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Items: 1 to 50 of 59

1.

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.

Vincent BM, Tardiff DF, Piotrowski JS, Aron R, Lucas MC, Chung CY, Bacherman H, Chen Y, Pires M, Subramaniam R, Doshi DB, Sadlish H, Raja WK, Solís EJ, Khurana V, Le Bourdonnec B, Scannevin RH, Rhodes KJ.

Cell Rep. 2018 Dec 4;25(10):2742-2754.e31. doi: 10.1016/j.celrep.2018.11.028.

2.

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.

Lin EYS, Silvian LF, Marcotte DJ, Banos CC, Jow F, Chan TR, Arduini RM, Qian F, Baker DP, Bergeron C, Hession CA, Huganir RL, Borenstein CF, Enyedy I, Zou J, Rohde E, Wittmann M, Kumaravel G, Rhodes KJ, Scannevin RH, Dunah AW, Guckian KM.

Sci Rep. 2018 Sep 7;8(1):13438. doi: 10.1038/s41598-018-31680-3.

3.

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.

Scannevin RH, Alexander R, Haarlander TM, Burke SL, Singer M, Huo C, Zhang YM, Maguire D, Spurlino J, Deckman I, Carroll KI, Lewandowski F, Devine E, Dzordzorme K, Tounge B, Milligan C, Bayoumy S, Williams R, Schalk-Hihi C, Leonard K, Jackson P, Todd M, Kuo LC, Rhodes KJ.

J Biol Chem. 2017 Oct 27;292(43):17963-17974. doi: 10.1074/jbc.M117.806075. Epub 2017 Aug 31.

4.

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms.

Brennan MS, Patel H, Allaire N, Thai A, Cullen P, Ryan S, Lukashev M, Bista P, Huang R, Rhodes KJ, Scannevin RH.

Antioxid Redox Signal. 2016 Jun 20;24(18):1058-71. doi: 10.1089/ars.2015.6622. Epub 2016 Apr 28.

PMID:
26980071
5.

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.

Scannevin RH, Chollate S, Brennan MS, Snodgrass-Belt PA, Peng H, Xu L, Jung MY, Bussiere T, Arastu MF, Talreja T, Xin Z, Dunstan RW, Fahrer D, Rohde E, Dunah AW, Wang J, Kumaravel G, Taveras AG, Moore Arnold H, Rhodes KJ.

Neuropharmacology. 2016 Apr;103:57-68. doi: 10.1016/j.neuropharm.2015.12.006. Epub 2015 Dec 12.

PMID:
26690893
6.

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

Brennan MS, Matos MF, Li B, Hronowski X, Gao B, Juhasz P, Rhodes KJ, Scannevin RH.

PLoS One. 2015 Mar 20;10(3):e0120254. doi: 10.1371/journal.pone.0120254. eCollection 2015.

7.

Synapto-depressive effects of amyloid beta require PICK1.

Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R.

Eur J Neurosci. 2014 Apr;39(7):1225-33. doi: 10.1111/ejn.12499.

8.

Visualizing the chemistry and structure dynamics in lithium-ion batteries by in-situ neutron diffraction.

Wang XL, An K, Cai L, Feng Z, Nagler SE, Daniel C, Rhodes KJ, Stoica AD, Skorpenske HD, Liang C, Zhang W, Kim J, Qi Y, Harris SJ.

Sci Rep. 2012;2:747. doi: 10.1038/srep00747. Epub 2012 Oct 19.

9.

Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.

Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ.

J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. doi: 10.1124/jpet.111.190132. Epub 2012 Jan 20.

PMID:
22267202
10.

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7277-80. doi: 10.1016/j.bmcl.2011.10.047. Epub 2011 Oct 19.

PMID:
22061640
11.

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.

Peng H, Talreja T, Xin Z, Cuervo JH, Kumaravel G, Humora MJ, Xu L, Rohde E, Gan L, Jung MY, Shackett MN, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH.

ACS Med Chem Lett. 2011 Aug 5;2(10):786-91. doi: 10.1021/ml200175q. eCollection 2011 Oct 13.

12.

Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy.

Wilson LJ, Wang B, Yang SM, Scannevin RH, Burke SL, Karnachi P, Rhodes KJ, Murray WV.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6485-90. doi: 10.1016/j.bmcl.2011.08.068. Epub 2011 Aug 28.

PMID:
21925881
13.

Extension of the thrombolytic time window with minocycline in experimental stroke.

Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH.

Stroke. 2008 Dec;39(12):3372-7. doi: 10.1161/STROKEAHA.108.514026. Epub 2008 Oct 16.

14.

Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.

Monaghan MM, Menegola M, Vacher H, Rhodes KJ, Trimmer JS.

Neuroscience. 2008 Oct 15;156(3):550-62. doi: 10.1016/j.neuroscience.2008.07.057. Epub 2008 Aug 6.

15.

Antibody-based validation of CNS ion channel drug targets.

Rhodes KJ, Trimmer JS.

J Gen Physiol. 2008 May;131(5):407-13. doi: 10.1085/jgp.200709926. Epub 2008 Apr 14. No abstract available.

16.

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification.

Yang SM, Scannevin RH, Wang B, Burke SL, Wilson LJ, Karnachi P, Rhodes KJ, Lagu B, Murray WV.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1135-9. Epub 2007 Dec 5.

PMID:
18086526
17.

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.

Yang SM, Scannevin RH, Wang B, Burke SL, Huang Z, Karnachi P, Wilson LJ, Rhodes KJ, Lagu B, Murray WV.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1140-5. Epub 2007 Dec 5.

PMID:
18083558
18.

1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke.

Zhang YM, Fan X, Chakaravarty D, Xiang B, Scannevin RH, Huang Z, Ma J, Burke SL, Karnachi P, Rhodes KJ, Jackson PF.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):409-13. Epub 2007 Oct 18.

PMID:
17981034
19.

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs).

Zhang YM, Fan X, Yang SM, Scannevin RH, Burke SL, Rhodes KJ, Jackson PF.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):405-8. Epub 2007 Oct 18.

PMID:
17980583
20.

Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators.

Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH.

Neurosci Lett. 2007 Apr 24;417(1):1-5. Epub 2007 Jan 11.

PMID:
17386975
21.

Antibodies as valuable neuroscience research tools versus reagents of mass distraction.

Rhodes KJ, Trimmer JS.

J Neurosci. 2006 Aug 2;26(31):8017-20. No abstract available.

22.

Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons.

Misonou H, Menegola M, Buchwalder L, Park EW, Meredith A, Rhodes KJ, Aldrich RW, Trimmer JS.

J Comp Neurol. 2006 May 20;496(3):289-302.

23.

Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells.

Strassle BW, Menegola M, Rhodes KJ, Trimmer JS.

J Comp Neurol. 2005 Apr 4;484(2):144-55.

PMID:
15736227
24.

Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.

Aimond F, Kwak SP, Rhodes KJ, Nerbonne JM.

Circ Res. 2005 Mar 4;96(4):451-8. Epub 2005 Jan 20.

PMID:
15662035
25.

KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.

Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS.

J Neurosci. 2004 Sep 8;24(36):7903-15.

26.

Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo.

Beyer CE, Ghavami A, Lin Q, Sung A, Rhodes KJ, Dawson LA, Schechter LE, Young KH.

Brain Res. 2004 Oct 1;1022(1-2):214-20.

PMID:
15353231
27.

Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue.

Zhang ZH, Rhodes KJ, Childers WE, Argentieri TM, Wang Q.

J Biol Chem. 2004 Jul 9;279(28):29226-30. Epub 2004 May 10.

28.

Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lü Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ.

Neuron. 2004 Feb 19;41(4):587-98.

29.

Localization of voltage-gated ion channels in mammalian brain.

Trimmer JS, Rhodes KJ.

Annu Rev Physiol. 2004;66:477-519. Review.

PMID:
14977411
30.

A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.

Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS.

J Biol Chem. 2003 Sep 19;278(38):36445-54. Epub 2003 Jun 26.

31.

Role of heteromultimers in the generation of myocardial transient outward K+ currents.

Guo W, Li H, Aimond F, Johns DC, Rhodes KJ, Trimmer JS, Nerbonne JM.

Circ Res. 2002 Mar 22;90(5):586-93.

PMID:
11909823
32.

Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein.

Beck EJ, Bowlby M, An WF, Rhodes KJ, Covarrubias M.

J Physiol. 2002 Feb 1;538(Pt 3):691-706.

33.

Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.

Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1035-40.

34.

Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking.

Campomanes CR, Carroll KI, Manganas LN, Hershberger ME, Gong B, Antonucci DE, Rhodes KJ, Trimmer JS.

J Biol Chem. 2002 Mar 8;277(10):8298-305. Epub 2001 Dec 17.

35.

Identification of a trafficking determinant localized to the Kv1 potassium channel pore.

Manganas LN, Wang Q, Scannevin RH, Antonucci DE, Rhodes KJ, Trimmer JS.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14055-9. Epub 2001 Nov 6.

36.
37.

Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins.

Holmqvist MH, Cao J, Knoppers MH, Jurman ME, Distefano PS, Rhodes KJ, Xie Y, An WF.

J Neurosci. 2001 Jun 15;21(12):4154-61.

38.

beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.

Kajkowski EM, Lo CF, Ning X, Walker S, Sofia HJ, Wang W, Edris W, Chanda P, Wagner E, Vile S, Ryan K, McHendry-Rinde B, Smith SC, Wood A, Rhodes KJ, Kennedy JD, Bard J, Jacobsen JS, Ozenberger BA.

J Biol Chem. 2001 Jun 1;276(22):18748-56. Epub 2001 Feb 20.

39.

Modulation of A-type potassium channels by a family of calcium sensors.

An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ.

Nature. 2000 Feb 3;403(6769):553-6.

PMID:
10676964
40.
41.

Probing the potassium channel Kv beta 1/Kv1.1 interaction using a random peptide display library.

Lombardi SJ, Truong A, Spence P, Rhodes KJ, Jones PG.

Ann N Y Acad Sci. 1999 Apr 30;868:427-30. No abstract available.

PMID:
10414314
42.

Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia.

Bradley SR, Standaert DG, Rhodes KJ, Rees HD, Testa CM, Levey AI, Conn PJ.

J Comp Neurol. 1999 Apr 28;407(1):33-46.

PMID:
10213186
44.

Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain.

Betty M, Harnish SW, Rhodes KJ, Cockett MI.

Neuroscience. 1998 Jul;85(2):475-86.

PMID:
9622245
45.

Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.

Rhodes KJ, Strassle BW, Monaghan MM, Bekele-Arcuri Z, Matos MF, Trimmer JS.

J Neurosci. 1997 Nov 1;17(21):8246-58.

46.

Selective aggregation of endogenous beta-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc.

Brown AM, Tummolo DM, Rhodes KJ, Hofmann JR, Jacobsen JS, Sonnenberg-Reines J.

J Neurochem. 1997 Sep;69(3):1204-12.

47.

Building (potassium) channels to the 21st century.

Trimmer JS, Rhodes KJ.

Trends Neurosci. 1997 Mar;20(3):99-100. No abstract available.

PMID:
9061860
48.

Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel.

Scannevin RH, Murakoshi H, Rhodes KJ, Trimmer JS.

J Cell Biol. 1996 Dec;135(6 Pt 1):1619-32.

49.

Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain.

Rhodes KJ, Monaghan MM, Barrezueta NX, Nawoschik S, Bekele-Arcuri Z, Matos MF, Nakahira K, Schechter LE, Trimmer JS.

J Neurosci. 1996 Aug 15;16(16):4846-60.

50.

Beta subunits promote K+ channel surface expression through effects early in biosynthesis.

Shi G, Nakahira K, Hammond S, Rhodes KJ, Schechter LE, Trimmer JS.

Neuron. 1996 Apr;16(4):843-52.

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