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Items: 1 to 50 of 209

1.

Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae.

Haribowo AG, Hannich JT, Michel AH, Megyeri M, Schuldiner M, Kornmann B, Riezman H.

Mol Biol Cell. 2019 Oct 15;30(22):2814-2826. doi: 10.1091/mbc.E19-07-0364. Epub 2019 Sep 11.

PMID:
31509475
2.

Author Correction: Understanding the diversity of membrane lipid composition.

Harayama T, Riezman H.

Nat Rev Mol Cell Biol. 2019 Sep 5. doi: 10.1038/s41580-019-0171-x. [Epub ahead of print]

PMID:
31488897
3.

Luciferase-Induced Photouncaging: Bioluminolysis.

Chang D, Lindberg E, Feng S, Angerani S, Riezman H, Winssinger N.

Angew Chem Int Ed Engl. 2019 Sep 3. doi: 10.1002/anie.201907734. [Epub ahead of print]

PMID:
31478317
4.

On the road to unraveling the molecular functions of ether lipids.

Jiménez-Rojo N, Riezman H.

FEBS Lett. 2019 Sep;593(17):2378-2389. doi: 10.1002/1873-3468.13465. Epub 2019 Jun 13. Review.

PMID:
31166014
5.

Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity.

Megyeri M, Prasad R, Volpert G, Sliwa-Gonzalez A, Haribowo AG, Aguilera-Romero A, Riezman H, Barral Y, Futerman AH, Schuldiner M.

J Cell Sci. 2019 Jun 24;132(12). pii: jcs228411. doi: 10.1242/jcs.228411.

6.

Vesicular and non-vesicular lipid export from the ER to the secretory pathway.

Funato K, Riezman H, Muñiz M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May 2. pii: S1388-1981(19)30066-6. doi: 10.1016/j.bbalip.2019.04.013. [Epub ahead of print] Review.

PMID:
31054928
7.

Optical control of sphingosine-1-phosphate formation and function.

Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D.

Nat Chem Biol. 2019 Jun;15(6):623-631. doi: 10.1038/s41589-019-0269-7. Epub 2019 Apr 29.

PMID:
31036923
8.

Sphingolipids and membrane targets for therapeutics.

Loewith R, Riezman H, Winssinger N.

Curr Opin Chem Biol. 2019 Jun;50:19-28. doi: 10.1016/j.cbpa.2019.02.015. Epub 2019 Mar 18. Review.

PMID:
30897494
9.

Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures.

Feng S, Harayama T, Chang D, Hannich JT, Winssinger N, Riezman H.

Chem Sci. 2018 Dec 26;10(8):2253-2258. doi: 10.1039/c8sc03614d. eCollection 2019 Feb 28.

10.

A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons.

Sundukova M, Prifti E, Bucci A, Kirillova K, Serrao J, Reymond L, Umebayashi M, Hovius R, Riezman H, Johnsson K, Heppenstall PA.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2341-2344. doi: 10.1002/anie.201812967. Epub 2019 Jan 25.

11.

Macrophages release plasma membrane-derived particles rich in accessible cholesterol.

He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8499-E8508. doi: 10.1073/pnas.1810724115. Epub 2018 Aug 20.

12.

Lysophospholipids Facilitate COPII Vesicle Formation.

Melero A, Chiaruttini N, Karashima T, Riezman I, Funato K, Barlowe C, Riezman H, Roux A.

Curr Biol. 2018 Jun 18;28(12):1950-1958.e6. doi: 10.1016/j.cub.2018.04.076. Epub 2018 Jun 7.

13.

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.

Perrin L, Loizides-Mangold U, Chanon S, Gobet C, Hulo N, Isenegger L, Weger BD, Migliavacca E, Charpagne A, Betts JA, Walhin JP, Templeman I, Stokes K, Thompson D, Tsintzas K, Robert M, Howald C, Riezman H, Feige JN, Karagounis LG, Johnston JD, Dermitzakis ET, Gachon F, Lefai E, Dibner C.

Elife. 2018 Apr 16;7. pii: e34114. doi: 10.7554/eLife.34114.

14.

Understanding the diversity of membrane lipid composition.

Harayama T, Riezman H.

Nat Rev Mol Cell Biol. 2018 May;19(5):281-296. doi: 10.1038/nrm.2017.138. Epub 2018 Feb 7. Review. Erratum in: Nat Rev Mol Cell Biol. 2019 Sep 5;:.

PMID:
29410529
15.

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function.

Feng S, Harayama T, Montessuit S, David FP, Winssinger N, Martinou JC, Riezman H.

Elife. 2018 Jan 29;7. pii: e34555. doi: 10.7554/eLife.34555.

16.

Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.

Kawano S, Tamura Y, Kojima R, Bala S, Asai E, Michel AH, Kornmann B, Riezman I, Riezman H, Sakae Y, Okamoto Y, Endo T.

J Cell Biol. 2018 Mar 5;217(3):959-974. doi: 10.1083/jcb.201704119. Epub 2017 Dec 26.

17.

mTORC2 Promotes Tumorigenesis via Lipid Synthesis.

Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P, Heim MH, Riezman I, Riezman H, Hall MN.

Cancer Cell. 2017 Dec 11;32(6):807-823.e12. doi: 10.1016/j.ccell.2017.11.011.

18.

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.

Loizides-Mangold U, Perrin L, Vandereycken B, Betts JA, Walhin JP, Templeman I, Chanon S, Weger BD, Durand C, Robert M, Paz Montoya J, Moniatte M, Karagounis LG, Johnston JD, Gachon F, Lefai E, Riezman H, Dibner C.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8565-E8574. doi: 10.1073/pnas.1705821114. Epub 2017 Sep 25.

19.

Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.

Shinde AB, Baboota RK, Denis S, Loizides-Mangold U, Peeters A, Espeel M, Malheiro AR, Riezman H, Vinckier S, Vaz FM, Brites P, Ferdinandusse S, Van Veldhoven PP, Baes M.

Mitochondrion. 2018 Mar;39:51-59. doi: 10.1016/j.mito.2017.08.013. Epub 2017 Sep 1.

PMID:
28866057
20.

The SAGA complex, together with transcription factors and the endocytic protein Rvs167p, coordinates the reprofiling of gene expression in response to changes in sterol composition in Saccharomyces cerevisiae.

Dewhurst-Maridor G, Abegg D, David FPA, Rougemont J, Scott CC, Adibekian A, Riezman H.

Mol Biol Cell. 2017 Oct 1;28(20):2637-2649. doi: 10.1091/mbc.E17-03-0169. Epub 2017 Aug 2.

21.

Membrane Phosphoproteomics of Yeast Early Response to Acetic Acid: Role of Hrk1 Kinase and Lipid Biosynthetic Pathways, in Particular Sphingolipids.

Guerreiro JF, Mira NP, Santos AXS, Riezman H, Sá-Correia I.

Front Microbiol. 2017 Jul 12;8:1302. doi: 10.3389/fmicb.2017.01302. eCollection 2017.

22.

Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens.

Dorsaz S, Snäkä T, Favre-Godal Q, Maudens P, Boulens N, Furrer P, Ebrahimi SN, Hamburger M, Allémann E, Gindro K, Queiroz EF, Riezman H, Wolfender JL, Sanglard D.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00829-17. doi: 10.1128/AAC.00829-17. Print 2017 Sep.

23.

Detection of genome-edited mutant clones by a simple competition-based PCR method.

Harayama T, Riezman H.

PLoS One. 2017 Jun 6;12(6):e0179165. doi: 10.1371/journal.pone.0179165. eCollection 2017.

24.

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network.

Capasso S, Sticco L, Rizzo R, Pirozzi M, Russo D, Dathan NA, Campelo F, van Galen J, Hölttä-Vuori M, Turacchio G, Hausser A, Malhotra V, Riezman I, Riezman H, Ikonen E, Luberto C, Parashuraman S, Luini A, D'Angelo G.

EMBO J. 2017 Jun 14;36(12):1736-1754. doi: 10.15252/embj.201696048. Epub 2017 May 10.

25.

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans.

Hannich JT, Mellal D, Feng S, Zumbuehl A, Riezman H.

Chem Sci. 2017 May 1;8(5):3676-3686. doi: 10.1039/c6sc04831e. Epub 2017 Mar 6.

26.

TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy.

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM.

Cell Rep. 2017 Feb 21;18(8):2073-2074. doi: 10.1016/j.celrep.2017.02.020. No abstract available.

27.

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.

Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F.

J Clin Invest. 2017 Mar 1;127(3):912-928. doi: 10.1172/JCI89626. Epub 2017 Feb 6.

28.

Making Sense of the Yeast Sphingolipid Pathway.

Megyeri M, Riezman H, Schuldiner M, Futerman AH.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4765-4775. doi: 10.1016/j.jmb.2016.09.010. Epub 2016 Sep 21. Review.

PMID:
27664439
29.

Limited ER quality control for GPI-anchored proteins.

Sikorska N, Lemus L, Aguilera-Romero A, Manzano-Lopez J, Riezman H, Muñiz M, Goder V.

J Cell Biol. 2016 Jun 20;213(6):693-704. doi: 10.1083/jcb.201602010.

30.

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism.

Savoglidis G, da Silveira Dos Santos AX, Riezman I, Angelino P, Riezman H, Hatzimanikatis V.

Metab Eng. 2016 Sep;37:46-62. doi: 10.1016/j.ymben.2016.04.002. Epub 2016 Apr 23.

31.

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.

Alfonso-García A, Pfisterer SG, Riezman H, Ikonen E, Potma EO.

J Biomed Opt. 2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.

32.

Intracellular sphingosine releases calcium from lysosomes.

Höglinger D, Haberkant P, Aguilera-Romero A, Riezman H, Porter FD, Platt FM, Galione A, Schultz C.

Elife. 2015 Nov 27;4. pii: e10616. doi: 10.7554/eLife.10616.

33.

Trafficking of glycosylphosphatidylinositol anchored proteins from the endoplasmic reticulum to the cell surface.

Muñiz M, Riezman H.

J Lipid Res. 2016 Mar;57(3):352-60. doi: 10.1194/jlr.R062760. Epub 2015 Oct 8. Review.

34.

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U, Riezman H, Bittman R, Ikonen E.

Nat Chem Biol. 2015 Oct;11(10):799-806. doi: 10.1038/nchembio.1889. Epub 2015 Aug 17.

PMID:
26280656
35.

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour.

Frechin M, Stoeger T, Daetwyler S, Gehin C, Battich N, Damm EM, Stergiou L, Riezman H, Pelkmans L.

Nature. 2015 Jul 2;523(7558):88-91. doi: 10.1038/nature14429. Epub 2015 May 25.

PMID:
26009010
36.

The SwissLipids knowledgebase for lipid biology.

Aimo L, Liechti R, Hyka-Nouspikel N, Niknejad A, Gleizes A, Götz L, Kuznetsov D, David FP, van der Goot FG, Riezman H, Bougueleret L, Xenarios I, Bridge A.

Bioinformatics. 2015 Sep 1;31(17):2860-6. doi: 10.1093/bioinformatics/btv285. Epub 2015 May 5.

37.

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae.

Suresh HG, da Silveira Dos Santos AX, Kukulski W, Tyedmers J, Riezman H, Bukau B, Mogk A.

Mol Biol Cell. 2015 May 1;26(9):1601-15. doi: 10.1091/mbc.E14-11-1559. Epub 2015 Mar 11.

38.

COPII coat composition is actively regulated by luminal cargo maturation.

Manzano-Lopez J, Perez-Linero AM, Aguilera-Romero A, Martin ME, Okano T, Silva DV, Seeberger PH, Riezman H, Funato K, Goder V, Wellinger RE, Muñiz M.

Curr Biol. 2015 Jan 19;25(2):152-162. doi: 10.1016/j.cub.2014.11.039. Epub 2014 Dec 31.

39.

HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis.

Loizides-Mangold U, Clément S, Alfonso-Garcia A, Branche E, Conzelmann S, Parisot C, Potma EO, Riezman H, Negro F.

PLoS One. 2014 Dec 18;9(12):e115309. doi: 10.1371/journal.pone.0115309. eCollection 2014.

40.

Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae.

Wilson-Zbinden C, dos Santos AX, Stoffel-Studer I, van der Vaart A, Hofmann K, Reggiori F, Riezman H, Kraft C, Peter M.

Genetics. 2015 Feb;199(2):475-85. doi: 10.1534/genetics.114.169797. Epub 2014 Dec 17.

41.

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.

da Silveira Dos Santos AX, Riezman I, Aguilera-Romero MA, David F, Piccolis M, Loewith R, Schaad O, Riezman H.

Mol Biol Cell. 2014 Oct 15;25(20):3234-46. doi: 10.1091/mbc.E14-03-0851. Epub 2014 Aug 20.

42.

Synthetic multivalent antifungal peptides effective against fungi.

Lakshminarayanan R, Liu S, Li J, Nandhakumar M, Aung TT, Goh E, Chang JY, Saraswathi P, Tang C, Safie SR, Lin LY, Riezman H, Lei Z, Verma CS, Beuerman RW.

PLoS One. 2014 Feb 3;9(2):e87730. doi: 10.1371/journal.pone.0087730. eCollection 2014.

43.

A fluorogenic probe for SNAP-tagged plasma membrane proteins based on the solvatochromic molecule Nile Red.

Prifti E, Reymond L, Umebayashi M, Hovius R, Riezman H, Johnsson K.

ACS Chem Biol. 2014 Mar 21;9(3):606-12. doi: 10.1021/cb400819c. Epub 2014 Jan 29.

44.

The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum.

Cohen Y, Megyeri M, Chen OC, Condomitti G, Riezman I, Loizides-Mangold U, Abdul-Sada A, Rimon N, Riezman H, Platt FM, Futerman AH, Schuldiner M.

PLoS One. 2013 Dec 31;8(12):e85519. doi: 10.1371/journal.pone.0085519. eCollection 2013.

45.

TORC1 inhibits GSK3-mediated Elo2 phosphorylation to regulate very long chain fatty acid synthesis and autophagy.

Zimmermann C, Santos A, Gable K, Epstein S, Gururaj C, Chymkowitch P, Pultz D, Rødkær SV, Clay L, Bjørås M, Barral Y, Chang A, Færgeman NJ, Dunn TM, Riezman H, Enserink JM.

Cell Rep. 2013 Nov 27;5(4):1036-46. doi: 10.1016/j.celrep.2013.10.024. Epub 2013 Nov 14. Erratum in: Cell Rep. 2017 Feb 21;18(8):2073-2074.

46.

Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast.

Kajiwara K, Ikeda A, Aguilera-Romero A, Castillon GA, Kagiwada S, Hanada K, Riezman H, Muñiz M, Funato K.

J Cell Sci. 2014 Jan 15;127(Pt 2):376-87. doi: 10.1242/jcs.132001. Epub 2013 Nov 8.

47.

Sphingolipid homeostasis in the web of metabolic routes.

Aguilera-Romero A, Gehin C, Riezman H.

Biochim Biophys Acta. 2014 May;1841(5):647-56. doi: 10.1016/j.bbalip.2013.10.014. Epub 2013 Nov 1. Review.

PMID:
24184514
48.

The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids.

Ding J, Loizides-Mangold U, Rando G, Zoete V, Michielin O, Reddy JK, Wahli W, Riezman H, Thorens B.

Cell Rep. 2013 Oct 17;5(1):248-58. doi: 10.1016/j.celrep.2013.08.032. Epub 2013 Sep 26.

49.

Lipidomic profiling of Saccharomyces cerevisiae and Zygosaccharomyces bailii reveals critical changes in lipid composition in response to acetic acid stress.

Lindberg L, Santos AX, Riezman H, Olsson L, Bettiga M.

PLoS One. 2013 Sep 4;8(9):e73936. doi: 10.1371/journal.pone.0073936. eCollection 2013.

50.

Dynamic amphiphile libraries to screen for the "fragrant" delivery of siRNA into HeLa cells and human primary fibroblasts.

Gehin C, Montenegro J, Bang EK, Cajaraville A, Takayama S, Hirose H, Futaki S, Matile S, Riezman H.

J Am Chem Soc. 2013 Jun 26;135(25):9295-8. doi: 10.1021/ja404153m. Epub 2013 Jun 14.

PMID:
23767803

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