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Items: 1 to 50 of 68

1.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Adbala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2018 Oct 4. pii: S1550-4131(18)30586-2. doi: 10.1016/j.cmet.2018.09.019. [Epub ahead of print]

PMID:
30318339
2.

Vimentin expression is required for the development of EMT-related renal fibrosis following unilateral ureteral obstruction in mice.

Wang Z, Divanyan A, Jourd'heuil FL, Goldman RD, Ridge KM, Jourd'heuil D, Lopez-Soler RI.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F769-F780. doi: 10.1152/ajprenal.00340.2017. Epub 2018 Apr 4.

PMID:
29631355
3.

A Beginner's Guide to Analysis of RNA Sequencing Data.

Koch CM, Chiu SF, Akbarpour M, Bharat A, Ridge KM, Bartom ET, Winter DR.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):145-157. doi: 10.1165/rcmb.2017-0430TR.

PMID:
29624415
4.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

PMID:
29546996
5.

Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.

Coates BM, Staricha KL, Koch CM, Cheng Y, Shumaker DK, Budinger GRS, Perlman H, Misharin AV, Ridge KM.

J Immunol. 2018 Apr 1;200(7):2391-2404. doi: 10.4049/jimmunol.1701543. Epub 2018 Feb 14.

PMID:
29445006
6.

Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection.

Coates BM, Staricha KL, Ravindran N, Koch CM, Cheng Y, Davis JM, Shumaker DK, Ridge KM.

Front Immunol. 2017 Jul 10;8:782. doi: 10.3389/fimmu.2017.00782. eCollection 2017.

7.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

8.

Lung Interstitial Macrophages: Establishing Identity and Uncovering Heterogeneity.

Koch CM, Chiu SF, Misharin AV, Ridge KM.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):7-9. doi: 10.1165/rcmb.2017-0150ED. No abstract available.

PMID:
28665216
9.

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.

Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA.

Front Immunol. 2017 Jun 1;8:623. doi: 10.3389/fimmu.2017.00623. eCollection 2017.

10.

Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis.

Kim SJ, Cheresh P, Eren M, Jablonski RP, Yeldandi A, Ridge KM, Budinger GRS, Kim DH, Wolf M, Vaughan DE, Kamp DW.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L16-L26. doi: 10.1152/ajplung.00063.2017. Epub 2017 Apr 20.

11.

The Role of Nucleotide-Binding Oligomerization Domain-Like Receptors in Pulmonary Infection.

Wiese KM, Coates BM, Ridge KM.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):151-161. doi: 10.1165/rcmb.2016-0375TR. Review.

12.

The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits.

Tokhtaeva E, Sun H, Deiss-Yehiely N, Wen Y, Soni PN, Gabrielli NM, Marcus EA, Ridge KM, Sachs G, Vazquez-Levin M, Sznajder JI, Vagin O, Dada LA.

J Cell Sci. 2016 Jun 15;129(12):2394-406. doi: 10.1242/jcs.186148. Epub 2016 May 3.

13.

Methods for Determining the Cellular Functions of Vimentin Intermediate Filaments.

Ridge KM, Shumaker D, Robert A, Hookway C, Gelfand VI, Janmey PA, Lowery J, Guo M, Weitz DA, Kuczmarski E, Goldman RD.

Methods Enzymol. 2016;568:389-426. doi: 10.1016/bs.mie.2015.09.036. Epub 2015 Dec 19.

14.

Influenza A Virus Infection, Innate Immunity, and Childhood.

Coates BM, Staricha KL, Wiese KM, Ridge KM.

JAMA Pediatr. 2015 Oct;169(10):956-63. doi: 10.1001/jamapediatrics.2015.1387. Review.

15.

Corrigendum: The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation.

Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, Dada L, Ridge KM, Chandel NS, Liu J.

Nat Immunol. 2015 Jul;16(7):785. doi: 10.1038/ni0715-785b. No abstract available.

PMID:
26086147
16.

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation.

Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, Dada L, Ridge KM, Chandel NS, Liu J.

Nat Immunol. 2015 May;16(5):458-66. doi: 10.1038/ni.3130. Epub 2015 Mar 23. Erratum in: Nat Immunol. 2015 Jul;16(7):785.

17.

Influenza virus-induced lung injury: pathogenesis and implications for treatment.

Herold S, Becker C, Ridge KM, Budinger GR.

Eur Respir J. 2015 May;45(5):1463-78. doi: 10.1183/09031936.00186214. Epub 2015 Mar 18. Review.

18.

Vimentin regulates activation of the NLRP3 inflammasome.

dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, Lam AP, Cheresh P, Kamp D, Shumaker DK, Budinger GR, Ridge KM.

Nat Commun. 2015 Mar 12;6:6574. doi: 10.1038/ncomms7574.

19.

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC.

20.

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion.

Arvanitis C, Khuon S, Spann R, Ridge KM, Chew TL.

PLoS One. 2014 Feb 24;9(2):e89758. doi: 10.1371/journal.pone.0089758. eCollection 2014.

21.

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.

Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Circulation. 2014 Apr 8;129(14):1510-23. doi: 10.1161/CIRCULATIONAHA.113.006402. Epub 2014 Jan 27.

PMID:
24470481
22.

The role of vimentin intermediate filaments in the progression of lung cancer.

Kidd ME, Shumaker DK, Ridge KM.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):1-6. doi: 10.1165/rcmb.2013-0314TR. Review.

23.

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.

Do-Umehara HC, Chen C, Urich D, Zhou L, Qiu J, Jang S, Zander A, Baker MA, Eilers M, Sporn PH, Ridge KM, Sznajder JI, Budinger GR, Mutlu GM, Lin A, Liu J.

Nat Immunol. 2013 May;14(5):461-9. doi: 10.1038/ni.2566. Epub 2013 Mar 24.

24.

The inflammasome in lung diseases.

dos Santos G, Kutuzov MA, Ridge KM.

Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15;303(8):L627-33. doi: 10.1152/ajplung.00225.2012. Epub 2012 Aug 17. Review.

25.

Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.

Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, Mutlu GM, De Vizcaya-Ruiz A, Budinger GR.

Sci Rep. 2012;2:275. doi: 10.1038/srep00275. Epub 2012 Feb 17.

26.

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells.

Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM.

FASEB J. 2011 Nov;25(11):3873-83. doi: 10.1096/fj.10-170795. Epub 2011 Jul 29.

27.

The role of the ubiquitin proteasome pathway in keratin intermediate filament protein degradation.

Rogel MR, Jaitovich A, Ridge KM.

Proc Am Thorac Soc. 2010 Feb;7(1):71-6. doi: 10.1513/pats.200908-089JS. Review.

28.

Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments.

Na N, Chandel NS, Litvan J, Ridge KM.

FASEB J. 2010 Mar;24(3):799-809. doi: 10.1096/fj.08-128967. Epub 2009 Nov 6.

29.

Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.

Sivaramakrishnan S, Schneider JL, Sitikov A, Goldman RD, Ridge KM.

Mol Biol Cell. 2009 Jun;20(11):2755-65. doi: 10.1091/mbc.E08-10-1028. Epub 2009 Apr 8.

30.

Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.

Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR.

FASEB J. 2009 Jul;23(7):2055-64. doi: 10.1096/fj.08-114546. Epub 2009 Feb 23.

31.

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.

Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR.

J Biol Chem. 2009 Jan 23;284(4):2176-86. doi: 10.1074/jbc.M808844200. Epub 2008 Nov 25.

32.

Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells.

Jaitovich A, Mehta S, Na N, Ciechanover A, Goldman RD, Ridge KM.

J Biol Chem. 2008 Sep 12;283(37):25348-55. doi: 10.1074/jbc.M801635200. Epub 2008 Jul 10.

33.

Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.

Adir Y, Welch LC, Dumasius V, Factor P, Sznajder JI, Ridge KM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1233-7. doi: 10.1152/ajplung.00076.2007. Epub 2008 Apr 18.

34.

Micromechanical properties of keratin intermediate filament networks.

Sivaramakrishnan S, DeGiulio JV, Lorand L, Goldman RD, Ridge KM.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):889-94. doi: 10.1073/pnas.0710728105. Epub 2008 Jan 16.

35.

Differential binding of plasminogen, plasmin, and angiostatin4.5 to cell surface beta-actin: implications for cancer-mediated angiogenesis.

Wang H, Doll JA, Jiang K, Cundiff DL, Czarnecki JS, Wilson M, Ridge KM, Soff GA.

Cancer Res. 2006 Jul 15;66(14):7211-5.

36.

Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption.

Litvan J, Briva A, Wilson MS, Budinger GR, Sznajder JI, Ridge KM.

J Biol Chem. 2006 Jul 21;281(29):19892-8. Epub 2006 Apr 24.

37.

Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.

Ridge KM, Linz L, Flitney FW, Kuczmarski ER, Chou YH, Omary MB, Sznajder JI, Goldman RD.

J Biol Chem. 2005 Aug 26;280(34):30400-5. Epub 2005 Jun 22.

38.

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.

Myrianthefs PM, Briva A, Lecuona E, Dumasius V, Rutschman DH, Ridge KM, Baltopoulos GJ, Sznajder JI.

Am J Respir Crit Care Med. 2005 Jun 1;171(11):1267-71. Epub 2005 Mar 11.

39.

Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.

Azzam ZS, Adir Y, Crespo A, Comellas A, Lecuona E, Dada LA, Krivoy N, Rutschman DH, Sznajder JI, Ridge KM.

Am J Respir Crit Care Med. 2004 Oct 1;170(7):730-6. Epub 2004 Jul 15.

PMID:
15256395
40.

Augmentation of endogenous dopamine production increases lung liquid clearance.

Adir Y, Azzam ZS, Lecuona E, Leal S, Pesce L, Dumasius V, Bertorello AM, Factor P, Young JB, Ridge KM, Sznajder JI.

Am J Respir Crit Care Med. 2004 Mar 15;169(6):757-63. Epub 2003 Dec 30.

PMID:
14701706
41.

Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance.

Sloniewsky DE, Ridge KM, Adir Y, Fries FP, Briva A, Sznajder JI, Sporn PH.

Am J Respir Crit Care Med. 2004 Feb 1;169(3):407-12. Epub 2003 Oct 24.

PMID:
14578215
42.

Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury.

Adir Y, Factor P, Dumasius V, Ridge KM, Sznajder JI.

Am J Respir Crit Care Med. 2003 Dec 15;168(12):1445-8. Epub 2003 Aug 28.

PMID:
12947023
43.

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.

Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI.

J Clin Invest. 2003 Apr;111(7):1057-64.

44.

Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.

Ridge KM, Olivera WG, Saldias F, Azzam Z, Horowitz S, Rutschman DH, Dumasius V, Factor P, Sznajder JI.

Circ Res. 2003 Mar 7;92(4):453-60. Epub 2003 Jan 30.

PMID:
12600893
45.

Pulmonary lymphatics and edema accumulation after brief lung injury.

Schraufnagel DE, Agaram NP, Faruqui A, Jain S, Jain L, Ridge KM, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L891-7. Epub 2003 Jan 24.

46.

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.

Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI.

Mol Biol Cell. 2002 Apr;13(4):1381-9.

47.

Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms.

Guerrero C, Pesce L, Lecuona E, Ridge KM, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1099-107.

48.

Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats.

Saldías FJ, Azzam ZS, Ridge KM, Yeldandi A, Rutschman DH, Schraufnagel D, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L591-7.

49.

Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms.

Guerrero C, Lecuona E, Pesce L, Ridge KM, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L79-85.

50.

Catecholamines increase lung edema clearance in rats with increased left atrial pressure.

Azzam ZS, Saldias FJ, Comellas A, Ridge KM, Rutschman DH, Sznajder JI.

J Appl Physiol (1985). 2001 Mar;90(3):1088-94.

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