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Items: 1 to 50 of 1105

1.

The Role of Extracellular Matrix Expression, ERK1/2 Signaling and Cell Cohesiveness for Cartilage Yield from iPSCs.

Buchert J, Diederichs S, Kreuser U, Merle C, Richter W.

Int J Mol Sci. 2019 Sep 2;20(17). pii: E4295. doi: 10.3390/ijms20174295.

2.

PKPD Assessment of the Anti-CD20 Antibody Obinutuzumab in Cynomolgus Monkey is Feasible Despite Marked Anti-Drug Antibody Response in This Species.

Grimm HP, Schick E, Hainzl D, Justies N, Yu L, Klein C, Husar E, Richter WF.

J Pharm Sci. 2019 Nov;108(11):3729-3736. doi: 10.1016/j.xphs.2019.07.013. Epub 2019 Jul 25.

PMID:
31351865
3.

Constraining the Neutron Star Compactness: Extraction of the ^{23}Al(p,γ) Reaction Rate for the rp Process.

Wolf C, Langer C, Montes F, Pereira J, Ong WJ, Poxon-Pearson T, Ahn S, Ayoub S, Baumann T, Bazin D, Bender PC, Brown BA, Browne J, Crawford H, Cyburt RH, Deleeuw E, Elman B, Fiebiger S, Gade A, Gastis P, Lipschutz S, Longfellow B, Meisel Z, Nunes FM, Perdikakis G, Reifarth R, Richter WA, Schatz H, Schmidt K, Schmitt J, Sullivan C, Titus R, Weisshaar D, Woods PJ, Zamora JC, Zegers RGT.

Phys Rev Lett. 2019 Jun 14;122(23):232701. doi: 10.1103/PhysRevLett.122.232701.

PMID:
31298878
4.

Infrared Intensification and Hydrogen Bond Stabilization: Beyond Point Charges.

Duarte LJ, Silva AF, Richter WE, Bruns RE.

J Phys Chem A. 2019 Aug 1;123(30):6482-6490. doi: 10.1021/acs.jpca.9b03105. Epub 2019 Jul 19.

PMID:
31276407
5.

Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease.

Nagel E, Greenwood JP, McCann GP, Bettencourt N, Shah AM, Hussain ST, Perera D, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, Richter WS, Puntmann VO, Schwenke C, Schulz-Menger J, Das R, Wong J, Hausenloy DJ, Steen H, Berry C; MR-INFORM Investigators.

N Engl J Med. 2019 Jun 20;380(25):2418-2428. doi: 10.1056/NEJMoa1716734.

PMID:
31216398
6.

Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles.

Jairam RK, Mallurwar SR, Sulochana SP, Chandrasekhar DV, Todmal U, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R.

AAPS PharmSciTech. 2019 Jun 18;20(6):221. doi: 10.1208/s12249-019-1434-8.

PMID:
31214899
7.

Simultaneous determination of bendamustine and γ-hydroxybendamustine in mice dried blood spots and its application in a mice pharmacokinetic study.

Kumar Saini N, Sulochana SP, Kiran V, Rangnathrao Mallurwar S, Richter W, Srinivas NR, Mullangi R.

J Pharm Biomed Anal. 2019 Sep 10;174:168-174. doi: 10.1016/j.jpba.2019.05.052. Epub 2019 May 28.

PMID:
31170630
8.

Team Approach in Esthetic Dentistry.

Hürzeler M, Zuhr O, Richter W, Ludwig B, Hürzeler B, Schoberer U.

Int J Esthet Dent. 2019;14(2):116-117. No abstract available.

PMID:
31061992
9.

Mechanosensitive MiRs regulated by anabolic and catabolic loading of human cartilage.

Hecht N, Johnstone B, Angele P, Walker T, Richter W.

Osteoarthritis Cartilage. 2019 Aug;27(8):1208-1218. doi: 10.1016/j.joca.2019.04.010. Epub 2019 Apr 19.

PMID:
31009748
10.

Experimental investigations of a manually versus an electrically driven skull drill for bedside usage.

Carolus A, Richter W, Fritzen CP, Schmieder K, Brenke C.

PLoS One. 2019 Apr 18;14(4):e0215171. doi: 10.1371/journal.pone.0215171. eCollection 2019.

11.

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy.

Diederichs S, Tonnier V, März M, Dreher SI, Geisbüsch A, Richter W.

Cell Mol Life Sci. 2019 Oct;76(19):3875-3889. doi: 10.1007/s00018-019-03099-0. Epub 2019 Apr 12.

PMID:
30980110
12.

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells.

Melnik S, Werth N, Boeuf S, Hahn EM, Gotterbarm T, Anton M, Richter W.

Stem Cell Res Ther. 2019 Mar 5;10(1):73. doi: 10.1186/s13287-019-1187-z.

13.

Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs.

Bothe F, Deubel AK, Hesse E, Lotz B, Groll J, Werner C, Richter W, Hagmann S.

Int J Mol Sci. 2019 Feb 2;20(3). pii: E653. doi: 10.3390/ijms20030653.

14.

High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths.

An B, Zhang M, Pu J, Shen S, Qu Y, Chen YJ, Huo S, Wang X, Polli JR, Balthasar JP, Herzog D, Ferrari L, Staack RF, Richter WF, Otteneder MB, Benincosa LJ, Zhou S, Vazvaei F, Qu J.

Anal Chem. 2019 Mar 5;91(5):3475-3483. doi: 10.1021/acs.analchem.8b05046. Epub 2019 Feb 15.

PMID:
30712341
15.

Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells.

Kufka R, Rennert R, Kaluđerović GN, Weber L, Richter W, Wessjohann LA.

Beilstein J Org Chem. 2019 Jan 10;15:96-105. doi: 10.3762/bjoc.15.11. eCollection 2019.

16.

Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler.

Perry J, Trautman B, Takher-Smith J, Kramer S, Kane K, Silverman M, Tan L, Haughie S, Richter W, Kirkov V, Arsova S, Ward J, Hava DL.

Br J Clin Pharmacol. 2019 Mar;85(3):580-589. doi: 10.1111/bcp.13831. Epub 2019 Jan 15.

PMID:
30521129
17.

StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer.

Kunisch E, Knauf AK, Hesse E, Freudenberg U, Werner C, Bothe F, Diederichs S, Richter W.

Biofabrication. 2018 Oct 30;11(1):015001. doi: 10.1088/1758-5090/aae75a.

PMID:
30376451
18.

Disc cell therapy with bone-marrow-derived autologous mesenchymal stromal cells in a large porcine disc degeneration model.

Omlor GW, Lorenz S, Nerlich AG, Guehring T, Richter W.

Eur Spine J. 2018 Oct;27(10):2639-2649. doi: 10.1007/s00586-018-5728-4. Epub 2018 Aug 23.

PMID:
30141058
19.

Influence of environmental conditions on the attenuation of ricin toxin on surfaces.

Wood JP, Richter W, Smiley MA, Rogers JV.

PLoS One. 2018 Aug 8;13(8):e0201857. doi: 10.1371/journal.pone.0201857. eCollection 2018.

20.

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities.

Bittner B, Richter W, Schmidt J.

BioDrugs. 2018 Oct;32(5):425-440. doi: 10.1007/s40259-018-0295-0. Review.

21.

FTIR and dispersive gas phase fundamental infrared intensities of the fluorochloromethanes: Comparison with QCISD/cc-pVTZ results.

Duarte LJ, Silva AF, Richter WE, Bruns RE.

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Dec 5;205:269-275. doi: 10.1016/j.saa.2018.07.020. Epub 2018 Jul 20.

PMID:
30029189
22.

Biomechanics of common fixation devices for first tarsometatarsal joint fusion-a comparative study with synthetic bones.

Burchard R, Massa R, Soost C, Richter W, Dietrich G, Ohrndorf A, Christ HJ, Fritzen CP, Graw JA, Schmitt J.

J Orthop Surg Res. 2018 Jul 11;13(1):176. doi: 10.1186/s13018-018-0876-0.

23.

Prediction of Human Pharmacokinetics of Bendamustine from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles.

Jairam RK, Mallurwar SR, Sulochana SP, Chandrasekar DV, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R.

Drug Res (Stuttg). 2019 Jan;69(1):32-39. doi: 10.1055/a-0640-8977. Epub 2018 Jul 11.

PMID:
29996173
24.

Stimulation of calvarial bone healing with human bone marrow stromal cells versus inhibition with adipose-tissue stromal cells on nanostructured β-TCP-collagen.

Bothe F, Lotz B, Seebach E, Fischer J, Hesse E, Diederichs S, Richter W.

Acta Biomater. 2018 Aug;76:135-145. doi: 10.1016/j.actbio.2018.06.026. Epub 2018 Jun 20.

PMID:
29933108
25.

Time-dependent contribution of BMP, FGF, IGF, and HH signaling to the proliferation of mesenchymal stroma cells during chondrogenesis.

Fischer J, Knoch N, Sims T, Rosshirt N, Richter W.

J Cell Physiol. 2018 Nov;233(11):8962-8970. doi: 10.1002/jcp.26832. Epub 2018 Jun 1.

PMID:
29856487
26.

CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies.

Bacac M, Colombetti S, Herter S, Sam J, Perro M, Chen S, Bianchi R, Richard M, Schoenle A, Nicolini V, Diggelmann S, Limani F, Schlenker R, Hüsser T, Richter W, Bray-French K, Hinton H, Giusti AM, Freimoser-Grundschober A, Lariviere L, Neumann C, Klein C, Umaña P.

Clin Cancer Res. 2018 Oct 1;24(19):4785-4797. doi: 10.1158/1078-0432.CCR-18-0455. Epub 2018 May 1.

27.

[New insights into the function of bone marrow].

Schett G, Bozec A, Bekeredjian-Ding I, Chang HD, David JP, Dörner T, Grässel S, Gunzer M, Manz R, Mei H, Mielenz D, Müller-Ladner U, Neumann E, Radbruch A, Richter W, Straub RH.

Z Rheumatol. 2018 May;77(Suppl 1):4-7. doi: 10.1007/s00393-018-0456-z. Review. German. No abstract available.

PMID:
29691692
28.

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC.

MAbs. 2018 Jul;10(5):803-813. doi: 10.1080/19420862.2018.1458808. Epub 2018 May 9.

29.

The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin.

Rühle A, Xia O, Perez RL, Trinh T, Richter W, Sarnowska A, Wuchter P, Debus J, Saffrich R, Huber PE, Nicolay NH.

Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1259-1269. doi: 10.1016/j.ijrobp.2018.01.015. Epub 2018 Jan 9.

PMID:
29452769
30.

Intramedullary nailing in opening wedge high tibial osteotomy-in vitro test for validation of a method of fixation.

Burchard R, Katerla D, Hammer M, Pahlkötter A, Soost C, Dietrich G, Ohrndorf A, Richter W, Lengsfeld M, Christ HJ, Graw JA, Fritzen CP.

Int Orthop. 2018 Aug;42(8):1835-1843. doi: 10.1007/s00264-018-3790-5. Epub 2018 Feb 1.

PMID:
29392383
31.

Caenorhabditis elegans Predation on Bacillus anthracis: Decontamination of Spore Contaminated Soil with Germinants and Nematodes.

Schelkle B, Choi Y, Baillie LW, Richter W, Buyuk F, Celik E, Wendling M, Sahin M, Gallagher T.

Front Microbiol. 2018 Jan 5;8:2601. doi: 10.3389/fmicb.2017.02601. eCollection 2017.

32.

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.

Ulrich P, Blaich G, Baumann A, Fagg R, Hey A, Kiessling A, Kronenberg S, Lindecrona RH, Mohl S, Richter WF, Tibbitts J, Crameri F, Weir L.

Regul Toxicol Pharmacol. 2018 Apr;94:91-100. doi: 10.1016/j.yrtph.2018.01.013. Epub 2018 Jan 28.

PMID:
29355662
33.

Extracellular matrix content and WNT/β-catenin levels of cartilage determine the chondrocyte response to compressive load.

Praxenthaler H, Krämer E, Weisser M, Hecht N, Fischer J, Grossner T, Richter W.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):851-859. doi: 10.1016/j.bbadis.2017.12.024. Epub 2017 Dec 19.

34.

Inactivation of Bacillus anthracis spores to decontaminate subway railcar and related materials via the fogging of peracetic acid and hydrogen peroxide sporicidal liquids.

Richter WR, Wood JP, Wendling MQS, Rogers JV.

J Environ Manage. 2018 Jan 15;206:800-806. doi: 10.1016/j.jenvman.2017.11.027. Epub 2017 Nov 22.

35.

Stimulation of a calcified cartilage connecting zone by GDF-5-augmented fibrin hydrogel in a novel layered ectopic in vivo model.

Diederichs S, Renz Y, Hagmann S, Lotz B, Seebach E, Richter W.

J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2214-2224. doi: 10.1002/jbm.b.34027. Epub 2017 Oct 25.

PMID:
29068568
36.

Quantum Theory of Atoms in Molecules Charge-Charge Transfer-Dipolar Polarization Classification of Infrared Intensities.

Duarte LJ, Richter WE, Silva AF, Bruns RE.

J Phys Chem A. 2017 Oct 26;121(42):8115-8123. doi: 10.1021/acs.jpca.7b08031. Epub 2017 Oct 13.

PMID:
28968500
37.

The verified neighbor approach to geoprivacy: An improved method for geographic masking.

Richter W.

J Expo Sci Environ Epidemiol. 2018 Mar;28(2):109-118. doi: 10.1038/jes.2017.17. Epub 2017 Sep 20.

PMID:
28930296
38.

LC-ESI-MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs.

Chandrasekhar DV, Suresh PS, Dittakavi S, Hiremath RA, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R.

Biomed Chromatogr. 2018 Feb;32(2). doi: 10.1002/bmc.4065. Epub 2017 Sep 25.

PMID:
28810079
39.

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice.

Barrow P, Villabruna L, Hoberman A, Bohrmann B, Richter WF, Schubert C.

Reprod Toxicol. 2017 Oct;73:362-371. doi: 10.1016/j.reprotox.2017.07.014. Epub 2017 Jul 25.

PMID:
28754630
40.

Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells.

Woitok M, Klose D, Di Fiore S, Richter W, Stein C, Gresch G, Grieger E, Barth S, Fischer R, Kolberg K, Niesen J.

Onco Targets Ther. 2017 Jul 6;10:3313-3327. doi: 10.2147/OTT.S140492. eCollection 2017.

41.

Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs.

Chandrashekar DV, Suresh PS, Kumar R, Bhamidipati RK, Mullangi R, Richter W, Srinivas NR.

Drug Res (Stuttg). 2017 Sep;67(9):497-508. doi: 10.1055/s-0043-108124. Epub 2017 May 30.

PMID:
28561238
42.

Is Total Disk Replacement a Cost-effective Treatment for Cervical Degenerative Disk Disease?

Wiedenhöfer B, Nacke J, Stephan M, Richter W, Carstens C, Eichler M.

Clin Spine Surg. 2017 Jun;30(5):E530-E534. doi: 10.1097/BSD.0000000000000189.

PMID:
28525473
43.

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.

Jadhav SB, Khaowroongrueng V, Fueth M, Otteneder MB, Richter W, Derendorf H.

J Pharm Sci. 2017 Sep;106(9):2853-2859. doi: 10.1016/j.xphs.2017.03.033. Epub 2017 Apr 13.

PMID:
28414146
44.

Atomic polarizations necessary for coherent infrared intensity modeling with theoretical calculations.

Richter WE, Silva AF, Bruns RE.

J Chem Phys. 2017 Apr 7;146(13):134107. doi: 10.1063/1.4979574.

PMID:
28390371
45.

Global chondrocyte gene expression after a single anabolic loading period: Time evolution and re-inducibility of mechano-responses.

Scholtes S, Krämer E, Weisser M, Roth W, Luginbühl R, Grossner T, Richter W.

J Cell Physiol. 2018 Jan;233(1):699-711. doi: 10.1002/jcp.25933. Epub 2017 May 19.

PMID:
28369921
46.

Peptide-functionalized starPEG/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo.

Hesse E, Freudenberg U, Niemietz T, Greth C, Weisser M, Hagmann S, Binner M, Werner C, Richter W.

J Tissue Eng Regen Med. 2018 Jan;12(1):229-239. doi: 10.1002/term.2404. Epub 2017 Jun 4.

PMID:
28083992
47.

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Zell M, Husser C, Staack RF, Jordan G, Richter WF, Schadt S, Pähler A.

Anal Chem. 2016 Dec 6;88(23):11670-11677. Epub 2016 Nov 18.

PMID:
27934109
48.

Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

Dexheimer V, Gabler J, Bomans K, Sims T, Omlor G, Richter W.

Sci Rep. 2016 Nov 16;6:36655. doi: 10.1038/srep36655.

49.

Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring.

Reisig G, Kreinest M, Richter W, Wagner-Ecker M, Dinter D, Attenberger U, Schneider-Wald B, Fickert S, Schwarz ML.

PLoS One. 2016 Nov 7;11(11):e0165897. doi: 10.1371/journal.pone.0165897. eCollection 2016.

50.

Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration.

Vasconcelos DM, Gonçalves RM, Almeida CR, Pereira IO, Oliveira MI, Neves N, Silva AM, Ribeiro AC, Cunha C, Almeida AR, Ribeiro CC, Gil AM, Seebach E, Kynast KL, Richter W, Lamghari M, Santos SG, Barbosa MA.

Biomaterials. 2016 Dec;111:163-178. doi: 10.1016/j.biomaterials.2016.10.004. Epub 2016 Oct 4.

PMID:
27728815

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