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Items: 27

1.

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.

Richardson TG, Hemani G, Gaunt TR, Relton CL, Davey Smith G.

Nat Commun. 2020 Jan 10;11(1):185. doi: 10.1038/s41467-019-13921-9.

2.

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization.

Treur JL, Demontis D, Smith GD, Sallis H, Richardson TG, Wiers RW, Børglum AD, Verweij KJH, Munafò MR.

Addict Biol. 2019 Nov 16:e12849. doi: 10.1111/adb.12849. [Epub ahead of print]

PMID:
31733098
3.

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease.

McGowan LM, Davey Smith G, Gaunt TR, Richardson TG.

Hum Mol Genet. 2019 Oct 1;28(19):3293-3300. doi: 10.1093/hmg/ddz155.

4.

DNA methylation links prenatal smoking exposure to later life health outcomes in offspring.

Wiklund P, Karhunen V, Richmond RC, Parmar P, Rodriguez A, De Silva M, Wielscher M, Rezwan FI, Richardson TG, Veijola J, Herzig KH, Holloway JW, Relton CL, Sebert S, Järvelin MR.

Clin Epigenetics. 2019 Jul 1;11(1):97. doi: 10.1186/s13148-019-0683-4.

5.

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility.

Richardson TG, Richmond RC, North TL, Hemani G, Davey Smith G, Sharp GC, Relton CL.

Int J Epidemiol. 2019 Jun 1;48(3):887-898. doi: 10.1093/ije/dyz119.

6.

Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns.

Kazmi N, Sharp GC, Reese SE, Vehmeijer FO, Lahti J, Page CM, Zhang W, Rifas-Shiman SL, Rezwan FI, Simpkin AJ, Burrows K, Richardson TG, Santos Ferreira DL, Fraser A, Harmon QE, Zhao S, Jaddoe VWV, Czamara D, Binder EB, Magnus MC, Håberg SE, Nystad W, Nohr EA, Starling AP, Kechris KJ, Yang IV, DeMeo DL, Litonjua AA, Baccarelli A, Oken E, Holloway JW, Karmaus W, Arshad SH, Dabelea D, Sørensen TIA, Laivuori H, Raikkonen K, Felix JF, London SJ, Hivert MF, Gaunt TR, Lawlor DA, Relton CL.

Hypertension. 2019 Aug;74(2):375-383. doi: 10.1161/HYPERTENSIONAHA.119.12634. Epub 2019 Jun 24. Review.

7.

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, Starling AP, Novoloaca A, Lent S, Roy R, Hoyo C, Breton CV, Allard C, Just AC, Bakulski KM, Holloway JW, Everson TM, Xu CJ, Huang RC, van der Plaat DA, Wielscher M, Merid SK, Ullemar V, Rezwan FI, Lahti J, van Dongen J, Langie SAS, Richardson TG, Magnus MC, Nohr EA, Xu Z, Duijts L, Zhao S, Zhang W, Plusquin M, DeMeo DL, Solomon O, Heimovaara JH, Jima DD, Gao L, Bustamante M, Perron P, Wright RO, Hertz-Picciotto I, Zhang H, Karagas MR, Gehring U, Marsit CJ, Beilin LJ, Vonk JM, Jarvelin MR, Bergström A, Örtqvist AK, Ewart S, Villa PM, Moore SE, Willemsen G, Standaert ARL, Håberg SE, Sørensen TIA, Taylor JA, Räikkönen K, Yang IV, Kechris K, Nawrot TS, Silver MJ, Gong YY, Richiardi L, Kogevinas M, Litonjua AA, Eskenazi B, Huen K, Mbarek H, Maguire RL, Dwyer T, Vrijheid M, Bouchard L, Baccarelli AA, Croen LA, Karmaus W, Anderson D, de Vries M, Sebert S, Kere J, Karlsson R, Arshad SH, Hämäläinen E, Routledge MN, Boomsma DI, Feinberg AP, Newschaffer CJ, Govarts E, Moisse M, Fallin MD, Melén E, Prentice AM, Kajantie E, Almqvist C, Oken E, Dabelea D, Boezen HM, Melton PE, Wright RJ, Koppelman GH, Trevisi L, Hivert MF, Sunyer J, Munthe-Kaas MC, Murphy SK, Corpeleijn E, Wiemels J, Holland N, Herceg Z, Binder EB, Davey Smith G, Jaddoe VWV, Lie RT, Nystad W, London SJ, Lawlor DA, Relton CL, Snieder H, Felix JF.

Nat Commun. 2019 Apr 23;10(1):1893. doi: 10.1038/s41467-019-09671-3.

8.

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome.

Richardson TG, Harrison S, Hemani G, Davey Smith G.

Elife. 2019 Mar 5;8. pii: e43657. doi: 10.7554/eLife.43657.

9.

Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease.

Hatcher C, Relton CL, Gaunt TR, Richardson TG.

Transl Psychiatry. 2019 Feb 28;9(1):105. doi: 10.1038/s41398-019-0437-2.

10.

Conditioning on a Collider May Induce Spurious Associations: Do the Results of Gale et al. (2017) Support a Health-Protective Effect of Neuroticism in Population Subgroups?

Richardson TG, Davey Smith G, Munafò MR.

Psychol Sci. 2019 Apr;30(4):629-632. doi: 10.1177/0956797618774532. Epub 2019 Feb 22. No abstract available.

PMID:
30794476
11.

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization.

Taylor K, Davey Smith G, Relton CL, Gaunt TR, Richardson TG.

Genome Med. 2019 Jan 31;11(1):6. doi: 10.1186/s13073-019-0613-2.

12.

Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate.

Howe LJ, Richardson TG, Arathimos R, Alvizi L, Passos-Bueno MR, Stanier P, Nohr E, Ludwig KU, Mangold E, Knapp M, Stergiakouli E, Pourcain BS, Smith GD, Sandy J, Relton CL, Lewis SJ, Hemani G, Sharp GC.

Epigenomics. 2019 Feb;11(2):133-145. doi: 10.2217/epi-2018-0091. Epub 2019 Jan 14.

13.

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE.

Am J Hum Genet. 2019 Jan 3;104(1):112-138. doi: 10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27.

14.

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA, Sargurupremraj M, Debette S, Boehnke M, Scott LJ, Luan J, Zhao JH, Willems SM, Thériault S, Shah N, Oldmeadow C, Almgren P, Li-Gao R, Verweij N, Boutin TS, Mangino M, Ntalla I, Feofanova E, Surendran P, Cook JP, Karthikeyan S, Lahrouchi N, Liu C, Sepúlveda N, Richardson TG, Kraja A, Amouyel P, Farrall M, Poulter NR; Understanding Society Scientific Group; International Consortium for Blood Pressure; Blood Pressure-International Consortium of Exome Chip Studies, Laakso M, Zeggini E, Sever P, Scott RA, Langenberg C, Wareham NJ, Conen D, Palmer CNA, Attia J, Chasman DI, Ridker PM, Melander O, Mook-Kanamori DO, Harst PV, Cucca F, Schlessinger D, Hayward C, Spector TD, Jarvelin MR, Hennig BJ, Timpson NJ, Wei WQ, Smith JC, Xu Y, Matheny ME, Siew EE, Lindgren C, Herzig KH, Dedoussis G, Denny JC, Psaty BM, Howson JMM, Munroe PB, Newton-Cheh C, Caulfield MJ, Elliott P, Gaziano JM, Concato J, Wilson PWF, Tsao PS, Velez Edwards DR, Susztak K; Million Veteran Program, O'Donnell CJ, Hung AM, Edwards TL.

Nat Genet. 2019 Jan;51(1):51-62. doi: 10.1038/s41588-018-0303-9. Epub 2018 Dec 21.

15.

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics.

Zheng J, Richardson TG, Millard LAC, Hemani G, Elsworth BL, Raistrick CA, Vilhjalmsson B, Neale BM, Haycock PC, Smith GD, Gaunt TR.

Gigascience. 2018 Aug 1;7(8). doi: 10.1093/gigascience/giy090.

16.

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.

Ye J, Richardson TG, McArdle WL, Relton CL, Gillespie KM, Suderman M, Hemani G.

J Autoimmun. 2018 Sep;93:66-75. doi: 10.1016/j.jaut.2018.06.005. Epub 2018 Jun 29.

PMID:
30146008
17.

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Richardson TG, Haycock PC, Zheng J, Timpson NJ, Gaunt TR, Davey Smith G, Relton CL, Hemani G.

Hum Mol Genet. 2018 Sep 15;27(18):3293-3304. doi: 10.1093/hmg/ddy210.

18.

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

Erzurumluoglu AM, Baird D, Richardson TG, Timpson NJ, Rodriguez S.

Genes (Basel). 2018 Jan 22;9(1). pii: E45. doi: 10.3390/genes9010045.

19.

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.

Richardson TG, Zheng J, Davey Smith G, Timpson NJ, Gaunt TR, Relton CL, Hemani G.

Am J Hum Genet. 2017 Oct 5;101(4):590-602. doi: 10.1016/j.ajhg.2017.09.003.

20.

A pathway-centric approach to rare variant association analysis.

Richardson TG, Timpson NJ, Campbell C, Gaunt TR.

Eur J Hum Genet. 2016 Jan;25(1):123-129. doi: 10.1038/ejhg.2016.113. Epub 2016 Aug 31.

21.

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.

Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, Ring SM, Rodriguez S, Campbell C, Smith GD, Relton CL, Timpson NJ, Gaunt TR.

Hum Mol Genet. 2016 Oct 1;25(19):4339-4349. doi: 10.1093/hmg/ddw283. Epub 2016 Aug 24.

22.

Incorporating Non-Coding Annotations into Rare Variant Analysis.

Richardson TG, Campbell C, Timpson NJ, Gaunt TR.

PLoS One. 2016 Apr 29;11(4):e0154181. doi: 10.1371/journal.pone.0154181. eCollection 2016.

23.

A Protein Domain and Family Based Approach to Rare Variant Association Analysis.

Richardson TG, Shihab HA, Rivas MA, McCarthy MI, Campbell C, Timpson NJ, Gaunt TR.

PLoS One. 2016 Apr 29;11(4):e0153803. doi: 10.1371/journal.pone.0153803. eCollection 2016.

24.

Identifying Highly Penetrant Disease Causal Mutations Using Next Generation Sequencing: Guide to Whole Process.

Erzurumluoglu AM, Rodriguez S, Shihab HA, Baird D, Richardson TG, Day IN, Gaunt TR.

Biomed Res Int. 2015;2015:923491. doi: 10.1155/2015/923491. Epub 2015 Apr 6. Review.

25.

Influence of adiposity-related genetic markers in a population of saudi arabians where other variables influencing obesity may be reduced.

Alharbi KK, Richardson TG, Khan IA, Syed R, Mohammed AK, Boustred CR, Gaunt TR, Tamimi W, Al-Daghri NM, Day IN.

Dis Markers. 2014;2014:758232. doi: 10.1155/2014/758232. Epub 2014 Nov 17.

26.

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.

Richardson TG, Minica C, Heron J, Tavare J, MacKenzie A, Day I, Lewis G, Hickman M, Vink JM, Gelernter J, Kranzler HR, Farrer LA, Munafò M, Wynick D.

Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):654-64. doi: 10.1002/ajmg.b.32270. Epub 2014 Sep 16.

27.

Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

Richardson TG, Thomas EC, Sessions RB, Lawlor DA, Tavaré JM, Day IN.

PLoS One. 2013 May 7;8(5):e63897. doi: 10.1371/journal.pone.0063897. Print 2013.

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