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The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA.

Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT.

Biochem J. 2019 Aug 30;476(16):2427-2447. doi: 10.1042/BCJ20190500.


Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.

Gianfrancesco MA, Dehairs J, L'homme L, Herinckx G, Esser N, Jansen O, Habraken Y, Lassence C, Swinnen JV, Rider MH, Piette J, Paquot N, Legrand-Poels S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1017-1030. doi: 10.1016/j.bbalip.2019.04.001. Epub 2019 Apr 4.


Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.

Johanns M, Kviklyte S, Chuang SJ, Corbeels K, Jacobs R, Herinckx G, Vertommen D, Schakman O, Duparc T, Cani PD, Bouzin C, Andersén H, Bohlooly-Y M, Van der Schueren B, Oscarsson J, Rider MH.

Mol Genet Metab. 2019 Apr;126(4):377-387. doi: 10.1016/j.ymgme.2019.01.017. Epub 2019 Feb 14.


Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

Ngoei KRW, Langendorf CG, Ling NXY, Hoque A, Varghese S, Camerino MA, Walker SR, Bozikis YE, Dite TA, Ovens AJ, Smiles WJ, Jacobs R, Huang H, Parker MW, Scott JW, Rider MH, Foitzik RC, Kemp BE, Baell JB, Oakhill JS.

Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. doi: 10.1016/j.chembiol.2018.03.008. Epub 2018 Apr 12.


HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation.

Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle VA, Havelange V, Rider MH, Vertommen D, Demoulin JB.

Cell Signal. 2018 Apr;44:158-170. doi: 10.1016/j.cellsig.2018.01.014. Epub 2018 Feb 16.


Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel, Ictidomys tridecemlineatus.

Herinckx G, Hussain N, Opperdoes FR, Storey KB, Rider MH, Vertommen D.

Physiol Genomics. 2017 Sep 1;49(9):462-472. doi: 10.1152/physiolgenomics.00038.2017. Epub 2017 Jul 10.


Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase.

Johanns M, Pyr Dit Ruys S, Houddane A, Vertommen D, Herinckx G, Hue L, Proud CG, Rider MH.

Cell Signal. 2017 Aug;36:212-221. doi: 10.1016/j.cellsig.2017.05.010. Epub 2017 May 11.


Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.

Kviklyte S, Vertommen D, Yerna X, Andersén H, Xu X, Gailly P, Bohlooly-Y M, Oscarsson J, Rider MH.

Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E48-E62. doi: 10.1152/ajpendo.00304.2016. Epub 2017 Mar 21.


Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.

Houddane A, Bultot L, Novellasdemunt L, Johanns M, Gueuning MA, Vertommen D, Coulie PG, Bartrons R, Hue L, Rider MH.

Cell Signal. 2017 Jun;34:23-37. doi: 10.1016/j.cellsig.2017.02.019. Epub 2017 Feb 22.


6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Ros S, Flöter J, Kaymak I, Da Costa C, Houddane A, Dubuis S, Griffiths B, Mitter R, Walz S, Blake S, Behrens A, Brindle KM, Zamboni N, Rider MH, Schulze A.

Oncogene. 2017 Jun 8;36(23):3287-3299. doi: 10.1038/onc.2016.477. Epub 2017 Jan 16.


Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.

Bultot L, Jensen TE, Lai YC, Madsen AL, Collodet C, Kviklyte S, Deak M, Yavari A, Foretz M, Ghaffari S, Bellahcene M, Ashrafian H, Rider MH, Richter EA, Sakamoto K.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719. doi: 10.1152/ajpendo.00237.2016. Epub 2016 Aug 30.


Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα.

Ratman D, Mylka V, Bougarne N, Pawlak M, Caron S, Hennuyer N, Paumelle R, De Cauwer L, Thommis J, Rider MH, Libert C, Lievens S, Tavernier J, Staels B, De Bosscher K.

Nucleic Acids Res. 2016 Dec 15;44(22):10539-10553. Epub 2016 Aug 30.


A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.

Collard F, Baldin F, Gerin I, Bolsée J, Noël G, Graff J, Veiga-da-Cunha M, Stroobant V, Vertommen D, Houddane A, Rider MH, Linster CL, Van Schaftingen E, Bommer GT.

Nat Chem Biol. 2016 Aug;12(8):601-7. doi: 10.1038/nchembio.2104. Epub 2016 Jun 13.


AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH.

Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856.


Role of AMP-activated protein kinase in metabolic depression in animals.

Rider MH.

J Comp Physiol B. 2016 Jan;186(1):1-16. doi: 10.1007/s00360-015-0920-x. Epub 2015 Jul 15. Review.


Effects of pharmacological AMP deaminase inhibition and Ampd1 deletion on nucleotide levels and AMPK activation in contracting skeletal muscle.

Plaideau C, Lai YC, Kviklyte S, Zanou N, Löfgren L, Andersén H, Vertommen D, Gailly P, Hue L, Bohlooly-Y M, Hallén S, Rider MH.

Chem Biol. 2014 Nov 20;21(11):1497-1510. doi: 10.1016/j.chembiol.2014.09.013.


Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling.

Wang X, Regufe da Mota S, Liu R, Moore CE, Xie J, Lanucara F, Agarwala U, Pyr Dit Ruys S, Vertommen D, Rider MH, Eyers CE, Proud CG.

Mol Cell Biol. 2014 Nov 15;34(22):4088-103. doi: 10.1128/MCB.01035-14. Epub 2014 Sep 2.


A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

Lai YC, Kviklyte S, Vertommen D, Lantier L, Foretz M, Viollet B, Hallén S, Rider MH.

Biochem J. 2014 Jun 15;460(3):363-75. doi: 10.1042/BJ20131673.


Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH.

Biochem J. 2013 Oct 15;455(2):195-206. doi: 10.1042/BJ20130644.


Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle.

Liu Y, Vertommen D, Rider MH, Lai YC.

Cell Signal. 2013 Sep;25(9):1877-86. doi: 10.1016/j.cellsig.2013.05.005. Epub 2013 May 22.


PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli.

Novellasdemunt L, Bultot L, Manzano A, Ventura F, Rosa JL, Vertommen D, Rider MH, Navarro-Sabate À, Bartrons R.

Biochem J. 2013 Jun 15;452(3):531-43. doi: 10.1042/BJ20121886.


Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.

Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.

Biochim Biophys Acta. 2013 Jun;1832(6):780-90. doi: 10.1016/j.bbadis.2013.02.015. Epub 2013 Mar 4.


A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.

Lai YC, Liu Y, Jacobs R, Rider MH.

Biochem J. 2012 Oct 1;447(1):137-47. doi: 10.1042/BJ20120772.


Overexpression of AMP-metabolizing enzymes controls adenine nucleotide levels and AMPK activation in HEK293T cells.

Plaideau C, Liu J, Hartleib-Geschwindner J, Bastin-Coyette L, Bontemps F, Oscarsson J, Hue L, Rider MH.

FASEB J. 2012 Jun;26(6):2685-94. doi: 10.1096/fj.11-198168. Epub 2012 Mar 13.


AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

Bultot L, Guigas B, Von Wilamowitz-Moellendorff A, Maisin L, Vertommen D, Hussain N, Beullens M, Guinovart JJ, Foretz M, Viollet B, Sakamoto K, Hue L, Rider MH.

Biochem J. 2012 Apr 1;443(1):193-203. doi: 10.1042/BJ20112026.


Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.

Pyr Dit Ruys S, Wang X, Smith EM, Herinckx G, Hussain N, Rider MH, Vertommen D, Proud CG.

Biochem J. 2012 Mar 15;442(3):681-92. doi: 10.1042/BJ20111530. Erratum in: Biochem J. 2012 Apr 1;443(1):328.


Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression.

Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M.

J Biol Chem. 2011 Dec 9;286(49):42162-79. doi: 10.1074/jbc.M111.299727. Epub 2011 Oct 14.


AMP-activated protein kinase and metabolic regulation in cold-hardy insects.

Rider MH, Hussain N, Dilworth SM, Storey JM, Storey KB.

J Insect Physiol. 2011 Nov;57(11):1453-62. doi: 10.1016/j.jinsphys.2011.07.006. Epub 2011 Jul 20.


Theiler's virus L* protein is targeted to the mitochondrial outer membrane.

Sorgeloos F, Vertommen D, Rider MH, Michiels T.

J Virol. 2011 Apr;85(7):3690-4. doi: 10.1128/JVI.02023-10. Epub 2011 Jan 12.


Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

Mouton V, Toussaint L, Vertommen D, Gueuning MA, Maisin L, Havaux X, Sanchez-Canedo C, Bertrand L, Dequiedt F, Hemmings BA, Hue L, Rider MH.

Biochem J. 2010 Oct 15;431(2):267-75. doi: 10.1042/BJ20101089.


Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.

Smal C, Vertommen D, Amsailale R, Arts A, Degand H, Morsomme P, Rider MH, Neste EV, Bontemps F.

Arch Biochem Biophys. 2010 Oct 1;502(1):44-52. doi: 10.1016/ Epub 2010 Jul 14.


Regulation of PIKfyve phosphorylation by insulin and osmotic stress.

Hill EV, Hudson CA, Vertommen D, Rider MH, Tavaré JM.

Biochem Biophys Res Commun. 2010 Jul 9;397(4):650-5. doi: 10.1016/j.bbrc.2010.05.134. Epub 2010 Jun 1.


AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.

Miranda L, Carpentier S, Platek A, Hussain N, Gueuning MA, Vertommen D, Ozkan Y, Sid B, Hue L, Courtoy PJ, Rider MH, Horman S.

Biochem Biophys Res Commun. 2010 Jun 4;396(3):656-61. doi: 10.1016/j.bbrc.2010.04.151. Epub 2010 May 8.


Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research.

Rider MH, Waelkens E, Derua R, Vertommen D.

Arch Physiol Biochem. 2009 Dec;115(5):298-310. doi: 10.3109/13813450903338108. Review.


Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways.

Rider MH, Hussain N, Dilworth SM, Storey KB.

Mol Cell Biochem. 2009 Dec;332(1-2):207-13. doi: 10.1007/s11010-009-0193-3. Epub 2009 Jul 5.


Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes.

Bultot L, Horman S, Neumann D, Walsh MP, Hue L, Rider MH.

FEBS Lett. 2009 Jan 5;583(1):25-8. doi: 10.1016/j.febslet.2008.11.022. Epub 2008 Dec 4.


AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase.

Horman S, Morel N, Vertommen D, Hussain N, Neumann D, Beauloye C, El Najjar N, Forcet C, Viollet B, Walsh MP, Hue L, Rider MH.

J Biol Chem. 2008 Jul 4;283(27):18505-12. doi: 10.1074/jbc.M802053200. Epub 2008 Apr 21.


Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis.

Martin M, Potente M, Janssens V, Vertommen D, Twizere JC, Rider MH, Goris J, Dimmeler S, Kettmann R, Dequiedt F.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4727-32. doi: 10.1073/pnas.0708455105. Epub 2008 Mar 13.


Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei.

Vertommen D, Van Roy J, Szikora JP, Rider MH, Michels PA, Opperdoes FR.

Mol Biochem Parasitol. 2008 Apr;158(2):189-201. doi: 10.1016/j.molbiopara.2007.12.008. Epub 2007 Dec 23.


Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF.

Cell Signal. 2008 Mar;20(3):543-56. doi: 10.1016/j.cellsig.2007.11.007. Epub 2007 Nov 26.


Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle.

Miranda L, Horman S, De Potter I, Hue L, Jensen J, Rider MH.

Pflugers Arch. 2008 Mar;455(6):1129-40. Epub 2007 Oct 24.


The AMP-activated protein kinase: more than an energy sensor.

Hue L, Rider MH.

Essays Biochem. 2007;43:121-37. Review.


Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells.

Smal C, Vertommen D, Bertrand L, Rider MH, van den Neste E, Bontemps F.

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1141-6.


New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R.

Mol Cell Biol. 2006 Oct;26(19):7086-102.


Stress-induced activation of the AMP-activated protein kinase in the freeze-tolerant frog Rana sylvatica.

Rider MH, Hussain N, Horman S, Dilworth SM, Storey KB.

Cryobiology. 2006 Dec;53(3):297-309. Epub 2006 Sep 14.


Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation.

Mouton V, Vertommen D, Bertrand L, Hue L, Rider MH.

Cell Signal. 2007 Jan;19(1):52-61. Epub 2006 Jun 3.


Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.

Smal C, Vertommen D, Bertrand L, Ntamashimikiro S, Rider MH, Van Den Neste E, Bontemps F.

J Biol Chem. 2006 Feb 24;281(8):4887-93. Epub 2005 Dec 16.


Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH.

J Biol Chem. 2006 Mar 3;281(9):5335-40. Epub 2005 Dec 9.

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