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Items: 46

1.

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.

Mukherjee M, Sabir S, O'Regan L, Sampson J, Richards MW, Huguenin-Dezot N, Ault JR, Chin JW, Zhuravleva A, Fry AM, Bayliss R.

Sci Signal. 2018 Aug 14;11(543). pii: eaao2464. doi: 10.1126/scisignal.aao2464.

PMID:
30108182
2.

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R.

EMBO J. 2018 Apr 13;37(8). pii: e97902. doi: 10.15252/embj.201797902. Epub 2018 Mar 6.

3.

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R.

ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30.

PMID:
29045126
4.

A moving target: structure and disorder in pursuit of Myc inhibitors.

Bayliss R, Burgess SG, Leen E, Richards MW.

Biochem Soc Trans. 2017 Jun 15;45(3):709-717. doi: 10.1042/BST20160328. Review.

5.

Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer.

Woo CG, Seo S, Kim SW, Jang SJ, Park KS, Song JY, Lee B, Richards MW, Bayliss R, Lee DH, Choi J.

Ann Oncol. 2017 Apr 1;28(4):791-797. doi: 10.1093/annonc/mdw693.

6.

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.

Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731. Epub 2016 Nov 11.

7.

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R.

Open Biol. 2016 Jul;6(7). pii: 160089. doi: 10.1098/rsob.160089.

8.

A closed conformation of the Caenorhabditis elegans separase-securin complex.

Bachmann G, Richards MW, Winter A, Beuron F, Morris E, Bayliss R.

Open Biol. 2016 Apr;6(4):160032. doi: 10.1098/rsob.160032. Epub 2016 Apr 13.

9.

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.

Bayliss R, Choi J, Fennell DA, Fry AM, Richards MW.

Cell Mol Life Sci. 2016 Mar;73(6):1209-24. doi: 10.1007/s00018-015-2117-6. Epub 2016 Jan 11. Review.

10.

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.

Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R.

Nat Commun. 2015 Nov 2;6:8771. doi: 10.1038/ncomms9771.

11.

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.

Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R.

Oncotarget. 2015 May 30;6(15):13019-35.

12.

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.

13.

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R.

Biochem J. 2015 May 1;467(3):529-36. doi: 10.1042/BJ20150039.

PMID:
25740311
14.

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain.

Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi: 10.1073/pnas.1322892111. Epub 2014 Mar 24.

15.

Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.

Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ.

J Cell Biol. 2013 Aug 5;202(3):463-78. doi: 10.1083/jcb.201211127.

16.

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR).

Oberoi J, Richards MW, Crumpler S, Brown N, Blagg J, Bayliss R.

J Biol Chem. 2010 Dec 10;285(50):39348-58. doi: 10.1074/jbc.M110.159855. Epub 2010 Sep 29.

17.

Late failure of a single-coil transvenous implantable cardioverter-defibrillator lead associated with conductor separation.

Richards MW, Warren CE, Anderson MH.

Europace. 2010 Aug;12(8):1191-2. doi: 10.1093/europace/euq082. Epub 2010 Mar 27.

PMID:
20348555
18.

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.

Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R.

Biochem J. 2010 Mar 15;427(1):19-28. doi: 10.1042/BJ20091530. Erratum in: Biochem J. 2010;427(3):551.

PMID:
20067443
19.

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R.

Mol Cell. 2009 Nov 25;36(4):560-70. doi: 10.1016/j.molcel.2009.09.038.

20.

A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.

Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R.

J Mol Biol. 2010 Feb 5;395(5):908-15. doi: 10.1016/j.jmb.2009.11.029. Epub 2009 Nov 17.

21.
22.

Measurement of clinicians' ability to hand torque dental implant components.

Kanawati A, Richards MW, Becker JJ, Monaco NE.

J Oral Implantol. 2009;35(4):185-8. doi: 10.1563/1548-1336-35.4.185.

PMID:
19813423
23.

Insights into the conformational variability and regulation of human Nek2 kinase.

Westwood I, Cheary DM, Baxter JE, Richards MW, van Montfort RL, Fry AM, Bayliss R.

J Mol Biol. 2009 Feb 20;386(2):476-85. doi: 10.1016/j.jmb.2008.12.033. Epub 2008 Dec 24.

24.

The HOOK-domain between the SH3 and the GK domains of Cavbeta subunits contains key determinants controlling calcium channel inactivation.

Richards MW, Leroy J, Pratt WS, Dolphin AC.

Channels (Austin). 2007 Mar-Apr;1(2):92-101. Epub 2007 Mar 15.

PMID:
18690022
25.

The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function.

Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC.

J Physiol. 2006 Jul 15;574(Pt 2):387-98. Epub 2006 Apr 20.

26.

Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels.

Martin SW, Butcher AJ, Berrow NS, Richards MW, Paddon RE, Turner DJ, Dolphin AC, Sihra TS, Fitzgerald EM.

Cell Calcium. 2006 Mar;39(3):275-92. Epub 2006 Jan 6.

PMID:
16406008
27.

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.

Cantí C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards MW, Hendrich J, Douglas L, Page KM, Davies A, Dolphin AC.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11230-5. Epub 2005 Aug 1.

28.

Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC.

J Neurosci. 2005 Jul 27;25(30):6984-96. Erratum in: J Neurosci. 2005 Oct 5;25(40):table of contents. Richards, Mark S [corrected to Richards, Mark W].

29.

Ca2+ channel beta-subunits: structural insights AID our understanding.

Richards MW, Butcher AJ, Dolphin AC.

Trends Pharmacol Sci. 2004 Dec;25(12):626-32. Review.

PMID:
15530640
30.

A simple screening test for color matching in dentistry.

Yorty JS, Richards MW, Kanawati A, Davis S, House RC, Okubo SR.

Gen Dent. 2000 May-Jun;48(3):272-6.

PMID:
11199592
31.

Working times and dimensional accuracy of the one-step putty/wash impression technique.

Richards MW, Zeiaei S, Bagby MD, Okubo S, Soltani J.

J Prosthodont. 1998 Dec;7(4):250-5.

PMID:
10196845
32.

Short report: hematologic changes in acute, imported Plasmodium falciparum malaria.

Richards MW, Behrens RH, Doherty JF.

Am J Trop Med Hyg. 1998 Dec;59(6):859.

PMID:
9886188
33.

Evaluation of visual and instrument shade matching.

Okubo SR, Kanawati A, Richards MW, Childress S.

J Prosthet Dent. 1998 Dec;80(6):642-8.

PMID:
9830067
34.

Photoelastic stress patterns produced by implant-retained overdentures.

Kenney R, Richards MW.

J Prosthet Dent. 1998 Nov;80(5):559-64.

PMID:
9813806
35.

Seating accuracy and fracture strength of vented and nonvented ceramic crowns luted with three cements.

Clark MT, Richards MW, Meiers JC.

J Prosthet Dent. 1995 Jul;74(1):18-24.

PMID:
7674185
36.

Dissolution of cast aluminum in different denture cleansers.

Sindel DW, Billy EJ, Richards MW, Rains TC, Li SH.

Int J Prosthodont. 1994 May-Jun;7(3):280-4.

PMID:
7916895
37.

Early erosion of glass-ionomer cement at crown margins.

Curtis SR, Richards MW, Meiers JC.

Int J Prosthodont. 1993 Nov-Dec;6(6):553-7.

PMID:
8148026
38.

Improving the accuracy of a new articulator.

Richards MW, Curtis S.

J Prosthet Dent. 1993 Sep;70(3):239-44.

PMID:
8410731
39.

Using computerized cephalometrics to analyze the vertical dimension of occlusion.

Edwards CL, Richards MW, Billy EJ, Neilans LC.

Int J Prosthodont. 1993 Jul-Aug;6(4):371-6.

PMID:
8240648
40.

Microwave processing for denture relines, repairs, and rebases.

Turck MD, Richards MW.

J Prosthet Dent. 1993 Mar;69(3):340-3.

PMID:
8445569
41.

Development and variation of the lateral vertebral foramen of the atlas in dogs.

Richards MW, Watson AG.

Anat Histol Embryol. 1991 Dec;20(4):363-8.

PMID:
1796788
42.
43.

Influence of naloxone and yohimbine administration on pulsatile LH secretion in luteal phase beef cows.

Schoenemann HM, Richards MW, Sangiah S, Wettemann RP.

Theriogenology. 1990 Feb;33(2):509-18.

PMID:
16726747
44.

Nutritional anestrus in beef cows: concentrations of glucose and nonesterified fatty acids in plasma and insulin in serum.

Richards MW, Wettemann RP, Schoenemann HM.

J Anim Sci. 1989 Sep;67(9):2354-62.

PMID:
2689418
45.
46.

Influence of Synchro-Mate-B and breed composition on estrous response and pregnancy rate in spring- and fall-bred Brahman crossbred beef cows.

Richards MW, Geisert RD, Rice LE, Buchanan DS, Castree JW.

Theriogenology. 1988 Apr;29(4):951-60.

PMID:
16726416

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