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Items: 1 to 50 of 643

1.

Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.

Patzak MS, Kari V, Patil S, Hamdan FH, Goetze RG, Brunner M, Gaedcke J, Kitz J, Jodrell DI, Richards FM, Pilarsky C, Gruetzmann R, Rümmele P, Knösel T, Hessmann E, Ellenrieder V, Johnsen SA, Neesse A.

EBioMedicine. 2019 Feb;40:394-405. doi: 10.1016/j.ebiom.2019.01.037. Epub 2019 Jan 30.

2.

Silent cerebral infarction and cognitive function following TAVI: an observational two-centre UK comparison of the first-generation CoreValve and second-generation Lotus valve.

Musa TA, Uddin A, Loveday C, Dobson LE, Igra M, Richards F, Swoboda PP, Singh A, Garg P, Foley JRJ, Fent GJ, Goddard AJP, Malkin C, Plein S, Blackman DJ, McCann GP, Greenwood JP.

BMJ Open. 2019 Jan 21;9(1):e022329. doi: 10.1136/bmjopen-2018-022329.

3.

Author Correction: Substantiating freedom from parasitic infection by combining transmission model predictions with disease surveys.

Michael E, Smith ME, Katabarwa MN, Byamukama E, Griswold E, Habomugisha P, Lakwo T, Tukahebwa E, Miri ES, Eigege A, Ngige E, Unnasch TR, Richards FO.

Nat Commun. 2018 Nov 19;9(1):4929. doi: 10.1038/s41467-018-07507-0.

4.

Substantiating freedom from parasitic infection by combining transmission model predictions with disease surveys.

Michael E, Smith ME, Katabarwa MN, Byamukama E, Griswold E, Habomugisha P, Lakwo T, Tukahebwa E, Miri ES, Eigege A, Ngige E, Unnasch TR, Richards FO.

Nat Commun. 2018 Oct 18;9(1):4324. doi: 10.1038/s41467-018-06657-5. Erratum in: Nat Commun. 2018 Nov 19;9(1):4929.

5.

Operational Performance of the Onchocerca volvulus "OEPA" Ov16 ELISA Serological Assay in Mapping, Guiding Decisions to Stop Mass Drug Administration, and Posttreatment Surveillance Surveys.

Richards FO, Katabarwa M, Bekele F, Tadesse Z, Mohammed A, Sauerbrey M, Dominguez-Vazquez A, Rodriguez-Perez MA, Fernández-Santos NA, Rizzo N, Schuler Martínez HR, Lovato Silva R, Morales Monroy Z, Habomugisha P, Oguttu DW, Zarroug IMA, Aziz NA, Unnasch TR.

Am J Trop Med Hyg. 2018 Sep;99(3):749-752. doi: 10.4269/ajtmh.18-0341. Epub 2018 Jul 12.

PMID:
30014821
6.

Evaluation of Treatment Coverage and Enhanced Mass Drug Administration for Onchocerciasis and Lymphatic Filariasis in Five Local Government Areas Treating Twice Per Year in Edo State, Nigeria.

Griswold E, Eigege A, Ityonzughul C, Emukah E, Miri ES, Anagbogu I, Saka YA, Kadiri S, Adelamo S, Ugbadamu P, Ikogho C, Richards FO.

Am J Trop Med Hyg. 2018 Aug;99(2):396-403. doi: 10.4269/ajtmh.17-1004. Epub 2018 Jun 21.

PMID:
29943709
7.

The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression.

Wallez Y, Dunlop CR, Johnson TI, Koh SB, Fornari C, Yates JWT, Bernaldo de Quirós Fernández S, Lau A, Richards FM, Jodrell DI.

Mol Cancer Ther. 2018 Aug;17(8):1670-1682. doi: 10.1158/1535-7163.MCT-18-0010. Epub 2018 Jun 11.

8.

In Southern Nigeria Loa loa Blood Microfilaria Density is Very Low Even in Areas with High Prevalence of Loiasis: Results of a Survey Using the New LoaScope Technology.

Emukah E, Rakers LJ, Kahansim B, Miri ES, Nwoke BEB, Griswold E, Saka Y, Anagbogu I, Davies E, Ityonzughul C, D'Ambrosio M, Bakalar M, Fletcher DA, Nutman T, Kamgno J, Richards FO.

Am J Trop Med Hyg. 2018 Jul;99(1):116-123. doi: 10.4269/ajtmh.18-0163. Epub 2018 May 10.

PMID:
29761763
9.

Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.

Koh SB, Wallez Y, Dunlop CR, Bernaldo de Quirós Fernández S, Bapiro TE, Richards FM, Jodrell DI.

Cancer Res. 2018 Jun 1;78(11):3054-3066. doi: 10.1158/0008-5472.CAN-17-3932. Epub 2018 May 7.

10.

The role of the NGDO Coordination Group for the Elimination of Onchocerciasis.

Elhassan E, Zhang Y, Bush S, Molyneux D, Kollmann MKH, Sodahlon Y, Richards F.

Int Health. 2018 Mar 1;10(suppl_1):i97-i101. doi: 10.1093/inthealth/ihx050.

PMID:
29471339
11.

The role of national committees in eliminating onchocerciasis.

Griswold E, Unnasch T, Eberhard M, Nwoke BEB, Morales Z, Muheki Tukahebwa E, Kebede B, Anagbogu I, Katabarwa M, Habomugisha P, Tadesse Z, Miri ES, Evans D, Cohn D, Elhassan E, Richards F.

Int Health. 2018 Mar 1;10(suppl_1):i60-i70. doi: 10.1093/inthealth/ihx048.

PMID:
29471337
12.

After 70 years of fighting an age-old scourge, onchocerciasis in Uganda, the end is in sight.

Katabarwa MN, Lakwo T, Habomugisha P, Unnasch TR, Garms R, Hudson-Davis L, Byamukama E, Khainza A, Ngorok J, Tukahebwa E, Richards FO.

Int Health. 2018 Mar 1;10(suppl_1):i79-i88. doi: 10.1093/inthealth/ihx044.

PMID:
29471335
13.

Progress toward elimination of onchocerciasis in the Americas.

Sauerbrey M, Rakers LJ, Richards FO.

Int Health. 2018 Mar 1;10(suppl_1):i71-i78. doi: 10.1093/inthealth/ihx039.

PMID:
29471334
14.

Mass Administration of Ivermectin in Areas Where Loa loa Is Endemic.

Richards FO Jr.

N Engl J Med. 2017 Nov 23;377(21):2088-2090. doi: 10.1056/NEJMe1712713. Epub 2017 Nov 8. No abstract available.

PMID:
29117480
15.

Criteria to Stop Mass Drug Administration for Lymphatic Filariasis Have Been Achieved Throughout Plateau and Nasarawa States, Nigeria.

Eigege A, Evans DS, Noland GS, Davies E, Umaru J, Adelamo SE, Mancha B, King JD, Miri ES, Okoeguale B, Griswold EP, Richards FO Jr.

Am J Trop Med Hyg. 2017 Sep;97(3):677-680. doi: 10.4269/ajtmh.16-0843. Epub 2017 Jul 27.

16.

Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.

Jackson RC, Di Veroli GY, Koh SB, Goldlust I, Richards FM, Jodrell DI.

PLoS Comput Biol. 2017 May 3;13(5):e1005529. doi: 10.1371/journal.pcbi.1005529. eCollection 2017 May.

17.
18.

Skin snips have no role in programmatic evaluations for onchocerciasis elimination: a reply to Bottomley et al.

Eberhard ML, Cupp EW, Katholi CR, Richards FO, Unnasch TR.

Parasit Vectors. 2017 Mar 23;10(1):154. doi: 10.1186/s13071-017-2090-z.

19.

Development of In Vitro Co-Culture Model in Anti-Cancer Drug Development Cascade.

Xu R, Richards FM.

Comb Chem High Throughput Screen. 2017;20(5):451-457. doi: 10.2174/1386207320666170202093538. Review.

PMID:
28155598
20.

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.

Hessmann E, Patzak MS, Klein L, Chen N, Kari V, Ramu I, Bapiro TE, Frese KK, Gopinathan A, Richards FM, Jodrell DI, Verbeke C, Li X, Heuchel R, Löhr JM, Johnsen SA, Gress TM, Ellenrieder V, Neesse A.

Gut. 2018 Mar;67(3):497-507. doi: 10.1136/gutjnl-2016-311954. Epub 2017 Jan 10.

21.

Interruption of the transmission of Onchocerca volvulus in the Kashoya-Kitomi focus, western Uganda by long-term ivermectin treatment and elimination of the vector Simulium neavei by larviciding.

Lakwo T, Garms R, Wamani J, Tukahebwa EM, Byamukama E, Onapa AW, Tukesiga E, Katamanywa J, Begumisa S, Habomugisha P, Oguttu D, Byamukama E, Richards F, Unnasch TR, Katabarwa M.

Acta Trop. 2017 Mar;167:128-136. doi: 10.1016/j.actatropica.2016.12.029. Epub 2016 Dec 26.

PMID:
28034767
22.

A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level.

Koh SB, Mascalchi P, Rodriguez E, Lin Y, Jodrell DI, Richards FM, Lyons SK.

J Cell Sci. 2017 Jan 15;130(2):512-520. doi: 10.1242/jcs.195164. Epub 2016 Nov 25.

23.

The First Confirmed Elimination of an Onchocerciasis Focus in Africa: Abu Hamed, Sudan.

Zarroug IM, Hashim K, ElMubark WA, Shumo ZA, Salih KA, ElNojomi NA, Awad HA, Aziz N, Katabarwa M, Hassan HK, Unnasch TR, Mackenzie CD, Richards F, Higazi TB.

Am J Trop Med Hyg. 2016 Nov 2;95(5):1037-1040. Epub 2016 Jun 27.

24.

A Knowledge, Attitudes and Practices Survey Conducted Three Years after Halting Ivermectin Mass Treatment for Onchocerciasis in Guatemala.

Richards FO Jr, Klein RE, de León O, Mendizábal-Cabrera R, Morales AL, Cama V, Crovella CG, Díaz Espinoza CE, Morales Z, Sauerbrey M, Rizzo N.

PLoS Negl Trop Dis. 2016 Jun 24;10(6):e0004777. doi: 10.1371/journal.pntd.0004777. eCollection 2016 Jun.

25.
26.

The Imaramagambo Onchocerciasis Focus in Southwestern Uganda: Interruption of Transmission After Disappearance of the Vector Simulium neavei and Its Associated Freshwater Crabs.

Katabarwa MN, Katamanywa J, Lakwo T, Habomugisha P, Byamukama E, Oguttu D, Nahabwe C, Ngabirano M, Tukesiga E, Khainza A, Tukahebwa E, Unnasch TR, Richards FO, Garms R.

Am J Trop Med Hyg. 2016 Aug 3;95(2):417-425. doi: 10.4269/ajtmh.16-0181. Epub 2016 May 23.

27.

Combenefit: an interactive platform for the analysis and visualization of drug combinations.

Di Veroli GY, Fornari C, Wang D, Mollard S, Bramhall JL, Richards FM, Jodrell DI.

Bioinformatics. 2016 Sep 15;32(18):2866-8. doi: 10.1093/bioinformatics/btw230. Epub 2016 Apr 25.

28.

Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma.

Carapuça EF, Gemenetzidis E, Feig C, Bapiro TE, Williams MD, Wilson AS, Delvecchio FR, Arumugam P, Grose RP, Lemoine NR, Richards FM, Kocher HM.

J Pathol. 2016 Jul;239(3):286-96. doi: 10.1002/path.4727. Epub 2016 May 25.

29.

Presence of Wuchereria bancrofti microfilaremia despite 7 years of annual ivermectin monotherapy mass drug administration for onchocerciasis control: a study in north-west Ethiopia.

Endeshaw T, Taye A, Tadesse Z, Katabarwa MN, Shafi O, Seid T, Richards FO Jr.

Pathog Glob Health. 2015;109(7):344-51. doi: 10.1080/20477724.2015.1103501.

30.

A Venue-Based Survey of Malaria, Anemia and Mobility Patterns among Migrant Farm Workers in Amhara Region, Ethiopia.

Schicker RS, Hiruy N, Melak B, Gelaye W, Bezabih B, Stephenson R, Patterson AE, Tadesse Z, Emerson PM, Richards FO Jr, Noland GS.

PLoS One. 2015 Nov 30;10(11):e0143829. doi: 10.1371/journal.pone.0143829. eCollection 2015.

31.

One Hundred Years After Its Discovery in Guatemala by Rodolfo Robles, Onchocerca volvulus Transmission Has Been Eliminated from the Central Endemic Zone.

Richards F Jr, Rizzo N, Diaz Espinoza CE, Monroy ZM, Crovella Valdez CG, de Cabrera RM, de Leon O, Zea-Flores G, Sauerbrey M, Morales AL, Rios D, Unnasch TR, Hassan HK, Klein R, Eberhard M, Cupp E, Domínguez A.

Am J Trop Med Hyg. 2015 Dec;93(6):1295-304. doi: 10.4269/ajtmh.15-0364. Epub 2015 Oct 26.

32.

Determinants of Bed Net Use in Southeast Nigeria following Mass Distribution of LLINs: Implications for Social Behavior Change Interventions.

Russell CL, Sallau A, Emukah E, Graves PM, Noland GS, Ngondi JM, Ozaki M, Nwankwo L, Miri E, McFarland DA, Richards FO, Patterson AE.

PLoS One. 2015 Oct 2;10(10):e0139447. doi: 10.1371/journal.pone.0139447. eCollection 2015.

33.

An automated fitting procedure and software for dose-response curves with multiphasic features.

Di Veroli GY, Fornari C, Goldlust I, Mills G, Koh SB, Bramhall JL, Richards FM, Jodrell DI.

Sci Rep. 2015 Oct 1;5:14701. doi: 10.1038/srep14701.

34.

Elimination of Onchocerciasis from Mexico.

Rodríguez-Pérez MA, Fernández-Santos NA, Orozco-Algarra ME, Rodríguez-Atanacio JA, Domínguez-Vázquez A, Rodríguez-Morales KB, Real-Najarro O, Prado-Velasco FG, Cupp EW, Richards FO Jr, Hassan HK, González-Roldán JF, Kuri-Morales PA, Unnasch TR.

PLoS Negl Trop Dis. 2015 Jul 10;9(7):e0003922. doi: 10.1371/journal.pntd.0003922. eCollection 2015.

35.

CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus.

Koh SB, Courtin A, Boyce RJ, Boyle RG, Richards FM, Jodrell DI.

Cancer Res. 2015 Sep 1;75(17):3583-95. doi: 10.1158/0008-5472.CAN-14-3347. Epub 2015 Jul 3.

36.

Onchocerciasis and lymphatic filariasis elimination in Africa: it's about time.

Evans DS, Unnasch TR, Richards FO.

Lancet. 2015 May 30;385(9983):2151-2. doi: 10.1016/S0140-6736(15)61022-4. No abstract available.

PMID:
26068266
37.

The Contributions of Onchocerciasis Control and Elimination Programs toward the Achievement of the Millennium Development Goals.

Dunn C, Callahan K, Katabarwa M, Richards F, Hopkins D, Withers PC Jr, Buyon LE, McFarland D.

PLoS Negl Trop Dis. 2015 May 21;9(5):e0003703. doi: 10.1371/journal.pntd.0003703. eCollection 2015 May. Review.

38.

From River Blindness to Neglected Tropical Diseases--Lessons Learned in Africa for Programme Implementation and Expansion by the Non-governmental Partners.

Cross C, Olamiju F, Richards F, Bush S, Hopkins A, Haddad D.

PLoS Negl Trop Dis. 2015 May 14;9(5):e0003506. doi: 10.1371/journal.pntd.0003506. eCollection 2015 May. No abstract available.

39.

Status of Onchocerciasis transmission after more than a decade of mass drug administration for onchocerciasis and lymphatic filariasis elimination in central Nigeria: challenges in coordinating the stop MDA decision.

Evans DS, Alphonsus K, Umaru J, Eigege A, Miri E, Mafuyai H, Gonzales-Peralta C, Adamani W, Pede E, Umbugadu C, Saka Y, Okoeguale B, Richards FO.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3113. doi: 10.1371/journal.pntd.0003113. eCollection 2014 Sep.

40.

The EGFR demonstrates linear signal transmission.

Oyarzún DA, Bramhall JL, López-Caamal F, Richards FM, Jodrell DI, Krippendorff BF.

Integr Biol (Camb). 2014 Aug;6(8):736-42. doi: 10.1039/c4ib00062e.

PMID:
24934872
41.

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

Bapiro TE, Frese KK, Courtin A, Bramhall JL, Madhu B, Cook N, Neesse A, Griffiths JR, Tuveson DA, Jodrell DI, Richards FM.

Br J Cancer. 2014 Jul 15;111(2):318-25. doi: 10.1038/bjc.2014.288. Epub 2014 May 29.

42.

Twice-yearly ivermectin for onchocerciasis: the time is now.

Katabarwa M, Richards F.

Lancet Infect Dis. 2014 May;14(5):373-4. doi: 10.1016/S1473-3099(14)70732-7. No abstract available.

PMID:
24758997
43.

Transmission of Onchocerca volvulus by Simulium neavei in Mount Elgon focus of Eastern Uganda has been interrupted.

Katabarwa M, Lakwo T, Habomugisha P, Agunyo S, Byamukama E, Oguttu D, Ndyomugyenyi R, Tukesiga E, Ochieng GO, Abwaimo F, Onapa A, Lwamafa DW, Walsh F, Unnasch TR, Richards FO.

Am J Trop Med Hyg. 2014 Jun;90(6):1159-66. doi: 10.4269/ajtmh.13-0501. Epub 2014 Mar 31.

44.

Malaria prevalence, anemia and baseline intervention coverage prior to mass net distributions in Abia and Plateau States, Nigeria.

Noland GS, Graves PM, Sallau A, Eigege A, Emukah E, Patterson AE, Ajiji J, Okorofor I, Oji OU, Umar M, Alphonsus K, Damen J, Ngondi J, Ozaki M, Cromwell E, Obiezu J, Eneiramo S, Okoro C, McClintic-Doyle R, Oresanya O, Miri E, Emerson PM, Richards FO Jr.

BMC Infect Dis. 2014 Mar 26;14:168. doi: 10.1186/1471-2334-14-168.

45.

Student filmmakers' attitudes towards mental illness and its cinematic representation - an evaluation of a training intervention for film students.

Dale J, Richards F, Bradburn J, Tadros G, Salama R.

J Ment Health. 2014 Feb;23(1):4-8. doi: 10.3109/09638237.2013.815336.

PMID:
24484185
46.

Serosurveillance to monitor onchocerciasis elimination: the Ugandan experience.

Oguttu D, Byamukama E, Katholi CR, Habomugisha P, Nahabwe C, Ngabirano M, Hassan HK, Lakwo T, Katabarwa M, Richards FO, Unnasch TR.

Am J Trop Med Hyg. 2014 Feb;90(2):339-45. doi: 10.4269/ajtmh.13-0546. Epub 2013 Dec 16.

47.

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.

Watts CA, Richards FM, Bender A, Bond PJ, Korb O, Kern O, Riddick M, Owen P, Myers RM, Raff J, Gergely F, Jodrell DI, Ley SV.

Chem Biol. 2013 Nov 21;20(11):1399-410. doi: 10.1016/j.chembiol.2013.09.012. Epub 2013 Oct 24.

48.

Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria.

Eigege A, Kal A, Miri E, Sallau A, Umaru J, Mafuyai H, Chuwang YS, Danjuma G, Danboyi J, Adelamo SE, Mancha BS, Okoeguale B, Patterson AE, Rakers L, Richards FO.

PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2508. doi: 10.1371/journal.pntd.0002508. eCollection 2013.

49.

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.

Neesse A, Frese KK, Chan DS, Bapiro TE, Howat WJ, Richards FM, Ellenrieder V, Jodrell DI, Tuveson DA.

Gut. 2014 Jun;63(6):974-83. doi: 10.1136/gutjnl-2013-305559. Epub 2013 Sep 25.

50.

Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria.

Richards FO, Emukah E, Graves PM, Nkwocha O, Nwankwo L, Rakers L, Mosher A, Patterson A, Ozaki M, Nwoke BE, Ukaga CN, Njoku C, Nwodu K, Obasi A, Miri ES.

Am J Trop Med Hyg. 2013 Sep;89(3):578-87. doi: 10.4269/ajtmh.12-0775. Epub 2013 Aug 12.

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