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Items: 21

1.

Long-acting β2-adrenoceptor agonists enhance glucocorticoid receptor (GR)-mediated transcription by gene-specific mechanisms rather than generic effects via GR.

Rider CF, Altonsy MO, Mostafa MM, Shah SV, Sasse S, Manson ML, Yan D, Karrman-Mardh C, Miller-Larsson A, Gerber AN, Giembycz MA, Newton R.

Mol Pharmacol. 2018 Jun 29. pii: mol.118.112755. doi: 10.1124/mol.118.112755. [Epub ahead of print]

2.

Effects of Controlled Diesel Exhaust and Allergen Exposure on microRNA and Gene Expression in Humans. Modulation of Lung Inflammatory Markers Associated with Asthma.

Rider CF, Yamamoto M, Günther OP, Singh A, Hirota JA, Tebbutt SJ, Carlsten C.

Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S130-S131. doi: 10.1513/AnnalsATS.201706-479MG.

PMID:
29676639
3.

Inhaled diesel exhaust alters the allergen-induced bronchial secretome in humans.

Mookherjee N, Piyadasa H, Ryu MH, Rider CF, Ezzati P, Spicer V, Carlsten C.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701385. doi: 10.1183/13993003.01385-2017. Print 2018 Jan.

PMID:
29371381
4.

Inhibition of ABCC4 potentiates combination beta agonist and glucocorticoid responses in human airway epithelial cells.

Huff RD, Rider CF, Yan D, Newton R, Giembycz MA, Carlsten C, Hirota JA.

J Allergy Clin Immunol. 2018 Mar;141(3):1127-1130.e5. doi: 10.1016/j.jaci.2017.10.011. Epub 2017 Dec 6. No abstract available.

PMID:
29103996
5.

Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways.

Maestre-Batlle D, Pena OM, Hirota JA, Gunawan E, Rider CF, Sutherland D, Alexis NE, Carlsten C.

Sci Rep. 2017 Feb 6;7:42214. doi: 10.1038/srep42214.

6.

Traffic-related air pollution and allergic disease: an update in the context of global urbanization.

Carlsten C, Rider CF.

Curr Opin Allergy Clin Immunol. 2017 Apr;17(2):85-89. doi: 10.1097/ACI.0000000000000351. Review.

PMID:
28141628
7.

An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti- and proinflammatory effector genes.

Leigh R, Mostafa MM, King EM, Rider CF, Shah S, Dumonceaux C, Traves SL, McWhae A, Kolisnik T, Kooi C, Slater DM, Kelly MM, Bieda M, Miller-Larsson A, Newton R.

Pharmacol Res Perspect. 2016 Jul 12;4(4):e00243. doi: 10.1002/prp2.243. eCollection 2016 Aug.

8.

Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers.

Rider CF, Yamamoto M, Günther OP, Hirota JA, Singh A, Tebbutt SJ, Carlsten C.

J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.

PMID:
27283384
9.

Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.

Rider CF, Shah S, Miller-Larsson A, Giembycz MA, Newton R.

PLoS One. 2015 Jan 27;10(1):e0116773. doi: 10.1371/journal.pone.0116773. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128728.

10.

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25.

11.

Modulation of transcriptional responses by poly(I:C) and human rhinovirus: effect of long-acting β₂-adrenoceptor agonists.

Rider CF, Miller-Larsson A, Proud D, Giembycz MA, Newton R.

Eur J Pharmacol. 2013 May 15;708(1-3):60-7. doi: 10.1016/j.ejphar.2013.02.056. Epub 2013 Mar 20.

PMID:
23523474
12.
13.

Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms.

King EM, Chivers JE, Rider CF, Minnich A, Giembycz MA, Newton R.

PLoS One. 2013;8(1):e53936. doi: 10.1371/journal.pone.0053936. Epub 2013 Jan 14.

14.

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.

15.

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide.

Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R.

Br J Pharmacol. 2012 Mar;165(6):1737-1747. doi: 10.1111/j.1476-5381.2011.01620.x.

16.

Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.

Rider CF, King EM, Holden NS, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. doi: 10.1124/jpet.111.181016. Epub 2011 May 27.

17.

Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

Holden NS, Rider CF, Bell MJ, Velayudhan J, King EM, Kaur M, Salmon M, Giembycz MA, Newton R.

Br J Pharmacol. 2010 May;160(2):410-20. doi: 10.1111/j.1476-5381.2010.00708.x.

18.

Glucocorticoids inhibit IL-1beta-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1.

Newton R, King EM, Gong W, Rider CF, Staples KJ, Holden NS, Bergmann MW.

Biochem J. 2010 Mar 15;427(1):113-24. doi: 10.1042/BJ20091038.

PMID:
20100175
19.

Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.

Wilson SM, Shen P, Rider CF, Traves SL, Proud D, Newton R, Giembycz MA.

J Immunol. 2009 Nov 15;183(10):6788-99. doi: 10.4049/jimmunol.0902738. Epub 2009 Oct 30.

20.

Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK.

King EM, Holden NS, Gong W, Rider CF, Newton R.

J Biol Chem. 2009 Sep 25;284(39):26803-15. doi: 10.1074/jbc.M109.028381. Epub 2009 Jul 31.

21.

Regulation of tristetraprolin expression by interleukin-1 beta and dexamethasone in human pulmonary epithelial cells: roles for nuclear factor-kappa B and p38 mitogen-activated protein kinase.

King EM, Kaur M, Gong W, Rider CF, Holden NS, Newton R.

J Pharmacol Exp Ther. 2009 Aug;330(2):575-85. doi: 10.1124/jpet.109.151423. Epub 2009 May 12.

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