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Items: 1 to 50 of 265

1.

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome.

Korneva A, Zilberberg L, Rifkin DB, Humphrey JD, Bellini C.

Biomech Model Mechanobiol. 2019 Feb;18(1):261-273. doi: 10.1007/s10237-018-1080-1. Epub 2018 Oct 10.

PMID:
30306291
2.

LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections.

Guo DC, Regalado ES, Pinard A, Chen J, Lee K, Rigelsky C, Zilberberg L, Hostetler EM, Aldred M, Wallace SE, Prakash SK; University of Washington Center for Mendelian Genomics, Leal SM, Bamshad MJ, Nickerson DA, Natowicz M, Rifkin DB, Milewicz DM.

Am J Hum Genet. 2018 Apr 5;102(4):706-712. doi: 10.1016/j.ajhg.2018.03.002.

3.

LTBPs in biology and medicine: LTBP diseases.

Rifkin DB, Rifkin WJ, Zilberberg L.

Matrix Biol. 2018 Oct;71-72:90-99. doi: 10.1016/j.matbio.2017.11.014. Epub 2017 Dec 5. Review.

PMID:
29217273
4.

Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.

Bellini C, Bersi MR, Caulk AW, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD.

J R Soc Interface. 2017 May;14(130). pii: 20161036. doi: 10.1098/rsif.2016.1036.

5.

Enamel and dental anomalies in latent-transforming growth factor beta-binding protein 3 mutant mice.

Morkmued S, Hemmerle J, Mathieu E, Laugel-Haushalter V, Dabovic B, Rifkin DB, Dollé P, Niederreither K, Bloch-Zupan A.

Eur J Oral Sci. 2017 Feb;125(1):8-17. doi: 10.1111/eos.12328.

6.

Latent TGF-β binding protein-1 deficiency decreases female fertility.

Dietzel E, Weiskirchen S, Floehr J, Horiguchi M, Todorovic V, Rifkin DB, Jahnen-Dechent W, Weiskirchen R.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1387-1392. doi: 10.1016/j.bbrc.2016.12.046. Epub 2016 Dec 9.

PMID:
27956181
7.

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.

Robertson IB, Rifkin DB.

Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6). pii: a021907. doi: 10.1101/cshperspect.a021907. Review.

8.

Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome.

Bellini C, Korneva A, Zilberberg L, Ramirez F, Rifkin DB, Humphrey JD.

J Biomech. 2016 Aug 16;49(12):2383-2389. doi: 10.1016/j.jbiomech.2015.11.059. Epub 2015 Dec 22.

9.

The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas.

Recouvreux MV, Camilletti MA, Rifkin DB, Díaz-Torga G.

J Endocrinol. 2016 Mar;228(3):R73-83. doi: 10.1530/JOE-15-0451. Epub 2015 Dec 23. Review.

10.

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.

Zilberberg L, Phoon CK, Robertson I, Dabovic B, Ramirez F, Rifkin DB.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14012-7. doi: 10.1073/pnas.1507652112. Epub 2015 Oct 22.

11.

L(59) TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice.

Hara M, Inoue I, Yamazaki Y, Kirita A, Matsuura T, Friedman SL, Rifkin DB, Kojima S.

Fibrogenesis Tissue Repair. 2015 Sep 15;8:17. doi: 10.1186/s13069-015-0034-9. eCollection 2015.

12.

Latent TGF-β-binding proteins.

Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB.

Matrix Biol. 2015 Sep;47:44-53. doi: 10.1016/j.matbio.2015.05.005. Epub 2015 May 8. Review.

13.

Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal.

Horiguchi M, Todorovic V, Hadjiolova K, Weiskirchen R, Rifkin DB.

Matrix Biol. 2015 Apr;43:61-70. doi: 10.1016/j.matbio.2015.03.006. Epub 2015 Mar 21.

14.

Isolation and cytokine analysis of lamina propria lymphocytes from mucosal biopsies of the human colon.

Bowcutt R, Malter LB, Chen LA, Wolff MJ, Robertson I, Rifkin DB, Poles M, Cho I, Loke P.

J Immunol Methods. 2015 Jun;421:27-35. doi: 10.1016/j.jim.2015.02.012. Epub 2015 Mar 10.

15.

Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta.

Huckert M, Stoetzel C, Morkmued S, Laugel-Haushalter V, Geoffroy V, Muller J, Clauss F, Prasad MK, Obry F, Raymond JL, Switala M, Alembik Y, Soskin S, Mathieu E, Hemmerlé J, Weickert JL, Dabovic BB, Rifkin DB, Dheedene A, Boudin E, Caluseriu O, Cholette MC, Mcleod R, Antequera R, Gellé MP, Coeuriot JL, Jacquelin LF, Bailleul-Forestier I, Manière MC, Van Hul W, Bertola D, Dollé P, Verloes A, Mortier G, Dollfus H, Bloch-Zupan A.

Hum Mol Genet. 2015 Jun 1;24(11):3038-49. doi: 10.1093/hmg/ddv053. Epub 2015 Feb 10.

16.

Mechanisms of tendon injury and repair.

Thomopoulos S, Parks WC, Rifkin DB, Derwin KA.

J Orthop Res. 2015 Jun;33(6):832-9. doi: 10.1002/jor.22806. Epub 2015 Mar 2. Review.

17.

Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development.

Dabovic B, Robertson IB, Zilberberg L, Vassallo M, Davis EC, Rifkin DB.

J Cell Physiol. 2015 Jan;230(1):226-36. doi: 10.1002/jcp.24704.

18.

LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis.

Hara M, Kirita A, Kondo W, Matsuura T, Nagatsuma K, Dohmae N, Ogawa S, Imajoh-Ohmi S, Friedman SL, Rifkin DB, Kojima S.

Springerplus. 2014 May 1;3:221. doi: 10.1186/2193-1801-3-221. eCollection 2014.

19.

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation.

Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE, Rifkin DB, McGrath JA, Fässler R.

Nat Med. 2014 Apr;20(4):350-9. doi: 10.1038/nm.3490. Epub 2014 Mar 30.

20.

Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue.

Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB.

Cancer Res. 2014 May 1;74(9):2642-51. doi: 10.1158/0008-5472.CAN-13-3404. Epub 2014 Mar 3.

21.

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature.

Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D.

Surg Neurol Int. 2014 Jan 21;5:8. doi: 10.4103/2152-7806.125629. eCollection 2014.

22.

Sex differences in the pituitary transforming growth factor-β1 system: studies in a model of resistant prolactinomas.

Recouvreux MV, Lapyckyj L, Camilletti MA, Guida MC, Ornstein A, Rifkin DB, Becu-Villalobos D, Díaz-Torga G.

Endocrinology. 2013 Nov;154(11):4192-205. doi: 10.1210/en.2013-1433. Epub 2013 Sep 5.

23.

Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation.

Robertson IB, Rifkin DB.

Cytokine Growth Factor Rev. 2013 Aug;24(4):355-72. doi: 10.1016/j.cytogfr.2013.06.003. Epub 2013 Jul 12. Review.

24.

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR.

Science. 2013 Jun 21;340(6139):1456-9. doi: 10.1126/science.1237013. Epub 2013 May 9.

25.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2852-7. doi: 10.1073/pnas.1215779110. Epub 2013 Feb 4.

26.

Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation.

Shibahara K, Ota M, Horiguchi M, Yoshinaga K, Melamed J, Rifkin DB.

Cancer Res. 2013 Jan 1;73(1):459-68. doi: 10.1158/0008-5472.CAN-12-3141. Epub 2012 Nov 1.

27.

Matrix control of transforming growth factor-β function.

Horiguchi M, Ota M, Rifkin DB.

J Biochem. 2012 Oct;152(4):321-9. Epub 2012 Aug 24. Review.

28.

Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1).

Recouvreux MV, Camilletti MA, Rifkin DB, Becu-Villalobos D, Díaz-Torga G.

Endocrinology. 2012 Aug;153(8):3861-71. doi: 10.1210/en.2012-1007. Epub 2012 Jun 14.

29.

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin.

Zilberberg L, Todorovic V, Dabovic B, Horiguchi M, Couroussé T, Sakai LY, Rifkin DB.

J Cell Physiol. 2012 Dec;227(12):3828-36. doi: 10.1002/jcp.24094.

30.

Is losartan the drug for all seasons?

Ramirez F, Rifkin DB.

Curr Opin Pharmacol. 2012 Apr;12(2):223-4. doi: 10.1016/j.coph.2012.02.007. Epub 2012 Mar 21. No abstract available.

31.

An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment.

Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian LM, Lynch CC.

PLoS One. 2012;7(1):e29862. doi: 10.1371/journal.pone.0029862. Epub 2012 Jan 4.

32.

LTBPs, more than just an escort service.

Todorovic V, Rifkin DB.

J Cell Biochem. 2012 Feb;113(2):410-8. doi: 10.1002/jcb.23385. Review.

33.

Active and total transforming growth factor-β1 are differentially regulated by dopamine and estradiol in the pituitary.

Recouvreux MV, Guida MC, Rifkin DB, Becu-Villalobos D, Díaz-Torga G.

Endocrinology. 2011 Jul;152(7):2722-30. doi: 10.1210/en.2010-1464. Epub 2011 Apr 26.

34.

Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development.

Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB.

Dev Dyn. 2011 Jan;240(1):176-87. doi: 10.1002/dvdy.22521.

35.

Control of lung development by latent TGF-β binding proteins.

Dabovic B, Chen Y, Choi J, Davis EC, Sakai LY, Todorovic V, Vassallo M, Zilberberg L, Singh A, Rifkin DB.

J Cell Physiol. 2011 Jun;226(6):1499-509. doi: 10.1002/jcp.22479.

36.

Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome.

Nistala H, Lee-Arteaga S, Carta L, Cook JR, Smaldone S, Siciliano G, Rifkin AN, Dietz HC, Rifkin DB, Ramirez F.

Hum Mol Genet. 2010 Dec 15;19(24):4790-8. doi: 10.1093/hmg/ddq409. Epub 2010 Sep 24. Erratum in: Hum Mol Genet. 2014 Nov 15;23(22):6137.

37.

Bone matrix to growth factors: location, location, location.

Rifkin DB, Todorovic V.

J Cell Biol. 2010 Sep 20;190(6):949-51. doi: 10.1083/jcb.201008116.

38.

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.

Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B.

J Clin Invest. 2010 Jul;120(7):2474-85. doi: 10.1172/JCI42150. Epub 2010 Jun 7.

39.

Microfibril structure masks fibrillin-2 in postnatal tissues.

Charbonneau NL, Jordan CD, Keene DR, Lee-Arteaga S, Dietz HC, Rifkin DB, Ramirez F, Sakai LY.

J Biol Chem. 2010 Jun 25;285(26):20242-51. doi: 10.1074/jbc.M109.087031. Epub 2010 Apr 19.

40.

Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development.

Urban Z, Hucthagowder V, Schürmann N, Todorovic V, Zilberberg L, Choi J, Sens C, Brown CW, Clark RD, Holland KE, Marble M, Sakai LY, Dabovic B, Rifkin DB, Davis EC.

Am J Hum Genet. 2009 Nov;85(5):593-605. doi: 10.1016/j.ajhg.2009.09.013. Epub 2009 Oct 15.

41.

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.

Ramirez F, Rifkin DB.

Curr Opin Cell Biol. 2009 Oct;21(5):616-22. doi: 10.1016/j.ceb.2009.05.005. Epub 2009 Jun 12. Review.

42.

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bächinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY.

J Biol Chem. 2009 Jun 19;284(25):16872-81. doi: 10.1074/jbc.M809348200. Epub 2009 Apr 6.

43.

p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice.

Carta L, Smaldone S, Zilberberg L, Loch D, Dietz HC, Rifkin DB, Ramirez F.

J Biol Chem. 2009 Feb 27;284(9):5630-6. doi: 10.1074/jbc.M806962200. Epub 2008 Dec 24.

44.

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Zhou Y, Koli K, Hagood JS, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE.

Am J Pathol. 2009 Jan;174(1):21-33. doi: 10.2353/ajpath.2009.080620. Epub 2008 Dec 4.

45.

Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors.

Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18758-63. doi: 10.1073/pnas.0805411105. Epub 2008 Nov 20.

46.

Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity.

Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB.

J Cell Physiol. 2009 Apr;219(1):14-22. doi: 10.1002/jcp.21643.

47.

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.

Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR.

Cell Host Microbe. 2008 Oct 16;4(4):337-49. doi: 10.1016/j.chom.2008.09.009.

48.

F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.

Attur MG, Palmer GD, Al-Mussawir HE, Dave M, Teixeira CC, Rifkin DB, Appleton CT, Beier F, Abramson SB.

FASEB J. 2009 Jan;23(1):79-89. doi: 10.1096/fj.08-114363. Epub 2008 Sep 9. Erratum in: FASEB J. 2009 Aug;23(8):2790.

49.

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS.

Blood. 2008 Nov 1;112(9):3650-60. doi: 10.1182/blood-2008-04-151753. Epub 2008 Jun 10.

50.

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix.

Wipff PJ, Rifkin DB, Meister JJ, Hinz B.

J Cell Biol. 2007 Dec 17;179(6):1311-23.

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