

Rigby SN, Stoesz BM, Jakobson LS.

Autism Res. 2018 Jun;11(6):942-955. doi: 10.1002/aur.1948. Epub 2018 Apr 10.


NADPH-Driven Organohalide Reduction by a Nonrespiratory Reductive Dehalogenase.

Collins FA, Fisher K, Payne KAP, Gaytan Mondragon S, Rigby SEJ, Leys D.

Biochemistry. 2018 Jun 26;57(25):3493-3502. doi: 10.1021/acs.biochem.8b00255. Epub 2018 Jun 13.


The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis.

Bailey SS, Payne KAP, Fisher K, Marshall SA, Cliff MJ, Spiess R, Parker DA, Rigby SEJ, Leys D.

J Biol Chem. 2018 Feb 16;293(7):2272-2287. doi: 10.1074/jbc.RA117.000881. Epub 2017 Dec 19.


Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.

Payer SE, Marshall SA, Bärland N, Sheng X, Reiter T, Dordic A, Steinkellner G, Wuensch C, Kaltwasser S, Fisher K, Rigby SEJ, Macheroux P, Vonck J, Gruber K, Faber K, Himo F, Leys D, Pavkov-Keller T, Glueck SM.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13893-13897. doi: 10.1002/anie.201708091. Epub 2017 Oct 2.


Corrigendum: Elucidation of the biosynthesis of the methane catalyst coenzyme F430.

Moore SJ, Sowa ST, Schuchardt C, Deery E, Lawrence AD, Ramos JV, Billig S, Birkemeyer C, Chivers PT, Howard MJ, Rigby SEJ, Layer G, Warren MJ.

Nature. 2017 May 3;545(7652):116. doi: 10.1038/nature22317. No abstract available.


Elucidation of the biosynthesis of the methane catalyst coenzyme F430.

Moore SJ, Sowa ST, Schuchardt C, Deery E, Lawrence AD, Ramos JV, Billig S, Birkemeyer C, Chivers PT, Howard MJ, Rigby SE, Layer G, Warren MJ.

Nature. 2017 Mar 2;543(7643):78-82. doi: 10.1038/nature21427. Epub 2017 Feb 22. Erratum in: Nature. 2017 May 3;545(7652):116.


The relationship between intimate partner violence and HIV: A model-based evaluation.

Rigby SW, Johnson LF.

Infect Dis Model. 2017 Feb 16;2(1):71-89. doi: 10.1016/j.idm.2017.02.002. eCollection 2017 Feb.


Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa.

Bonnard T, Tennant Z, Niego B, Kanojia R, Alt K, Jagdale S, Law LS, Rigby S, Medcalf RL, Peter K, Hagemeyer CE.

J Am Heart Assoc. 2017 Feb 3;6(2). pii: e004535. doi: 10.1161/JAHA.116.004535.


Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis.

Marshall SA, Fisher K, Ní Cheallaigh A, White MD, Payne KA, Parker DA, Rigby SE, Leys D.

J Biol Chem. 2017 Mar 17;292(11):4623-4637. doi: 10.1074/jbc.M116.762732. Epub 2017 Jan 5.


Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE.

Matthews S, Belcher JD, Tee KL, Girvan HM, McLean KJ, Rigby SE, Levy CW, Leys D, Parker DA, Blankley RT, Munro AW.

J Biol Chem. 2017 Mar 24;292(12):5128-5143. doi: 10.1074/jbc.M116.762336. Epub 2017 Jan 4.


Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.

J Biol Chem. 2017 Jan 27;292(4):1310-1329. doi: 10.1074/jbc.M116.748822. Epub 2016 Dec 8.


An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

Ortmayer M, Lafite P, Menon BR, Tralau T, Fisher K, Denkhaus L, Scrutton NS, Rigby SE, Munro AW, Hay S, Leys D.

Nature. 2016 Nov 24;539(7630):593-597. doi: 10.1038/nature20159. Epub 2016 Nov 16.


Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis.

Narayan N, Rigby S, Carlucci F.

Clin Rheumatol. 2017 Feb;36(2):477-479. doi: 10.1007/s10067-016-3420-9. Epub 2016 Oct 24.


Why are we waiting? Patients' perspectives for accessing emergency department services with non-urgent complaints.

Unwin M, Kinsman L, Rigby S.

Int Emerg Nurs. 2016 Nov;29:3-8. doi: 10.1016/j.ienj.2016.09.003. Epub 2016 Oct 21.


Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.

Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW.

Biochemistry. 2016 Sep 13;55(36):5073-83. doi: 10.1021/acs.biochem.6b00204. Epub 2016 Sep 1.


Blast Quantification Using Hopkinson Pressure Bars.

Clarke SD, Fay SD, Rigby SE, Tyas A, Warren JA, Reay JJ, Fuller BJ, Gant MT, Elgy ID.

J Vis Exp. 2016 Jul 5;(113). doi: 10.3791/53412.


Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.

Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW.

Sci Rep. 2016 May 26;6:26628. doi: 10.1038/srep26628.


ADVICE for a healthier life: Adult Vaccination Campaign in Europe.

Ozisik L, Tanriover MD, Rigby S, Unal S; European Federation of Internal Medicine ADVICE Working Group.

Eur J Intern Med. 2016 Sep;33:14-20. doi: 10.1016/j.ejim.2016.04.021. Epub 2016 May 12. Review.


Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.

Rogers NJ, Hill-Casey F, Stupic KF, Six JS, Lesbats C, Rigby SP, Fraissard J, Pavlovskaya GE, Meersmann T.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3164-8. doi: 10.1073/pnas.1600379113. Epub 2016 Mar 9.


Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media.

Jin C, Langston PA, Pavlovskaya GE, Hall MR, Rigby SP.

Phys Rev E. 2016 Jan;93(1):013122. doi: 10.1103/PhysRevE.93.013122. Epub 2016 Jan 19.


Incorporation of Cobalt-Cyclen Complexes into Templated Nanogels Results in Enhanced Activity.

Jorge AR, Chernobryva M, Rigby SE, Watkinson M, Resmini M.

Chemistry. 2016 Mar 7;22(11):3764-74. doi: 10.1002/chem.201503946. Epub 2015 Dec 10.


Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification.

Payne KA, Fisher K, Sjuts H, Dunstan MS, Bellina B, Johannissen L, Barran P, Hay S, Rigby SE, Leys D.

J Biol Chem. 2015 Nov 13;290(46):27572-81. doi: 10.1074/jbc.M115.685693. Epub 2015 Sep 16.


Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations.

Beech KE, Biddlecombe JG, van der Walle CF, Stevens LA, Rigby SP, Burley JC, Allen S.

Eur J Pharm Biopharm. 2015 Oct;96:247-54. doi: 10.1016/j.ejpb.2015.07.029. Epub 2015 Aug 4.


New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.

Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D.

Nature. 2015 Jun 25;522(7557):497-501. doi: 10.1038/nature14560. Epub 2015 Jun 17.


UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis.

White MD, Payne KA, Fisher K, Marshall SA, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Rigby SE, Scrutton NS, Hay S, Leys D.

Nature. 2015 Jun 25;522(7557):502-6. doi: 10.1038/nature14559. Epub 2015 Jun 17.


Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase.

Menon BR, Menon N, Fisher K, Rigby SE, Leys D, Scrutton NS.

FEBS J. 2015 Apr;282(7):1242-55. doi: 10.1111/febs.13215. Epub 2015 Feb 12.


Towards the free energy landscape for catalysis in mammalian nitric oxide synthases.

Leferink NG, Hay S, Rigby SE, Scrutton NS.

FEBS J. 2015 Aug;282(16):3016-29. doi: 10.1111/febs.13171. Epub 2014 Dec 26. Review.


What is the role of general internists in the tertiary or academic setting?

Tanriover MD, Rigby S, van Hulsteijn LH, Ferreira F, Oliveira N, Schumm-Draeger PM, Weidanz F, Kramer MH; Working Group on Professional Issues, European Federation of Internal Medicine (EFIM).

Eur J Intern Med. 2015 Jan;26(1):9-11. doi: 10.1016/j.ejim.2014.11.004. Epub 2014 Dec 2.


Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation.

Payne KA, Quezada CP, Fisher K, Dunstan MS, Collins FA, Sjuts H, Levy C, Hay S, Rigby SE, Leys D.

Nature. 2015 Jan 22;517(7535):513-516. doi: 10.1038/nature13901. Epub 2014 Oct 19.


Flow cytometry is a promising and rapid method for differentiating between freely suspended Escherichia coli and E. coli attached to clay particles.

Liang X, Soupir ML, Rigby S, Jarboe LR, Zhang W.

J Appl Microbiol. 2014 Dec;117(6):1730-9. doi: 10.1111/jam.12660. Epub 2014 Nov 4.


A conformational sampling model for radical catalysis in pyridoxal phosphate- and cobalamin-dependent enzymes.

Menon BR, Fisher K, Rigby SE, Scrutton NS, Leys D.

J Biol Chem. 2014 Dec 5;289(49):34161-74. doi: 10.1074/jbc.M114.590471. Epub 2014 Sep 11.


Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.

Keegan R, Lebedev A, Erskine P, Guo J, Wood SP, Hopper DJ, Rigby SE, Cooper JB.

Acta Crystallogr D Biol Crystallogr. 2014 Sep;70(Pt 9):2444-54. doi: 10.1107/S1399004714015053. Epub 2014 Aug 29.


Implication of a shift in the bioanalytical skills base to the training of new bioanalysts.

Rigby S.

Bioanalysis. 2014;6(12):1577-9. doi: 10.4155/bio.14.137. No abstract available.


FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR).

Lawrence AD, Taylor SL, Scott A, Rowe ML, Johnson CM, Rigby SE, Geeves MA, Pickersgill RW, Howard MJ, Warren MJ.

Biosci Rep. 2014 Jul 4;34(4). pii: e00120. doi: 10.1042/BSR20140060.


Combining mercury thermoporometry with integrated gas sorption and mercury porosimetry to improve accuracy of pore-size distributions for disordered solids.

Bafarawa B, Nepryahin A, Ji L, Holt EM, Wang J, Rigby SP.

J Colloid Interface Sci. 2014 Jul 15;426:72-9. doi: 10.1016/j.jcis.2014.03.053. Epub 2014 Apr 4.


Tissue imprints: assessing their potential for routine biobanking collection.

Greenspan R, O'Donnell A, Meyer J, Kane J, Mamula K, Lubert S, Deyarmin B, Larson C, Rigby S, Greenawalt A, Vatanian N, Mural R, Shriver C, Somiari S.

Biopreserv Biobank. 2013 Dec;11(6):359-65. doi: 10.1089/bio.2013.0030. Epub 2013 Nov 22.


Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: sortase-mediated coupling of copper-64 to a single-chain antibody.

Paterson BM, Alt K, Jeffery CM, Price RI, Jagdale S, Rigby S, Williams CC, Peter K, Hagemeyer CE, Donnelly PS.

Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6115-9. doi: 10.1002/anie.201402613. Epub 2014 Apr 28.


NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles.

Gopinathan N, Yang B, Lowe JP, Edler KJ, Rigby SP.

Int J Pharm. 2014 Jul 20;469(1):146-58. doi: 10.1016/j.ijpharm.2014.04.018. Epub 2014 Apr 12.


Effect of colesevelam HCl monotherapy on lipid particles in type 2 diabetes mellitus.

Rosenson RS, Rigby SP, Jones MR, Chou HS.

Cardiovasc Drugs Ther. 2014 Jun;28(3):229-36. doi: 10.1007/s10557-014-6516-y.


Energy landscapes and catalysis in nitric-oxide synthase.

Sobolewska-Stawiarz A, Leferink NG, Fisher K, Heyes DJ, Hay S, Rigby SE, Scrutton NS.

J Biol Chem. 2014 Apr 25;289(17):11725-38. doi: 10.1074/jbc.M114.548834. Epub 2014 Mar 7.


Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3.

Butler CF, Peet C, McLean KJ, Baynham MT, Blankley RT, Fisher K, Rigby SE, Leys D, Voice MW, Munro AW.

Biochem J. 2014 Jun 1;460(2):247-59. doi: 10.1042/BJ20140030.


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