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Items: 1 to 50 of 362

1.

NO /RUNX3/Kynurenine Metabolic Signaling Enhances Disease Aggressiveness in Pancreatic Cancer.

Wang L, Tang W, Yang S, He P, Wang J, Gaedcke J, Strobel P, Azizian A, Ried T, Gaida MM, Yfantis HG, Lee DH, Lal A, Van den Eynde BJ, Alexander HR, Ghadimi BM, Hanna N, Hussain SP.

Int J Cancer. 2019 Oct 14. doi: 10.1002/ijc.32733. [Epub ahead of print]

PMID:
31609478
2.

Bile acid-induced "Minority MOMP" promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1.

Xu Y, Surman DR, Diggs L, Xi S, Gao S, Gurusamy D, McLoughlin K, Drake J, Feingold P, Brown K, Wangsa D, Wangsa D, Zhang X, Ried T, Davis JL, Hernandez J, Hoang C, Souza RF, Schrump DS, Taylor Ripley R.

Oncogene. 2019 Sep 30. doi: 10.1038/s41388-019-1029-6. [Epub ahead of print]

PMID:
31570787
3.

The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome.

Ried T, Meijer GA, Harrison DJ, Grech G, Franch-Expósito S, Briffa R, Carvalho B, Camps J.

Mol Aspects Med. 2019 Oct;69:48-61. doi: 10.1016/j.mam.2019.07.007. Epub 2019 Aug 6. Review.

4.

Genome-wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine-phosphate-guanine methylation and histological subtypes.

Fiedler D, Hirsch D, El Hajj N, Yang HH, Hu Y, Sticht C, Nanda I, Belle S, Rueschoff J, Lee MP, Ried T, Haaf T, Gaiser T.

Genes Chromosomes Cancer. 2019 Nov;58(11):783-797. doi: 10.1002/gcc.22787. Epub 2019 Aug 10.

PMID:
31334584
5.

Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.

Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casadesús M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T.

Neoplasia. 2019 Jul;21(7):721-729. doi: 10.1016/j.neo.2019.04.009. Epub 2019 Jun 4.

6.

Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression.

Braun R, Ronquist S, Wangsa D, Chen H, Anthuber L, Gemoll T, Wangsa D, Koparde V, Hunn C, Habermann JK, Heselmeyer-Haddad K, Rajapakse I, Ried T.

Neoplasia. 2019 Apr;21(4):401-412. doi: 10.1016/j.neo.2019.02.003. Epub 2019 Mar 22.

7.

Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts.

Póti Á, Berta K, Xiao Y, Pipek O, Klus GT, Ried T, Csabai I, Wilcoxen K, Mikule K, Szallasi Z, Szüts D.

Br J Cancer. 2018 Nov;119(11):1392-1400. doi: 10.1038/s41416-018-0312-6. Epub 2018 Nov 14.

8.

Quantitative analysis of somatically acquired and constitutive uniparental disomy in gastrointestinal cancers.

Torabi K, Erola P, Alvarez-Mora MI, Díaz-Gay M, Ferrer Q, Castells A, Castellví-Bel S, Milà M, Lozano JJ, Miró R, Ried T, Ponsa I, Camps J.

Int J Cancer. 2019 Feb 1;144(3):513-524. doi: 10.1002/ijc.31936. Epub 2018 Dec 3.

9.

Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence.

Fiedler D, Heselmeyer-Haddad K, Hirsch D, Hernandez LS, Torres I, Wangsa D, Hu Y, Zapata L, Rueschoff J, Belle S, Ried T, Gaiser T.

Int J Cancer. 2019 Apr 1;144(7):1561-1573. doi: 10.1002/ijc.31869. Epub 2018 Dec 11.

PMID:
30229897
10.

Trac-looping measures genome structure and chromatin accessibility.

Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K.

Nat Methods. 2018 Sep;15(9):741-747. doi: 10.1038/s41592-018-0107-y. Epub 2018 Aug 27.

PMID:
30150754
11.

Effects of human sex chromosome dosage on spatial chromosome organization.

Jowhar Z, Shachar S, Gudla PR, Wangsa D, Torres E, Russ JL, Pegoraro G, Ried T, Raznahan A, Misteli T.

Mol Biol Cell. 2018 Oct 1;29(20):2458-2469. doi: 10.1091/mbc.E18-06-0359. Epub 2018 Aug 9.

12.

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V.

Mol Cell. 2018 Jul 5;71(1):129-141.e8. doi: 10.1016/j.molcel.2018.06.008.

13.

Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.

Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T.

Clin Cancer Res. 2018 Oct 15;24(20):4997-5011. doi: 10.1158/1078-0432.CCR-18-0630. Epub 2018 Jul 2.

14.

Sex-chromosome dosage effects on gene expression in humans.

Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7398-7403. doi: 10.1073/pnas.1802889115. Epub 2018 Jun 26.

15.

The Evolution of Single Cell-derived Colorectal Cancer Cell Lines is Dominated by the Continued Selection of Tumor Specific Genomic Imbalances, Despite Random Chromosomal Instability.

Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T.

Carcinogenesis. 2018 May 23. doi: 10.1093/carcin/bgy068. [Epub ahead of print]

16.

Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.

Hu G, Cui K, Fang D, Hirose S, Wang X, Wangsa D, Jin W, Ried T, Liu P, Zhu J, Rothenberg EV, Zhao K.

Immunity. 2018 Feb 20;48(2):227-242.e8. doi: 10.1016/j.immuni.2018.01.013.

17.

Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness.

Wangsa D, Quintanilla I, Torabi K, Vila-Casadesús M, Ercilla A, Klus G, Yuce Z, Galofré C, Cuatrecasas M, Lozano JJ, Agell N, Cimini D, Castells A, Ried T, Camps J.

FASEB J. 2018 Jul;32(7):3502-3517. doi: 10.1096/fj.201700247RR. Epub 2018 Feb 8.

18.

HiCTMap: Detection and analysis of chromosome territory structure and position by high-throughput imaging.

Jowhar Z, Gudla PR, Shachar S, Wangsa D, Russ JL, Pegoraro G, Ried T, Raznahan A, Misteli T.

Methods. 2018 Jun 1;142:30-38. doi: 10.1016/j.ymeth.2018.01.013. Epub 2018 Feb 10.

19.

Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.

Oltmann J, Heselmeyer-Haddad K, Hernandez LS, Meyer R, Torres I, Hu Y, Doberstein N, Killian JK, Petersen D, Zhu YJ, Edelman DC, Meltzer PS, Schwartz R, Gertz EM, Schäffer AA, Auer G, Habermann JK, Ried T.

Genes Chromosomes Cancer. 2018 Apr;57(4):165-175. doi: 10.1002/gcc.22515. Epub 2018 Jan 9.

20.

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery.

Hu Y, Gaedcke J, Emons G, Beissbarth T, Grade M, Jo P, Yeager M, Chanock SJ, Wolff H, Camps J, Ghadimi BM, Ried T.

Genes Chromosomes Cancer. 2018 Mar;57(3):140-149. doi: 10.1002/gcc.22512. Epub 2017 Nov 28.

21.

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

Rausch V, Krieg A, Camps J, Behrens B, Beier M, Wangsa D, Heselmeyer-Haddad K, Baldus SE, Knoefel WT, Ried T, Stoecklein NH.

BMC Res Notes. 2017 Nov 6;10(1):560. doi: 10.1186/s13104-017-2886-0.

22.

SMYD5 Controls Heterochromatin and Chromosome Integrity during Embryonic Stem Cell Differentiation.

Kidder BL, He R, Wangsa D, Padilla-Nash HM, Bernardo MM, Sheng S, Ried T, Zhao K.

Cancer Res. 2017 Dec 1;77(23):6729-6745. doi: 10.1158/0008-5472.CAN-17-0828. Epub 2017 Sep 26.

23.

Trichostatin A preferentially reverses the upregulation of gene-expression levels induced by gain of chromosome 7 in colorectal cancer cell lines.

Buishand FO, Cardin E, Hu Y, Ried T.

Genes Chromosomes Cancer. 2018 Jan;57(1):35-41. doi: 10.1002/gcc.22505. Epub 2017 Oct 30.

24.

ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.

Shukla V, Rao M, Zhang H, Beers J, Wangsa D, Wangsa D, Buishand FO, Wang Y, Yu Z, Stevenson HS, Reardon ES, McLoughlin KC, Kaufman AS, Payabyab EC, Hong JA, Zhang M, Davis S, Edelman D, Chen G, Miettinen MM, Restifo NP, Ried T, Meltzer PA, Schrump DS.

Cancer Res. 2017 Nov 15;77(22):6267-6281. doi: 10.1158/0008-5472.CAN-17-0570. Epub 2017 Sep 21.

25.

A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.

Chen C, Choudhury S, Wangsa D, Lescott CJ, Wilkins DJ, Sripadhan P, Liu X, Wangsa D, Ried T, Moskaluk C, Wick MJ, Glasgow E, Schlegel R, Agarwal S.

Sci Rep. 2017 Sep 12;7(1):11410. doi: 10.1038/s41598-017-11764-2.

26.

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, Heßmann E, Gaedcke J, Ghadimi BM, Johnsen SA, Ried T, Grade M.

Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15.

27.

Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor.

Rozenblum E, Sotelo-Silveira JR, Kim GY, Zhu JY, Lau CC, McNeil N, Korolevich S, Liao H, Cherry JM, Munroe DJ, Ried T, Meltzer PS, Kuehl WM, Roschke AV.

PLoS One. 2017 Aug 7;12(8):e0182610. doi: 10.1371/journal.pone.0182610. eCollection 2017.

28.

Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).

Yang Y, Vocke CD, Ricketts CJ, Wei D, Padilla-Nash HM, Lang M, Sourbier C, Killian JK, Boyle SL, Worrell R, Meltzer PS, Ried T, Merino MJ, Metwalli AR, Linehan WM.

Genes Chromosomes Cancer. 2017 Oct;56(10):719-729. doi: 10.1002/gcc.22476. Epub 2017 Jul 24.

29.

The 4D Nucleome.

Ried T, Rajapakse I.

Methods. 2017 Jul 1;123:1-2. doi: 10.1016/j.ymeth.2017.06.031. No abstract available.

PMID:
28734317
30.

Microscopy and Image Analysis.

McNamara G, Difilippantonio M, Ried T, Bieber FR.

Curr Protoc Hum Genet. 2017 Jul 11;94:4.4.1-4.4.89. doi: 10.1002/cphg.42. Review.

PMID:
28696557
31.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M.

Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006.

32.

HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer.

Acun T, Doberstein N, Habermann JK, Gemoll T, Thorns C, Oztas E, Ried T.

OMICS. 2017 May;21(5):257-265. doi: 10.1089/omi.2017.0016.

33.

HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes.

Yuan H, Krawczyk E, Blancato J, Albanese C, Zhou D, Wang N, Paul S, Alkhilaiwi F, Palechor-Ceron N, Dakic A, Fang S, Choudhary S, Hou TW, Zheng YL, Haddad BR, Usuda Y, Hartmann D, Symer D, Gillison M, Agarwal S, Wangsa D, Ried T, Liu X, Schlegel R.

Sci Rep. 2017 Apr 5;7:45617. doi: 10.1038/srep45617.

34.

Transcription-dependent radial distribution of TCF7L2 regulated genes in chromosome territories.

Torabi K, Wangsa D, Ponsa I, Brown M, Bosch A, Vila-Casadesús M, Karpova TS, Calvo M, Castells A, Miró R, Ried T, Camps J.

Chromosoma. 2017 Oct;126(5):655-667. doi: 10.1007/s00412-017-0629-6. Epub 2017 Mar 25.

PMID:
28343235
35.

Nucleome Analysis Reveals Structure-Function Relationships for Colon Cancer.

Seaman L, Chen H, Brown M, Wangsa D, Patterson G, Camps J, Omenn GS, Ried T, Rajapakse I.

Mol Cancer Res. 2017 Jul;15(7):821-830. doi: 10.1158/1541-7786.MCR-16-0374. Epub 2017 Mar 3.

36.

Targeting colorectal cancer (stem-like) cells using LGR5 directed antibody drug conjugates.

Hirsch D, Ried T.

Ann Transl Med. 2016 Dec;4(24):508. doi: 10.21037/atm.2016.11.78. No abstract available.

37.

Chromosome conformation and gene expression patterns differ profoundly in human fibroblasts grown in spheroids versus monolayers.

Chen H, Seaman L, Liu S, Ried T, Rajapakse I.

Nucleus. 2017 Jul 4;8(4):383-391. doi: 10.1080/19491034.2017.1280209. Epub 2017 Jan 27.

38.

Novel mouse model recapitulates genome and transcriptome alterations in human colorectal carcinomas.

McNeil NE, Padilla-Nash HM, Buishand FO, Hue Y, Ried T.

Genes Chromosomes Cancer. 2017 Mar;56(3):199-213. doi: 10.1002/gcc.22426. Epub 2016 Nov 1.

PMID:
27750367
39.

Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer.

Wang J, Yang S, He P, Schetter AJ, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Gaida MM, Hanna N, Alexander HR, Hussain SP.

Clin Cancer Res. 2016 Dec 15;22(24):5992-6001. Epub 2016 Jul 8.

40.

Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer.

Wang J, He P, Gaida M, Yang S, Schetter AJ, Gaedcke J, Ghadimi BM, Ried T, Yfantis H, Lee D, Weiss JM, Stauffer J, Hanna N, Alexander HR, Hussain SP.

Oncotarget. 2016 Aug 16;7(33):52993-53004. doi: 10.18632/oncotarget.10323.

41.

FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.

Gertz EM, Chowdhury SA, Lee WJ, Wangsa D, Heselmeyer-Haddad K, Ried T, Schwartz R, Schäffer AA.

PLoS One. 2016 Jun 30;11(6):e0158569. doi: 10.1371/journal.pone.0158569. eCollection 2016.

42.

A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

Yang S, He P, Wang J, Schetter A, Tang W, Funamizu N, Yanaga K, Uwagawa T, Satoskar AR, Gaedcke J, Bernhardt M, Ghadimi BM, Gaida MM, Bergmann F, Werner J, Ried T, Hanna N, Alexander HR, Hussain SP.

Cancer Res. 2016 Jul 1;76(13):3838-50. doi: 10.1158/0008-5472.CAN-15-2841. Epub 2016 Apr 20.

43.

Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2.

Zepeda-Mendoza CJ, Mukhopadhyay S, Wong ES, Harder N, Splinter E, de Wit E, Eckersley-Maslin MA, Ried T, Eils R, Rohr K, Mills A, de Laat W, Flicek P, Sengupta AM, Spector DL.

BMC Genomics. 2015 Nov 21;16:982. doi: 10.1186/s12864-015-2137-5.

44.

Transcriptome profiling of LGR5 positive colorectal cancer cells.

Hirsch D, Hu Y, Ried T, Moll R, Gaiser T.

Genom Data. 2014 Jun 14;2:212-5. doi: 10.1016/j.gdata.2014.06.005. eCollection 2014 Dec.

45.

ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans.

Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL 3rd, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC 3rd, Ried T, Hodes RJ.

Blood. 2015 Nov 12;126(20):2291-301. doi: 10.1182/blood-2015-06-654749. Epub 2015 Sep 23.

46.

Genetic Instability and Disease Prognostication.

Gemoll T, Auer G, Ried T, Habermann JK.

Recent Results Cancer Res. 2015;200:81-94. doi: 10.1007/978-3-319-20291-4_4. Review.

PMID:
26376873
47.

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer.

Torabi K, Miró R, Fernández-Jiménez N, Quintanilla I, Ramos L, Prat E, del Rey J, Pujol N, Killian JK, Meltzer PS, Fernández PL, Ried T, Lozano JJ, Camps J, Ponsa I.

Carcinogenesis. 2015 Oct;36(10):1103-10. doi: 10.1093/carcin/bgv115. Epub 2015 Aug 4.

48.

Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis.

Wangsa D, Chowdhury SA, Ryott M, Gertz EM, Elmberger G, Auer G, Åvall Lundqvist E, Küffer S, Ströbel P, Schäffer AA, Schwartz R, Munck-Wikland E, Ried T, Heselmeyer-Haddad K.

Int J Cancer. 2016 Jan 1;138(1):98-109. doi: 10.1002/ijc.29691. Epub 2015 Aug 28.

49.

Functional organization of the human 4D Nucleome.

Chen H, Chen J, Muir LA, Ronquist S, Meixner W, Ljungman M, Ried T, Smale S, Rajapakse I.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8002-7. doi: 10.1073/pnas.1505822112. Epub 2015 Jun 15.

50.

An Improved Breast Epithelial Sampling Method for Molecular Profiling and Biomarker Analysis in Women at Risk for Breast Cancer.

Danforth DN, Warner AC, Wangsa D, Ried T, Duelli D, Filie AC, Prindiville SA.

Breast Cancer (Auckl). 2015 Jun 8;9:31-40. doi: 10.4137/BCBCR.S23577. eCollection 2015.

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