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Local application of a gentamicin-loaded hydrogel early after injury is superior to peri-operative systemic prophylaxis in a rabbit open fracture model.

Vallejo A, Deimling C, Morgenstern M, DʼEste M, Puetzler J, Zeiter S, Arens D, Metsemakers WJ, Richards RG, Eglin D, Moriarty TF.

J Orthop Trauma. 2019 Dec 6. doi: 10.1097/BOT.0000000000001707. [Epub ahead of print]


Late screw-related complications in locking plating of proximal humerus fractures: A systematic review.

Panagiotopoulou VC, Varga P, Richards RG, Gueorguiev B, Giannoudis PV.

Injury. 2019 Dec;50(12):2176-2195. doi: 10.1016/j.injury.2019.11.002. Epub 2019 Nov 6. Review.


General treatment principles for fracture-related infection: recommendations from an international expert group.

Metsemakers WJ, Morgenstern M, Senneville E, Borens O, Govaert GAM, Onsea J, Depypere M, Richards RG, Trampuz A, Verhofstad MHJ, Kates SL, Raschke M, McNally MA, Obremskey WT; Fracture-Related Infection (FRI) group.

Arch Orthop Trauma Surg. 2019 Oct 29. doi: 10.1007/s00402-019-03287-4. [Epub ahead of print]


Intervertebral disc organ culture for the investigation of disc pathology and regeneration - benefits, limitations, and future directions of bioreactors.

Pfannkuche JJ, Guo W, Cui S, Ma J, Lang G, Peroglio M, Richards RG, Alini M, Grad S, Li Z.

Connect Tissue Res. 2019 Sep 26:1-18. doi: 10.1080/03008207.2019.1665652. [Epub ahead of print]


Bacterial osteomyelitis in veterinary orthopaedics: Pathophysiology, clinical presentation and advances in treatment across multiple species.

Gieling F, Peters S, Erichsen C, Richards RG, Zeiter S, Moriarty TF.

Vet J. 2019 Aug;250:44-54. doi: 10.1016/j.tvjl.2019.06.003. Epub 2019 Jun 25. Review.


Secondary Perforation Risk in Plate Osteosynthesis of Unstable Proximal Humerus Fractures: A Biomechanical Investigation of the Effect of Screw Length.

Ciric D, Mischler D, Qawasmi F, Wenzel L, Richards RG, Gueorguiev B, Windolf M, Varga P.

J Orthop Res. 2019 Dec;37(12):2625-2633. doi: 10.1002/jor.24429. Epub 2019 Aug 8.


Computed Tomography Analysis for Quantification of Displacement of the Distal Fibula in Different Foot Positions With Weightbearing and Sequentially Increased Instability: An Anatomic Cadaveric Study on Syndesmosis.

Hagen JE, Rausch S, Simons P, Richards RG, Lenz M, Knobe M, Gueorguiev B, Klos K.

J Foot Ankle Surg. 2019 Jul;58(4):734-738. doi: 10.1053/j.jfas.2018.12.013.


Screw configuration in proximal humerus plating has a significant impact on fixation failure risk predicted by finite element models.

Fletcher JWA, Windolf M, Richards RG, Gueorguiev B, Varga P.

J Shoulder Elbow Surg. 2019 Sep;28(9):1816-1823. doi: 10.1016/j.jse.2019.02.013. Epub 2019 Apr 26.


The influence of screw length on predicted cut-out failures for proximal humeral fracture fixations predicted by finite element simulations.

Fletcher JWA, Windolf M, Grünwald L, Richards RG, Gueorguiev B, Varga P.

Arch Orthop Trauma Surg. 2019 Aug;139(8):1069-1074. doi: 10.1007/s00402-019-03175-x. Epub 2019 Mar 20.


Introduction of the Anspach drill as a novel surgical driller for creating calvarial defects in animal models.

Guillaume O, Schmid T, Kluge K, Weber FE, Richards RG, Eberli U, Eglin D, Zeiter S.

J Orthop Res. 2019 May;37(5):1183-1191. doi: 10.1002/jor.24265. Epub 2019 Apr 1.


Intraoperative loading of calcium phosphate-coated implants with gentamicin prevents experimental Staphylococcus aureus infection in vivo.

Thompson K, Petkov S, Zeiter S, Sprecher CM, Richards RG, Moriarty TF, Eijer H.

PLoS One. 2019 Feb 1;14(2):e0210402. doi: 10.1371/journal.pone.0210402. eCollection 2019.


Importance of locking plate positioning in proximal humeral fractures as predicted by computer simulations.

Fletcher JWA, Windolf M, Richards RG, Gueorguiev B, Buschbaum J, Varga P.

J Orthop Res. 2019 Apr;37(4):957-964. doi: 10.1002/jor.24235. Epub 2019 Mar 20.


Recommendations for design and conduct of preclinical in vivo studies of orthopedic device-related infection.

Moriarty TF, Harris LG, Mooney RA, Wenke JC, Riool M, Zaat SAJ, Moter A, Schaer TP, Khanna N, Kuehl R, Alt V, Montali A, Liu J, Zeiter S, Busscher HJ, Grainger DW, Richards RG.

J Orthop Res. 2019 Feb;37(2):271-287. doi: 10.1002/jor.24230. Epub 2019 Feb 21. Review.


3D statistical model of the pelvic ring - a CT-based statistical evaluation of anatomical variation.

Arand C, Wagner D, Richards RG, Noser H, Kamer L, Sawaguchi T, Rommens PM.

J Anat. 2019 Mar;234(3):376-383. doi: 10.1111/joa.12928. Epub 2018 Dec 21.


Infection burden and immunological responses are equivalent for polymeric and metallic implant materials in vitro and in a murine model of fracture-related infection.

Rochford ETJ, Sabaté Brescó M, Poulsson AHC, Kluge K, Zeiter S, Ziegler M, O'Mahony L, Richards RG, Moriarty TF.

J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1095-1106. doi: 10.1002/jbm.b.34202. Epub 2018 Oct 17.


Preclinical in vivo models of fracture-related infection: a systematic review and critical appraisal.

Vanvelk N, Morgenstern M, Moriarty TF, Richards RG, Nijs S, Metsemakers WJ.

Eur Cell Mater. 2018 Oct 17;36:184-199. doi: 10.22203/eCM.v036a14.


A critical review of the in vitro and in vivo models for the evaluation of anti-infective meshes.

Guillaume O, Pérez Kohler B, Fortelny R, Redl H, Moriarty F, Richards RG, Eglin D, Petter Puchner A.

Hernia. 2018 Dec;22(6):961-974. doi: 10.1007/s10029-018-1807-z. Epub 2018 Aug 28. Review.


Dual-functional 3D-printed composite scaffold for inhibiting bacterial infection and promoting bone regeneration in infected bone defect models.

Yang Y, Chu L, Yang S, Zhang H, Qin L, Guillaume O, Eglin D, Richards RG, Tang T.

Acta Biomater. 2018 Oct 1;79:265-275. doi: 10.1016/j.actbio.2018.08.015. Epub 2018 Aug 18.


Axial and shear pullout forces of composite, porcine and human metatarsal and cuboid bones.

Lenz M, Gueorguiev B, Garces JBG, Swords MP, Rammelt S, Hofmann GO, Zderic I, Ernst M, Richards RG, Sands AK.

J Orthop Translat. 2018 Jun 28;14:67-73. doi: 10.1016/ eCollection 2018 Jul.


Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes.

Gao MM, Su QN, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY, Zou NX.

Eur Cell Mater. 2018 Jul 25;36:1-14. doi: 10.22203/eCM.v036a01.


Biomechanical evaluation of a new gliding screw concept for the fixation of proximal humeral fractures.

Acklin YP, Zderic I, Inzana JA, Grechenig S, Schwyn R, Richards RG, Gueorguiev B.

Bone Joint Res. 2018 Jul 7;7(6):422-429. doi: 10.1302/2046-3758.76.BJR-2017-0356.R1. eCollection 2018 Jun.


Phenotype and Viability of MLO-Y4 Cells Is Maintained by TGFβ₃ in a Serum-Dependent Manner within a 3D-Co-Culture with MG-63 Cells.

Jähn K, Mason DJ, Ralphs JR, Evans BAJ, Archer CW, Richards RG, Stoddart MJ.

Int J Mol Sci. 2018 Jun 30;19(7). pii: E1932. doi: 10.3390/ijms19071932.


Benefits of hardware removal after plating.

Acklin YP, Bircher A, Morgenstern M, Richards RG, Sommer C.

Injury. 2018 Jun;49 Suppl 1:S91-S95. doi: 10.1016/S0020-1383(18)30311-5. Review.


LagLoc-a new surgical technique for locking plate systems.

Triana M, Gueorguiev B, Sommer C, Stoffel K, Agarwal Y, Zderic I, Helfen T, Krieg JC, Krause F, Knobe M, Richards RG, Lenz M.

J Orthop Res. 2018 Nov;36(11):2886-2891. doi: 10.1002/jor.24069. Epub 2018 Jul 13.


Is augmented LISS plating biomechanically advantageous over conventional LISS plating in unstable osteoporotic distal femoral fractures?

Todorov D, Zderic I, Richards RG, Lenz M, Knobe M, Enchev D, Baltov A, Gueorguiev B, Stoffel K.

J Orthop Res. 2018 Oct;36(10):2604-2611. doi: 10.1002/jor.24047. Epub 2018 Jun 13.


Fragility fractures of the sacrum occur in elderly patients with severe loss of sacral bone mass.

Wagner D, Hofmann A, Kamer L, Sawaguchi T, Richards RG, Noser H, Gruszka D, Rommens PM.

Arch Orthop Trauma Surg. 2018 Jul;138(7):971-977. doi: 10.1007/s00402-018-2938-5. Epub 2018 Apr 26.


The impact of translational orthopaedic research: Journal of Orthopaedic Translation indexed in Science Citation Index Expanded.

Qin L, Chen CH, Genant HK, Guo XD, Li G, O'Keefe R, Richards RG, Tang TT, Chan KM.

J Orthop Translat. 2018 Feb 3;12:A1-A2. doi: 10.1016/ eCollection 2018 Jan. No abstract available.


Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration.

Zhou Z, Zeiter S, Schmid T, Sakai D, Iatridis JC, Zhou G, Richards RG, Alini M, Grad S, Li Z.

Cartilage. 2018 Mar 1:1947603518764263. doi: 10.1177/1947603518764263. [Epub ahead of print]


Antibiotic Prophylaxis With Cefuroxime: Influence of Duration on Infection Rate With Staphylococcus aureus in a Contaminated Open Fracture Model.

Puetzler J, Metsemakers WJ, Arens D, Zeiter S, Kuehl R, Raschke MJ, Richards RG, Moriarty TF.

J Orthop Trauma. 2018 Apr;32(4):190-195. doi: 10.1097/BOT.0000000000001053.


Infections associated with mesh repairs of abdominal wall hernias: Are antimicrobial biomaterials the longed-for solution?

Guillaume O, Pérez-Tanoira R, Fortelny R, Redl H, Moriarty TF, Richards RG, Eglin D, Petter Puchner A.

Biomaterials. 2018 Jun;167:15-31. doi: 10.1016/j.biomaterials.2018.03.017. Epub 2018 Mar 12. Review.


Local application of a gentamicin-loaded thermo-responsive hydrogel allows for fracture healing upon clearance of a high Staphylococcus aureus load in a rabbit model.

Ter Boo GJ, Schmid T, Zderic I, Nehrbass D, Camenisch K, Richards RG, Grijpma DW, Moriarty TF, Eglin D.

Eur Cell Mater. 2018 Mar 2;35:151-164. doi: 10.22203/eCM.v035a11.


International survey among orthopaedic trauma surgeons: Lack of a definition of fracture-related infection.

Morgenstern M, Moriarty TF, Kuehl R, Richards RG, McNally MA, Verhofstad MHJ, Borens O, Zalavras C, Raschke M, Kates SL, Metsemakers WJ.

Injury. 2018 Mar;49(3):491-496. doi: 10.1016/j.injury.2018.02.001. Epub 2018 Feb 6.


An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition.

Lang G, Liu Y, Geries J, Zhou Z, Kubosch D, Südkamp N, Richards RG, Alini M, Grad S, Li Z.

J Tissue Eng Regen Med. 2018 Apr;12(4):e2051-e2061. doi: 10.1002/term.2636. Epub 2018 Feb 6.


The role of a small posterior malleolar fragment in trimalleolar fractures: a biomechanical study.

Evers J, Fischer M, Zderic I, Wähnert D, Richards RG, Gueorguiev B, Raschke MJ, Ochman S.

Bone Joint J. 2018 Jan;100-B(1):95-100. doi: 10.1302/0301-620X.100B1.BJJ-2017-0435.R1.


Influence of tibialis posterior muscle activation on foot anatomy under axial loading: A biomechanical CT human cadaveric study.

Dullaert K, Hagen JE, Simons P, Gras F, Gueorguiev B, Richards RG, Klos K.

Foot Ankle Surg. 2017 Dec;23(4):250-254. doi: 10.1016/j.fas.2016.07.003. Epub 2016 Jul 20.


Influence of fracture stability on Staphylococcus epidermidis and Staphylococcus aureus infection in a murine femoral fracture model.

Sabaté Brescó M, O'Mahony L, Zeiter S, Kluge K, Ziegler M, Berset C, Nehrbass D, Richards RG, Moriarty TF.

Eur Cell Mater. 2017 Nov 21;34:321-340. doi: 10.22203/eCM.v034a20.


Drug delivery systems functionalized with bone mineral seeking agents for bone targeted therapeutics.

Rotman SG, Grijpma DW, Richards RG, Moriarty TF, Eglin D, Guillaume O.

J Control Release. 2018 Jan 10;269:88-99. doi: 10.1016/j.jconrel.2017.11.009. Epub 2017 Nov 8. Review.


Biomechanical investigation of four different fixation techniques in sacrum Denis type II fracture with low bone mineral density.

Acklin YP, Zderic I, Richards RG, Schmitz P, Gueorguiev B, Grechenig S.

J Orthop Res. 2018 Jun;36(6):1624-1629. doi: 10.1002/jor.23798. Epub 2017 Dec 5.


Reamed locked intramedullary nailing for studying femur fracture and its complications.

Yoshino O, Brady J, Young K, Hardy B, Matthys R, Buxton T, Appleyard R, Tomka J, Dabirrahmani D, Woodford P, Fadia M, Steck R, Quail A, Richards RG, Balogh ZJ.

Eur Cell Mater. 2017 Sep 11;34:99-107. doi: 10.22203/eCM.v034a07.


Fracture-related infection: A consensus on definition from an international expert group.

Metsemakers WJ, Morgenstern M, McNally MA, Moriarty TF, McFadyen I, Scarborough M, Athanasou NA, Ochsner PE, Kuehl R, Raschke M, Borens O, Xie Z, Velkes S, Hungerer S, Kates SL, Zalavras C, Giannoudis PV, Richards RG, Verhofstad MHJ.

Injury. 2018 Mar;49(3):505-510. doi: 10.1016/j.injury.2017.08.040. Epub 2017 Aug 24.


A large animal model for a failed two-stage revision of intramedullary nail-related infection by methicillin-resistant Staphylococcus aureus.

Moriarty TF, Schmid T, Post V, Samara E, Kates S, Schwarz EM, Zeiter S, Richards RG.

Eur Cell Mater. 2017 Aug 30;34:83-98. doi: 10.22203/eCM.v034a06.


Pathogenic Mechanisms and Host Interactions in Staphylococcus epidermidis Device-Related Infection.

Sabaté Brescó M, Harris LG, Thompson K, Stanic B, Morgenstern M, O'Mahony L, Richards RG, Moriarty TF.

Front Microbiol. 2017 Aug 2;8:1401. doi: 10.3389/fmicb.2017.01401. eCollection 2017. Review.


Comparative Genomics Study of Staphylococcus epidermidis Isolates from Orthopedic-Device-Related Infections Correlated with Patient Outcome.

Post V, Harris LG, Morgenstern M, Mageiros L, Hitchings MD, Méric G, Pascoe B, Sheppard SK, Richards RG, Moriarty TF.

J Clin Microbiol. 2017 Oct;55(10):3089-3103. doi: 10.1128/JCM.00881-17. Epub 2017 Aug 9.


Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement.

Samara E, Moriarty TF, Decosterd LA, Richards RG, Gautier E, Wahl P.

Bone Joint Res. 2017 May;6(5):296-306. doi: 10.1302/2046-3758.65.BJR-2017-0276.R1.


Orthopaedic device-related infection: current and future interventions for improved prevention and treatment.

Moriarty TF, Kuehl R, Coenye T, Metsemakers WJ, Morgenstern M, Schwarz EM, Riool M, Zaat SAJ, Khana N, Kates SL, Richards RG.

EFORT Open Rev. 2017 Mar 13;1(4):89-99. doi: 10.1302/2058-5241.1.000037. eCollection 2016 Apr.


High-Resolution Tomography-Based Quantification of Cortical Porosity and Cortical Thickness at the Surgical Neck of the Humerus During Aging.

Helfen T, Sprecher CM, Eberli U, Gueorguiev B, Müller PE, Richards RG, Schmidutz F.

Calcif Tissue Int. 2017 Sep;101(3):271-279. doi: 10.1007/s00223-017-0279-y. Epub 2017 Apr 21.


Morphometry of the sacrum and its implication on trans-sacral corridors using a computed tomography data-based three-dimensional statistical model.

Wagner D, Kamer L, Sawaguchi T, Richards RG, Noser H, Hofmann A, Rommens PM.

Spine J. 2017 Aug;17(8):1141-1147. doi: 10.1016/j.spinee.2017.03.023. Epub 2017 Mar 31.


Influence of steel implant surface microtopography on soft and hard tissue integration.

Hayes JS, Klöppel H, Wieling R, Sprecher CM, Richards RG.

J Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):705-715. doi: 10.1002/jbm.b.33878. Epub 2017 Mar 21.


Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair.

Guillaume O, Geven MA, Sprecher CM, Stadelmann VA, Grijpma DW, Tang TT, Qin L, Lai Y, Alini M, de Bruijn JD, Yuan H, Richards RG, Eglin D.

Acta Biomater. 2017 May;54:386-398. doi: 10.1016/j.actbio.2017.03.006. Epub 2017 Mar 7.


Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice.

Metsemakers WJ, Kortram K, Morgenstern M, Moriarty TF, Meex I, Kuehl R, Nijs S, Richards RG, Raschke M, Borens O, Kates SL, Zalavras C, Giannoudis PV, Verhofstad MHJ.

Injury. 2018 Mar;49(3):497-504. doi: 10.1016/j.injury.2017.02.010. Epub 2017 Feb 20. Review.

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