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Synthetic mRNA with Superior Properties that Mimics the Intracellular Fates of Natural Histone mRNA.

Su W, Slevin MK, Marzluff WF, Rhoads RE.

Methods Mol Biol. 2016;1428:93-114. doi: 10.1007/978-1-4939-3625-0_6.


Synthetic mRNA: Production, Introduction into Cells, and Physiological Consequences.

Rhoads RE.

Methods Mol Biol. 2016;1428:3-27. doi: 10.1007/978-1-4939-3625-0_1.


Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.

Ziemniak M, Mugridge JS, Kowalska J, Rhoads RE, Gross JD, Jemielity J.

RNA. 2016 Apr;22(4):518-29. doi: 10.1261/rna.055152.115. Epub 2016 Jan 29.


Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.

Korneeva NL, Song A, Gram H, Edens MA, Rhoads RE.

J Biol Chem. 2016 Feb 12;291(7):3455-67. doi: 10.1074/jbc.M115.694190. Epub 2015 Dec 14.


Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.

Kowalska J, Wypijewska del Nogal A, Darzynkiewicz ZM, Buck J, Nicola C, Kuhn AN, Lukaszewicz M, Zuberek J, Strenkowska M, Ziemniak M, Maciejczyk M, Bojarska E, Rhoads RE, Darzynkiewicz E, Sahin U, Jemielity J.

Nucleic Acids Res. 2014;42(16):10245-64. doi: 10.1093/nar/gku757. Epub 2014 Aug 22.


Deep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes.

Slevin MK, Meaux S, Welch JD, Bigler R, Miliani de Marval PL, Su W, Rhoads RE, Prins JF, Marzluff WF.

Mol Cell. 2014 Mar 20;53(6):1020-30. doi: 10.1016/j.molcel.2014.02.027.


CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells.

Grudzien-Nogalska E, Reed BC, Rhoads RE.

J Cell Sci. 2014 May 15;127(Pt 10):2326-38. doi: 10.1242/jcs.144956. Epub 2014 Mar 14.


Synthesis and evaluation of fluorescent cap analogues for mRNA labelling.

Ziemniak M, Szabelski M, Lukaszewicz M, Nowicka A, Darzynkiewicz E, Rhoads RE, Wieczorek Z, Jemielity J.

RSC Adv. 2013;3(43). doi: 10.1039/C3RA42769B.


Synthetic mRNAs with superior translation and stability properties.

Grudzien-Nogalska E, Kowalska J, Su W, Kuhn AN, Slepenkov SV, Darzynkiewicz E, Sahin U, Jemielity J, Rhoads RE.

Methods Mol Biol. 2013;969:55-72. doi: 10.1007/978-1-62703-260-5_4. Review.


mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end.

Su W, Slepenkov SV, Slevin MK, Lyons SM, Ziemniak M, Kowalska J, Darzynkiewicz E, Jemielity J, Marzluff WF, Rhoads RE.

RNA. 2013 Jan;19(1):1-16. doi: 10.1261/rna.034470.112. Epub 2012 Nov 27.


Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.

Senkovich OA, Yin J, Ekshyyan V, Conant C, Traylor J, Adegboyega P, McGee DJ, Rhoads RE, Slepenkov S, Testerman TL.

Infect Immun. 2011 Aug;79(8):3106-16. doi: 10.1128/IAI.01275-10. Epub 2011 May 16.


Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH.

Su W, Slepenkov S, Grudzien-Nogalska E, Kowalska J, Kulis M, Zuberek J, Lukaszewicz M, Darzynkiewicz E, Jemielity J, Rhoads RE.

RNA. 2011 May;17(5):978-88. doi: 10.1261/rna.2430711. Epub 2011 Mar 29.


Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.

Korneeva NL, Soung YH, Kim HI, Giordano A, Rhoads RE, Gram H, Chung J.

Mol Cancer Res. 2010 Dec;8(12):1571-8. doi: 10.1158/1541-7786.MCR-10-0091. Epub 2010 Oct 21.


Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

Strenkowska M, Kowalska J, Lukaszewicz M, Zuberek J, Su W, Rhoads RE, Darzynkiewicz E, Jemielity J.

New J Chem. 2010 Jan 1;34(5):993-1007.


A C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins.

Song A, Labella S, Korneeva NL, Keiper BD, Aamodt EJ, Zetka M, Rhoads RE.

J Cell Sci. 2010 Jul 1;123(Pt 13):2228-37. doi: 10.1242/jcs.063107. Epub 2010 Jun 8.


miRNA regulation of the translational machinery. Preface.

Rhoads RE.

Prog Mol Subcell Biol. 2010;50:v-vi. No abstract available.


eIF4E: new family members, new binding partners, new roles.

Rhoads RE.

J Biol Chem. 2009 Jun 19;284(25):16711-5. doi: 10.1074/jbc.R900002200. Epub 2009 Feb 23. Review.


Turnip mosaic virus genome-linked protein VPg binds C-terminal region of cap-bound initiation factor 4E orthologue without exhibiting host cellular specificity.

Okade H, Fujita Y, Miyamoto S, Tomoo K, Muto S, Miyoshi H, Natsuaki T, Rhoads RE, Ishida T.

J Biochem. 2009 Mar;145(3):299-307. doi: 10.1093/jb/mvn180. Epub 2009 Jan 3.


Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex.

Slepenkov SV, Korneeva NL, Rhoads RE.

J Biol Chem. 2008 Sep 12;283(37):25227-37. doi: 10.1074/jbc.M801786200. Epub 2008 Jul 9.


Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.

Kowalska J, Lewdorowicz M, Zuberek J, Grudzien-Nogalska E, Bojarska E, Stepinski J, Rhoads RE, Darzynkiewicz E, Davis RE, Jemielity J.

RNA. 2008 Jun;14(6):1119-31. doi: 10.1261/rna.990208. Epub 2008 Apr 22.


Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.

Tesfay MZ, Yin J, Gardner CL, Khoretonenko MV, Korneeva NL, Rhoads RE, Ryman KD, Klimstra WB.

J Virol. 2008 Mar;82(6):2620-30. Epub 2007 Dec 26.


Mechanism and regulation of translation in C. elegans.

Rhoads RE, Dinkova TD, Korneeva NL.

WormBook. 2006 Jan 28:1-18. Review.


Translational regulation of milk protein synthesis at secretory activation.

Rhoads RE, Grudzien-Nogalska E.

J Mammary Gland Biol Neoplasia. 2007 Dec;12(4):283-92. Epub 2007 Nov 17. Review.


Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability.

Grudzien-Nogalska E, Stepinski J, Jemielity J, Zuberek J, Stolarski R, Rhoads RE, Darzynkiewicz E.

Methods Enzymol. 2007;431:203-27. Review.


Approaches for analyzing the differential activities and functions of eIF4E family members.

Rhoads RE, Dinkova TD, Jagus R.

Methods Enzymol. 2007;429:261-97.


Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells.

Grudzien-Nogalska E, Jemielity J, Kowalska J, Darzynkiewicz E, Rhoads RE.

RNA. 2007 Oct;13(10):1745-55. Epub 2007 Aug 24.


Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

LeFebvre AK, Korneeva NL, Trutschl M, Cvek U, Duzan RD, Bradley CA, Hershey JW, Rhoads RE.

J Biol Chem. 2006 Aug 11;281(32):22917-32. Epub 2006 Jun 9.


mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.

Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC Jr.

EMBO J. 2006 Apr 19;25(8):1659-68. Epub 2006 Mar 16.


Differential inhibition of mRNA degradation pathways by novel cap analogs.

Grudzien E, Kalek M, Jemielity J, Darzynkiewicz E, Rhoads RE.

J Biol Chem. 2006 Jan 27;281(4):1857-67. Epub 2005 Oct 28.


Synthesis and biochemical properties of novel mRNA 5' cap analogs resistant to enzymatic hydrolysis.

Kalek M, Jemielity J, Grudzien E, Zuberek J, Bojarska E, Cohen LS, Stepinski J, Stolarski R, Davis RE, Rhoads RE, Darzynkiewicz E.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):615-21.


The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.

Westman B, Beeren L, Grudzien E, Stepinski J, Worch R, Zuberek J, Jemielity J, Stolarski R, Darzynkiewicz E, Rhoads RE, Preiss T.

RNA. 2005 Oct;11(10):1505-13. Epub 2005 Aug 30.


Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.

Ryman KD, Meier KC, Nangle EM, Ragsdale SL, Korneeva NL, Rhoads RE, MacDonald MR, Klimstra WB.

J Virol. 2005 Feb;79(3):1487-99.


Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity.

Korneeva NL, First EA, Benoit CA, Rhoads RE.

J Biol Chem. 2005 Jan 21;280(3):1872-81. Epub 2004 Nov 4.


Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency.

Grudzien E, Stepinski J, Jankowska-Anyszka M, Stolarski R, Darzynkiewicz E, Rhoads RE.

RNA. 2004 Sep;10(9):1479-87.


Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.

Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA.

J Biol Chem. 2004 Sep 10;279(37):38649-57. Epub 2004 Jul 2.


Insulin and prolactin synergistically stimulate beta-casein messenger ribonucleic acid translation by cytoplasmic polyadenylation.

Choi KM, Barash I, Rhoads RE.

Mol Endocrinol. 2004 Jul;18(7):1670-86. Epub 2004 Apr 7.


Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues.

Zuberek J, Jemielity J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1703-6.


Synthesis of novel mRNA 5' cap-analogues: dinucleoside P1, P3-tri-, P1, P4-tetra-, and P1, P5-pentaphosphates.

Jemielity J, Stepinski J, Jaremko M, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):691-4.


Novel "anti-reverse" cap analogs with superior translational properties.

Jemielity J, Fowler T, Zuberek J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Stolarski R, Darzynkiewicz E, Rhoads RE.

RNA. 2003 Sep;9(9):1108-22.


Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease.

Zhao X, Lamphear BJ, Xiong D, Knowlton K, Rhoads RE.

J Biol Chem. 2003 Feb 14;278(7):4449-57. Epub 2002 Dec 9.


Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.

Stachelska A, Wieczorek Z, Ruszczyńska K, Stolarski R, Pietrzak M, Lamphear BJ, Rhoads RE, Darzynkiewicz E, Jankowska-Anyszka M.

Acta Biochim Pol. 2002;49(3):671-82.


Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E.

Miyoshi H, Dwyer DS, Keiper BD, Jankowska-Anyszka M, Darzynkiewicz E, Rhoads RE.

EMBO J. 2002 Sep 2;21(17):4680-90.


Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms.

Bradley CA, Padovan JC, Thompson TL, Benoit CA, Chait BT, Rhoads RE.

J Biol Chem. 2002 Apr 12;277(15):12559-71. Epub 2002 Jan 30.


New ways of initiating translation in eukaryotes.

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M.

Mol Cell Biol. 2001 Dec;21(23):8238-46. No abstract available.


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