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Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.

Patel A, Wilson R, Harrell AW, Taskar KS, Taylor M, Tracey H, Riddell K, Georgiou A, Cahn AP, Marotti M, Hessel EM.

Drug Metab Dispos. 2020 Apr;48(4):307-316. doi: 10.1124/dmd.119.089003. Epub 2020 Feb 2.


An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.

Harrell AW, Wilson R, Man YL, Riddell K, Jarvis E, Young G, Chambers R, Crossman L, Georgiou A, Pereira A, Kenworthy D, Beaumont C, Marotti M, Wilkes D, Hessel EM, Fahy WA.

Drug Metab Dispos. 2019 Dec;47(12):1457-1468. doi: 10.1124/dmd.119.088344. Epub 2019 Oct 24.


Pandemic Uropathogenic Fluoroquinolone-resistant Escherichia coli Have Enhanced Ability to Persist in the Gut and Cause Bacteriuria in Healthy Women.

Tchesnokova VL, Rechkina E, Chan D, Haile HG, Larson L, Ferrier K, Schroeder DW, Solyanik T, Shibuya S, Hansen K, Ralston JD, Riddell K, Scholes D, Sokurenko EV.

Clin Infect Dis. 2020 Feb 14;70(5):937-939. doi: 10.1093/cid/ciz547.


Evaluation of a method to estimate the point prevalence of cognitive impairment and delirium in a multi-campus Australian health service.

Casey P, Dārziņš P, Webb-St Mart M, Baldwin C, Riddell K, Johnson C, Cross W.

Australas J Ageing. 2019 Dec;38(4):258-266. doi: 10.1111/ajag.12666. Epub 2019 May 14.


Hospital discharge data under-reports delirium occurrence: results from a point prevalence survey of delirium in a major Australian health service.

Casey P, Cross W, Mart MW, Baldwin C, Riddell K, Dārziņš P.

Intern Med J. 2019 Mar;49(3):338-344. doi: 10.1111/imj.14066.


Anti-inflammatory duration of action of fluticasone furoate/vilanterol trifenatate in asthma: a cross-over randomised controlled trial.

Bardsley G, Daley-Yates P, Baines A, Kempsford R, Williams M, Mallon T, Braithwaite I, Riddell K, Joshi S, Bareille P, Beasley R, Fingleton J; study team.

Respir Res. 2018 Jul 13;19(1):133. doi: 10.1186/s12931-018-0836-6.


Rapid and Extensive Expansion in the United States of a New Multidrug-resistant Escherichia coli Clonal Group, Sequence Type 1193.

Tchesnokova VL, Rechkina E, Larson L, Ferrier K, Weaver JL, Schroeder DW, She R, Butler-Wu SM, Aguero-Rosenfeld ME, Zerr D, Fang FC, Ralston J, Riddell K, Scholes D, Weissman S, Parker K, Spellberg B, Johnson JR, Sokurenko EV.

Clin Infect Dis. 2019 Jan 7;68(2):334-337. doi: 10.1093/cid/ciy525.


The Uropathogenic Escherichia coli Subclone Sequence Type 131-H30 Is Responsible for Most Antibiotic Prescription Errors at an Urgent Care Clinic.

Tchesnokova V, Riddell K, Scholes D, Johnson JR, Sokurenko EV.

Clin Infect Dis. 2019 Feb 15;68(5):781-787. doi: 10.1093/cid/ciy523.


Identification of Conserved Amino Acid Substitutions During Serial Infection of Pregnant Cattle and Sheep With Bovine Viral Diarrhea Virus.

Kuca T, Passler T, Newcomer BW, Neill JD, Galik PK, Riddell KP, Zhang Y, Walz PH.

Front Microbiol. 2018 Jun 6;9:1109. doi: 10.3389/fmicb.2018.01109. eCollection 2018.


Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2.

Walz PH, Riddell KP, Newcomer BW, Neill JD, Falkenberg SM, Cortese VS, Scruggs DW, Short TH.

Vaccine. 2018 Jun 18;36(26):3853-3860. doi: 10.1016/j.vaccine.2018.04.005. Epub 2018 Apr 24.


Virus detection by PCR following vaccination of naive calves with intranasal or injectable multivalent modified-live viral vaccines.

Walz PH, Newcomer BW, Riddell KP, Scruggs DW, Cortese VS.

J Vet Diagn Invest. 2017 Sep;29(5):628-635. doi: 10.1177/1040638717709039. Epub 2017 May 26.


Pharmacokinetic Comparison of a Unit Dose Dry Powder Inhaler with a Multidose Dry Powder Inhaler for Delivery of Fluticasone Furoate.

Mehta R, Moore A, Riddell K, Joshi S, Chan R.

J Aerosol Med Pulm Drug Deliv. 2017 Oct;30(5):332-338. doi: 10.1089/jamp.2016.1322. Epub 2017 May 2.


Bacterial clonal diagnostics as a tool for evidence-based empiric antibiotic selection.

Tchesnokova V, Avagyan H, Rechkina E, Chan D, Muradova M, Haile HG, Radey M, Weissman S, Riddell K, Scholes D, Johnson JR, Sokurenko EV.

PLoS One. 2017 Mar 28;12(3):e0174132. doi: 10.1371/journal.pone.0174132. eCollection 2017.


Pharmacokinetics of Salbutamol Delivered from the Unit Dose Dry Powder Inhaler: Comparison with the Metered Dose Inhaler and Diskus Dry Powder Inhaler.

Moore A, Riddell K, Joshi S, Chan R, Mehta R.

J Aerosol Med Pulm Drug Deliv. 2017 Jun;30(3):164-172. doi: 10.1089/jamp.2015.1277. Epub 2017 Feb 7.


Impact of a killed Tritrichomonas foetus vaccine on clearance of the organism and subsequent fertility of heifers following experimental inoculation.

Edmondson MA, Joiner KS, Spencer JA, Riddell KP, Rodning SP, Gard JA, Givens MD.

Theriogenology. 2017 Mar 1;90:245-251. doi: 10.1016/j.theriogenology.2016.09.056. Epub 2016 Nov 14.


Serologic survey for antibodies against three genotypes of bovine parainfluenza 3 virus in unvaccinated ungulates in Alabama.

Newcomer BW, Neill JD, Galik PK, Riddell KP, Zhang Y, Passler T, Velayudhan BT, Walz PH.

Am J Vet Res. 2017 Feb;78(2):239-243. doi: 10.2460/ajvr.78.2.239.


Evaluation of reproductive protection against bovine viral diarrhea virus and bovine herpesvirus-1 afforded by annual revaccination with modified-live viral or combination modified-live/killed viral vaccines after primary vaccination with modified-live viral vaccine.

Walz PH, Givens MD, Rodning SP, Riddell KP, Brodersen BW, Scruggs D, Short T, Grotelueschen D.

Vaccine. 2017 Feb 15;35(7):1046-1054. doi: 10.1016/j.vaccine.2017.01.006. Epub 2017 Jan 19.


Open-Label, Randomized, 6-Way Crossover, Single-Dose Study to Determine the Pharmacokinetics of Batefenterol (GSK961081) and Fluticasone Furoate When Administered Alone or in Combination.

Ambery C, Riddell K, Daley-Yates P.

Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407. doi: 10.1002/cpdd.274. Epub 2016 Jun 26.


The Pandemic H30 Subclone of Escherichia coli Sequence Type 131 Is Associated With Persistent Infections and Adverse Outcomes Independent From Its Multidrug Resistance and Associations With Compromised Hosts.

Johnson JR, Thuras P, Johnston BD, Weissman SJ, Limaye AP, Riddell K, Scholes D, Tchesnokova V, Sokurenko E.

Clin Infect Dis. 2016 Jun 15;62(12):1529-1536. doi: 10.1093/cid/ciw193. Epub 2016 Mar 29.


A Novel 7-Single Nucleotide Polymorphism-Based Clonotyping Test Allows Rapid Prediction of Antimicrobial Susceptibility of Extraintestinal Escherichia coli Directly From Urine Specimens.

Tchesnokova V, Avagyan H, Billig M, Chattopadhyay S, Aprikian P, Chan D, Pseunova J, Rechkina E, Riddell K, Scholes D, Fang FC, Johnson JR, Sokurenko EV.

Open Forum Infect Dis. 2016 Jan 18;3(1):ofw002. doi: 10.1093/ofid/ofw002. eCollection 2016 Jan.


Can Sarcopenia Quantified by Ultrasound of the Rectus Femoris Muscle Predict Adverse Outcome of Surgical Intensive Care Unit Patients as well as Frailty? A Prospective, Observational Cohort Study.

Mueller N, Murthy S, Tainter CR, Lee J, Riddell K, Fintelmann FJ, Grabitz SD, Timm FP, Levi B, Kurth T, Eikermann M.

Ann Surg. 2016 Dec;264(6):1116-1124.


Comparison of reproductive performance of primiparous dairy cattle following revaccination with either modified-live or killed multivalent viral vaccines in early lactation.

Walz PH, Montgomery T, Passler T, Riddell KP, Braden TD, Zhang Y, Galik PK, Zuidhof S.

J Dairy Sci. 2015 Dec;98(12):8753-63. doi: 10.3168/jds.2015-9760. Epub 2015 Oct 9.


Efficacy of multivalent, modified- live virus (MLV) vaccines administered to early weaned beef calves subsequently challenged with virulent Bovine viral diarrhea virus type 2.

Chamorro MF, Walz PH, Passler T, van Santen E, Gard J, Rodning SP, Riddell KP, Galik PK, Zhang Y.

BMC Vet Res. 2015 Feb 10;11:29. doi: 10.1186/s12917-015-0342-8.


Comparison of the Pharmacokinetics of Salmeterol and Fluticasone Propionate 50/100 µg Delivered in Combination as a Dry Powder Via a Capsule-Based Inhaler and a Multi-Dose Inhaler.

Mehta R, Riddell K, Gupta A, Louey MD, Chan RH.

Clin Drug Investig. 2015 May;35(5):319-26. doi: 10.1007/s40261-015-0282-x.


Effect of vaccination with a multivalent modified-live viral vaccine on reproductive performance in synchronized beef heifers.

Walz PH, Edmondson MA, Riddell KP, Braden TD, Gard JA, Bayne J, Joiner KS, Galik PK, Zuidhof S, Givens MD.

Theriogenology. 2015 Mar 15;83(5):822-31. doi: 10.1016/j.theriogenology.2014.11.015. Epub 2014 Nov 21.


Chronic opioid therapy urine drug testing in primary care: prevalence and predictors of aberrant results.

Turner JA, Saunders K, Shortreed SM, LeResche L, Riddell K, Rapp SE, Von Korff M.

J Gen Intern Med. 2014 Dec;29(12):1663-71. doi: 10.1007/s11606-014-3010-y. Epub 2014 Sep 13.


Experimental infection of pregnant goats with bovine viral diarrhea virus (BVDV) 1 or 2.

Passler T, Riddell KP, Edmondson MA, Chamorro MF, Neill JD, Brodersen BW, Walz HL, Galik PK, Zhang Y, Walz PH.

Vet Res. 2014 Apr 4;45:38. doi: 10.1186/1297-9716-45-38.


Laboratory diagnosis and transmissibility of bovine viral diarrhea virus from a bull with a persistent testicular infection.

Newcomer BW, Toohey-Kurth K, Zhang Y, Brodersen BW, Marley MS, Joiner KS, Zhang Y, Galik PK, Riddell KP, Givens MD.

Vet Microbiol. 2014 Jun 4;170(3-4):246-57. doi: 10.1016/j.vetmic.2014.02.028. Epub 2014 Mar 2.


The epidemic of extended-spectrum-β-lactamase-producing Escherichia coli ST131 is driven by a single highly pathogenic subclone, H30-Rx.

Price LB, Johnson JR, Aziz M, Clabots C, Johnston B, Tchesnokova V, Nordstrom L, Billig M, Chattopadhyay S, Stegger M, Andersen PS, Pearson T, Riddell K, Rogers P, Scholes D, Kahl B, Keim P, Sokurenko EV.

mBio. 2013 Dec 17;4(6):e00377-13. doi: 10.1128/mBio.00377-13.


Chronic opioid therapy risk reduction initiative: impact on urine drug testing rates and results.

Turner JA, Saunders K, Shortreed SM, Rapp SE, Thielke S, LeResche L, Riddell KM, Von Korff M.

J Gen Intern Med. 2014 Feb;29(2):305-11. doi: 10.1007/s11606-013-2651-6. Epub 2013 Oct 19.


Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus.

Newcomer BW, Marley MS, Galik PK, Zhang Y, Riddell KP, Boykin DW, Kumar A, Kuhnt LA, Gard JA, Givens MD.

Can J Vet Res. 2013 Jul;77(3):170-6.


Predictive diagnostics for Escherichia coli infections based on the clonal association of antimicrobial resistance and clinical outcome.

Tchesnokova V, Billig M, Chattopadhyay S, Linardopoulou E, Aprikian P, Roberts PL, Skrivankova V, Johnston B, Gileva A, Igusheva I, Toland A, Riddell K, Rogers P, Qin X, Butler-Wu S, Cookson BT, Fang FC, Kahl B, Price LB, Weissman SJ, Limaye A, Scholes D, Johnson JR, Sokurenko EV.

J Clin Microbiol. 2013 Sep;51(9):2991-9. doi: 10.1128/JCM.00984-13. Epub 2013 Jul 10.


Evaluation of methods to improve the diagnosis of systemic inflammation in alpacas.

Passler T, Chamorro MF, Riddell KP, Edmondson MA, van Santen E, Cray C, Maxwell HS, Walz PH.

J Vet Intern Med. 2013 Jul-Aug;27(4):970-6. doi: 10.1111/jvim.12102. Epub 2013 May 10.


Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.

Johnson JR, Tchesnokova V, Johnston B, Clabots C, Roberts PL, Billig M, Riddell K, Rogers P, Qin X, Butler-Wu S, Price LB, Aziz M, Nicolas-Chanoine MH, Debroy C, Robicsek A, Hansen G, Urban C, Platell J, Trott DJ, Zhanel G, Weissman SJ, Cookson BT, Fang FC, Limaye AP, Scholes D, Chattopadhyay S, Hooper DC, Sokurenko EV.

J Infect Dis. 2013 Mar 15;207(6):919-28. doi: 10.1093/infdis/jis933. Epub 2013 Jan 3.


Reproductive and economic impact following controlled introduction of cattle persistently infected with bovine viral diarrhea virus into a naive group of heifers.

Rodning SP, Givens MD, Marley MS, Zhang Y, Riddell KP, Galik PK, Hathcock TL, Gard JA, Prevatt JW, Owsley WF.

Theriogenology. 2012 Oct 15;78(7):1508-16. doi: 10.1016/j.theriogenology.2012.05.031.


Protective effects against abortion and fetal infection following exposure to bovine viral diarrhea virus and bovine herpesvirus 1 during pregnancy in beef heifers that received two doses of a multivalent modified-live virus vaccine prior to breeding.

Givens MD, Marley MS, Jones CA, Ensley DT, Galik PK, Zhang Y, Riddell KP, Joiner KS, Brodersen BW, Rodning SP.

J Am Vet Med Assoc. 2012 Aug 15;241(4):484-95. doi: 10.2460/javma.241.4.484.


Comparative effectiveness of membrane bioreactors, conventional secondary treatment, and chlorine and UV disinfection to remove microorganisms from municipal wastewaters.

Francy DS, Stelzer EA, Bushon RN, Brady AM, Williston AG, Riddell KR, Borchardt MA, Spencer SK, Gellner TM.

Water Res. 2012 Sep 1;46(13):4164-78. doi: 10.1016/j.watres.2012.04.044. Epub 2012 May 15.


High-resolution two-locus clonal typing of extraintestinal pathogenic Escherichia coli.

Weissman SJ, Johnson JR, Tchesnokova V, Billig M, Dykhuizen D, Riddell K, Rogers P, Qin X, Butler-Wu S, Cookson BT, Fang FC, Scholes D, Chattopadhyay S, Sokurenko E.

Appl Environ Microbiol. 2012 Mar;78(5):1353-60. doi: 10.1128/AEM.06663-11. Epub 2012 Jan 6.


Antiviral treatment of calves persistently infected with bovine viral diarrhoea virus.

Newcomer BW, Marley MS, Galik PK, Walz PH, Zhang Y, Riddell KP, Dykstra CC, Boykin DW, Kumar A, Cruz-Espindola C, Boothe DM, Joiner KS, Givens MD.

Antivir Chem Chemother. 2012 Jan 17;22(4):171-9. doi: 10.3851/IMP1903.


Inactivation at various temperatures of bovine viral diarrhea virus in beef derived from persistently infected cattle.

Bratcher CL, Wilborn BS, Finegan HM, Rodning SP, Galik PK, Riddell KP, Marley MS, Zhang Y, Bell LN, Givens MD.

J Anim Sci. 2012 Feb;90(2):635-41. doi: 10.2527/jas.2011-4232. Epub 2011 Sep 30.


AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.

Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Sci Signal. 2011 Aug 30;4(188):ra56. doi: 10.1126/scisignal.2001754.


Longitudinal study describing the clinical signs observed in horses naturally infected with equine influenza.

Faehrmann P, Riddell K, Read AJ.

Aust Vet J. 2011 Jul;89 Suppl 1:22-3. doi: 10.1111/j.1751-0813.2011.00733.x.


Risk and prevention of bovine viral diarrhea virus (BVDV) transmission through embryo production via somatic cell nuclear transfer (SCNT) using oocytes from persistently infected donors.

Gregg K, Riddell KP, Chen SH, Galik PK, Xiang T, Guerra T, Marley MS, Polejaeva I, Givens MD.

Theriogenology. 2010 Jul 1;74(1):1-10. doi: 10.1016/j.theriogenology.2009.12.013. Epub 2010 Feb 25.


Comparison of three commercial vaccines for preventing persistent infection with bovine viral diarrhea virus.

Rodning SP, Marley MS, Zhang Y, Eason AB, Nunley CL, Walz PH, Riddell KP, Galik PK, Brodersen BW, Givens MD.

Theriogenology. 2010 May;73(8):1154-63. doi: 10.1016/j.theriogenology.2010.01.017. Epub 2010 Feb 23.


Intrauterine inoculation of seronegative heifers with bovine viral diarrhea virus concurrent with transfer of in vivo-derived bovine embryos.

Gard JA, Givens MD, Marley MS, Galik PK, Riddell KP, Edmondson MA, Rodning SP.

Theriogenology. 2010 May;73(8):1009-17. doi: 10.1016/j.theriogenology.2009.11.022. Epub 2010 Feb 2.


Amplification of bovine viral diarrhoea virus introduced into an in vitro embryo production system via oocytes from persistently infected cattle.

Marley MS, Givens MD, Galik PK, Riddell KP, Stringfellow DA.

Reprod Domest Anim. 2009 Jun;44(3):532-5.


Epidemiology of prolonged testicular infections with bovine viral diarrhea virus.

Givens MD, Riddell KP, Edmondson MA, Walz PH, Gard JA, Zhang Y, Galik PK, Brodersen BW, Carson RL, Stringfellow DA.

Vet Microbiol. 2009 Oct 20;139(1-2):42-51. doi: 10.1016/j.vetmic.2009.04.029. Epub 2009 May 3.


Bovine viral diarrhea virus (BVDV) associated with single in vivo-derived and in vitro-produced preimplantation bovine embryos following artificial exposure.

Gard JA, Givens MD, Marley MS, Galik PK, Riddell KP, Stringfellow DA, Zhang Y, Edmondson MA.

Theriogenology. 2009 May;71(8):1238-44. doi: 10.1016/j.theriogenology.2009.01.005. Epub 2009 Feb 26.


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