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Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin.

Apostolidis SA, Stifano G, Tabib T, Rice LM, Morse CM, Kahaleh B, Lafyatis R.

Front Immunol. 2018 Oct 1;9:2191. doi: 10.3389/fimmu.2018.02191. eCollection 2018.


Proteins that control the geometry of microtubules at the ends of cilia.

Louka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR 3rd, Jiang YY, Lechtreck K, Dentler W, Gaertig J.

J Cell Biol. 2018 Dec 3;217(12):4298-4313. doi: 10.1083/jcb.201804141. Epub 2018 Sep 14.


Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis.

Rice LM, Mantero JC, Stratton EA, Warburton R, Roberts K, Hill N, Simms RW, Domsic R, Farber HW, Layfatis R.

Arthritis Res Ther. 2018 Aug 16;20(1):185. doi: 10.1186/s13075-018-1679-8.


ACTG2-Associated Visceral Myopathy With Chronic Intestinal Pseudoobstruction, Intestinal Malrotation, Hypertrophic Pyloric Stenosis, Choledochal Cyst, and a Novel Missense Mutation.

Collins RRJ, Barth B, Megison S, Pfeifer CM, Rice LM, Harris S, Timmons CF, Rakheja D.

Int J Surg Pathol. 2018 Jul 1:1066896918786586. doi: 10.1177/1066896918786586. [Epub ahead of print]


A new look for the growing microtubule end?

Rice LM.

J Cell Biol. 2018 Aug 6;217(8):2609-2611. doi: 10.1083/jcb.201807036. Epub 2018 Jul 13.


Design principles of a microtubule polymerase.

Geyer EA, Miller MP, Brautigam CA, Biggins S, Rice LM.

Elife. 2018 Jun 13;7. pii: e34574. doi: 10.7554/eLife.34574.


Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis.

Stifano G, Sornasse T, Rice LM, Na L, Chen-Harris H, Khanna D, Jahreis A, Zhang Y, Siegel J, Lafyatis R.

Arthritis Rheumatol. 2018 Jun;70(6):912-919. doi: 10.1002/art.40455.


An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue.

Majumdar S, Kim T, Chen Z, Munyoki S, Tso SC, Brautigam CA, Rice LM.

Mol Biol Cell. 2018 Jun 1;29(11):1359-1375. doi: 10.1091/mbc.E17-12-0748. Epub 2018 Apr 5.


Microtubule dynamics: an interplay of biochemistry and mechanics.

Brouhard GJ, Rice LM.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):451-463. doi: 10.1038/s41580-018-0009-y. Review.


Structural and functional differences between porcine brain and budding yeast microtubules.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

Cell Cycle. 2018;17(3):278-287. doi: 10.1080/15384101.2017.1415680. Epub 2018 Jan 30.


A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.

Arellano-Santoyo H, Geyer EA, Stokasimov E, Chen GY, Su X, Hancock W, Rice LM, Pellman D.

Dev Cell. 2017 Jul 10;42(1):37-51.e8. doi: 10.1016/j.devcel.2017.06.011.


Structural differences between yeast and mammalian microtubules revealed by cryo-EM.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

J Cell Biol. 2017 Sep 4;216(9):2669-2677. doi: 10.1083/jcb.201612195. Epub 2017 Jun 26.


Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips.

Driver JW, Geyer EA, Bailey ME, Rice LM, Asbury CL.

Elife. 2017 Jun 19;6. pii: e28433. doi: 10.7554/eLife.28433.


GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe.

Piedra FA, Kim T, Garza ES, Geyer EA, Burns A, Ye X, Rice LM.

Mol Biol Cell. 2016 Nov 7;27(22):3515-3525. Epub 2016 May 4.


Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.

Pusey M, Bail S, Xu Y, Buiakova O, Nestor M, Yang JJ, Rice LM.

Tumour Biol. 2016 Sep;37(9):11835-11842. Epub 2016 Apr 5.


A Proteome-Derived Longitudinal Pharmacodynamic Biomarker for Diffuse Systemic Sclerosis Skin.

Rice LM, Mantero JC, Stifano G, Ziemek J, Simms RW, Gordon J, Domsic R, Lafyatis R.

J Invest Dermatol. 2017 Jan;137(1):62-70. doi: 10.1016/j.jid.2016.08.027. Epub 2016 Sep 14.


Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90.

Nazari B, Rice LM, Stifano G, Barron AM, Wang YM, Korndorf T, Lee J, Bhawan J, Lafyatis R, Browning JL.

Am J Pathol. 2016 Oct;186(10):2650-64. doi: 10.1016/j.ajpath.2016.06.020. Epub 2016 Aug 23.


May I check your cap?

Geyer EA, Majumdar S, Rice LM.

Elife. 2016 Apr 6;5:e15570. doi: 10.7554/eLife.15570.


A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics.

Geyer EA, Burns A, Lalonde BA, Ye X, Piedra FA, Huffaker TC, Rice LM.

Elife. 2015 Oct 6;4:e10113. doi: 10.7554/eLife.10113.


Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis.

Rice LM, Stifano G, Ziemek J, Lafyatis R.

Rheumatology (Oxford). 2016 Feb;55(2):377-9. doi: 10.1093/rheumatology/kev335. Epub 2015 Sep 5. No abstract available.


Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model.

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G 3rd, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR.

Arthritis Rheumatol. 2015 Dec;67(12):3146-57. doi: 10.1002/art.39321.


A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis.

Rice LM, Ziemek J, Stratton EA, McLaughlin SR, Padilla CM, Mathes AL, Christmann RB, Stifano G, Browning JL, Whitfield ML, Spiera RF, Gordon JK, Simms RW, Zhang Y, Lafyatis R.

Arthritis Rheumatol. 2015 Nov;67(11):3004-15. doi: 10.1002/art.39287.


Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.

Rice LM, Padilla CM, McLaughlin SR, Mathes A, Ziemek J, Goummih S, Nakerakanti S, York M, Farina G, Whitfield ML, Spiera RF, Christmann RB, Gordon JK, Weinberg J, Simms RW, Lafyatis R.

J Clin Invest. 2015 Jul 1;125(7):2795-807. doi: 10.1172/JCI77958. Epub 2015 Jun 22.


Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.

Pallai R, Bhaskar A, Barnett-Bernodat N, Gallo-Ebert C, Pusey M, Nickels JT Jr, Rice LM.

Tumour Biol. 2015 Aug;36(8):6383-90. doi: 10.1007/s13277-015-3326-1. Epub 2015 Apr 2.


Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin.

Pallai R, Bhaskar A, Barnett-Bernodat N, Gallo-Ebert C, Nickels JT Jr, Rice LM.

Tumour Biol. 2015 Aug;36(8):6067-74. doi: 10.1007/s13277-015-3284-7. Epub 2015 Mar 4.


Computer-Assisted Face Processing Instruction Improves Emotion Recognition, Mentalizing, and Social Skills in Students with ASD.

Rice LM, Wall CA, Fogel A, Shic F.

J Autism Dev Disord. 2015 Jul;45(7):2176-86. doi: 10.1007/s10803-015-2380-2.


The contribution of αβ-tubulin curvature to microtubule dynamics.

Brouhard GJ, Rice LM.

J Cell Biol. 2014 Nov 10;207(3):323-34. doi: 10.1083/jcb.201407095. Review.


Virtual Barcoding using LATE-PCR and Lights-On/Lights-Off probes: identification of nematode species in a closed-tube reaction.

Rice LM, Reis AH Jr, Wangh LJ.

Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27(2):1358-63. doi: 10.3109/19401736.2014.947581. Epub 2014 Aug 11.


A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.

Ayaz P, Munyoki S, Geyer EA, Piedra FA, Vu ES, Bromberg R, Otwinowski Z, Grishin NV, Brautigam CA, Rice LM.

Elife. 2014 Aug 5;3:e03069. doi: 10.7554/eLife.03069.


Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis.

Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B, Lee J, Christmann RB, Lafyatis R.

Arthritis Res Ther. 2014 Jul 1;16(4):R136. doi: 10.1186/ar4598.


PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells.

Wandzioch E, Pusey M, Werda A, Bail S, Bhaskar A, Nestor M, Yang JJ, Rice LM.

Cancer Res. 2014 Aug 15;74(16):4295-305. doi: 10.1158/0008-5472.CAN-13-3130. Epub 2014 Jun 13.


Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding.

Rice LM, Donigan M, Yang M, Liu W, Pandya D, Joseph BK, Sodi V, Gearhart TL, Yip J, Bouchard M, Nickels JT Jr.

J Biol Chem. 2014 Jun 13;289(24):17268-79. doi: 10.1074/jbc.M114.570390. Epub 2014 Apr 26.


Regulation of microtubule motors by tubulin isotypes and post-translational modifications.

Sirajuddin M, Rice LM, Vale RD.

Nat Cell Biol. 2014 Apr;16(4):335-44. doi: 10.1038/ncb2920. Epub 2014 Mar 16.


Design and construction of a single tube, quantitative endpoint, LATE-PCR multiplex assay for ventilator-associated pneumonia.

Rice LM, Reis AH Jr, Mistry R, Khan H, Khosla P, Bharya S, Wangh LJ.

J Appl Microbiol. 2013 Sep;115(3):818-27. doi: 10.1111/jam.12281. Epub 2013 Jul 9.


Design and Construction of a Single-Tube, LATE-PCR, Multiplex Endpoint Assay with Lights-On/Lights-Off Probes for the Detection of Pathogens Associated with Sepsis.

Carver-Brown RK, Reis AH Jr, Rice LM, Czajka JW, Wangh LJ.

J Pathog. 2012;2012:424808. doi: 10.1155/2012/424808. Epub 2012 Dec 26.


Verification of monoplex and multiplex linear-after-the-exponential PCR gene-specific sepsis assays using clinical isolates.

Gentile NL, Dillier AM, Williams GV, Ackers J, Reis AH Jr, Rice LM, Wangh LJ, Czajka JW, Kost GJ.

J Appl Microbiol. 2013 Feb;114(2):586-94. doi: 10.1111/jam.12062. Epub 2013 Jan 7.


Design of a single-tube, endpoint, linear-after-the-exponential-PCR assay for 17 pathogens associated with sepsis.

Rice LM, Reis AH Jr, Ronish B, Carver-Brown RK, Czajka JW, Gentile N, Kost G, Wangh LJ.

J Appl Microbiol. 2013 Feb;114(2):457-69. doi: 10.1111/jam.12061. Epub 2012 Dec 20.


Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells.

Pallai R, Bhaskar A, Sodi V, Rice LM.

Transcription. 2012 Nov-Dec;3(6):323-35. doi: 10.4161/trns.22518. Epub 2012 Nov 1.


A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.

Ayaz P, Ye X, Huddleston P, Brautigam CA, Rice LM.

Science. 2012 Aug 17;337(6096):857-60. doi: 10.1126/science.1221698.


Fluorescent signatures for variable DNA sequences.

Rice JE, Reis AH Jr, Rice LM, Carver-Brown RK, Wangh LJ.

Nucleic Acids Res. 2012 Nov;40(21):e164. doi: 10.1093/nar/gks731. Epub 2012 Aug 8.


Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.

Johnson V, Ayaz P, Huddleston P, Rice LM.

Biochemistry. 2011 Oct 11;50(40):8636-44. doi: 10.1021/bi2005174. Epub 2011 Sep 16.


PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.

Nolt JK, Rice LM, Gallo-Ebert C, Bisher ME, Nickels JT.

Cell Cycle. 2011 May 1;10(9):1420-34. Epub 2011 May 1.


Altering sphingolipid metabolism in Saccharomyces cerevisiae cells lacking the amphiphysin ortholog Rvs161 reinitiates sugar transporter endocytosis.

Morgan J, McCourt P, Rankin L, Swain E, Rice LM, Nickels JT Jr.

Eukaryot Cell. 2009 May;8(5):779-89. doi: 10.1128/EC.00037-09. Epub 2009 Mar 13.


Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90.

Krukenberg KA, Förster F, Rice LM, Sali A, Agard DA.

Structure. 2008 May;16(5):755-65. doi: 10.1016/j.str.2008.01.021.


The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly.

Rice LM, Montabana EA, Agard DA.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5378-83. doi: 10.1073/pnas.0801155105. Epub 2008 Apr 3.


The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation.

Kollman JM, Zelter A, Muller EG, Fox B, Rice LM, Davis TN, Agard DA.

Mol Biol Cell. 2008 Jan;19(1):207-15. Epub 2007 Oct 31.


Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.

Aldaz H, Rice LM, Stearns T, Agard DA.

Nature. 2005 May 26;435(7041):523-7.


Centriole duplication: centrin in on answers?

Rice LM, Agard DA.

Curr Biol. 2002 Sep 17;12(18):R618-9. Review.


Single-wavelength anomalous diffraction phasing revisited.

Rice LM, Earnest TN, Brunger AT.

Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1413-20.


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