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Oxidative stress and dietary micronutrient deficiencies contribute to overexpression of epigenetically regulated genes by lupus T cells.

Ray D, Strickland FM, Richardson BC.

Clin Immunol. 2018 Nov;196:97-102. doi: 10.1016/j.clim.2018.04.003. Epub 2018 Apr 11.


CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.

Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH.

J Autoimmun. 2018 Jan;86:19-28. doi: 10.1016/j.jaut.2017.09.011. Epub 2017 Oct 20.


Oxidative T Cell Modifications in Lupus and Sjogren's Syndrome.

Strickland FM, Mau T, O'Brien M, Ghosh A, Richardson BC, Yung R.

Lupus (Los Angel). 2017 Apr;2(1). pii: 121. Epub 2017 Jan 10.


Correction: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.

Richardson BC, Halaby SL, Gustafson MA, Fromme JC.

Elife. 2016 Jun 9;5. pii: e18204. doi: 10.7554/eLife.18204. No abstract available.


The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.

Richardson BC, Halaby SL, Gustafson MA, Fromme JC.

Elife. 2016 Jan 14;5. pii: e12411. doi: 10.7554/eLife.12411. Erratum in: Elife. 2016;5. pii: e18204. doi: 10.7554/eLife.18204.


Biochemical methods for studying kinetic regulation of Arf1 activation by Sec7.

Richardson BC, Fromme JC.

Methods Cell Biol. 2015;130:101-26. doi: 10.1016/bs.mcb.2015.03.020. Epub 2015 Jun 11.


CD4(+) T cells epigenetically modified by oxidative stress cause lupus-like autoimmunity in mice.

Strickland FM, Li Y, Johnson K, Sun Z, Richardson BC.

J Autoimmun. 2015 Aug;62:75-80. doi: 10.1016/j.jaut.2015.06.004. Epub 2015 Jul 9.


Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE.

Kennedy WP, Maciuca R, Wolslegel K, Tew W, Abbas AR, Chaivorapol C, Morimoto A, McBride JM, Brunetta P, Richardson BC, Davis JC Jr, Behrens TW, Townsend MJ.

Lupus Sci Med. 2015 Mar 28;2(1):e000080. doi: 10.1136/lupus-2014-000080. eCollection 2015.


Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis.

Paczkowski JE, Richardson BC, Fromme JC.

Trends Cell Biol. 2015 Jul;25(7):408-16. doi: 10.1016/j.tcb.2015.02.005. Epub 2015 Mar 17. Review.


Environmental exposures, epigenetic changes and the risk of lupus.

Somers EC, Richardson BC.

Lupus. 2014 May;23(6):568-76. doi: 10.1177/0961203313499419. Review.


Oxidative stress, T cell DNA methylation, and lupus.

Li Y, Gorelik G, Strickland FM, Richardson BC.

Arthritis Rheumatol. 2014 Jun;66(6):1574-82. doi: 10.1002/art.38427.


Epigenetics in 2013. DNA methylation and miRNA: key roles in systemic autoimmunity.

Richardson BC, Patel DR.

Nat Rev Rheumatol. 2014 Feb;10(2):72-4. doi: 10.1038/nrrheum.2013.211. Epub 2014 Jan 14. Review.


Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.

Strickland FM, Hewagama A, Wu A, Sawalha AH, Delaney C, Hoeltzel MF, Yung R, Johnson K, Mickelson B, Richardson BC.

Arthritis Rheum. 2013 Jul;65(7):1872-81. doi: 10.1002/art.37967.


The exomer cargo adaptor features a flexible hinge domain.

Richardson BC, Fromme JC.

Structure. 2013 Mar 5;21(3):486-92. doi: 10.1016/j.str.2013.01.003. Epub 2013 Feb 7.


Dissecting complex epigenetic alterations in human lupus.

Patel DR, Richardson BC.

Arthritis Res Ther. 2013 Jan 29;15(1):201. doi: 10.1186/ar4125. Review.


The exomer cargo adaptor structure reveals a novel GTPase-binding domain.

Paczkowski JE, Richardson BC, Strassner AM, Fromme JC.

EMBO J. 2012 Nov 5;31(21):4191-203. doi: 10.1038/emboj.2012.268. Epub 2012 Sep 21.


Autoregulation of Sec7 Arf-GEF activity and localization by positive feedback.

Richardson BC, Fromme JC.

Small GTPases. 2012 Oct-Dec;3(4):240-3. doi: 10.4161/sgtp.21828. Epub 2012 Sep 20.


Prostaglandin E₂ increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.

Huang SK, Scruggs AM, Donaghy J, McEachin RC, Fisher AS, Richardson BC, Peters-Golden M.

FASEB J. 2012 Sep;26(9):3703-14. doi: 10.1096/fj.11-203323. Epub 2012 May 29.


Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells.

Gorelik GJ, Yarlagadda S, Patel DR, Richardson BC.

Arthritis Rheum. 2012 Sep;64(9):2964-74. doi: 10.1002/art.34503. Erratum in: Arthritis Rheum. 2014 Mar;66(3):769. Patel, Dipak R [added].


The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback.

Richardson BC, McDonold CM, Fromme JC.

Dev Cell. 2012 Apr 17;22(4):799-810. doi: 10.1016/j.devcel.2012.02.006.


Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.

Strickland FM, Hewagama A, Lu Q, Wu A, Hinderer R, Webb R, Johnson K, Sawalha AH, Delaney C, Yung R, Richardson BC.

J Autoimmun. 2012 May;38(2-3):J135-43. doi: 10.1016/j.jaut.2011.11.001. Epub 2011 Dec 3.


Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcón GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vilá LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcón-Riquelme ME; BIOLUPUS Network, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH.

Ann Rheum Dis. 2012 May;71(5):694-9. doi: 10.1136/annrheumdis-2011-200385. Epub 2011 Nov 21.


Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

Hughes T, Adler A, Kelly JA, Kaufman KM, Williams AH, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martín J, Niewold TB, Vilá LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcón-Riquelme ME; BIOLUPUS Network, Harley JB, Richardson BC, Sawalha AH.

Arthritis Rheum. 2012 Feb;64(2):485-92. doi: 10.1002/art.33354.


Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.

Sánchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vilá LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ; International Consortium on the Genetics of Systemic Lupus Erythematosus, Gaffney PM, Jacob CO, Niewold TB, Richardson BC, Harley JB, Alarcón-Riquelme ME, Sawalha AH.

Arthritis Rheum. 2011 Nov;63(11):3493-501. doi: 10.1002/art.30563.


Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Gilkeson GS, Ziegler JT, Langefeld CD, Alarcón GS, Edberg JC, Ramsey-Goldman R, Petri M, Brown EE, Kimberly RP, Reveille JD, Vilá LM, Merrill JT, Anaya JM, James JA, Pons-Estel BA, Martin J, Park SY, Bang SY, Bae SC, Moser KL, Vyse TJ, Criswell LA, Gaffney PM, Tsao BP, Jacob CO, Harley JB, Alarcón-Riquelme ME; BIOLUPUS and GENLES, Sawalha AH.

Ann Rheum Dis. 2011 Oct;70(10):1752-7. doi: 10.1136/ard.2011.154104. Epub 2011 Jun 30.


Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.

Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC, Peters-Golden M.

Am J Pathol. 2010 Nov;177(5):2245-55. doi: 10.2353/ajpath.2010.100446. Epub 2010 Oct 1.


Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.

Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcón-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH.

Ann Rheum Dis. 2011 Jan;70(1):151-6. doi: 10.1136/ard.2010.141697. Epub 2010 Sep 29.


Characterization of the metabolic phenotype of chronically activated lymphocytes.

Wahl DR, Petersen B, Warner R, Richardson BC, Glick GD, Opipari AW.

Lupus. 2010 Nov;19(13):1492-501. doi: 10.1177/0961203310373109. Epub 2010 Jul 20.


Epigenetic mechanisms in lupus.

Patel DR, Richardson BC.

Curr Opin Rheumatol. 2010 Sep;22(5):478-82. doi: 10.1097/BOR.0b013e32833ae915. Review.


The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.

Yen WL, Shintani T, Nair U, Cao Y, Richardson BC, Li Z, Hughson FM, Baba M, Klionsky DJ.

J Cell Biol. 2010 Jan 11;188(1):101-14. doi: 10.1083/jcb.200904075.


Decreased ERK and JNK signaling contribute to gene overexpression in "senescent" CD4+CD28- T cells through epigenetic mechanisms.

Chen Y, Gorelik GJ, Strickland FM, Richardson BC.

J Leukoc Biol. 2010 Jan;87(1):137-45. doi: 10.1189/jlb.0809562. Epub 2009 Oct 20.


Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells.

Basu D, Liu Y, Wu A, Yarlagadda S, Gorelik GJ, Kaplan MJ, Hewagama A, Hinderer RC, Strickland FM, Richardson BC.

J Immunol. 2009 Sep 1;183(5):3481-7. doi: 10.4049/jimmunol.0900034. Epub 2009 Aug 12.


Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.

Richardson BC, Smith RD, Ungar D, Nakamura A, Jeffrey PD, Lupashin VV, Hughson FM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13329-34. doi: 10.1073/pnas.0901966106. Epub 2009 Jul 27.


Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis.

Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC.

Genes Immun. 2009 Jul;10(5):509-16. doi: 10.1038/gene.2009.12. Epub 2009 Mar 12.


Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease.

Cooper GS, Gilbert KM, Greidinger EL, James JA, Pfau JC, Reinlib L, Richardson BC, Rose NR.

Environ Health Perspect. 2008 Jun;116(6):695-702. doi: 10.1289/ehp.11092. Review.


Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.

Strickland FM, Richardson BC.

Autoimmunity. 2008 May;41(4):278-86. doi: 10.1080/08916930802024616. Review.


Epigenetics and autoimmunity. Overview.

Richardson BC.

Autoimmunity. 2008 May;41(4):243-4. doi: 10.1080/08916930802024129. No abstract available.


Structural analysis of conserved oligomeric Golgi complex subunit 2.

Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J, Hughson FM.

J Biol Chem. 2007 Aug 10;282(32):23418-26. Epub 2007 Jun 12.


Epigenetics, disease, and therapeutic interventions.

Lu Q, Qiu X, Hu N, Wen H, Su Y, Richardson BC.

Ageing Res Rev. 2006 Nov;5(4):449-67. Epub 2006 Sep 11. Review.


The epigenetic face of systemic lupus erythematosus.

Ballestar E, Esteller M, Richardson BC.

J Immunol. 2006 Jun 15;176(12):7143-7. Review.


Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus.

Denny MF, Chandaroy P, Killen PD, Caricchio R, Lewis EE, Richardson BC, Lee KD, Gavalchin J, Kaplan MJ.

J Immunol. 2006 Feb 15;176(4):2095-104.


Estrogen regulates CCR gene expression and function in T lymphocytes.

Mo R, Chen J, Grolleau-Julius A, Murphy HS, Richardson BC, Yung RL.

J Immunol. 2005 May 15;174(10):6023-9.


The MAPK signalling pathways and colorectal cancer.

Fang JY, Richardson BC.

Lancet Oncol. 2005 May;6(5):322-7. Review.


Reciprocal fusions of two genes in the formaldehyde detoxification pathway in ciliates and diatoms.

Stover NA, Cavalcanti AR, Li AJ, Richardson BC, Landweber LF.

Mol Biol Evol. 2005 Jul;22(7):1539-42. Epub 2005 Apr 27. Erratum in: Mol Biol Evol. 2005 Aug;22(8):1749.


Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment.

Murphy HS, Sun Q, Murphy BA, Mo R, Huo J, Chen J, Chensue SW, Adams M, Richardson BC, Yung R.

Microvasc Res. 2004 Nov;68(3):273-85.


Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity.

Rajagopalan S, Somers EC, Brook RD, Kehrer C, Pfenninger D, Lewis E, Chakrabarti A, Richardson BC, Shelden E, McCune WJ, Kaplan MJ.

Blood. 2004 May 15;103(10):3677-83. Epub 2004 Jan 15.


Age-related changes in mature CD4+ T cells: cell cycle analysis.

Hale TJ, Richardson BC, Sweet LI, McElligott DL, Riggs JE, Chu EB, Glynn JM, LaFrenz D, Ernst DN, Rochford R, Hobbs MV.

Cell Immunol. 2002 Nov;220(1):51-62.


Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine.

Bednarski JJ, Warner RE, Rao T, Leonetti F, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW Jr, Glick GD.

Arthritis Rheum. 2003 Mar;48(3):757-66.


The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.

Kaplan MJ, Lewis EE, Shelden EA, Somers E, Pavlic R, McCune WJ, Richardson BC.

J Immunol. 2002 Nov 15;169(10):6020-9.

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