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Items: 1 to 50 of 204

1.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.

Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaau6722. doi: 10.1126/scitranslmed.aau6722.

PMID:
31167929
2.

Functional Amyloids.

Otzen D, Riek R.

Cold Spring Harb Perspect Biol. 2019 May 14. pii: a033860. doi: 10.1101/cshperspect.a033860. [Epub ahead of print]

PMID:
31088827
3.

Probing Ion Binding in the Selectivity Filter of the KcsA Potassium Channel.

Eichmann C, Frey L, Maslennikov I, Riek R.

J Am Chem Soc. 2019 May 8;141(18):7391-7398. doi: 10.1021/jacs.9b01092. Epub 2019 Apr 29.

PMID:
30973010
4.

Rational Structure-Based Design of Fluorescent Probes for Amyloid Folds.

Orts J, Aulikki Wälti M, Ghosh D, Campioni S, Saupe SJ, Riek R.

Chembiochem. 2019 May 2;20(9):1161-1166. doi: 10.1002/cbic.201800664. Epub 2019 Mar 7.

PMID:
30548150
5.

Cooperative Induction of Ordered Peptide and Fatty Acid Aggregates.

Bomba R, Kwiatkowski W, Sánchez-Ferrer A, Riek R, Greenwald J.

Biophys J. 2018 Dec 18;115(12):2336-2347. doi: 10.1016/j.bpj.2018.10.031. Epub 2018 Nov 10.

PMID:
30503535
6.

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins.

Jemth P, Karlsson E, Vögeli B, Guzovsky B, Andersson E, Hultqvist G, Dogan J, Güntert P, Riek R, Chi CN.

Sci Adv. 2018 Oct 24;4(10):eaau4130. doi: 10.1126/sciadv.aau4130. eCollection 2018 Oct.

7.

15N transverse relaxation measurements for the characterization of µs-ms dynamics are deteriorated by the deuterium isotope effect on 15N resulting from solvent exchange.

Kumari P, Frey L, Sobol A, Lakomek NA, Riek R.

J Biomol NMR. 2018 Dec;72(3-4):125-137. doi: 10.1007/s10858-018-0211-4. Epub 2018 Oct 10.

PMID:
30306288
8.

Lipid- and Cholesterol-Mediated Time-Scale-Specific Modulation of the Outer Membrane Protein X Dynamics in Lipid Bilayers.

Frey L, Hiller S, Riek R, Bibow S.

J Am Chem Soc. 2018 Nov 14;140(45):15402-15411. doi: 10.1021/jacs.8b09188. Epub 2018 Oct 23.

9.

Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402.

10.

Peptide Amyloids in the Origin of Life.

Greenwald J, Kwiatkowski W, Riek R.

J Mol Biol. 2018 Oct 12;430(20):3735-3750. doi: 10.1016/j.jmb.2018.05.046. Epub 2018 Jun 8. Review.

PMID:
29890117
11.

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.

Seuring C, Ayyer K, Filippaki E, Barthelmess M, Longchamp JN, Ringler P, Pardini T, Wojtas DH, Coleman MA, Dörner K, Fuglerud S, Hammarin G, Habenstein B, Langkilde AE, Loquet A, Meents A, Riek R, Stahlberg H, Boutet S, Hunter MS, Koglin J, Liang M, Ginn HM, Millane RP, Frank M, Barty A, Chapman HN.

Nat Commun. 2018 May 9;9(1):1836. doi: 10.1038/s41467-018-04116-9.

12.

Quantitative mass imaging of single biological macromolecules.

Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA, Tkachenko O, Allen J, Crispin M, Billington N, Takagi Y, Sellers JR, Eichmann C, Selenko P, Frey L, Riek R, Galpin MR, Struwe WB, Benesch JLP, Kukura P.

Science. 2018 Apr 27;360(6387):423-427. doi: 10.1126/science.aar5839.

13.

A prebiotic template-directed peptide synthesis based on amyloids.

Rout SK, Friedmann MP, Riek R, Greenwald J.

Nat Commun. 2018 Jan 16;9(1):234. doi: 10.1038/s41467-017-02742-3.

14.

NOE-Derived Methyl Distances from a 360 kDa Proteasome Complex.

Chi CN, Strotz D, Riek R, Vögeli B.

Chemistry. 2018 Feb 9;24(9):2270-2276. doi: 10.1002/chem.201705551. Epub 2018 Jan 17.

PMID:
29265588
15.

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH.

ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4.

PMID:
29178774
16.

Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR.

Meier BH, Riek R, Böckmann A.

Trends Biochem Sci. 2017 Oct;42(10):777-787. doi: 10.1016/j.tibs.2017.08.001. Epub 2017 Sep 12. Review.

PMID:
28916413
17.

Proton-Detected NMR Spectroscopy of Nanodisc-Embedded Membrane Proteins: MAS Solid-State vs Solution-State Methods.

Lakomek NA, Frey L, Bibow S, Böckmann A, Riek R, Meier BH.

J Phys Chem B. 2017 Aug 17;121(32):7671-7680. doi: 10.1021/acs.jpcb.7b06944. Epub 2017 Aug 8.

PMID:
28737919
18.

eNORA2 Exact NOE Analysis Program.

Strotz D, Orts J, Chi CN, Riek R, Vögeli B.

J Chem Theory Comput. 2017 Sep 12;13(9):4336-4346. doi: 10.1021/acs.jctc.7b00436. Epub 2017 Aug 3.

PMID:
28727914
19.

Lipid Internal Dynamics Probed in Nanodiscs.

Martinez D, Decossas M, Kowal J, Frey L, Stahlberg H, Dufourc EJ, Riek R, Habenstein B, Bibow S, Loquet A.

Chemphyschem. 2017 Oct 6;18(19):2651-2657. doi: 10.1002/cphc.201700450. Epub 2017 Jun 30.

20.

Fast NMR-Based Determination of the 3D Structure of the Binding Site of Protein-Ligand Complexes with Weak Affinity Binders.

Wälti MA, Riek R, Orts J.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5208-5211. doi: 10.1002/anie.201612304. Epub 2017 Apr 7.

PMID:
28387455
21.

Quenched hydrogen-deuterium exchange NMR of a disease-relevant Aβ(1-42) amyloid polymorph.

Wälti MA, Orts J, Riek R.

PLoS One. 2017 Mar 20;12(3):e0172862. doi: 10.1371/journal.pone.0172862. eCollection 2017.

22.

Structures of the First Extracellular Domain of CRF Receptors.

Zelenay V, Perrin M, Riek R.

Curr Mol Pharmacol. 2017;10(4):318-324. doi: 10.2174/1874467210666170110120301. Review.

PMID:
28103782
23.

Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different.

Seuring C, Verasdonck J, Ringler P, Cadalbert R, Stahlberg H, Böckmann A, Meier BH, Riek R.

J Phys Chem B. 2017 Mar 2;121(8):1783-1792. doi: 10.1021/acs.jpcb.6b10624. Epub 2017 Feb 20.

PMID:
28075583
24.

High-density lipoprotein-like particle formation of Synuclein variants.

Eichmann C, Kumari P, Riek R.

FEBS Lett. 2017 Jan;591(2):304-311. doi: 10.1002/1873-3468.12543. Epub 2017 Jan 18.

25.

Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.

Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R.

Nat Struct Mol Biol. 2017 Feb;24(2):187-193. doi: 10.1038/nsmb.3345. Epub 2016 Dec 26.

PMID:
28024148
26.

More than a Rumor Spreads in Parkinson's Disease.

Prymaczok NC, Riek R, Gerez J.

Front Hum Neurosci. 2016 Dec 2;10:608. eCollection 2016. Review.

27.

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ.

Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19.

28.

Micelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics.

Frey L, Lakomek NA, Riek R, Bibow S.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):380-383. doi: 10.1002/anie.201608246. Epub 2016 Nov 24.

PMID:
27882643
29.

The activities of amyloids from a structural perspective.

Riek R, Eisenberg DS.

Nature. 2016 Nov 10;539(7628):227-235. doi: 10.1038/nature20416. Review.

PMID:
27830791
30.

The Three-Dimensional Structures of Amyloids.

Riek R.

Cold Spring Harb Perspect Biol. 2017 Feb 1;9(2). pii: a023572. doi: 10.1101/cshperspect.a023572. Review.

31.

The Neurite Outgrowth Inhibitory Nogo-A-Δ20 Region Is an Intrinsically Disordered Segment Harbouring Three Stretches with Helical Propensity.

Zelenay V, Arzt ME, Bibow S, Schwab ME, Riek R.

PLoS One. 2016 Sep 9;11(9):e0161813. doi: 10.1371/journal.pone.0161813. eCollection 2016.

32.

Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions.

Greenwald J, Friedmann MP, Riek R.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11609-13. doi: 10.1002/anie.201605321. Epub 2016 Aug 11.

33.

The Dynamic Basis for Signal Propagation in Human Pin1-WW.

Olsson S, Strotz D, Vögeli B, Riek R, Cavalli A.

Structure. 2016 Sep 6;24(9):1464-75. doi: 10.1016/j.str.2016.06.013. Epub 2016 Aug 4.

34.

S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.

Eichmann C, Tzitzilonis C, Nakamura T, Kwiatkowski W, Maslennikov I, Choe S, Lipton SA, Riek R.

J Mol Biol. 2016 Sep 25;428(19):3737-51. doi: 10.1016/j.jmb.2016.07.010. Epub 2016 Jul 27.

35.

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.

Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4976-84. doi: 10.1073/pnas.1600749113. Epub 2016 Jul 28.

36.

The HET-S/s Prion Motif in the Control of Programmed Cell Death.

Riek R, Saupe SJ.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a023515. doi: 10.1101/cshperspect.a023515. Review.

37.

Solid-state NMR sequential assignment of an Amyloid-β(1-42) fibril polymorph.

Ravotti F, Wälti MA, Güntert P, Riek R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Oct;10(2):269-76. doi: 10.1007/s12104-016-9682-y. Epub 2016 May 10.

PMID:
27165577
38.

Solid-state NMR sequential assignment of the β-endorphin peptide in its amyloid form.

Seuring C, Gath J, Verasdonck J, Cadalbert R, Rivier J, Böckmann A, Meier BH, Riek R.

Biomol NMR Assign. 2016 Oct;10(2):259-68. doi: 10.1007/s12104-016-9681-z. Epub 2016 May 10.

PMID:
27165576
39.

NMR-Based Determination of the 3D Structure of the Ligand-Protein Interaction Site without Protein Resonance Assignment.

Orts J, Wälti MA, Marsh M, Vera L, Gossert AD, Güntert P, Riek R.

J Am Chem Soc. 2016 Apr 6;138(13):4393-400. doi: 10.1021/jacs.5b12391. Epub 2016 Mar 23.

PMID:
26943491
40.

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles.

Eichmann C, Campioni S, Kowal J, Maslennikov I, Gerez J, Liu X, Verasdonck J, Nespovitaya N, Choe S, Meier BH, Picotti P, Rizo J, Stahlberg H, Riek R.

J Biol Chem. 2016 Apr 15;291(16):8516-27. doi: 10.1074/jbc.M115.707968. Epub 2016 Feb 4.

41.

The Exact NOE as an Alternative in Ensemble Structure Determination.

Vögeli B, Olsson S, Güntert P, Riek R.

Biophys J. 2016 Jan 5;110(1):113-26. doi: 10.1016/j.bpj.2015.11.031.

42.

Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils.

Nespovitaya N, Gath J, Barylyuk K, Seuring C, Meier BH, Riek R.

J Am Chem Soc. 2016 Jan 27;138(3):846-56. doi: 10.1021/jacs.5b08694. Epub 2016 Jan 13.

PMID:
26699104
43.

Towards Prebiotic Catalytic Amyloids Using High Throughput Screening.

Friedmann MP, Torbeev V, Zelenay V, Sobol A, Greenwald J, Riek R.

PLoS One. 2015 Dec 9;10(12):e0143948. doi: 10.1371/journal.pone.0143948. eCollection 2015.

44.

Compiled data set of exact NOE distance limits, residual dipolar couplings and scalar couplings for the protein GB3.

Vögeli B, Olsson S, Riek R, Güntert P.

Data Brief. 2015 Sep 4;5:99-106. doi: 10.1016/j.dib.2015.08.020. eCollection 2015 Dec.

45.

Uncovering the Mechanism of Aggregation of Human Transthyretin.

Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS.

J Biol Chem. 2015 Nov 27;290(48):28932-43. doi: 10.1074/jbc.M115.659912. Epub 2015 Oct 12.

46.

A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution.

Chi CN, Vögeli B, Bibow S, Strotz D, Orts J, Güntert P, Riek R.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11657-61. doi: 10.1002/anie.201503698. Epub 2015 Aug 10.

PMID:
26265096
47.

Complementarity and congruence between exact NOEs and traditional NMR probes for spatial decoding of protein dynamics.

Vögeli B, Olsson S, Riek R, Güntert P.

J Struct Biol. 2015 Sep;191(3):306-17. doi: 10.1016/j.jsb.2015.07.008. Epub 2015 Jul 20.

PMID:
26206511
48.

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation.

Ghosh D, Singh PK, Sahay S, Jha NN, Jacob RS, Sen S, Kumar A, Riek R, Maji SK.

Sci Rep. 2015 Mar 18;5:9228. doi: 10.1038/srep09228.

49.

Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals.

Chi CN, Strotz D, Riek R, Vögeli B.

J Biomol NMR. 2015 May;62(1):63-9. doi: 10.1007/s10858-015-9917-8. Epub 2015 Mar 8.

PMID:
25749872
50.

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.

Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU.

Mol Cell. 2015 Mar 19;57(6):1011-1021. doi: 10.1016/j.molcel.2015.01.026. Epub 2015 Feb 26.

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