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Advances in genome editing through control of DNA repair pathways.

Yeh CD, Richardson CD, Corn JE.

Nat Cell Biol. 2019 Dec;21(12):1468-1478. doi: 10.1038/s41556-019-0425-z. Epub 2019 Dec 2. Review.


Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells.

Tai CJ, Liu CH, Pan YC, Wong SH, Tai CJ, Richardson CD, Lin LT.

Sci Rep. 2019 May 1;9(1):6767. doi: 10.1038/s41598-019-43047-3.


Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE.

Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18.


Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy.

Jassey A, Liu CH, Changou CA, Richardson CD, Hsu HY, Lin LT.

Cells. 2019 Mar 29;8(4). pii: E290. doi: 10.3390/cells8040290.


Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding.

Lin CJ, Liu CH, Wang JY, Lin CC, Li YF, Richardson CD, Lin LT.

Emerg Microbes Infect. 2018 Sep 26;7(1):162. doi: 10.1038/s41426-018-0165-3.


CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE.

Nat Genet. 2018 Aug;50(8):1132-1139. doi: 10.1038/s41588-018-0174-0. Epub 2018 Jul 27.


Transmission genetics of drug-resistant hepatitis C virus.

van Buuren N, Tellinghuisen TL, Richardson CD, Kirkegaard K.

Elife. 2018 Mar 28;7. pii: e32579. doi: 10.7554/eLife.32579.


Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.

Ha MN, Delpeut S, Noyce RS, Sisson G, Black KM, Lin LT, Bilimoria D, Plemper RK, Privé GG, Richardson CD.

J Virol. 2017 Nov 14;91(23). pii: e01026-17. doi: 10.1128/JVI.01026-17. Print 2017 Dec 1.


Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway.

Delpeut S, Sisson G, Black KM, Richardson CD.

J Virol. 2017 Apr 28;91(10). pii: e02191-16. doi: 10.1128/JVI.02191-16. Print 2017 May 15.


Re-emergence of Peste des Petits Ruminants virus in 2015 in Morocco: Molecular characterization and experimental infection in Alpine goats.

Fakri F, Embarki T, Parida S, Bamouh Z, Jazouli M, Mahapatra M, Tadlaoui K, Fassi-Fihri O, Richardson CD, Elharrak M.

Vet Microbiol. 2016 Dec 25;197:137-141. doi: 10.1016/j.vetmic.2016.11.006. Epub 2016 Nov 13.


Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes.

Richardson CD, Ray GJ, Bray NL, Corn JE.

Nat Commun. 2016 Aug 17;7:12463. doi: 10.1038/ncomms12463.


Highly bioavailable silibinin nanoparticles inhibit HCV infection.

Liu CH, Lin CC, Hsu WC, Chung CY, Lin CC, Jassey A, Chang SP, Tai CJ, Tai CJ, Shields J, Richardson CD, Yen MH, Tyrrell DLJ, Lin LT.

Gut. 2017 Oct;66(10):1853-1861. doi: 10.1136/gutjnl-2016-312019. Epub 2016 Jul 19.


Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry.

Chung CY, Liu CH, Burnouf T, Wang GH, Chang SP, Jassey A, Tai CJ, Tai CJ, Huang CJ, Richardson CD, Yen MH, Lin CC, Lin LT.

Antiviral Res. 2016 Jun;130:58-68. doi: 10.1016/j.antiviral.2016.03.012. Epub 2016 Mar 21.


Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.

Richardson CD, Ray GJ, DeWitt MA, Curie GL, Corn JE.

Nat Biotechnol. 2016 Mar;34(3):339-44. doi: 10.1038/nbt.3481. Epub 2016 Jan 20.


VeroNectin-4 is a highly sensitive cell line that can be used for the isolation and titration of Peste des Petits Ruminants virus.

Fakri F, Elarkam A, Daouam S, Tadlaoui K, Fassi-Fihri O, Richardson CD, Elharrak M.

J Virol Methods. 2016 Feb;228:135-9. doi: 10.1016/j.jviromet.2015.11.017. Epub 2015 Nov 23.


Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry.

Hsu WC, Chang SP, Lin LC, Li CL, Richardson CD, Lin CC, Lin LT.

Antiviral Res. 2015 Jun;118:139-47. doi: 10.1016/j.antiviral.2015.04.003. Epub 2015 Apr 9.


TnBP⁄Triton X-45 treatment of plasma for transfusion efficiently inactivates hepatitis C virus.

Chou ML, Burnouf T, Chang SP, Hung TC, Lin CC, Richardson CD, Lin LT.

PLoS One. 2015 Feb 6;10(2):e0117800. doi: 10.1371/journal.pone.0117800. eCollection 2015.


Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.

Lin LT, Chung CY, Hsu WC, Chang SP, Hung TC, Shields J, Russell RS, Lin CC, Li CF, Yen MH, Tyrrell DL, Lin CC, Richardson CD.

J Hepatol. 2015 Mar;62(3):541-8. doi: 10.1016/j.jhep.2014.10.040. Epub 2014 Nov 4. Erratum in: J Hepatol. 2015 Jul;63(1):292.


Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements.

Richardson CD, Li JJ.

PLoS Genet. 2014 Jun 19;10(6):e1004358. doi: 10.1371/journal.pgen.1004358. eCollection 2014 Jun.


The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses.

Delpeut S, Noyce RS, Richardson CD.

Viruses. 2014 Jun 2;6(6):2268-86. doi: 10.3390/v6062268. Review.


The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread.

Delpeut S, Noyce RS, Richardson CD.

Virology. 2014 Apr;454-455:109-17. doi: 10.1016/j.virol.2014.02.014. Epub 2014 Feb 28.


Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry.

Lin LT, Chen TY, Lin SC, Chung CY, Lin TC, Wang GH, Anderson R, Lin CC, Richardson CD.

BMC Microbiol. 2013 Aug 7;13:187. doi: 10.1186/1471-2180-13-187.


Dog nectin-4 is an epithelial cell receptor for canine distemper virus that facilitates virus entry and syncytia formation.

Noyce RS, Delpeut S, Richardson CD.

Virology. 2013 Feb 5;436(1):210-20. doi: 10.1016/j.virol.2012.11.011. Epub 2012 Dec 20.


Viral replication--in search of the perfect host.

Nagy PD, Richardson CD.

Curr Opin Virol. 2012 Dec;2(6):663-8. No abstract available.


Host factors and measles virus replication.

Delpeut S, Noyce RS, Siu RW, Richardson CD.

Curr Opin Virol. 2012 Dec;2(6):773-83. doi: 10.1016/j.coviro.2012.10.008. Epub 2012 Nov 10. Review.


Nectin 4 is the epithelial cell receptor for measles virus.

Noyce RS, Richardson CD.

Trends Microbiol. 2012 Sep;20(9):429-39. doi: 10.1016/j.tim.2012.05.006. Epub 2012 Jun 20. Review.


Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.

Noyce RS, Bondre DG, Ha MN, Lin LT, Sisson G, Tsao MS, Richardson CD.

PLoS Pathog. 2011 Aug;7(8):e1002240. doi: 10.1371/journal.ppat.1002240. Epub 2011 Aug 25.


RIG-I is required for the inhibition of measles virus by retinoids.

Soye KJ, Trottier C, Richardson CD, Ward BJ, Miller WH Jr.

PLoS One. 2011;6(7):e22323. doi: 10.1371/journal.pone.0022323. Epub 2011 Jul 19.


Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread.

Lin LT, Chen TY, Chung CY, Noyce RS, Grindley TB, McCormick C, Lin TC, Wang GH, Lin CC, Richardson CD.

J Virol. 2011 May;85(9):4386-98. doi: 10.1128/JVI.01492-10. Epub 2011 Feb 9.


Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation.

Wilson JA, Zhang C, Huys A, Richardson CD.

J Virol. 2011 Mar;85(5):2342-50. doi: 10.1128/JVI.02046-10. Epub 2010 Dec 22.


Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells.

Liao PC, Ng LT, Lin LT, Richardson CD, Wang GH, Lin CC.

J Med Food. 2010 Dec;13(6):1415-23. doi: 10.1089/jmf.2010.1126. Epub 2010 Oct 14.


Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity.

Vivithanaporn P, Maingat F, Lin LT, Na H, Richardson CD, Agrawal B, Cohen EA, Jhamandas JH, Power C.

PLoS One. 2010 Sep 21;5(9):e12856. doi: 10.1371/journal.pone.0012856.


Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122.

Lin LT, Noyce RS, Pham TN, Wilson JA, Sisson GR, Michalak TI, Mossman KL, Richardson CD.

J Virol. 2010 Sep;84(18):9170-80. doi: 10.1128/JVI.00559-10. Epub 2010 Jun 30.


Viral interactions with macroautophagy: a double-edged sword.

Lin LT, Dawson PW, Richardson CD.

Virology. 2010 Jun 20;402(1):1-10. doi: 10.1016/j.virol.2010.03.026. Epub 2010 Apr 21. Review.


Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150).

Ferreira CS, Frenzke M, Leonard VH, Welstead GG, Richardson CD, Cattaneo R.

J Virol. 2010 Mar;84(6):3033-42. doi: 10.1128/JVI.01559-09. Epub 2009 Dec 30.


Future promise of siRNA and other nucleic acid based therapeutics for the treatment of chronic HCV.

Wilson JA, Richardson CD.

Infect Disord Drug Targets. 2006 Mar;6(1):43-56. Review.


Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice.

Welstead GG, Iorio C, Draker R, Bayani J, Squire J, Vongpunsawad S, Cattaneo R, Richardson CD.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16415-20. Epub 2005 Oct 31.


Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.

Tsuchihara K, Lapin V, Bakal C, Okada H, Brown L, Hirota-Tsuchihara M, Zaugg K, Ho A, Itie-Youten A, Harris-Brandts M, Rottapel R, Richardson CD, Benchimol S, Mak TW.

Cancer Res. 2005 Aug 1;65(15):6685-91.


Mechanism of CD150 (SLAM) down regulation from the host cell surface by measles virus hemagglutinin protein.

Welstead GG, Hsu EC, Iorio C, Bolotin S, Richardson CD.

J Virol. 2004 Sep;78(18):9666-74.


Induction of RNA interference using short interfering RNA expression vectors in cell culture and animal systems.

Wilson JA, Richardson CD.

Curr Opin Mol Ther. 2003 Aug;5(4):389-96. Review.


Selective functions of angiopoietins and vascular endothelial growth factor on blood vessels: the concept of "vascular domain".

Sato TN, Loughna S, Davis EC, Visconti RP, Richardson CD.

Cold Spring Harb Symp Quant Biol. 2002;67:171-80. No abstract available.


Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers.

Hsu EC, Hsi B, Hirota-Tsuchihara M, Ruland J, Iorio C, Sarangi F, Diao J, Migliaccio G, Tyrrell DL, Kneteman N, Richardson CD.

Nat Biotechnol. 2003 May;21(5):519-25. Epub 2003 Apr 21.


RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.

Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2783-8. Epub 2003 Feb 19.


Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF).

Visconti RP, Richardson CD, Sato TN.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8219-24. Epub 2002 Jun 4.


CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.

Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM.

Nature. 2001 Jan 18;409(6818):349-54.


CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus.

Hsu EC, Iorio C, Sarangi F, Khine AA, Richardson CD.

Virology. 2001 Jan 5;279(1):9-21. Erratum in: Virology 2001 Mar 1;281(1):151.


X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.

Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD.

J Biol Chem. 2001 Mar 16;276(11):8328-40. Epub 2000 Nov 30.

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