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Items: 33

1.

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC.

MAbs. 2018 Jul;10(5):803-813. doi: 10.1080/19420862.2018.1458808. Epub 2018 May 9.

PMID:
29621428
2.

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.

Ulrich P, Blaich G, Baumann A, Fagg R, Hey A, Kiessling A, Kronenberg S, Lindecrona RH, Mohl S, Richter WF, Tibbitts J, Crameri F, Weir L.

Regul Toxicol Pharmacol. 2018 Apr;94:91-100. doi: 10.1016/j.yrtph.2018.01.013. Epub 2018 Jan 28.

PMID:
29355662
3.

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice.

Barrow P, Villabruna L, Hoberman A, Bohrmann B, Richter WF, Schubert C.

Reprod Toxicol. 2017 Oct;73:362-371. doi: 10.1016/j.reprotox.2017.07.014. Epub 2017 Jul 25.

PMID:
28754630
4.

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Zell M, Husser C, Staack RF, Jordan G, Richter WF, Schadt S, Pähler A.

Anal Chem. 2016 Dec 6;88(23):11670-11677. Epub 2016 Nov 18.

PMID:
27934109
5.

Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights.

Blaich G, Baumann A, Kronenberg S, de Haan L, Ulrich P, Richter WF, Tibbitts J, Chivers S, Tarcsa E, Caldwell R, Crameri F.

Regul Toxicol Pharmacol. 2016 Oct;80S:S1-S14. doi: 10.1016/j.yrtph.2016.08.012. Epub 2016 Aug 27.

PMID:
27578450
6.

Immunogenicity, Inflammation, and Lipid Accumulation in Cynomolgus Monkeys Infused with a Lipidated Tetranectin-ApoA-I Fusion Protein.

Regenass-Lechner F, Staack RF, Mary JL, Richter WF, Winter M, Jordan G, Justies N, Langenkamp A, Garrido R, Albassam M, Singer T, Atzpodien EA.

Toxicol Sci. 2016 Apr;150(2):378-89. doi: 10.1093/toxsci/kfw004. Epub 2016 Jan 18.

PMID:
26781512
7.

Neonatal Immune Tolerance Induction to Allow Long-Term Studies With an Immunogenic Therapeutic Monoclonal Antibody in Mice.

Piccand M, Bessa J, Schick E, Senn C, Bourquin C, Richter WF.

AAPS J. 2016 Mar;18(2):354-61. doi: 10.1208/s12248-015-9850-5. Epub 2015 Nov 24.

8.

Subcutaneous absorption of biotherapeutics: knowns and unknowns.

Richter WF, Jacobsen B.

Drug Metab Dispos. 2014 Nov;42(11):1881-9. doi: 10.1124/dmd.114.059238. Epub 2014 Aug 6.

9.

New challenges and opportunities in nonclinical safety testing of biologics.

Baumann A, Flagella K, Forster R, de Haan L, Kronenberg S, Locher M, Richter WF, Theil FP, Todd M.

Regul Toxicol Pharmacol. 2014 Jul;69(2):226-33. doi: 10.1016/j.yrtph.2014.04.005. Epub 2014 Apr 19.

PMID:
24755365
10.

Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab.

Bittner B, Richter WF, Hourcade-Potelleret F, Herting F, Schmidt J.

Drug Res (Stuttg). 2014 Nov;64(11):569-75. doi: 10.1055/s-0033-1363993. Epub 2014 Jan 22. Review.

PMID:
24452524
11.

Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys.

Mao CP, Brovarney MR, Dabbagh K, Birnböck HF, Richter WF, Del Nagro CJ.

PLoS One. 2013 Nov 12;8(11):e80533. doi: 10.1371/journal.pone.0080533. eCollection 2013.

12.

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds.

Röver S, Andjelkovic M, Bénardeau A, Chaput E, Guba W, Hebeisen P, Mohr S, Nettekoven M, Obst U, Richter WF, Ullmer C, Waldmeier P, Wright MB.

J Med Chem. 2013 Dec 27;56(24):9874-96. doi: 10.1021/jm4010708. Epub 2013 Nov 20.

PMID:
24175572
13.

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Sakurai T, Takai R, Bürgin H, Shioda A, Sakamoto Y, Amano J, Grimm HP, Richter WF, Higuchi Y, Chiba S, Kawamura A, Suzuki M, Müller L.

Birth Defects Res B Dev Reprod Toxicol. 2013 Apr;98(2):170-82. doi: 10.1002/bdrb.21053. Epub 2013 Mar 25.

PMID:
23529913
14.

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.

Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG Jr, Benevolenskaya EV.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18499-504. doi: 10.1073/pnas.1216724109. Epub 2012 Oct 23.

15.

Development of a subcutaneous formulation for trastuzumab - nonclinical and clinical bridging approach to the approved intravenous dosing regimen.

Bittner B, Richter WF, Hourcade-Potelleret F, McIntyre C, Herting F, Zepeda ML, Schmidt J.

Arzneimittelforschung. 2012 Sep;62(9):401-9. doi: 10.1055/s-0032-1321831. Epub 2012 Aug 23. Review. Erratum in: Arzneimittelforschung. 2013 Nov;63(11):602.

PMID:
22918857
16.

Mechanistic determinants of biotherapeutics absorption following SC administration.

Richter WF, Bhansali SG, Morris ME.

AAPS J. 2012 Sep;14(3):559-70. doi: 10.1208/s12248-012-9367-0. Epub 2012 May 23. Review.

17.

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF.

MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1.

18.

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.

Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H.

J Alzheimers Dis. 2012;28(1):49-69. doi: 10.3233/JAD-2011-110977.

PMID:
21955818
19.

Co-regulation of histone-modifying enzymes in cancer.

Islam AB, Richter WF, Jacobs LA, Lopez-Bigas N, Benevolenskaya EV.

PLoS One. 2011;6(8):e24023. doi: 10.1371/journal.pone.0024023. Epub 2011 Aug 23.

20.

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components.

Richter WF, Grimm HP, Theil FP.

J Pharmacokinet Pharmacodyn. 2011 Oct;38(5):581-93. doi: 10.1007/s10928-011-9209-1. Epub 2011 Jul 21.

PMID:
21779940
21.

Selective targeting of histone methylation.

Islam AB, Richter WF, Lopez-Bigas N, Benevolenskaya EV.

Cell Cycle. 2011 Feb 1;10(3):413-24. Epub 2011 Feb 1.

22.

Genome-wide analysis using ChIP to identify isoform-specific gene targets.

Beshiri ML, Islam A, DeWaal DC, Richter WF, Love J, Lopez-Bigas N, Benevolenskaya EV.

J Vis Exp. 2010 Jul 7;(41). pii: 2101. doi: 10.3791/2101.

23.

Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry.

Signor L, Varesio E, Staack RF, Starke V, Richter WF, Hopfgartner G.

J Mass Spectrom. 2007 Jul;42(7):900-9.

PMID:
17534860
24.

The distribution pattern of radioactivity across different tissues in quantitative whole-body autoradiography (QWBA) studies.

Richter WF, Starke V, Whitby B.

Eur J Pharm Sci. 2006 May;28(1-2):155-65. Epub 2006 Feb 28.

PMID:
16510271
25.

Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors.

Wang Q, Anzick S, Richter WF, Meltzer P, Simons SS Jr.

J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):197-210.

PMID:
15336697
26.
27.

Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins.

Richter WF, Heizmann P, Meyer J, Starke V, Lave T.

J Pharm Sci. 1998 Apr;87(4):496-500.

PMID:
9548904
28.

Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

Ridley RG, Matile H, Jaquet C, Dorn A, Hofheinz W, Leupin W, Masciadri R, Theil FP, Richter WF, Girometta MA, Guenzi A, Urwyler H, Gocke E, Potthast JM, Csato M, Thomas A, Peters W.

Antimicrob Agents Chemother. 1997 Mar;41(3):677-86.

29.

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.

Ridley RG, Hofheinz W, Matile H, Jaquet C, Dorn A, Masciadri R, Jolidon S, Richter WF, Guenzi A, Girometta MA, Urwyler H, Huber W, Thaithong S, Peters W.

Antimicrob Agents Chemother. 1996 Aug;40(8):1846-54.

30.

Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.

Van Zee KJ, Moldawer LL, Oldenburg HS, Thompson WA, Stackpole SA, Montegut WJ, Rogy MA, Meschter C, Gallati H, Schiller CD, Richter WF, Loetscher H, Ashkenazi A, Chamow SM, Wurm F, Calvano SE, Lowry SF, Lesslauer W.

J Immunol. 1996 Mar 15;156(6):2221-30.

PMID:
8690912
31.

Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals.

Richter WF, Whitby BR, Chou RC.

Xenobiotica. 1996 Mar;26(3):243-54.

PMID:
8730917
32.
33.

On the mechanism of isomerization of cephalosporin esters.

Richter WF, Chong YH, Stella VJ.

J Pharm Sci. 1990 Feb;79(2):185-6. No abstract available.

PMID:
2324969

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