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ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5.

Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC.

Nat Chem Biol. 2019 Dec;15(12):1232-1240. doi: 10.1038/s41589-019-0399-y. Epub 2019 Nov 18.


Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine.

Gulati S, Pennington MW, Czerwinski A, Carter D, Zheng B, Nowak NA, DeOliveira RB, Shaughnessy J, Reed GW, Ram S, Rice PA.

MBio. 2019 Nov 5;10(6). pii: e02552-19. doi: 10.1128/mBio.02552-19.


Structure of the P element transpososome reveals new twists on the DD(E/D) theme.

Rice PA.

Nat Struct Mol Biol. 2019 Nov;26(11):989-990. doi: 10.1038/s41594-019-0329-4. No abstract available.


Target highlights in CASP13: Experimental target structures through the eyes of their authors.

Lepore R, Kryshtafovych A, Alahuhta M, Veraszto HA, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN Jr, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T.

Proteins. 2019 Dec;87(12):1037-1057. doi: 10.1002/prot.25805. Epub 2019 Sep 9.


A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.

Koirala D, Shao Y, Koldobskaya Y, Fuller JR, Watkins AM, Shelke SA, Pilipenko EV, Das R, Rice PA, Piccirilli JA.

Nat Commun. 2019 Aug 9;10(1):3629. doi: 10.1038/s41467-019-11585-z.


Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S.

PLoS Biol. 2019 Jun 19;17(6):e3000323. doi: 10.1371/journal.pbio.3000323. eCollection 2019 Jun.


Complement-Dependent Serum Bactericidal Assays for Neisseria gonorrhoeae.

Gulati S, Rice PA, Ram S.

Methods Mol Biol. 2019;1997:267-280. doi: 10.1007/978-1-4939-9496-0_16.


Biology of the Gonococcus: Disease and Pathogenesis.

Shaughnessy J, Ram S, Rice PA.

Methods Mol Biol. 2019;1997:1-27. doi: 10.1007/978-1-4939-9496-0_1.


Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance.

Li Y, Su X, Le W, Li S, Yang Z, Chaisson C, Madico G, Gong X, Reed GW, Wang B, Rice PA.

Clin Infect Dis. 2019 Apr 11. pii: ciz294. doi: 10.1093/cid/ciz294. [Epub ahead of print]


Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.

Zhou H, Sathyamoorthy B, Stelling A, Xu Y, Xue Y, Pigli YZ, Case DA, Rice PA, Al-Hashimi HM.

Biochemistry. 2019 Apr 16;58(15):1963-1974. doi: 10.1021/acs.biochem.9b00027. Epub 2019 Apr 5.


Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine.

Gulati S, Shaughnessy J, Ram S, Rice PA.

Front Immunol. 2019 Feb 27;10:321. doi: 10.3389/fimmu.2019.00321. eCollection 2019. Review.


Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

Cristillo AD, Bristow CC, Torrone E, Dillon JA, Kirkcaldy RD, Dong H, Grad YH, Nicholas RA, Rice PA, Lawrence K, Oldach D, Shafer WM, Zhou P, Wi TE, Morris SR, Klausner JD.

Sex Transm Dis. 2019 Mar;46(3):e18-e25. doi: 10.1097/OLQ.0000000000000929.


Static Kinks or Flexible Hinges: Multiple Conformations of Bent DNA Bound to Integration Host Factor Revealed by Fluorescence Lifetime Measurements.

Connolly M, Arra A, Zvoda V, Steinbach PJ, Rice PA, Ansari A.

J Phys Chem B. 2018 Dec 13;122(49):11519-11534. doi: 10.1021/acs.jpcb.8b07405. Epub 2018 Nov 7.


Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae.

Shaughnessy J, Lewis LA, Zheng B, Carr C, Bass I, Gulati S, DeOliveira RB, Gose S, Reed GW, Botto M, Rice PA, Ram S.

J Immunol. 2018 Nov 1;201(9):2700-2709. doi: 10.4049/jimmunol.1701666. Epub 2018 Sep 28.


A new twist on V(D)J recombination.

Dyda F, Rice PA.

Nat Struct Mol Biol. 2018 Aug;25(8):648-649. doi: 10.1038/s41594-018-0107-8. No abstract available.


Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements.

Mir-Sanchis I, Pigli YZ, Rice PA.

Structure. 2018 Aug 7;26(8):1144-1150.e3. doi: 10.1016/j.str.2018.05.016. Epub 2018 Jul 12.


Transcriptome Analysis of Neisseria gonorrhoeae during Natural Infection Reveals Differential Expression of Antibiotic Resistance Determinants between Men and Women.

Nudel K, McClure R, Moreau M, Briars E, Abrams AJ, Tjaden B, Su XH, Trees D, Rice PA, Massari P, Genco CA.

mSphere. 2018 Jun 27;3(3). pii: e00312-18. doi: 10.1128/mSphereDirect.00312-18. Print 2018 Aug 29.


A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity.

Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, Rice PA.

Infect Immun. 2018 Jul 23;86(8). pii: e00285-18. doi: 10.1128/IAI.00285-18. Print 2018 Aug.


Resistant gonorrhoea: east meets west.

Rice PA, Su XH.

Lancet Infect Dis. 2018 Jul;18(7):702-703. doi: 10.1016/S1473-3099(18)30276-7. Epub 2018 May 15. No abstract available.


Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion.

Ermert D, Weckel A, Magda M, Mörgelin M, Shaughnessy J, Rice PA, Björck L, Ram S, Blom AM.

J Immunol. 2018 May 15;200(10):3495-3505. doi: 10.4049/jimmunol.1800090. Epub 2018 Apr 6.


Increasing Resistance to Azithromycin in Neisseria gonorrhoeae in Eastern Chinese Cities: Resistance Mechanisms and Genetic Diversity among Isolates from Nanjing.

Wan C, Li Y, Le WJ, Liu YR, Li S, Wang BX, Rice PA, Su XH.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02499-17. doi: 10.1128/AAC.02499-17. Print 2018 May.


Snapshots of a molecular swivel in action.

Trejo CS, Rock RS, Stark WM, Boocock MR, Rice PA.

Nucleic Acids Res. 2018 Jun 1;46(10):5286-5296. doi: 10.1093/nar/gkx1309.


Mu transpososome activity-profiling yields hyperactive MuA variants for highly efficient genetic and genome engineering.

Rasila TS, Pulkkinen E, Kiljunen S, Haapa-Paananen S, Pajunen MI, Salminen A, Paulin L, Vihinen M, Rice PA, Savilahti H.

Nucleic Acids Res. 2018 May 18;46(9):4649-4661. doi: 10.1093/nar/gkx1281.


Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein.

Velmurugu Y, Vivas P, Connolly M, Kuznetsov SV, Rice PA, Ansari A.

Nucleic Acids Res. 2018 Feb 28;46(4):1741-1755. doi: 10.1093/nar/gkx1215.


Guest editorial: Mobile genetic elements and horizontal gene transfer in prokaryotes.

Lang A, Thomas Beatty J, Rice PA.

Curr Opin Microbiol. 2017 Aug;38:v-vii. doi: 10.1016/j.mib.2017.09.018. No abstract available.


Neisseria gonorrhoeae: Drug Resistance, Mouse Models, and Vaccine Development.

Rice PA, Shafer WM, Ram S, Jerse AE.

Annu Rev Microbiol. 2017 Sep 8;71:665-686. doi: 10.1146/annurev-micro-090816-093530. Review.


Transposable phages, DNA reorganization and transfer.

Toussaint A, Rice PA.

Curr Opin Microbiol. 2017 Aug;38:88-94. doi: 10.1016/j.mib.2017.04.009. Epub 2017 May 25. Review.


Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics.

Ram S, Shaughnessy J, de Oliveira RB, Lewis LA, Gulati S, Rice PA.

Pathog Dis. 2017 Jun 1;75(4). doi: 10.1093/femspd/ftx049.


cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles.

Collier TL, Yokell DL, Livni E, Rice PA, Celen S, Serdons K, Neelamegam R, Bormans G, Harris D, Walji A, Hostetler ED, Bennacef I, Vasdev N.

J Labelled Comp Radiopharm. 2017 May 15;60(5):263-269. doi: 10.1002/jlcr.3496. Epub 2017 Mar 23.


Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal.

Fuller JR, Rice PA.

Elife. 2017 Feb 13;6. pii: e21777. doi: 10.7554/eLife.21777.


A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18 F]-THK-5351.

Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G.

J Labelled Comp Radiopharm. 2017 Feb;60(2):140-146. doi: 10.1002/jlcr.3482. Epub 2017 Jan 25.


Genotype-Specific Concordance of Chlamydia trachomatis Genital Infection Within Heterosexual Partnerships.

Schillinger JA, Katz BP, Markowitz LE, Braslins PG, Shrier LA, Madico G, Van Der Pol B, Orr DP, Rice PA, Batteiger BE.

Sex Transm Dis. 2016 Dec;43(12):741-749.


Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative.

Mir-Sanchis I, Roman CA, Misiura A, Pigli YZ, Boyle-Vavra S, Rice PA.

Nat Struct Mol Biol. 2016 Oct;23(10):891-898. doi: 10.1038/nsmb.3286. Epub 2016 Aug 29.


Desialylation of Neisseria gonorrhoeae Lipooligosaccharide by Cervicovaginal Microbiome Sialidases: The Potential for Enhancing Infectivity in Men.

Ketterer MR, Rice PA, Gulati S, Kiel S, Byerly L, Fortenberry JD, Soper DE, Apicella MA.

J Infect Dis. 2016 Dec 1;214(11):1621-1628. Epub 2016 Jul 28.


Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD.

Clin Vaccine Immunol. 2016 Aug 5;23(8):656-63. doi: 10.1128/CVI.00230-16. Print 2016 Aug. Review.


Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae.

Ram S, Shaughnessy J, DeOliveira RB, Lewis LA, Gulati S, Rice PA.

Immunobiology. 2016 Oct;221(10):1110-23. doi: 10.1016/j.imbio.2016.05.016. Epub 2016 Jun 1. Review.


Phase-Variable Heptose I Glycan Extensions Modulate Efficacy of 2C7 Vaccine Antibody Directed against Neisseria gonorrhoeae Lipooligosaccharide.

Chakraborti S, Lewis LA, Cox AD, St Michael F, Li J, Rice PA, Ram S.

J Immunol. 2016 Jun 1;196(11):4576-86. doi: 10.4049/jimmunol.1600374. Epub 2016 May 2.


Mobile genetic elements: in silico, in vitro, in vivo.

Arkhipova IR, Rice PA.

Mol Ecol. 2016 Mar;25(5):1027-31. doi: 10.1111/mec.13543. Epub 2016 Feb 15.


A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.

Shaughnessy J, Gulati S, Agarwal S, Unemo M, Ohnishi M, Su XH, Monks BG, Visintin A, Madico G, Lewis LA, Golenbock DT, Reed GW, Rice PA, Ram S.

J Immunol. 2016 Feb 15;196(4):1732-40. doi: 10.4049/jimmunol.1500292. Epub 2016 Jan 15.


Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics.

Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, Reed GW, Varki A, Rice PA, Ram S.

PLoS Pathog. 2015 Dec 2;11(12):e1005290. doi: 10.1371/journal.ppat.1005290. eCollection 2015 Dec.


Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914).

Su XH, Wang BX, Le WJ, Liu YR, Wan C, Li S, Alm RA, Mueller JP, Rice PA.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):621-3. doi: 10.1128/AAC.01211-15. Print 2016 Jan.


Crystal structure of the Varkud satellite ribozyme.

Suslov NB, DasGupta S, Huang H, Fuller JR, Lilley DM, Rice PA, Piccirilli JA.

Nat Chem Biol. 2015 Nov;11(11):840-6. doi: 10.1038/nchembio.1929. Epub 2015 Sep 28.


The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women.

McClure R, Nudel K, Massari P, Tjaden B, Su X, Rice PA, Genco CA.

PLoS One. 2015 Aug 5;10(8):e0133982. doi: 10.1371/journal.pone.0133982. eCollection 2015.


C6-Perfluorinated Compounds: The New Greaseproofing Agents in Food Packaging.

Rice PA.

Curr Environ Health Rep. 2015 Mar;2(1):33-40. doi: 10.1007/s40572-014-0039-3.


Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors.

Ermert D, Shaughnessy J, Joeris T, Kaplan J, Pang CJ, Kurt-Jones EA, Rice PA, Ram S, Blom AM.

PLoS Pathog. 2015 Jul 22;11(7):e1005043. doi: 10.1371/journal.ppat.1005043. eCollection 2015 Jul.


Serine Resolvases.

Rice PA.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0045-2014. doi: 10.1128/microbiolspec.MDNA3-0045-2014. Review.


Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX.

Ling L, Montaño SP, Sauer RT, Rice PA, Baker TA.

J Mol Biol. 2015 Sep 11;427(18):2966-82. doi: 10.1016/j.jmb.2015.03.008. Epub 2015 Mar 19.


Antibody to reduction modifiable protein increases the bacterial burden and the duration of gonococcal infection in a mouse model.

Gulati S, Mu X, Zheng B, Reed GW, Ram S, Rice PA.

J Infect Dis. 2015 Jul 15;212(2):311-5. doi: 10.1093/infdis/jiv024. Epub 2015 Jan 16.

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