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Items: 43


Editorial: Podocytes as Active Participants in Lupus Nephritis.

Rifkin IR, Bonegio RG.

Arthritis Rheumatol. 2017 Aug;69(8):1517-1520. doi: 10.1002/art.40157. Epub 2017 Jun 30. No abstract available.


TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM.

J Exp Med. 2017 May 1;214(5):1297-1311. doi: 10.1084/jem.20161141. Epub 2017 Apr 11.


Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.

Das A, Heesters BA, Bialas A, O'Flynn J, Rifkin IR, Ochando J, Mittereder N, Carlesso G, Herbst R, Carroll MC.

Immunity. 2017 Jan 17;46(1):106-119. doi: 10.1016/j.immuni.2016.12.014.


Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model.

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G 3rd, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR.

Arthritis Rheumatol. 2015 Dec;67(12):3146-57. doi: 10.1002/art.39321.


The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.

Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR.

Int J Parasitol. 2015 Mar;45(4):203-7. doi: 10.1016/j.ijpara.2014.12.006. Epub 2015 Feb 7.


IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.

Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR.

J Immunol. 2015 Feb 15;194(4):1467-79. doi: 10.4049/jimmunol.1402807. Epub 2015 Jan 16.


CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin.

Mathes AL, Rice L, Affandi AJ, DiMarzio M, Rifkin IR, Stifano G, Christmann RB, Lafyatis R.

Exp Dermatol. 2015 Feb;24(2):133-9. doi: 10.1111/exd.12603. Epub 2015 Jan 12.


Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways.

Ericson JA, Duffau P, Yasuda K, Ortiz-Lopez A, Rothamel K, Rifkin IR, Monach PA; ImmGen Consortium.

PLoS One. 2014 Oct 3;9(10):e108553. doi: 10.1371/journal.pone.0108553. eCollection 2014.


Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.

Yasuda K, Watkins AA, Kochar GS, Wilson GE, Laskow B, Richez C, Bonegio RG, Rifkin IR.

PLoS One. 2014 Jul 30;9(7):e103478. doi: 10.1371/journal.pone.0103478. eCollection 2014.


Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus.

Watkins AA, Bonegio RG, Rifkin IR.

Methods Mol Biol. 2014;1169:143-58. doi: 10.1007/978-1-4939-0882-0_14.


Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus.

Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR.

Immunology. 2014 Jul;142(3):363-73. doi: 10.1111/imm.12256.


The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus.

Richez C, Richards RJ, Duffau P, Weitzner Z, Andry CD, Rifkin IR, Aprahamian T.

PLoS One. 2013;8(4):e61042. doi: 10.1371/journal.pone.0061042. Epub 2013 Apr 8.


Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.

Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR.

Int Immunol. 2013 May;25(5):295-306. doi: 10.1093/intimm/dxs114. Epub 2013 Jan 4.


Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis.

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R.

J Invest Dermatol. 2010 Nov;130(11):2583-93. doi: 10.1038/jid.2010.200. Epub 2010 Jul 8.


IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.

Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2010 Jan 15;184(2):796-806. doi: 10.4049/jimmunol.0901748. Epub 2009 Dec 9.


Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes.

Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2009 Sep 1;183(5):3109-17. doi: 10.4049/jimmunol.0900399. Epub 2009 Jul 31.


Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A.

J Immunol. 2009 Aug 1;183(3):1569-76. doi: 10.4049/jimmunol.0803899. Epub 2009 Jul 8.


DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo.

Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A.

Arthritis Res Ther. 2009;11(3):R79. doi: 10.1186/ar2710. Epub 2009 May 28.


TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.

Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR.

J Immunol. 2009 Jan 15;182(2):820-8.


The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin.

Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR.

J Immunol. 2009 Jan 1;182(1):340-6.


Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.

Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2007 Jun 1;178(11):6876-85.


DNA and RNA autoantigens as autoadjuvants.

Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A.

J Endotoxin Res. 2006;12(6):379-84.


A 57-year-old woman with recently diagnosed SLE, proteinuria, and microhematuria.

Bijol V, Agrawal N, Abernethy VE, Rifkin IR, Nosé V, Rennke HG.

Am J Kidney Dis. 2006 Dec;48(6):1004-8. No abstract available.


Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.

Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K.

J Immunol. 2006 Sep 1;177(5):3028-34.


B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells.

Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2006 Jul 1;177(1):45-52.


Lupus nephritis.

Agrawal N, Chiang LK, Rifkin IR.

Semin Nephrol. 2006 Mar;26(2):95-104. Review.


RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A.

J Exp Med. 2005 Nov 7;202(9):1171-7. Epub 2005 Oct 31.


Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A.

Immunol Rev. 2005 Apr;204:27-42. Review.


Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells.

Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR.

J Endotoxin Res. 2004;10(4):247-51.


The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity.

Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA.

Rheum Dis Clin North Am. 2004 Aug;30(3):559-74, ix. Review.


Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR.

J Exp Med. 2004 Jun 21;199(12):1631-40. Epub 2004 Jun 14.


T-bet: the Toll-bridge to class-switch recombination?

Rifkin IR, Marshak-Rothstein A.

Nat Immunol. 2003 Jul;4(7):650-2. No abstract available.


Toll-like receptors and activation of autoreactive B cells.

Leadbetter EA, Rifkin IR, Marshak-Rothstein A.

Curr Dir Autoimmun. 2003;6:105-22. Review. No abstract available.


Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.

Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A.

Nature. 2002 Apr 11;416(6881):603-7.


Fas and Fas ligand in autoimmunity.

Rifkin IR, Marshak-Rothstein A.

Curr Dir Autoimmun. 1999;1:31-55. Review. No abstract available.


Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells.

Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A.

J Immunol. 2000 Aug 1;165(3):1626-33.


Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha.

Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC.

J Immunol. 1998 Nov 15;161(10):5164-70.


Rhabdomyolysis associated with lithium-induced hyperosmolal state.

Bateman AM, Larner AJ, McCartney SA, Rifkin IR.

Nephrol Dial Transplant. 1991;6(3):203-5. No abstract available.


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