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Label-free spectroscopic tissue characterization using fluorescence excitation-scanning spectral imaging.

Favreau PF, Deal JA, Harris B, Weber DS, Rich TC, Leavesley SJ.

J Biophotonics. 2019 Sep 30. doi: 10.1002/jbio.201900183. [Epub ahead of print]


Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging.

Deal J, Mayes S, Browning C, Hill S, Rider P, Boudreaux C, Rich TC, Leavesley SJ.

J Biomed Opt. 2018 Dec;24(2):1-11. doi: 10.1117/1.JBO.24.2.021207.


Spectral imaging of FRET-based sensors reveals sustained cAMP gradients in three spatial dimensions.

Annamdevula NS, Sweat R, Griswold JR, Trinh K, Hoffman C, West S, Deal J, Britain AL, Jalink K, Rich TC, Leavesley SJ.

Cytometry A. 2018 Oct;93(10):1029-1038. doi: 10.1002/cyto.a.23572. Epub 2018 Sep 3.


Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.

Xu Y, Jiang YQ, Li C, He M, Rusyniak WG, Annamdevula N, Ochoa J, Leavesley SJ, Xu J, Rich TC, Lin MT, Zha XM.

FASEB J. 2018 Jul;32(7):3832-3843. doi: 10.1096/fj.201701367R. Epub 2018 Feb 15.


A theoretical-experimental methodology for assessing the sensitivity of biomedical spectral imaging platforms, assays, and analysis methods.

Leavesley SJ, Sweat B, Abbott C, Favreau P, Rich TC.

J Biophotonics. 2018 Jan;11(1). doi: 10.1002/jbio.201600227. Epub 2017 May 9. Review.


Breeding system and spatial isolation from congeners strongly constrain seed set in an insect-pollinated apomictic tree: Sorbus subcuneata (Rosaceae).

Hamston TJ, Wilson RJ, de Vere N, Rich TC, Stevens JR, Cresswell JE.

Sci Rep. 2017 Mar 24;7:45122. doi: 10.1038/srep45122.


Hyperspectral imaging fluorescence excitation scanning for colon cancer detection.

Leavesley SJ, Walters M, Lopez C, Baker T, Favreau PF, Rich TC, Rider PF, Boudreaux CW.

J Biomed Opt. 2016 Oct 1;21(10):104003. doi: 10.1117/1.JBO.21.10.104003.


Overcoming limitations of FRET measurements.

Leavesley SJ, Rich TC.

Cytometry A. 2016 Apr;89(4):325-7. doi: 10.1002/cyto.a.22851. No abstract available.


Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.

Morrow KA, Seifert R, Kaever V, Britain AL, Sayner SL, Ochoa CD, Cioffi EA, Frank DW, Rich TC, Stevens T.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1199-207. doi: 10.1152/ajplung.00165.2015. Epub 2015 Sep 18.


Estimating the magnitude of near-membrane PDE4 activity in living cells.

Xin W, Feinstein WP, Britain AL, Ochoa CD, Zhu B, Richter W, Leavesley SJ, Rich TC.

Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C415-24. doi: 10.1152/ajpcell.00090.2015. Epub 2015 Jul 22.


Channel-based reporters for cAMP detection.

Rich TC, Xin W, Leavesley SJ, Taylor MS.

Methods Mol Biol. 2015;1294:71-84. doi: 10.1007/978-1-4939-2537-7_6.


Automated image analysis of FRET signals for subcellular cAMP quantification.

Leavesley SJ, Nakhmani A, Gao Y, Rich TC.

Methods Mol Biol. 2015;1294:59-70. doi: 10.1007/978-1-4939-2537-7_5.


Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.

Xu N, Cioffi DL, Alexeyev M, Rich TC, Stevens T.

Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C277-88. doi: 10.1152/ajpcell.00063.2014. Epub 2014 Nov 26.


DNA barcoding for plants.

de Vere N, Rich TC, Trinder SA, Long C.

Methods Mol Biol. 2015;1245:101-18. doi: 10.1007/978-1-4939-1966-6_8.


FRET: signals hidden within the noise.

Leavesley SJ, Rich TC.

Cytometry A. 2014 Nov;85(11):918-20. doi: 10.1002/cyto.a.22568. Epub 2014 Sep 19. No abstract available.


β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.

Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB.

J Biol Chem. 2014 Aug 15;289(33):23065-74. doi: 10.1074/jbc.M114.557652. Epub 2014 Jun 27.


Excitation-scanning hyperspectral imaging microscope.

Favreau PF, Hernandez C, Heaster T, Alvarez DF, Rich TC, Prabhat P, Leavesley SJ.

J Biomed Opt. 2014 Apr;19(4):046010. doi: 10.1117/1.JBO.19.4.046010.


Can we decipher the information content contained within cyclic nucleotide signals?

Rich TC, Webb KJ, Leavesley SJ.

J Gen Physiol. 2014 Jan;143(1):17-27. doi: 10.1085/jgp.201311095. No abstract available.


Assessing FRET using spectral techniques.

Leavesley SJ, Britain AL, Cichon LK, Nikolaev VO, Rich TC.

Cytometry A. 2013 Oct;83(10):898-912. doi: 10.1002/cyto.a.22340. Epub 2013 Aug 8.


An approach for characterizing and comparing hyperspectral microscopy systems.

Annamdevula NS, Sweat B, Favreau P, Lindsey AS, Alvarez DF, Rich TC, Leavesley SJ.

Sensors (Basel). 2013 Jul 19;13(7):9267-93. doi: 10.3390/s130709267.


Hyperspectral imaging of FRET-based cGMP probes.

Rich TC, Britain AL, Stedman T, Leavesley SJ.

Methods Mol Biol. 2013;1020:73-88. doi: 10.1007/978-1-62703-459-3_5.


Breeding systems, hybridization and continuing evolution in Avon Gorge Sorbus.

Ludwig S, Robertson A, Rich TC, Djordjevic M, Cerovic R, Houston L, Harris SA, Hiscock SJ.

Ann Bot. 2013 Apr;111(4):563-75. doi: 10.1093/aob/mct013. Epub 2013 Feb 13.


Cytotype diversity in the Sorbus complex (Rosaceae) in Britain: sorting out the puzzle.

Pellicer J, Clermont S, Houston L, Rich TC, Fay MF.

Ann Bot. 2012 Nov;110(6):1185-93. doi: 10.1093/aob/mcs185. Epub 2012 Aug 23.


Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.

Henesy MB, Britain AL, Zhu B, Amable L, Honkanen RE, Corbin JD, Francis SH, Rich TC.

PLoS One. 2012;7(8):e41711. doi: 10.1371/journal.pone.0041711. Epub 2012 Aug 2.


DNA barcoding the native flowering plants and conifers of Wales.

de Vere N, Rich TC, Ford CR, Trinder SA, Long C, Moore CW, Satterthwaite D, Davies H, Allainguillaume J, Ronca S, Tatarinova T, Garbett H, Walker K, Wilkinson MJ.

PLoS One. 2012;7(6):e37945. doi: 10.1371/journal.pone.0037945. Epub 2012 Jun 6.


A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle.

Horvat SJ, Deshpande DA, Yan H, Panettieri RA, Codina J, DuBose TD Jr, Xin W, Rich TC, Penn RB.

FASEB J. 2012 Sep;26(9):3670-9. doi: 10.1096/fj.11-201020. Epub 2012 May 30.


Hieracium maccoshiana, a new Scottish hawkweed related to H. dovrense (Section Alpestria, Asteraceae).

Rich TC.

PhytoKeys. 2011;(3):1-8. doi: 10.3897/phytokeys.3.920. Epub 2011 May 30.


Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.

Feinstein WP, Zhu B, Leavesley SJ, Sayner SL, Rich TC.

Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C839-52. doi: 10.1152/ajpcell.00361.2011. Epub 2011 Nov 23.


Hyperspectral imaging microscopy for identification and quantitative analysis of fluorescently-labeled cells in highly autofluorescent tissue.

Leavesley SJ, Annamdevula N, Boni J, Stocker S, Grant K, Troyanovsky B, Rich TC, Alvarez DF.

J Biophotonics. 2012 Jan;5(1):67-84. doi: 10.1002/jbio.201100066. Epub 2011 Oct 11.


All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.

Xin W, Yang X, Rich TC, Krieg T, Barrington R, Cohen MV, Downey JM.

J Cardiovasc Pharmacol Ther. 2012 Jun;17(2):190-8. doi: 10.1177/1074248411416815. Epub 2011 Aug 9.


Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP.

Xie M, Rich TC, Scheitrum C, Conti M, Richter W.

Mol Pharmacol. 2011 Aug;80(2):281-93. doi: 10.1124/mol.111.071134. Epub 2011 May 6.


A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin.

Yang X, Xin W, Yang XM, Kuno A, Rich TC, Cohen MV, Downey JM.

Br J Pharmacol. 2011 Jul;163(5):995-1006. doi: 10.1111/j.1476-5381.2011.01288.x.


PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.

Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M.

J Biol Chem. 2011 Apr 8;286(14):12590-601. doi: 10.1074/jbc.M110.203604. Epub 2011 Feb 1.


Hybridization and polyploidy as drivers of continuing evolution and speciation in Sorbus.

Robertson A, Rich TC, Allen AM, Houston L, Roberts C, Bridle JR, Harris SA, Hiscock SJ.

Mol Ecol. 2010 Apr;19(8):1675-90. doi: 10.1111/j.1365-294X.2010.04585.x. Epub 2010 Mar 12.


Quantitative modeling of GRK-mediated beta2AR regulation.

Vayttaden SJ, Friedman J, Tran TM, Rich TC, Dessauer CW, Clark RB.

PLoS Comput Biol. 2010 Jan 22;6(1):e1000647. doi: 10.1371/journal.pcbi.1000647.


Receptor reserve reflects differential intrinsic efficacy associated with opioid diastereomers.

Carliss RD, Keefer JF, Perschke S, Welch S, Rich TC, Weissman AD.

Pharmacol Biochem Behav. 2009 May;92(3):495-502. doi: 10.1016/j.pbb.2009.01.019. Epub 2009 Jan 31.


Development of a high-throughput assay for monitoring cAMP levels in cardiac ventricular myocytes.

Walsh KB, Rich TC, Coffman ZJ.

J Cardiovasc Pharmacol. 2009 Mar;53(3):223-30. doi: 10.1097/FJC.0b013e31819b5479.


Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.

Xin W, Tran TM, Richter W, Clark RB, Rich TC.

J Gen Physiol. 2008 Apr;131(4):349-64. doi: 10.1085/jgp.200709881. Epub 2008 Mar 17.


Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.

Rich TC, Xin W, Mehats C, Hassell KA, Piggott LA, Le X, Karpen JW, Conti M.

Am J Physiol Cell Physiol. 2007 Jan;292(1):C319-31. Epub 2006 Aug 9.


Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments.

Piggott LA, Hassell KA, Berkova Z, Morris AP, Silberbach M, Rich TC.

J Gen Physiol. 2006 Jul;128(1):3-14. Epub 2006 Jun 12.


High-throughput screening of phosphodiesterase activity in living cells.

Rich TC, Karpen JW.

Methods Mol Biol. 2005;307:45-61.


Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors.

Karpen JW, Rich TC.

Proc West Pharmacol Soc. 2004;47:1-5.


Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation.

Brady JD, Rich TC, Le X, Stafford K, Fowler CJ, Lynch L, Karpen JW, Brown RL, Martens JR.

Mol Pharmacol. 2004 Mar;65(3):503-11.


Probing the roles of protein kinases in g-protein-coupled receptor desensitization.

Clark RB, Rich TC.

Mol Pharmacol. 2003 Nov;64(5):1015-7. No abstract available.


Review article: cyclic AMP sensors in living cells: what signals can they actually measure?

Rich TC, Karpen JW.

Ann Biomed Eng. 2002 Sep;30(8):1088-99. Review.


Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.

Rich TC, Yeola SW, Tamkun MM, Snyders DJ.

Am J Physiol Cell Physiol. 2002 Jan;282(1):C161-71.


A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell.

Rich TC, Fagan KA, Tse TE, Schaack J, Cooper DM, Karpen JW.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13049-54. Epub 2001 Oct 16. Erratum in: Proc Natl Acad Sci U S A 2001 Dec 4;98(25):14744.


The fourth dimension in cellular signaling.

Karpen JW, Rich TC.

Science. 2001 Sep 21;293(5538):2204-5. No abstract available.


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