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Items: 1 to 50 of 138

1.

Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.

Makhaeva GF, Boltneva NP, Lushchekina SV, Rudakova EV, Serebryakova OG, Kulikova LN, Beloglazkin AA, Borisov RS, Richardson RJ.

Bioorg Med Chem. 2018 Sep 1;26(16):4716-4725. doi: 10.1016/j.bmc.2018.08.010. Epub 2018 Aug 6.

PMID:
30104121
2.

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8077-E8085. doi: 10.1073/pnas.1804764115. Epub 2018 Aug 3.

3.

Metabolites of n-Butylparaben and iso-Butylparaben Exhibit Estrogenic Properties in MCF-7 and T47D Human Breast Cancer Cell Lines.

Gonzalez TL, Moos RK, Gersch CL, Johnson MD, Richardson RJ, Koch HM, Rae JM.

Toxicol Sci. 2018 Jul 1;164(1):50-59. doi: 10.1093/toxsci/kfy063.

PMID:
29945225
4.

The presence of algae mitigates the toxicity of copper-based algaecides to a nontarget organism.

Bishop WM, Willis BE, Richardson RJ, Cope WG.

Environ Toxicol Chem. 2018 Aug;37(8):2132-2142. doi: 10.1002/etc.4166. Epub 2018 Jun 20.

PMID:
29736933
5.

Influence of Phoslock® on legacy phosphorus, nutrient ratios, and algal assemblage composition in hypereutrophic water resources.

Bishop WM, Richardson RJ.

Environ Sci Pollut Res Int. 2018 Feb;25(5):4544-4557. doi: 10.1007/s11356-017-0832-2. Epub 2017 Nov 29.

PMID:
29188598
6.

9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.

Makhaeva GF, Lushchekina SV, Boltneva NP, Serebryakova OG, Rudakova EV, Ustyugov AA, Bachurin SO, Shchepochkin AV, Chupakhin ON, Charushin VN, Richardson RJ.

Bioorg Med Chem. 2017 Nov 1;25(21):5981-5994. doi: 10.1016/j.bmc.2017.09.028. Epub 2017 Sep 20.

PMID:
28986116
7.

Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression.

Gobinath AR, Richardson RJ, Chow C, Workman JL, Lieblich SE, Barr AM, Galea LAM.

Neuropharmacology. 2018 Jan;128:106-118. doi: 10.1016/j.neuropharm.2017.09.017. Epub 2017 Sep 28.

PMID:
28964735
8.

Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.

Shchegol'kov EV, Makhaeva GF, Boltneva NP, Lushchekina SV, Serebryakova OG, Rudakova EV, Kovaleva NV, Burgart YV, Saloutin VI, Chupakhin ON, Bachurin SO, Richardson RJ.

Bioorg Med Chem. 2017 Aug 1;25(15):3997-4007. doi: 10.1016/j.bmc.2017.05.045. Epub 2017 May 20.

PMID:
28578994
9.

Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo.

Makhaeva GF, Rudakova EV, Serebryakova OG, Aksinenko AY, Lushchekina SV, Bachurin SO, Richardson RJ.

Chem Biol Interact. 2016 Nov 25;259(Pt B):332-342. doi: 10.1016/j.cbi.2016.05.002. Epub 2016 May 3.

PMID:
27154493
10.

Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.

Makhaeva GF, Rudakova EV, Sigolaeva LV, Kurochkin IN, Richardson RJ.

J Appl Toxicol. 2016 Nov;36(11):1468-75. doi: 10.1002/jat.3305. Epub 2016 Mar 11.

11.

Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.

Makhaeva GF, Boltneva NP, Lushchekina SV, Serebryakova OG, Stupina TS, Terentiev AA, Serkov IV, Proshin AN, Bachurin SO, Richardson RJ.

Bioorg Med Chem. 2016 Mar 1;24(5):1050-62. doi: 10.1016/j.bmc.2016.01.031. Epub 2016 Jan 18.

PMID:
26827140
12.

A review of epidemiologic studies of low-level exposures to organophosphorus insecticides in non-occupational populations.

Reiss R, Chang ET, Richardson RJ, Goodman M.

Crit Rev Toxicol. 2015;45(7):531-641. doi: 10.3109/10408444.2015.1043976. Review.

PMID:
26153436
13.

Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.

Hufnagel RB, Arno G, Hein ND, Hersheson J, Prasad M, Anderson Y, Krueger LA, Gregory LC, Stoetzel C, Jaworek TJ, Hull S, Li A, Plagnol V, Willen CM, Morgan TM, Prows CA, Hegde RS, Riazuddin S, Grabowski GA, Richardson RJ, Dieterich K, Huang T, Revesz T, Martinez-Barbera JP, Sisk RA, Jefferies C, Houlden H, Dattani MT, Fink JK, Dollfus H, Moore AT, Ahmed ZM.

J Med Genet. 2015 Feb;52(2):85-94. doi: 10.1136/jmedgenet-2014-102856. Epub 2014 Dec 5.

PMID:
25480986
14.

Crystal structure of patatin-17 in complex with aged and non-aged organophosphorus compounds.

Wijeyesakere SJ, Richardson RJ, Stuckey JA.

PLoS One. 2014 Sep 23;9(9):e108245. doi: 10.1371/journal.pone.0108245. eCollection 2014.

15.

Periderm prevents pathological epithelial adhesions during embryogenesis.

Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R, Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ.

J Clin Invest. 2014 Sep;124(9):3891-900. doi: 10.1172/JCI71946. Epub 2014 Aug 18.

16.

Evaluation of von Willebrand factor and von Willebrand factor propeptide in models of vascular endothelial cell activation, perturbation, and/or injury.

Brott DA, Katein A, Thomas H, Lawton M, Montgomery RR, Richardson RJ, Louden CS.

Toxicol Pathol. 2014 Jun;42(4):672-83. doi: 10.1177/0192623313518664. Epub 2014 Feb 4.

17.

Effects of occupational exposure to chlorpyrifos on neuropsychological function: a prospective longitudinal study.

Berent S, Giordani B, Albers JW, Garabrant DH, Cohen SS, Garrison RP, Richardson RJ.

Neurotoxicology. 2014 Mar;41:44-53. doi: 10.1016/j.neuro.2013.12.010. Epub 2014 Jan 18.

PMID:
24447827
18.

Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds.

Makhaeva GF, Rudakova EV, Hein ND, Serebryakova OG, Kovaleva NV, Boltneva NP, Fink JK, Richardson RJ.

J Appl Toxicol. 2014 Dec;34(12):1426-35. doi: 10.1002/jat.2977. Epub 2014 Jan 7.

19.

AMACO is a component of the basement membrane-associated Fraser complex.

Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R.

J Invest Dermatol. 2014 May;134(5):1313-1322. doi: 10.1038/jid.2013.492. Epub 2013 Nov 14.

20.

Kinetics and mechanism of inhibition of serine esterases by fluorinated carbethoxy 1-aminophosphonates.

Makhaeva GF, Lushchekina SV, Serebryakova OG, Aksinenko AY, Goreva TV, Richardson RJ, Martynov IV.

Dokl Biochem Biophys. 2013 Jul-Aug;451:203-6. doi: 10.1134/S1607672913040091. Epub 2013 Aug 23. No abstract available.

PMID:
23975401
21.

Neuropathy target esterase (NTE): overview and future.

Richardson RJ, Hein ND, Wijeyesakere SJ, Fink JK, Makhaeva GF.

Chem Biol Interact. 2013 Mar 25;203(1):238-44. doi: 10.1016/j.cbi.2012.10.024. Epub 2012 Dec 3. Review.

PMID:
23220002
22.

Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects.

Makhaeva GF, Radchenko EV, Palyulin VA, Rudakova EV, Aksinenko AY, Sokolov VB, Zefirov NS, Richardson RJ.

Chem Biol Interact. 2013 Mar 25;203(1):231-7. doi: 10.1016/j.cbi.2012.10.012. Epub 2012 Nov 2.

PMID:
23123251
23.

Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism and Alzheimer's disease.

Makhaeva GF, Radchenko EV, Baskin II, Palyulin VA, Richardson RJ, Zefirov NS.

SAR QSAR Environ Res. 2012 Oct;23(7-8):627-47. doi: 10.1080/1062936X.2012.679690. Epub 2012 May 15.

PMID:
22587543
24.

Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects.

Rudakova EV, Makhaeva GF, Galenko TG, Aksinenko AY, Sokolov VB, Richardson RJ, Martynov IV.

Dokl Biochem Biophys. 2012 Mar-Apr;443:81-5. doi: 10.1134/S1607672912020068. Epub 2012 May 5. No abstract available.

PMID:
22562631
25.

Evidence for the nitric oxide pathway as a potential mode of action in fenoldopam-induced vascular injury.

Brott DA, Richardson RJ, Louden CS.

Toxicol Pathol. 2012 Aug;40(6):874-86. doi: 10.1177/0192623312444027. Epub 2012 May 1.

PMID:
22549976
26.

Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain.

Wang Y, Liu X, Schneider B, Zverina EA, Russ K, Wijeyesakere SJ, Fierke CA, Richardson RJ, Philbert MA.

Toxicol Sci. 2012 Feb;125(2):509-21. doi: 10.1093/toxsci/kfr317. Epub 2011 Nov 21.

27.

Motor neuron disease due to neuropathy target esterase gene mutation: clinical features of the index families.

Rainier S, Albers JW, Dyck PJ, Eldevik OP, Wilcock S, Richardson RJ, Fink JK.

Muscle Nerve. 2011 Jan;43(1):19-25. doi: 10.1002/mus.21777.

28.

Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.

Hein ND, Rainier SR, Richardson RJ, Fink JK.

Toxicol Lett. 2010 Nov 10;199(1):1-5. doi: 10.1016/j.toxlet.2010.06.020. Epub 2010 Sep 17.

29.

Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

Hein ND, Stuckey JA, Rainier SR, Fink JK, Richardson RJ.

Toxicol Lett. 2010 Jul 1;196(2):67-73. doi: 10.1016/j.toxlet.2010.03.1120. Epub 2010 Apr 9.

30.

Influence of lysophospholipid hydrolysis by the catalytic domain of neuropathy target esterase on the fluidity of bilayer lipid membranes.

Greiner AJ, Richardson RJ, Worden RM, Ofoli RY.

Biochim Biophys Acta. 2010 Aug;1798(8):1533-9. doi: 10.1016/j.bbamem.2010.03.015. Epub 2010 Mar 25.

31.

Biosensor analysis of blood esterases for organophosphorus compounds exposure assessment: approaches to simultaneous determination of several esterases.

Sigolaeva L, Makhaeva G, Rudakova E, Boltneva N, Porus M, Dubacheva G, Eremenko A, Kurochkin I, Richardson RJ.

Chem Biol Interact. 2010 Sep 6;187(1-3):312-7. doi: 10.1016/j.cbi.2010.01.028. Epub 2010 Jan 25.

PMID:
20097186
32.

Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates.

Makhaeva GF, Aksinenko AY, Sokolov VB, Baskin II, Palyulin VA, Zefirov NS, Hein ND, Kampf JW, Wijeyesakere SJ, Richardson RJ.

Chem Biol Interact. 2010 Sep 6;187(1-3):177-84. doi: 10.1016/j.cbi.2009.12.018. Epub 2009 Dec 23.

33.

Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.

Makhaeva GF, Aksinenko AY, Sokolov VB, Serebryakova OG, Richardson RJ.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. doi: 10.1016/j.bmcl.2009.08.065. Epub 2009 Aug 21.

PMID:
19717305
34.

Connectivity patterns revealed by mapping of active inputs on dendrites of thalamorecipient neurons in the auditory cortex.

Richardson RJ, Blundon JA, Bayazitov IT, Zakharenko SS.

J Neurosci. 2009 May 20;29(20):6406-17. doi: 10.1523/JNEUROSCI.0258-09.2009.

35.

Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.

Richardson RJ, Dixon J, Jiang R, Dixon MJ.

Hum Mol Genet. 2009 Jul 15;18(14):2632-42. doi: 10.1093/hmg/ddp201. Epub 2009 May 13.

36.

Paraoxonase status and plasma butyrylcholinesterase activity in chlorpyrifos manufacturing workers.

Albers JW, Garabrant DH, Berent S, Richardson RJ.

J Expo Sci Environ Epidemiol. 2010 Jan;20(1):79-89. doi: 10.1038/jes.2009.9. Epub 2009 Feb 18.

PMID:
19223938
37.

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ.

Nature. 2009 Jan 29;457(7229):603-7. doi: 10.1038/nature07589. Epub 2008 Dec 17.

38.

Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate.

Wijeyesakere SJ, Nasser FA, Kampf JW, Aksinenko AY, Sokolov VB, Malygin VV, Makhaeva GF, Richardson RJ.

Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 1;64(Pt 8):o1425. doi: 10.1107/S1600536808020175. Epub 2008 Jul 5.

39.

Novel mutations in GJA1 cause oculodentodigital syndrome.

Fenwick A, Richardson RJ, Butterworth J, Barron MJ, Dixon MJ.

J Dent Res. 2008 Nov;87(11):1021-6.

40.

Network analysis of toxic chemicals and symptoms: implications for designing first-responder systems.

Bhavnani SK, Abraham A, Demeniuk C, Gebrekristos M, Gong A, Nainwal S, Vallabha GK, Richardson RJ.

AMIA Annu Symp Proc. 2007 Oct 11:51-5.

41.

Differential requirement for beta-catenin in epithelial and fiber cells during lens development.

Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU.

Dev Biol. 2008 Sep 15;321(2):420-33. doi: 10.1016/j.ydbio.2008.07.002. Epub 2008 Jul 9.

42.

Neuropathy target esterase gene mutations cause motor neuron disease.

Rainier S, Bui M, Mark E, Thomas D, Tokarz D, Ming L, Delaney C, Richardson RJ, Albers JW, Matsunami N, Stevens J, Coon H, Leppert M, Fink JK.

Am J Hum Genet. 2008 Mar;82(3):780-5. doi: 10.1016/j.ajhg.2007.12.018. Epub 2008 Feb 28.

43.

Slow presynaptic and fast postsynaptic components of compound long-term potentiation.

Bayazitov IT, Richardson RJ, Fricke RG, Zakharenko SS.

J Neurosci. 2007 Oct 24;27(43):11510-21.

44.

The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing.

Cannon JR, Hua Y, Richardson RJ, Xi G, Keep RF, Schallert T.

Behav Brain Res. 2007 Nov 2;183(2):161-8. Epub 2007 Jun 13.

45.

Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress.

Makhaeva GF, Malygin VV, Strakhova NN, Sigolaeva LV, Sokolovskaya LG, Eremenko AV, Kurochkin IN, Richardson RJ.

Hum Exp Toxicol. 2007 Apr;26(4):273-82.

PMID:
17615108
46.

Nanostructured biosensor for measuring neuropathy target esterase activity.

Kohli N, Srivastava D, Sun J, Richardson RJ, Lee I, Worden RM.

Anal Chem. 2007 Jul 15;79(14):5196-203. Epub 2007 Jun 8.

PMID:
17555296
47.

Dose-effect analyses of occupational chlorpyrifos exposure and peripheral nerve electrophysiology.

Albers JW, Garabrant DH, Mattsson JL, Burns CJ, Cohen SS, Sima C, Garrison RP, Richardson RJ, Berent S.

Toxicol Sci. 2007 May;97(1):196-204. Epub 2007 Feb 25.

PMID:
17324952
48.

Mechanism of aging of mipafox-inhibited butyrylcholinesterase.

Kropp TJ, Richardson RJ.

Chem Res Toxicol. 2007 Mar;20(3):504-10. Epub 2007 Feb 27.

PMID:
17323978
49.

Modeling the tertiary structure of the patatin domain of neuropathy target esterase.

Wijeyesakere SJ, Richardson RJ, Stuckey JA.

Protein J. 2007 Apr;26(3):165-72.

PMID:
17216363
50.

Current status and future directions for diagnostic markers of drug-induced vascular injury.

Brott DA, Jones HB, Gould S, Valentin JP, Evans G, Richardson RJ, Louden C.

Cancer Biomark. 2005;1(1):15-28. Review.

PMID:
17192029

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