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Epigenetic Regulation of MDR1 and BCRP Transporters by HDAC Inhibition.

You D, Richardson JR, Aleksunes LM.

Drug Metab Dispos. 2020 Mar 19. pii: dmd.119.089953. doi: 10.1124/dmd.119.089953. [Epub ahead of print]


Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model.

Richardson JR, O'Dell LE, Nazarian A.

Neurosci Lett. 2020 Mar 16;721:134825. doi: 10.1016/j.neulet.2020.134825. Epub 2020 Feb 6.


Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.

Neal ML, Fleming SM, Budge KM, Boyle AM, Kim C, Alam G, Beier EE, Wu LJ, Richardson JR.

FASEB J. 2020 Jan;34(1):1679-1694. doi: 10.1096/fj.201900567RR. Epub 2019 Dec 4.


Nerve Growth Factor Protects Against Pyrethroid-Induced Endoplasmic Reticulum (ER) Stress in Primary Hippocampal Neurons.

Hossain MM, Richardson JR.

Toxicol Sci. 2020 Mar 1;174(1):147-158. doi: 10.1093/toxsci/kfz239.


Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter.

Green AL, Eid A, Zhan L, Zarbl H, Guo GL, Richardson JR.

Front Genet. 2019 Nov 4;10:1099. doi: 10.3389/fgene.2019.01099. eCollection 2019.


Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice.

Peng J, Liu Y, Umpierre AD, Xie M, Tian DS, Richardson JR, Wu LJ.

Mol Brain. 2019 Aug 19;12(1):71. doi: 10.1186/s13041-019-0492-x.


Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain.

Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z, Liu XG, Wu LJ.

Cell Rep. 2019 Jun 25;27(13):3844-3859.e6. doi: 10.1016/j.celrep.2019.05.087.


Neurotoxicity of pesticides.

Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG.

Acta Neuropathol. 2019 Sep;138(3):343-362. doi: 10.1007/s00401-019-02033-9. Epub 2019 Jun 13. Review.


Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus.

Feng L, Murugan M, Bosco DB, Liu Y, Peng J, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen Y, Wu LJ.

Glia. 2019 Aug;67(8):1434-1448. doi: 10.1002/glia.23616. Epub 2019 Apr 5.


PSM Peptides From Community-Associated Methicillin-Resistant Staphylococcus aureus Impair the Adaptive Immune Response via Modulation of Dendritic Cell Subsets in vivo.

Richardson JR, Armbruster NS, Günter M, Biljecki M, Klenk J, Heumos S, Autenrieth SE.

Front Immunol. 2019 May 10;10:995. doi: 10.3389/fimmu.2019.00995. eCollection 2019.


Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling.

You D, Wen X, Gorczyca L, Morris A, Richardson JR, Aleksunes LM.

Mol Neurobiol. 2019 Oct;56(10):6986-7002. doi: 10.1007/s12035-019-1565-7. Epub 2019 Apr 8.


Brain region-specific regulation of histone acetylation and efflux transporters in mice.

You D, Shin HM, Mosaad F, Richardson JR, Aleksunes LM.

J Biochem Mol Toxicol. 2019 Mar 21:e22318. doi: 10.1002/jbt.22318. [Epub ahead of print]


Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine.

Eid A, Mhatre I, Richardson JR.

Pharmacol Ther. 2019 Jul;199:173-187. doi: 10.1016/j.pharmthera.2019.03.005. Epub 2019 Mar 12. Review.


Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM.

Toxicology. 2019 Mar 15;416:15-22. doi: 10.1016/j.tox.2019.01.014. Epub 2019 Jan 24.


Corrigendum to "Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin".

Hossain MM, Sivaram G, Richardson JR.

Toxicol Sci. 2019 Mar 1;168(1):281. doi: 10.1093/toxsci/kfy305. No abstract available.


Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells.

Richardson JR, Armbruster NS, Günter M, Henes J, Autenrieth SE.

Front Immunol. 2018 Nov 13;9:2603. doi: 10.3389/fimmu.2018.02603. eCollection 2018.


Time to get Personal: A Framework for Personalized Targeting of Oxidative Stress in Neurotoxicity and Neurodegenerative Disease.

Neal M, Richardson JR.

Curr Opin Toxicol. 2018 Feb;7:127-132. doi: 10.1016/j.cotox.2018.02.003. Epub 2018 Feb 15.


Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin.

Hossain MM, Sivaram G, Richardson JR.

Toxicol Sci. 2019 Jan 1;167(1):249-257. doi: 10.1093/toxsci/kfy238. Erratum in: Toxicol Sci. 2019 Mar 1;168(1):281.


Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase.

Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2018 Nov 15;359:102-107. doi: 10.1016/j.taap.2018.09.011. Epub 2018 Sep 15.


Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells.

Tiethof AK, Richardson JR, Hart RP.

Toxics. 2018 Sep 1;6(3). pii: E52. doi: 10.3390/toxics6030052.


The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.

Hossain MM, Weig B, Reuhl K, Gearing M, Wu LJ, Richardson JR.

Exp Neurol. 2018 Oct;308:111-119. doi: 10.1016/j.expneurol.2018.07.005. Epub 2018 Jul 12.


RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

Bosco DB, Zheng J, Xu Z, Peng J, Eyo UB, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson JR, Wang H, Wu LJ.

Mol Brain. 2018 Jun 20;11(1):34. doi: 10.1186/s13041-018-0376-5.


Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.

Gould FDH, Gross A, German RZ, Richardson JR.

Parkinsons Dis. 2018 Mar 11;2018:6537072. doi: 10.1155/2018/6537072. eCollection 2018.


The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.

Neal ML, Boyle AM, Budge KM, Safadi FF, Richardson JR.

J Neuroinflammation. 2018 Mar 8;15(1):73. doi: 10.1186/s12974-018-1100-1.


Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.

Neal M, Richardson JR.

Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):432-443. doi: 10.1016/j.bbadis.2017.11.004. Epub 2017 Nov 4. Review.


MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.

Geldenhuys WJ, Benkovic SA, Lin L, Yonutas HM, Crish SD, Sullivan PG, Darvesh AS, Brown CM, Richardson JR.

ACS Chem Neurosci. 2017 Dec 20;8(12):2759-2765. doi: 10.1021/acschemneuro.7b00287. Epub 2017 Sep 27.


Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.

Budge KM, Neal ML, Richardson JR, Safadi FF.

Mol Neurobiol. 2018 Jun;55(6):5167-5176. doi: 10.1007/s12035-017-0707-z. Epub 2017 Aug 30. Review.


Corrigendum to "Ephrin-A5 regulates inter-male aggression in mice" [Behav. Brain Res. 286 (June) (2015) 300-307].

Sheleg M, Yochum CL, Richardson JR, Wagner GC, Zhou R.

Behav Brain Res. 2017 Sep 29;335:223. doi: 10.1016/j.bbr.2017.08.019. Epub 2017 Aug 18. No abstract available.


Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.

Beier EE, Neal M, Alam G, Edler M, Wu LJ, Richardson JR.

Neurobiol Dis. 2017 Dec;108:115-127. doi: 10.1016/j.nbd.2017.08.009. Epub 2017 Aug 18.


Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.

Green AL, Zhan L, Eid A, Zarbl H, Guo GL, Richardson JR.

Neuropharmacology. 2017 Oct;125:189-196. doi: 10.1016/j.neuropharm.2017.07.020. Epub 2017 Jul 22.


The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.

Schumacher JD, Kong B, Pan Y, Zhan L, Sun R, Aa J, Rizzolo D, Richardson JR, Chen A, Goedken M, Aleksunes LM, Laskin DL, Guo GL.

Toxicol Appl Pharmacol. 2017 Sep 1;330:1-8. doi: 10.1016/j.taap.2017.06.023. Epub 2017 Jul 1.


Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.

Alam G, Edler M, Burchfield S, Richardson JR.

Neurotoxicology. 2017 May;60:99-106. doi: 10.1016/j.neuro.2017.03.008. Epub 2017 Apr 1.


Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats.

Harton LR, Richardson JR, Armendariz A, Nazarian A.

Brain Res. 2017 Mar 1;1658:36-41. doi: 10.1016/j.brainres.2017.01.011. Epub 2017 Jan 12.


Variables associated with administration of analgesia, nurse-initiated analgesia and early analgesia in the emergency department.

Taylor DM, Chen J, Khan M, Lee M, Rajee M, Yeoh M, Richardson JR, Ugoni AM.

Emerg Med J. 2017 Jan;34(1):13-19. doi: 10.1136/emermed-2016-206044. Epub 2016 Oct 27.


Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels.

Hossain MM, Liu J, Richardson JR.

Toxicol Sci. 2017 Jan;155(1):112-123. doi: 10.1093/toxsci/kfw187. Epub 2016 Sep 21.


Staphylococcus aureus PSM peptides induce tolerogenic dendritic cells upon treatment with ligands of extracellular and intracellular TLRs.

Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Autenrieth SE.

Int J Med Microbiol. 2016 Dec;306(8):666-674. doi: 10.1016/j.ijmm.2016.09.002. Epub 2016 Sep 3.


Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione.

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD.

Ann N Y Acad Sci. 2016 Aug;1378(1):80-86. doi: 10.1111/nyas.13156. Epub 2016 Jul 21. Review.


The TARGET pain study: Lessons from a painful marathon.

Thom ON, Keijzers G, Taylor DM, Fatovich DM, Finucci DP, Furyk J, Jin SW, Macdonald SP, Mitenko HM, Richardson JR, Ting JY, Gibbs CR, Chalkley DR.

Emerg Med Australas. 2016 Oct;28(5):603-6. doi: 10.1111/1742-6723.12583. Epub 2016 Jun 26.


Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression.

Magby JP, Richardson JR.

Neurotoxicology. 2017 May;60:274-279. doi: 10.1016/j.neuro.2016.04.002. Epub 2016 Apr 4.


Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus.

Weig BC, Richardson JR, Lowndes HE, Reuhl KR.

Neurotoxicology. 2016 May;54:72-80. doi: 10.1016/j.neuro.2016.03.023. Epub 2016 Apr 1.


Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD.

Toxicol Sci. 2016 May;151(1):150-9. doi: 10.1093/toxsci/kfw031. Epub 2016 Feb 14.


PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming.

Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Kretschmer D, Pöschel S, Schenke-Layland K, Kalbacher H, Clark K, Autenrieth SE.

J Immunol. 2016 Feb 1;196(3):1284-92. doi: 10.4049/jimmunol.1502232. Epub 2016 Jan 4.


Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma: technique and results.

Abu Hilal M, Richardson JR, de Rooij T, Dimovska E, Al-Saati H, Besselink MG.

Surg Endosc. 2016 Sep;30(9):3830-8. doi: 10.1007/s00464-015-4685-9. Epub 2015 Dec 16.


Best-practice pain management in the emergency department: A cluster-randomised, controlled, intervention trial.

Taylor DM, Fatovich DM, Finucci DP, Furyk J, Jin SW, Keijzers G, Macdonald SP, Mitenko HM, Richardson JR, Ting JY, Thom ON, Ugoni AM, Hughes JA, Bost N, Ward ML, Gibbs CR, Macdonald E, Chalkley DR.

Emerg Med Australas. 2015 Dec;27(6):549-557. doi: 10.1111/1742-6723.12498. Epub 2015 Nov 24.


Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice.

Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR.

Parkinsons Dis. 2015;2015:812532. doi: 10.1155/2015/812532. Epub 2015 Aug 9.


Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication.

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2015 Oct 1;288(1):114-20. doi: 10.1016/j.taap.2015.07.023. Epub 2015 Jul 23.


Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.

Baker AA, Guo GL, Aleksunes LM, Richardson JR.

J Biochem Mol Toxicol. 2015 Dec;29(12):545-51. doi: 10.1002/jbt.21725. Epub 2015 Jul 15.


Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD.

Genskow KR, Bradner JM, Hossain MM, Richardson JR, Caudle WM.

Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):162-9. doi: 10.1016/ Epub 2015 Jun 12.


Association of pyrethroid pesticide exposure with attention-deficit/hyperactivity disorder in a nationally representative sample of U.S. children.

Wagner-Schuman M, Richardson JR, Auinger P, Braun JM, Lanphear BP, Epstein JN, Yolton K, Froehlich TE.

Environ Health. 2015 May 28;14:44. doi: 10.1186/s12940-015-0030-y.


Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells.

Green AL, Hossain MM, Tee SC, Zarbl H, Guo GL, Richardson JR.

Neurochem Res. 2015 Jul;40(7):1372-8. doi: 10.1007/s11064-015-1601-6. Epub 2015 May 12.

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