Format

Send to

Choose Destination
Sci Rep. 2018 Feb 14;8(1):3033. doi: 10.1038/s41598-018-21336-7.

Fluvastatin protects cochleae from damage by high-level noise.

Author information

1
Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, United States of America.
2
Department of Biomedical Engineering, Northwestern University, Evanston, United States of America.
3
The Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, United States of America.
4
Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
5
Advanced Photon Source, Argonne National Laboratory, Argonne, United States of America.
6
Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, United States of America. Whitlon@northwestern.edu.
7
The Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, United States of America. Whitlon@northwestern.edu.
8
Interdepartmental Neurosciences Program, Northwestern University, Chicago, United States of America. Whitlon@northwestern.edu.

Abstract

Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond hearing aids and cochlear implants, there have been no other FDA approved drug interventions established in the clinic that would either protect or reverse the effects of hearing loss. Using Auditory Brainstem Responses (ABR) in a guinea pig model, we demonstrate that fluvastatin, an inhibitor of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, protects against loss of cochlear function initiated by high intensity noise. A novel synchrotron radiation based X-ray tomographic method that imaged soft tissues at micrometer resolution in unsectioned cochleae, allowed an efficient, qualitative evaluation of the three-dimensional internal structure of the intact organ. For quantitative measures, plastic embedded cochleae were sectioned followed by hair cell counting. Protection in noise-exposed cochleae is associated with retention of inner and outer hair cells. This study demonstrates the potential of HMG-CoA reductase inhibitors, already vetted in human medicine for other purposes, to protect against noise induced hearing loss.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center