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Items: 1 to 50 of 211

1.

Neurodegenerative diseases distinguished through protein-structure analysis.

Gerez JA, Riek R.

Nature. 2020 Feb;578(7794):223-224. doi: 10.1038/d41586-020-00131-3. No abstract available.

PMID:
32042086
2.

Atto Thio 12 as a promising dye for photo-CIDNP.

Sobol A, Torres F, Aicher A, Renn A, Riek R.

J Chem Phys. 2019 Dec 21;151(23):234201. doi: 10.1063/1.5128575.

PMID:
31864237
3.

Carbonyl Sulfide as a Prebiotic Activation Agent for Stereo- and Sequence-Selective, Amyloid-Templated Peptide Elongation.

Bomba R, Rout SK, Bütikofer M, Kwiatkowski W, Riek R, Greenwald J.

Orig Life Evol Biosph. 2019 Dec;49(4):213-224. doi: 10.1007/s11084-019-09586-5. Epub 2019 Dec 16.

PMID:
31845164
4.

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Guerrero-Ferreira R, Taylor NM, Arteni AA, Kumari P, Mona D, Ringler P, Britschgi M, Lauer ME, Makky A, Verasdonck J, Riek R, Melki R, Meier BH, Böckmann A, Bousset L, Stahlberg H.

Elife. 2019 Dec 9;8. pii: e48907. doi: 10.7554/eLife.48907.

5.

Regulation of α-synuclein by chaperones in mammalian cells.

Burmann BM, Gerez JA, Matečko-Burmann I, Campioni S, Kumari P, Ghosh D, Mazur A, Aspholm EE, Šulskis D, Wawrzyniuk M, Bock T, Schmidt A, Rüdiger SGD, Riek R, Hiller S.

Nature. 2020 Jan;577(7788):127-132. doi: 10.1038/s41586-019-1808-9. Epub 2019 Dec 4.

PMID:
31802003
6.

Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity.

Soste M, Charmpi K, Lampert F, Gerez JA, van Oostrum M, Malinovska L, Boersema PJ, Prymaczok NC, Riek R, Peter M, Vanni S, Beyer A, Picotti P.

Cell Syst. 2019 Sep 25;9(3):309-320.e8. doi: 10.1016/j.cels.2019.07.010. Epub 2019 Sep 11.

7.

Nuclear Magnetic Resonance Solution Structure and Functional Behavior of the Human Proton Channel.

Bayrhuber M, Maslennikov I, Kwiatkowski W, Sobol A, Wierschem C, Eichmann C, Frey L, Riek R.

Biochemistry. 2019 Oct 1;58(39):4017-4027. doi: 10.1021/acs.biochem.9b00471. Epub 2019 Sep 21.

8.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.

Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaau6722. doi: 10.1126/scitranslmed.aau6722.

PMID:
31167929
9.

Functional Amyloids.

Otzen D, Riek R.

Cold Spring Harb Perspect Biol. 2019 Dec 2;11(12). pii: a033860. doi: 10.1101/cshperspect.a033860. Review.

PMID:
31088827
10.

Probing Ion Binding in the Selectivity Filter of the KcsA Potassium Channel.

Eichmann C, Frey L, Maslennikov I, Riek R.

J Am Chem Soc. 2019 May 8;141(18):7391-7398. doi: 10.1021/jacs.9b01092. Epub 2019 Apr 29.

PMID:
30973010
11.

Rational Structure-Based Design of Fluorescent Probes for Amyloid Folds.

Orts J, Aulikki Wälti M, Ghosh D, Campioni S, Saupe SJ, Riek R.

Chembiochem. 2019 May 2;20(9):1161-1166. doi: 10.1002/cbic.201800664. Epub 2019 Mar 7.

PMID:
30548150
12.

Cooperative Induction of Ordered Peptide and Fatty Acid Aggregates.

Bomba R, Kwiatkowski W, Sánchez-Ferrer A, Riek R, Greenwald J.

Biophys J. 2018 Dec 18;115(12):2336-2347. doi: 10.1016/j.bpj.2018.10.031. Epub 2018 Nov 10.

13.

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins.

Jemth P, Karlsson E, Vögeli B, Guzovsky B, Andersson E, Hultqvist G, Dogan J, Güntert P, Riek R, Chi CN.

Sci Adv. 2018 Oct 24;4(10):eaau4130. doi: 10.1126/sciadv.aau4130. eCollection 2018 Oct.

14.

15N transverse relaxation measurements for the characterization of µs-ms dynamics are deteriorated by the deuterium isotope effect on 15N resulting from solvent exchange.

Kumari P, Frey L, Sobol A, Lakomek NA, Riek R.

J Biomol NMR. 2018 Dec;72(3-4):125-137. doi: 10.1007/s10858-018-0211-4. Epub 2018 Oct 10.

PMID:
30306288
15.

Lipid- and Cholesterol-Mediated Time-Scale-Specific Modulation of the Outer Membrane Protein X Dynamics in Lipid Bilayers.

Frey L, Hiller S, Riek R, Bibow S.

J Am Chem Soc. 2018 Nov 14;140(45):15402-15411. doi: 10.1021/jacs.8b09188. Epub 2018 Oct 23.

16.

Cryo-EM structure of alpha-synuclein fibrils.

Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H.

Elife. 2018 Jul 3;7. pii: e36402. doi: 10.7554/eLife.36402.

17.

Peptide Amyloids in the Origin of Life.

Greenwald J, Kwiatkowski W, Riek R.

J Mol Biol. 2018 Oct 12;430(20):3735-3750. doi: 10.1016/j.jmb.2018.05.046. Epub 2018 Jun 8. Review.

PMID:
29890117
18.

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.

Seuring C, Ayyer K, Filippaki E, Barthelmess M, Longchamp JN, Ringler P, Pardini T, Wojtas DH, Coleman MA, Dörner K, Fuglerud S, Hammarin G, Habenstein B, Langkilde AE, Loquet A, Meents A, Riek R, Stahlberg H, Boutet S, Hunter MS, Koglin J, Liang M, Ginn HM, Millane RP, Frank M, Barty A, Chapman HN.

Nat Commun. 2018 May 9;9(1):1836. doi: 10.1038/s41467-018-04116-9.

19.

Quantitative mass imaging of single biological macromolecules.

Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA, Tkachenko O, Allen J, Crispin M, Billington N, Takagi Y, Sellers JR, Eichmann C, Selenko P, Frey L, Riek R, Galpin MR, Struwe WB, Benesch JLP, Kukura P.

Science. 2018 Apr 27;360(6387):423-427. doi: 10.1126/science.aar5839.

20.

A prebiotic template-directed peptide synthesis based on amyloids.

Rout SK, Friedmann MP, Riek R, Greenwald J.

Nat Commun. 2018 Jan 16;9(1):234. doi: 10.1038/s41467-017-02742-3.

21.

NOE-Derived Methyl Distances from a 360 kDa Proteasome Complex.

Chi CN, Strotz D, Riek R, Vögeli B.

Chemistry. 2018 Feb 9;24(9):2270-2276. doi: 10.1002/chem.201705551. Epub 2018 Jan 17.

PMID:
29265588
22.

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH.

ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4.

PMID:
29178774
23.

Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR.

Meier BH, Riek R, Böckmann A.

Trends Biochem Sci. 2017 Oct;42(10):777-787. doi: 10.1016/j.tibs.2017.08.001. Epub 2017 Sep 12. Review.

PMID:
28916413
24.

Proton-Detected NMR Spectroscopy of Nanodisc-Embedded Membrane Proteins: MAS Solid-State vs Solution-State Methods.

Lakomek NA, Frey L, Bibow S, Böckmann A, Riek R, Meier BH.

J Phys Chem B. 2017 Aug 17;121(32):7671-7680. doi: 10.1021/acs.jpcb.7b06944. Epub 2017 Aug 8.

PMID:
28737919
25.

eNORA2 Exact NOE Analysis Program.

Strotz D, Orts J, Chi CN, Riek R, Vögeli B.

J Chem Theory Comput. 2017 Sep 12;13(9):4336-4346. doi: 10.1021/acs.jctc.7b00436. Epub 2017 Aug 3.

PMID:
28727914
26.

Lipid Internal Dynamics Probed in Nanodiscs.

Martinez D, Decossas M, Kowal J, Frey L, Stahlberg H, Dufourc EJ, Riek R, Habenstein B, Bibow S, Loquet A.

Chemphyschem. 2017 Oct 6;18(19):2651-2657. doi: 10.1002/cphc.201700450. Epub 2017 Jun 30.

27.

Fast NMR-Based Determination of the 3D Structure of the Binding Site of Protein-Ligand Complexes with Weak Affinity Binders.

Wälti MA, Riek R, Orts J.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5208-5211. doi: 10.1002/anie.201612304. Epub 2017 Apr 7.

PMID:
28387455
28.

Quenched hydrogen-deuterium exchange NMR of a disease-relevant Aβ(1-42) amyloid polymorph.

Wälti MA, Orts J, Riek R.

PLoS One. 2017 Mar 20;12(3):e0172862. doi: 10.1371/journal.pone.0172862. eCollection 2017.

29.

Structures of the First Extracellular Domain of CRF Receptors.

Zelenay V, Perrin M, Riek R.

Curr Mol Pharmacol. 2017;10(4):318-324. doi: 10.2174/1874467210666170110120301. Review.

PMID:
28103782
30.

Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different.

Seuring C, Verasdonck J, Ringler P, Cadalbert R, Stahlberg H, Böckmann A, Meier BH, Riek R.

J Phys Chem B. 2017 Mar 2;121(8):1783-1792. doi: 10.1021/acs.jpcb.6b10624. Epub 2017 Feb 20.

PMID:
28075583
31.

High-density lipoprotein-like particle formation of Synuclein variants.

Eichmann C, Kumari P, Riek R.

FEBS Lett. 2017 Jan;591(2):304-311. doi: 10.1002/1873-3468.12543. Epub 2017 Jan 18.

32.

Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.

Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R.

Nat Struct Mol Biol. 2017 Feb;24(2):187-193. doi: 10.1038/nsmb.3345. Epub 2016 Dec 26.

PMID:
28024148
33.

More than a Rumor Spreads in Parkinson's Disease.

Prymaczok NC, Riek R, Gerez J.

Front Hum Neurosci. 2016 Dec 2;10:608. eCollection 2016. Review.

34.

Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.

Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ.

Nat Chem Biol. 2017 Feb;13(2):235-242. doi: 10.1038/nchembio.2266. Epub 2016 Dec 19.

35.

Micelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics.

Frey L, Lakomek NA, Riek R, Bibow S.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):380-383. doi: 10.1002/anie.201608246. Epub 2016 Nov 24.

36.

The activities of amyloids from a structural perspective.

Riek R, Eisenberg DS.

Nature. 2016 Nov 10;539(7628):227-235. doi: 10.1038/nature20416. Review.

PMID:
27830791
37.

The Three-Dimensional Structures of Amyloids.

Riek R.

Cold Spring Harb Perspect Biol. 2017 Feb 1;9(2). pii: a023572. doi: 10.1101/cshperspect.a023572. Review.

38.

The Neurite Outgrowth Inhibitory Nogo-A-Δ20 Region Is an Intrinsically Disordered Segment Harbouring Three Stretches with Helical Propensity.

Zelenay V, Arzt ME, Bibow S, Schwab ME, Riek R.

PLoS One. 2016 Sep 9;11(9):e0161813. doi: 10.1371/journal.pone.0161813. eCollection 2016.

39.

Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions.

Greenwald J, Friedmann MP, Riek R.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11609-13. doi: 10.1002/anie.201605321. Epub 2016 Aug 11.

40.

The Dynamic Basis for Signal Propagation in Human Pin1-WW.

Olsson S, Strotz D, Vögeli B, Riek R, Cavalli A.

Structure. 2016 Sep 6;24(9):1464-75. doi: 10.1016/j.str.2016.06.013. Epub 2016 Aug 4.

41.

S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.

Eichmann C, Tzitzilonis C, Nakamura T, Kwiatkowski W, Maslennikov I, Choe S, Lipton SA, Riek R.

J Mol Biol. 2016 Sep 25;428(19):3737-51. doi: 10.1016/j.jmb.2016.07.010. Epub 2016 Jul 27.

42.

Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.

Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4976-84. doi: 10.1073/pnas.1600749113. Epub 2016 Jul 28.

43.

The HET-S/s Prion Motif in the Control of Programmed Cell Death.

Riek R, Saupe SJ.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a023515. doi: 10.1101/cshperspect.a023515. Review.

44.

Solid-state NMR sequential assignment of an Amyloid-β(1-42) fibril polymorph.

Ravotti F, Wälti MA, Güntert P, Riek R, Böckmann A, Meier BH.

Biomol NMR Assign. 2016 Oct;10(2):269-76. doi: 10.1007/s12104-016-9682-y. Epub 2016 May 10.

PMID:
27165577
45.

Solid-state NMR sequential assignment of the β-endorphin peptide in its amyloid form.

Seuring C, Gath J, Verasdonck J, Cadalbert R, Rivier J, Böckmann A, Meier BH, Riek R.

Biomol NMR Assign. 2016 Oct;10(2):259-68. doi: 10.1007/s12104-016-9681-z. Epub 2016 May 10.

PMID:
27165576
46.

NMR-Based Determination of the 3D Structure of the Ligand-Protein Interaction Site without Protein Resonance Assignment.

Orts J, Wälti MA, Marsh M, Vera L, Gossert AD, Güntert P, Riek R.

J Am Chem Soc. 2016 Apr 6;138(13):4393-400. doi: 10.1021/jacs.5b12391. Epub 2016 Mar 23.

PMID:
26943491
47.

Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles.

Eichmann C, Campioni S, Kowal J, Maslennikov I, Gerez J, Liu X, Verasdonck J, Nespovitaya N, Choe S, Meier BH, Picotti P, Rizo J, Stahlberg H, Riek R.

J Biol Chem. 2016 Apr 15;291(16):8516-27. doi: 10.1074/jbc.M115.707968. Epub 2016 Feb 4.

48.

The Exact NOE as an Alternative in Ensemble Structure Determination.

Vögeli B, Olsson S, Güntert P, Riek R.

Biophys J. 2016 Jan 5;110(1):113-26. doi: 10.1016/j.bpj.2015.11.031.

49.

Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils.

Nespovitaya N, Gath J, Barylyuk K, Seuring C, Meier BH, Riek R.

J Am Chem Soc. 2016 Jan 27;138(3):846-56. doi: 10.1021/jacs.5b08694. Epub 2016 Jan 13.

PMID:
26699104
50.

Towards Prebiotic Catalytic Amyloids Using High Throughput Screening.

Friedmann MP, Torbeev V, Zelenay V, Sobol A, Greenwald J, Riek R.

PLoS One. 2015 Dec 9;10(12):e0143948. doi: 10.1371/journal.pone.0143948. eCollection 2015.

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