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Items: 50

1.

Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.

Comess KM, McLoughlin SM, Oyer JA, Richardson PL, Stöckmann H, Vasudevan A, Warder SE.

J Med Chem. 2018 Jun 6. doi: 10.1021/acs.jmedchem.7b01921. [Epub ahead of print]

PMID:
29718665
2.

Flight speed and performance of the wandering albatross with respect to wind.

Richardson PL, Wakefield ED, Phillips RA.

Mov Ecol. 2018 Mar 7;6:3. doi: 10.1186/s40462-018-0121-9. eCollection 2018.

3.

Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation.

Zhou L, Todorovic V, Kakavas S, Sielaff B, Medina L, Wang L, Sadhukhan R, Stockmann H, Richardson PL, DiGiammarino E, Sun C, Scott V.

J Biol Chem. 2018 Jan 12;293(2):403-411. doi: 10.1074/jbc.M117.805739. Epub 2017 Nov 27.

PMID:
29180446
4.

Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.

Stockmann H, Todorovic V, Richardson PL, Marin V, Scott V, Gerstein C, Lake M, Wang L, Sadhukhan R, Vasudevan A.

J Am Chem Soc. 2017 Nov 22;139(46):16822-16829. doi: 10.1021/jacs.7b09359. Epub 2017 Nov 9.

PMID:
29068676
5.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Curtin ML, Heyman HR, Clark RF, Sorensen BK, Doherty GA, Hansen TM, Frey RR, Sarris KA, Aguirre AL, Shrestha A, Tu N, Woller K, Pliushchev MA, Sweis RF, Cheng M, Wilsbacher JL, Kovar PJ, Guo J, Cheng D, Longenecker KL, Raich D, Korepanova AV, Soni NB, Algire MA, Richardson PL, Marin VL, Badagnani I, Vasudevan A, Buchanan FG, Maag D, Chiang GG, Tse C, Michaelides MR.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3317-3325. doi: 10.1016/j.bmcl.2017.06.018. Epub 2017 Jun 14.

PMID:
28610984
6.

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.

Wilsbacher JL, Cheng M, Cheng D, Trammell SAJ, Shi Y, Guo J, Koeniger SL, Kovar PJ, He Y, Selvaraju S, Heyman HR, Sorensen BK, Clark RF, Hansen TM, Longenecker KL, Raich D, Korepanova AV, Cepa S, Towne DL, Abraham VC, Tang H, Richardson PL, McLoughlin SM, Badagnani I, Curtin ML, Michaelides MR, Maag D, Buchanan FG, Chiang GG, Gao W, Rosenberg SH, Brenner C, Tse C.

Mol Cancer Ther. 2017 Jul;16(7):1236-1245. doi: 10.1158/1535-7163.MCT-16-0819. Epub 2017 May 3.

7.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Curtin ML, Pliushchev MA, Li HQ, Torrent M, Dietrich JD, Jakob CG, Zhu H, Zhao H, Wang Y, Ji Z, Clark RF, Sarris KA, Selvaraju S, Shaw B, Algire MA, He Y, Richardson PL, Sweis RF, Sun C, Chiang GG, Michaelides MR.

Bioorg Med Chem Lett. 2017 Apr 1;27(7):1576-1583. doi: 10.1016/j.bmcl.2017.02.030. Epub 2017 Feb 20.

PMID:
28254486
8.

Development of inverse electron demand Diels-Alder ligation and TR-FRET assays for the determination of ligand-protein target occupancy in live cells.

Marjanovic J, Baranczak A, Marin V, Stockmann H, Richardson PL, Vasudevan A.

Medchemcomm. 2017 Feb 21;8(4):789-795. doi: 10.1039/c7md00049a. eCollection 2017 Apr 1.

9.

Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform.

Tang H, Duggan S, Richardson PL, Marin V, Warder SE, McLoughlin SM.

J Biomol Screen. 2016 Feb;21(2):201-11. doi: 10.1177/1087057115622431. Epub 2015 Dec 16.

PMID:
26676096
10.

Glycan-Mediated, Ligand-Controlled Click Chemistry for Drug-Target Identification.

Stöckmann H, Marin VL, Nimmer P, Balut CM, Davidson DJ, Richardson PL, Vasudevan A.

Chembiochem. 2016 Jan;17(2):150-4. doi: 10.1002/cbic.201500590. Epub 2015 Dec 23.

PMID:
26574896
11.

Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.

Goedken ER, O'Brien RF, Xiang T, Banach DL, Marchie SC, Barlow EH, Hubbard S, Mankovich JA, Jiang J, Richardson PL, Cuff CA, Cherniack AD.

Protein Expr Purif. 2011 Jan;75(1):55-62. doi: 10.1016/j.pep.2010.08.013. Epub 2010 Sep 6.

PMID:
20826216
12.

Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.

Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. doi: 10.1016/j.bmcl.2009.11.076. Epub 2009 Nov 20.

PMID:
20004576
13.

The surgical management and outcomes for spheno-orbital meningiomas: a 7-year review of multi-disciplinary practice.

Cannon PS, Rutherford SA, Richardson PL, King A, Leatherbarrow B.

Orbit. 2009;28(6):371-6. doi: 10.3109/01676830903104645.

PMID:
19929662
14.

Thorotrast-induced primary cerebral angiosarcoma: case report.

Balamurali G, du Plessis DG, Wengoy M, Bryan N, Herwadkar A, Richardson PL.

Neurosurgery. 2009 Jul;65(1):E210-1; discussion E211. doi: 10.1227/01.NEU.0000348294.05571.D9.

PMID:
19574803
15.

Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).

Longenecker KL, Ruan Q, Fry EH, Saldana SC, Brophy SE, Richardson PL, Tetin SY.

Proteins. 2009 Aug 15;76(3):536-47. doi: 10.1002/prot.22366.

PMID:
19274732
16.

Structural characterization of a soluble amyloid beta-peptide oligomer.

Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET.

Biochemistry. 2009 Mar 10;48(9):1870-7. doi: 10.1021/bi802046n.

PMID:
19216516
17.

Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.

Warder SE, Tucker LA, McLoughlin SM, Strelitzer TJ, Meuth JL, Zhang Q, Sheppard GS, Richardson PL, Lesniewski R, Davidsen SK, Bell RL, Rogers JC, Wang J.

J Proteome Res. 2008 Nov;7(11):4807-20. doi: 10.1021/pr800388p. Epub 2008 Oct 2.

PMID:
18828628
18.

Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry.

Colletti LM, Liu Y, Koev G, Richardson PL, Chen CM, Kati W.

Anal Biochem. 2008 Dec 15;383(2):186-93. doi: 10.1016/j.ab.2008.08.012. Epub 2008 Aug 22.

PMID:
18790690
19.

Choreathetoid movement as an unusual presentation of subdural haematoma.

Young VE, Pickett G, Richardson PL, Leach P.

Acta Neurochir (Wien). 2008 Jul;150(7):733-5; discussion 735. doi: 10.1007/s00701-008-1591-0. Epub 2008 May 30.

PMID:
18511997
20.

Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease.

Konstantinidis AK, Richardson PL, Kurtz KA, Tripathi R, Chen CM, Huang P, Randolph J, Towne D, Donnelly J, Warrior U, Middleton T, Kati WM.

Anal Biochem. 2007 Sep 15;368(2):156-67. Epub 2007 Jun 17.

PMID:
17644059
21.

Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.

Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ.

Chem Biol Drug Des. 2007 Jul;70(1):1-12.

PMID:
17630989
22.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

Sun C, Song D, Davis-Taber RA, Barrett LW, Scott VE, Richardson PL, Pereda-Lopez A, Uchic ME, Solomon LR, Lake MR, Walter KA, Hajduk PJ, Olejniczak ET.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7875-80. Epub 2007 Apr 30.

23.

Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery.

Stewart KD, Steffy K, Harris K, Harlan JE, Stoll VS, Huth JR, Walter KA, Gramling-Evans E, Mendoza RR, Severin JM, Richardson PL, Barrett LW, Matayoshi ED, Swift KM, Betz SF, Muchmore SW, Kempf DJ, Molla A.

J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):121-30. Epub 2007 Feb 9.

PMID:
17294246
24.

Interactions of two monoclonal antibodies with BNP: high resolution epitope mapping using fluorescence correlation spectroscopy.

Tetin SY, Ruan Q, Saldana SC, Pope MR, Chen Y, Wu H, Pinkus MS, Jiang J, Richardson PL.

Biochemistry. 2006 Nov 28;45(47):14155-65.

PMID:
17115710
25.

A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.

Kage KL, Richardson PL, Traphagen L, Severin J, Pereda-Lopez A, Lubben T, Davis-Taber R, Vos MH, Bartley D, Walter K, Harlan J, Solomon L, Warrior U, Holzman TF, Faltynek C, Surowy CS, Scott VE.

J Neurosci Methods. 2007 Mar 30;161(1):47-54. Epub 2006 Nov 2.

PMID:
17083980
26.

A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A.

Liu Y, Jiang J, Richardson PL, Reddy RD, Johnson DD, Kati WM.

Anal Biochem. 2006 Sep 1;356(1):100-7. Epub 2006 May 12.

PMID:
16737676
27.

High-level bacterial expression and purification of human SirT2 protein for NMR studies.

Sun C, Song D, Marcotte PA, Richardson PL, Hajduk PJ.

Protein Expr Purif. 2006 Jul;48(1):56-60. Epub 2006 Jan 10.

PMID:
16442310
28.

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.

Marcotte PA, Richardson PL, Guo J, Barrett LW, Xu N, Gunasekera A, Glaser KB.

Anal Biochem. 2004 Sep 1;332(1):90-9. Erratum in: Anal Biochem. 2006 Mar 15;350(2):316. Richardson, Paul R [corrected to Richardson, Paul L].

PMID:
15301953
29.

Solitary skull vault plasmacytoma masquerading as an extradural haematoma.

Rutherford SA, Leach PA, Richardson PL.

Acta Neurochir (Wien). 2004 Aug;146(8):863-4. Epub 2004 Jun 7. No abstract available.

PMID:
15254810
30.

Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase.

Anderson SN, Cool BL, Kifle L, Chiou W, Egan DA, Barrett LW, Richardson PL, Frevert EU, Warrior U, Kofron JL, Burns DJ.

J Biomol Screen. 2004 Mar;9(2):112-21.

PMID:
15006134
31.

Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure.

Liu Y, Stoll VS, Richardson PL, Saldivar A, Klaus JL, Molla A, Kohlbrenner W, Kati WM.

Arch Biochem Biophys. 2004 Jan 15;421(2):207-16.

PMID:
14984200
32.

Alpha-keto amides as inhibitors of histone deacetylase.

Wada CK, Frey RR, Ji Z, Curtin ML, Garland RB, Holms JH, Li J, Pease LJ, Guo J, Glaser KB, Marcotte PA, Richardson PL, Murphy SS, Bouska JJ, Tapang P, Magoc TJ, Albert DH, Davidsen SK, Michaelides MR.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5.

PMID:
12951120
33.

Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor.

Liu Y, Saldivar A, Bess J, Solomon L, Chen CM, Tripathi R, Barrett L, Richardson PL, Molla A, Kohlbrenner W, Kati W.

Biochemistry. 2003 Jul 29;42(29):8862-9.

PMID:
12873147
34.

Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.

Dai Y, Guo Y, Guo J, Pease LJ, Li J, Marcotte PA, Glaser KB, Tapang P, Albert DH, Richardson PL, Davidsen SK, Michaelides MR.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1897-901.

PMID:
12749893
35.

Directly measured mid-depth circulation in the northeastern North Atlantic Ocean.

Bower AS, Le Cann B, Rossby T, Zenk W, Gould J, Speer K, Richardson PL, Prater MD, Zhang HM.

Nature. 2002 Oct 10;419(6907):603-7.

PMID:
12374975
36.

The determination and use of optimized protease substrates in drug discovery and development.

Richardson PL.

Curr Pharm Des. 2002;8(28):2559-81. Review.

PMID:
12369940
37.

Magnetic resonance study of multiple primitive neuroectodermal tumours of the cerebrum, cerebellum and spinal cord in an adult.

Gnanalingham KK, Gillespie J, Richardson PL.

Clin Radiol. 2001 Jul;56(7):588-90. Review. No abstract available.

PMID:
11446758
38.

Discovering novel ligands for macromolecules using X-ray crystallographic screening.

Nienaber VL, Richardson PL, Klighofer V, Bouska JJ, Giranda VL, Greer J.

Nat Biotechnol. 2000 Oct;18(10):1105-8.

PMID:
11017052
39.

Vim thalamotomy for the relief of the intention tremor of multiple sclerosis.

Critchley GR, Richardson PL.

Br J Neurosurg. 1998 Dec;12(6):559-62.

PMID:
10070467
40.

Methoxyamericanolide B.

Richardson PL, Rodríguez AD, Boulanger A, Huang SD.

Acta Crystallogr C. 1998 Jan 15;54 ( Pt 1):66-8.

PMID:
9485568
41.

A clinical, genetic and audiological study of patients and families with bilateral acoustic neurofibromatosis.

Neary WJ, Newton VE, Vidler M, Ramsden RT, Lye RH, Dutton JE, Richardson PL, Harris R, Evans DG, Strachan T.

J Laryngol Otol. 1993 Jan;107(1):6-11.

PMID:
8445320
42.

Haemangiopericytoma of the temporal bone.

Birzgalis AR, Ramsden RT, Lye RH, Richardson PL.

J Laryngol Otol. 1990 Dec;104(12):998-1003.

PMID:
2280162
43.

Emergency surgery for haematoma-forming aneurysmal haemorrhage.

Page RD, Richardson PL.

Br J Neurosurg. 1990;4(3):199-204.

PMID:
2397045
44.

Spinal cord compression: delay in the diagnosis and referral of a common neurosurgical emergency.

Maurice-Williams RS, Richardson PL.

Br J Neurosurg. 1988;2(1):55-60.

PMID:
3268162
45.

Progressive change in cerebral blood flow during the first three weeks after subarachnoid hemorrhage.

Meyer CH, Lowe D, Meyer M, Richardson PL, Neil-Dwyer G.

Neurosurgery. 1983 Jan;12(1):58-76.

PMID:
6402715
46.

Subarachnoid haemorrhage: older patients have low cerebral blood flow.

Meyer CH, Lowe D, Meyer M, Richardson PL, Neil-Dwyer G.

Br Med J (Clin Res Ed). 1982 Oct 23;285(6349):1149-53.

47.

Cardiac sequelae of acute head injury.

McLeod AA, Neil-Dwyer G, Meyer CH, Richardson PL, Cruickshank J, Bartlett J.

Br Heart J. 1982 Mar;47(3):221-6.

48.

North Atlantic Subtropical Gyre: SOFAR Floats Tracked by Moored Listening Stations.

Richardson PL, Price JF, Owens WB, Schmitz WJ, Rossby HT, Bradley AM, Valdes JR, Webb DC.

Science. 1981 Jul 24;213(4506):435-7.

PMID:
17760187
49.

Benjamin Franklin and Timothy Folger's First Printed Chart of the Gulf Stream.

Richardson PL.

Science. 1980 Feb 8;207(4431):643-5.

PMID:
17749327
50.

Endodontic treatment of 20 teeth in a patient with cerebral palsy.

Torabinejad M, Richardson PL.

J Endod. 1979 Mar;5(3):91-3. No abstract available.

PMID:
296249

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