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Items: 1 to 50 of 62

1.

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, Mitsiades CS, Richardson HE, Penninger JM.

PLoS Genet. 2018 Oct 16;14(10):e1007688. doi: 10.1371/journal.pgen.1007688. eCollection 2018 Oct.

2.

Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation.

Roesley SNA, La Marca JE, Deans AJ, Mckenzie L, Suryadinata R, Burke P, Portela M, Wang H, Bernard O, Sarcevic B, Richardson HE.

Cell Cycle. 2018;17(13):1559-1578. doi: 10.1080/15384101.2018.1493414. Epub 2018 Jul 14.

PMID:
29963966
3.

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.

Portela M, Yang L, Paul S, Li X, Veraksa A, Parsons LM, Richardson HE.

Sci Signal. 2018 Jun 5;11(533). pii: eaar1976. doi: 10.1126/scisignal.aar1976.

PMID:
29871910
4.

Src Cooperates with Oncogenic Ras in Tumourigenesis via the JNK and PI3K Pathways in Drosophila epithelial Tissue.

Poon CLC, Brumby AM, Richardson HE.

Int J Mol Sci. 2018 May 27;19(6). pii: E1585. doi: 10.3390/ijms19061585.

5.

Modelling Cooperative Tumorigenesis in Drosophila.

Richardson HE, Portela M.

Biomed Res Int. 2018 Mar 6;2018:4258387. doi: 10.1155/2018/4258387. eCollection 2018. Review.

6.

POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation.

Ma X, Guo X, Richardson HE, Xu T, Xue L.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2150-2155. doi: 10.1073/pnas.1715165115. Epub 2018 Feb 12.

7.

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

Stephens R, Lim K, Portela M, Kvansakul M, Humbert PO, Richardson HE.

J Mol Biol. 2018 Sep 28;430(19):3585-3612. doi: 10.1016/j.jmb.2018.01.011. Epub 2018 Feb 8. Review.

PMID:
29409995
8.

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO, Richardson HE, Kvansakul M.

J Biol Chem. 2018 Mar 23;293(12):4519-4531. doi: 10.1074/jbc.M117.817528. Epub 2018 Jan 29.

PMID:
29378849
9.

miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila.

Daniel SG, Russ AD, Guthridge KM, Raina AI, Estes PS, Parsons LM, Richardson HE, Schroeder JA, Zarnescu DC.

Biol Open. 2018 Jan 26;7(1). pii: bio027391. doi: 10.1242/bio.027391.

10.

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5658-5660. doi: 10.1038/onc.2017.239.

PMID:
28980625
11.

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues.

Parsons LM, Grzeschik NA, Amaratunga K, Burke P, Quinn LM, Richardson HE.

G3 (Bethesda). 2017 Aug 7;7(8):2497-2509. doi: 10.1534/g3.117.043513.

12.

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5576-5592. doi: 10.1038/onc.2017.175. Epub 2017 Jun 5. Erratum in: Oncogene. 2017 Oct 5;36(40):5658-5660.

13.

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.

Willoughby LF, Manent J, Allan K, Lee H, Portela M, Wiede F, Warr C, Meng TC, Tiganis T, Richardson HE.

FEBS J. 2017 Jul;284(14):2231-2250. doi: 10.1111/febs.14118. Epub 2017 Jun 30.

14.

Tissue growth and tumorigenesis in Drosophila: cell polarity and the Hippo pathway.

Richardson HE, Portela M.

Curr Opin Cell Biol. 2017 Oct;48:1-9. doi: 10.1016/j.ceb.2017.03.006. Epub 2017 Mar 29. Review.

PMID:
28364663
15.

Robo-Enabled Tumor Cell Extrusion.

Richardson HE, Portela M.

Dev Cell. 2016 Dec 19;39(6):629-631. doi: 10.1016/j.devcel.2016.12.008.

16.

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.

Doggett K, Turkel N, Willoughby LF, Ellul J, Murray MJ, Richardson HE, Brumby AM.

PLoS One. 2015 Jul 24;10(7):e0132987. doi: 10.1371/journal.pone.0132987. eCollection 2015.

17.

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis.

Turkel N, Portela M, Poon C, Li J, Brumby AM, Richardson HE.

Biol Open. 2015 Jul 17;4(8):1024-39. doi: 10.1242/bio.012815.

18.

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor.

Portela M, Parsons LM, Grzeschik NA, Richardson HE.

Cell Cycle. 2015;14(10):1496-506. doi: 10.1080/15384101.2015.1026515.

19.

Lgl regulates Notch signaling via endocytosis, independently of the apical aPKC-Par6-Baz polarity complex.

Parsons LM, Portela M, Grzeschik NA, Richardson HE.

Curr Biol. 2014 Sep 22;24(18):2073-2084. doi: 10.1016/j.cub.2014.07.075. Epub 2014 Sep 11.

20.

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK.

Parsons LM, Grzeschik NA, Richardson HE.

Cancers (Basel). 2014 Apr 16;6(2):879-96. doi: 10.3390/cancers6020879.

21.

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.

Koe CT, Li S, Rossi F, Wong JJ, Wang Y, Zhang Z, Chen K, Aw SS, Richardson HE, Robson P, Sung WK, Yu F, Gonzalez C, Wang H.

Elife. 2014 Mar 11;3:e01906. doi: 10.7554/eLife.01906.

22.

The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state.

Turkel N, Sahota VK, Bolden JE, Goulding KR, Doggett K, Willoughby LF, Blanco E, Martin-Blanco E, Corominas M, Ellul J, Aigaki T, Richardson HE, Brumby AM.

PLoS Genet. 2013;9(7):e1003627. doi: 10.1371/journal.pgen.1003627. Epub 2013 Jul 18.

23.

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.

Khoo P, Allan K, Willoughby L, Brumby AM, Richardson HE.

Dis Model Mech. 2013 May;6(3):661-78. doi: 10.1242/dmm.010066. Epub 2013 Jan 11.

24.

Death takes a holiday--non-apoptotic role for caspases in cell migration and invasion.

Portela M, Richardson HE.

EMBO Rep. 2013 Feb;14(2):107-8. doi: 10.1038/embor.2012.224. Epub 2013 Jan 15. No abstract available.

25.

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO, Brumby AM.

Dis Model Mech. 2013 Mar;6(2):521-9. doi: 10.1242/dmm.009985. Epub 2012 Sep 20.

26.

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

Elsum I, Yates L, Humbert PO, Richardson HE.

Essays Biochem. 2012;53:141-68. doi: 10.1042/bse0530141. Review.

PMID:
22928514
27.

When cell cycle meets development.

Kaldis P, Richardson HE.

Development. 2012 Jan;139(2):225-30. doi: 10.1242/dev.073288. Epub 2011 Nov 30. Review.

28.
29.

Actin up for Hippo.

Richardson HE.

EMBO J. 2011 Jun 15;30(12):2307-9. doi: 10.1038/emboj.2011.174. Review. No abstract available.

30.

Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.

Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE.

Genetics. 2011 May;188(1):105-25. doi: 10.1534/genetics.111.127910. Epub 2011 Mar 2.

31.

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.

Grusche FA, Degoutin JL, Richardson HE, Harvey KF.

Dev Biol. 2011 Feb 15;350(2):255-66. doi: 10.1016/j.ydbio.2010.11.020. Epub 2010 Nov 25.

32.

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.

Parsons LM, Grzeschik NA, Allott ML, Richardson HE.

Fly (Austin). 2010 Oct-Dec;4(4):288-93. Epub 2010 Oct 21. Review.

33.

Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

Grzeschik NA, Parsons LM, Richardson HE.

Cell Cycle. 2010 Aug 15;9(16):3202-12. doi: 10.4161/cc.9.16.12633. Epub 2010 Aug 10.

PMID:
20724829
34.

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner.

Mitchell NC, Johanson TM, Cranna NJ, Er AL, Richardson HE, Hannan RD, Quinn LM.

Development. 2010 Sep 1;137(17):2875-84. doi: 10.1242/dev.049585. Epub 2010 Jul 28.

35.

Upstream regulation of the hippo size control pathway.

Grusche FA, Richardson HE, Harvey KF.

Curr Biol. 2010 Jul 13;20(13):R574-82. doi: 10.1016/j.cub.2010.05.023. Review.

36.

Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila.

Herr A, Mckenzie L, Suryadinata R, Sadowski M, Parsons LM, Sarcevic B, Richardson HE.

Dev Biol. 2010 Aug 1;344(1):36-51. doi: 10.1016/j.ydbio.2010.04.006. Epub 2010 Apr 21.

37.

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy.

Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik NA, Bellosta P, Strand D, Richardson HE, Pession A, Grifoni D.

BMC Biol. 2010 Apr 7;8:33. doi: 10.1186/1741-7007-8-33.

38.

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE.

Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.

39.

Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs.

Leong GR, Goulding KR, Amin N, Richardson HE, Brumby AM.

BMC Biol. 2009 Sep 24;7:62. doi: 10.1186/1741-7007-7-62.

40.

Making brundlefly, one gene at a time.

Zhang X, Richardson HE, Harvey KF.

Cell Res. 2009 Jan;19(1):5-7. doi: 10.1038/cr.2009.2. No abstract available.

PMID:
19125154
41.

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.

Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE.

Oncogene. 2008 Nov 24;27(55):6888-907. doi: 10.1038/onc.2008.341. Review.

PMID:
19029932
42.

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.

Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO.

Oncogene. 2008 Oct 9;27(46):5988-6001. doi: 10.1038/onc.2008.219. Epub 2008 Jul 21.

PMID:
18641685
43.

Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells.

Deb DK, Tanaka-Matakatsu M, Jones L, Richardson HE, Du W.

Mech Dev. 2008 Sep-Oct;125(9-10):857-64. doi: 10.1016/j.mod.2008.06.006. Epub 2008 Jun 19.

44.

APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle.

Narbonne-Reveau K, Senger S, Pal M, Herr A, Richardson HE, Asano M, Deak P, Lilly MA.

Development. 2008 Apr;135(8):1451-61. doi: 10.1242/dev.016295. Epub 2008 Mar 5.

45.

Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE.

Dev Biol. 2007 Nov 1;311(1):106-23. Epub 2007 Aug 17.

46.

Vinegar flies turn to porto for cell division cycle meeting.

Richardson HE.

Dev Cell. 2006 Aug;11(2):141-6.

47.

Using Drosophila melanogaster to map human cancer pathways.

Brumby AM, Richardson HE.

Nat Rev Cancer. 2005 Aug;5(8):626-39. Review.

PMID:
16034367
48.

New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.

Humbert PO, Brumby AM, Quinn LM, Richardson HE.

Curr Opin Cell Biol. 2004 Dec;16(6):614-22. Review.

PMID:
15530771
49.

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.

Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE, Humbert PO.

Oncogene. 2003 Dec 18;22(58):9225-30.

PMID:
14681682
50.

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