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Items: 20


Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis.

Mostafavi M, Wang L, Xie L, Takeoka KT, Richie DL, Casey F, Ruzin A, Sawyer WS, Rath CM, Wei JR, Dean CR.

mSphere. 2018 Oct 31;3(5). pii: e00508-18. doi: 10.1128/mSphere.00508-18.


A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii.

Richie DL, Wang L, Chan H, De Pascale G, Six DA, Wei JR, Dean CR.

PLoS One. 2018 Mar 5;13(3):e0193851. doi: 10.1371/journal.pone.0193851. eCollection 2018.


LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.

Wei JR, Richie DL, Mostafavi M, Metzger LE 4th, Rath CM, Sawyer WS, Takeoka KT, Dean CR.

mSphere. 2017 Jul 26;2(4). pii: e00199-17. doi: 10.1128/mSphere.00199-17. eCollection 2017 Jul-Aug.


Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.

Richie DL, Takeoka KT, Bojkovic J, Metzger LE 4th, Rath CM, Sawyer WS, Wei JR, Dean CR.

PLoS One. 2016 Aug 15;11(8):e0160918. doi: 10.1371/journal.pone.0160918. eCollection 2016.


A Fluorescence-Based High-Throughput Screening Assay to Identify Growth Inhibitors of the Pathogenic Fungus Aspergillus fumigatus.

Smith TM, Richie DL, Tao J.

Methods Mol Biol. 2016;1439:171-9. doi: 10.1007/978-1-4939-3673-1_11.


Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.

Bojkovic J, Richie DL, Six DA, Rath CM, Sawyer WS, Hu Q, Dean CR.

J Bacteriol. 2015 Dec 14;198(4):731-41. doi: 10.1128/JB.00639-15.


Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space.

Ross AG, Benton BM, Chin D, De Pascale G, Fuller J, Leeds JA, Reck F, Richie DL, Vo J, LaMarche MJ.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3468-75. doi: 10.1016/j.bmcl.2015.07.010. Epub 2015 Jul 9.


Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents.

Richie DL, Thompson KV, Studer C, Prindle VC, Aust T, Riedl R, Estoppey D, Tao J, Sexton JA, Zabawa T, Drumm J, Cotesta S, Eichenberger J, Schuierer S, Hartmann N, Movva NR, Tallarico JA, Ryder NS, Hoepfner D.

Antimicrob Agents Chemother. 2013 May;57(5):2272-80. doi: 10.1128/AAC.01809-12. Epub 2013 Mar 11.


Effects of a defective endoplasmic reticulum-associated degradation pathway on the stress response, virulence, and antifungal drug susceptibility of the mold pathogen Aspergillus fumigatus.

Krishnan K, Feng X, Powers-Fletcher MV, Bick G, Richie DL, Woollett LA, Askew DS.

Eukaryot Cell. 2013 Apr;12(4):512-9. doi: 10.1128/EC.00319-12. Epub 2013 Jan 25.


Nonspecific effect of Mycograb on amphotericin B MIC.

Richie DL, Ghannoum MA, Isham N, Thompson KV, Ryder NS.

Antimicrob Agents Chemother. 2012 Jul;56(7):3963-4. doi: 10.1128/AAC.00435-12. Epub 2012 Apr 16.


HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.

Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latgé JP, Woollett L, Newman SL, Cramer RA Jr, Rhodes JC, Askew DS.

PLoS Pathog. 2011 Oct;7(10):e1002330. doi: 10.1371/journal.ppat.1002330. Epub 2011 Oct 20.


The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR).

Richie DL, Feng X, Hartl L, Aimanianda V, Krishnan K, Powers-Fletcher MV, Watson DS, Galande AK, White SM, Willett T, Latgé JP, Rhodes JC, Askew DS.

Virulence. 2011 Jan-Feb;2(1):12-21. Epub 2011 Jan 1.


Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus.

Fuller KK, Richie DL, Feng X, Krishnan K, Stephens TJ, Wikenheiser-Brokamp KA, Askew DS, Rhodes JC.

Mol Microbiol. 2011 Feb;79(4):1045-62. doi: 10.1111/j.1365-2958.2010.07509.x. Epub 2011 Jan 6.


Secretion stress and antifungal resistance: an Achilles' heel of Aspergillus fumigatus?

Richie DL, Feng X, Krishnan K, Askew DS.

Med Mycol. 2011 Apr;49 Suppl 1:S101-6. doi: 10.3109/13693786.2010.497504. Epub 2010 Jul 7. Review.


Autophagy in the filamentous fungus Aspergillus fumigatus.

Richie DL, Askew DS.

Methods Enzymol. 2008;451:241-50. doi: 10.1016/S0076-6879(08)03217-5.


A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus.

Richie DL, Hartl L, Aimanianda V, Winters MS, Fuller KK, Miley MD, White S, McCarthy JW, Latgé JP, Feldmesser M, Rhodes JC, Askew DS.

PLoS Pathog. 2009 Jan;5(1):e1000258. doi: 10.1371/journal.ppat.1000258. Epub 2009 Jan 9.


Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus.

Bhabhra R, Richie DL, Kim HS, Nierman WC, Fortwendel J, Aris JP, Rhodes JC, Askew DS.

Eukaryot Cell. 2008 Apr;7(4):575-83. doi: 10.1128/EC.00412-07. Epub 2008 Feb 22.


Autophagy: a role in metal ion homeostasis?

Richie DL, Askew DS.

Autophagy. 2008 Jan;4(1):115-7. Epub 2007 Nov 2.


Unexpected link between metal ion deficiency and autophagy in Aspergillus fumigatus.

Richie DL, Fuller KK, Fortwendel J, Miley MD, McCarthy JW, Feldmesser M, Rhodes JC, Askew DS.

Eukaryot Cell. 2007 Dec;6(12):2437-47. Epub 2007 Oct 5.


The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress.

Richie DL, Miley MD, Bhabhra R, Robson GD, Rhodes JC, Askew DS.

Mol Microbiol. 2007 Jan;63(2):591-604. Epub 2006 Dec 14.

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