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Items: 34

1.

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.

Barkholt P, Rigbolt KTG, Falkenhahn M, Hübschle T, Schwahn U, Fernandez-Cachon ML, Schmidt T, Theis S, Hansen HH, Hay-Schmidt A, Pedersen PJ, Vrang N, Jelsing J.

Sci Rep. 2019 Nov 6;9(1):16161. doi: 10.1038/s41598-019-52257-8.

2.

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH.

Roth JD, Veidal SS, Fensholdt LKD, Rigbolt KTG, Papazyan R, Nielsen JC, Feigh M, Vrang N, Young M, Jelsing J, Adorini L, Hansen HH.

Sci Rep. 2019 Jun 21;9(1):9046. doi: 10.1038/s41598-019-45178-z.

3.

Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways.

Kristiansen MNB, Veidal SS, Christoffersen C, Jelsing J, Rigbolt KTG.

Lipids. 2019 Jan;54(1):109-115. doi: 10.1002/lipd.12121. Epub 2019 Feb 5.

PMID:
30723896
4.

Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.

Suppli MP, Rigbolt KTG, Veidal SS, Heebøll S, Eriksen PL, Demant M, Bagger JI, Nielsen JC, Oró D, Thrane SW, Lund A, Strandberg C, Kønig MJ, Vilsbøll T, Vrang N, Thomsen KL, Grønbæk H, Jelsing J, Hansen HH, Knop FK.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G462-G472. doi: 10.1152/ajpgi.00358.2018. Epub 2019 Jan 17.

PMID:
30653341
5.

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis.

Tølbøl KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schönberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A.

Dig Dis Sci. 2019 May;64(5):1238-1256. doi: 10.1007/s10620-018-5395-7. Epub 2018 Dec 3.

6.

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis.

Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M.

World J Gastroenterol. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195.

7.

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M.

World J Gastroenterol. 2018 Jan 14;24(2):179-194. doi: 10.3748/wjg.v24.i2.179.

8.

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.

Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J.

Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28.

PMID:
29289697
9.

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes.

Skarbaliene J, Rigbolt KT, Fosgerau K, Billestrup N.

Eur J Pharmacol. 2017 Nov 15;815:181-189. doi: 10.1016/j.ejphar.2017.09.026. Epub 2017 Sep 18.

PMID:
28928089
10.

Mouse models of nonalcoholic steatohepatitis in preclinical drug development.

Hansen HH, Feigh M, Veidal SS, Rigbolt KT, Vrang N, Fosgerau K.

Drug Discov Today. 2017 Nov;22(11):1707-1718. doi: 10.1016/j.drudis.2017.06.007. Epub 2017 Jul 4. Review.

11.

Degradation of protein translation machinery by amino acid starvation-induced macroautophagy.

Gretzmeier C, Eiselein S, Johnson GR, Engelke R, Nowag H, Zarei M, Küttner V, Becker AC, Rigbolt KTG, Høyer-Hansen M, Andersen JS, Münz C, Murphy RF, Dengjel J.

Autophagy. 2017 Jun 3;13(6):1064-1075. doi: 10.1080/15548627.2016.1274485. Epub 2017 Apr 28.

12.

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.

Diedrich B, Rigbolt KT, Röring M, Herr R, Kaeser-Pebernard S, Gretzmeier C, Murphy RF, Brummer T, Dengjel J.

EMBO J. 2017 Mar 1;36(5):646-663. doi: 10.15252/embj.201694732. Epub 2017 Jan 16.

13.

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy.

Kristiansen MN, Veidal SS, Rigbolt KT, Tølbøl KS, Roth JD, Jelsing J, Vrang N, Feigh M.

World J Hepatol. 2016 Jun 8;8(16):673-84. doi: 10.4254/wjh.v8.i16.673.

14.

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking.

Francavilla C, Papetti M, Rigbolt KT, Pedersen AK, Sigurdsson JO, Cazzamali G, Karemore G, Blagoev B, Olsen JV.

Nat Struct Mol Biol. 2016 Jun;23(6):608-18. doi: 10.1038/nsmb.3218. Epub 2016 May 2.

PMID:
27136326
15.

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake.

Dalbøge LS, Pedersen SL, van Witteloostuijn SB, Rasmussen JE, Rigbolt KT, Jensen KJ, Holst B, Vrang N, Jelsing J.

J Pept Sci. 2015 Feb;21(2):85-94. doi: 10.1002/psc.2727. Epub 2014 Dec 17.

PMID:
25521062
16.

Phosphorylation site dynamics of early T-cell receptor signaling.

Chylek LA, Akimov V, Dengjel J, Rigbolt KT, Hu B, Hlavacek WS, Blagoev B.

PLoS One. 2014 Aug 22;9(8):e104240. doi: 10.1371/journal.pone.0104240. eCollection 2014.

17.

StUbEx: Stable tagged ubiquitin exchange system for the global investigation of cellular ubiquitination.

Akimov V, Henningsen J, Hallenborg P, Rigbolt KT, Jensen SS, Nielsen MM, Kratchmarova I, Blagoev B.

J Proteome Res. 2014 Sep 5;13(9):4192-204. doi: 10.1021/pr500549h. Epub 2014 Aug 15.

PMID:
25093938
18.

Characterization of early autophagy signaling by quantitative phosphoproteomics.

Rigbolt KT, Zarei M, Sprenger A, Becker AC, Diedrich B, Huang X, Eiselein S, Kristensen AR, Gretzmeier C, Andersen JS, Zi Z, Dengjel J.

Autophagy. 2014 Feb;10(2):356-71. doi: 10.4161/auto.26864. Epub 2013 Nov 21.

19.

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy.

Abeliovich H, Zarei M, Rigbolt KT, Youle RJ, Dengjel J.

Nat Commun. 2013;4:2789. doi: 10.1038/ncomms3789.

20.

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Francavilla C, Rigbolt KT, Emdal KB, Carraro G, Vernet E, Bekker-Jensen DB, Streicher W, Wikström M, Sundström M, Bellusci S, Cavallaro U, Blagoev B, Olsen JV.

Mol Cell. 2013 Sep 26;51(6):707-22. doi: 10.1016/j.molcel.2013.08.002. Epub 2013 Sep 5.

21.

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.

Halbach S, Rigbolt KT, Wöhrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J.

Cell Commun Signal. 2013 Apr 22;11(1):30. doi: 10.1186/1478-811X-11-30.

22.

Global remodelling of cellular microenvironment due to loss of collagen VII.

Küttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J.

Mol Syst Biol. 2013 Apr 16;9:657. doi: 10.1038/msb.2013.17.

23.

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.

Müller PJ, Rigbolt KT, Paterok D, Piehler J, Vanselow J, Lasonder E, Andersen JS, Schaper F, Sobota RM.

J Proteomics. 2013 Jun 12;84:132-47. doi: 10.1016/j.jprot.2013.04.005. Epub 2013 Apr 11.

PMID:
23584145
24.

Quantitative phosphoproteomics to characterize signaling networks.

Rigbolt KT, Blagoev B.

Semin Cell Dev Biol. 2012 Oct;23(8):863-71. doi: 10.1016/j.semcdb.2012.05.006. Epub 2012 Jun 5. Review.

PMID:
22677334
25.

Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.

Akimov V, Rigbolt KT, Nielsen MM, Blagoev B.

Mol Biosyst. 2011 Dec;7(12):3223-33. doi: 10.1039/c1mb05185g. Epub 2011 Sep 28.

PMID:
21956701
26.

GProX, a user-friendly platform for bioinformatics analysis and visualization of quantitative proteomics data.

Rigbolt KT, Vanselow JT, Blagoev B.

Mol Cell Proteomics. 2011 Aug;10(8):O110.007450. doi: 10.1074/mcp.O110.007450. Epub 2011 May 20.

27.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B.

Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570.

28.

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

Broemer M, Tenev T, Rigbolt KT, Hempel S, Blagoev B, Silke J, Ditzel M, Meier P.

Mol Cell. 2010 Dec 10;40(5):810-22. doi: 10.1016/j.molcel.2010.11.011.

29.

Proteome-wide quantitation by SILAC.

Rigbolt KT, Blagoev B.

Methods Mol Biol. 2010;658:187-204. doi: 10.1007/978-1-60761-780-8_11.

PMID:
20839105
30.

Dynamics of the skeletal muscle secretome during myoblast differentiation.

Henningsen J, Rigbolt KT, Blagoev B, Pedersen BK, Kratchmarova I.

Mol Cell Proteomics. 2010 Nov;9(11):2482-96. doi: 10.1074/mcp.M110.002113. Epub 2010 Jul 14.

31.

GABAB receptor constituents revealed by tandem affinity purification from transgenic mice.

Bartoi T, Rigbolt KT, Du D, Köhr G, Blagoev B, Kornau HC.

J Biol Chem. 2010 Jul 2;285(27):20625-33. doi: 10.1074/jbc.M109.049700. Epub 2010 Apr 20.

32.

MSQuant, an open source platform for mass spectrometry-based quantitative proteomics.

Mortensen P, Gouw JW, Olsen JV, Ong SE, Rigbolt KT, Bunkenborg J, Cox J, Foster LJ, Heck AJ, Blagoev B, Andersen JS, Mann M.

J Proteome Res. 2010 Jan;9(1):393-403. doi: 10.1021/pr900721e.

PMID:
19888749
33.

Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells.

Prokhorova TA, Rigbolt KT, Johansen PT, Henningsen J, Kratchmarova I, Kassem M, Blagoev B.

Mol Cell Proteomics. 2009 May;8(5):959-70. doi: 10.1074/mcp.M800287-MCP200. Epub 2009 Jan 17.

34.

Inactivation of effector caspases through nondegradative polyubiquitylation.

Ditzel M, Broemer M, Tenev T, Bolduc C, Lee TV, Rigbolt KT, Elliott R, Zvelebil M, Blagoev B, Bergmann A, Meier P.

Mol Cell. 2008 Nov 21;32(4):540-53. doi: 10.1016/j.molcel.2008.09.025.

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