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Items: 40

1.

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.

Gjini E, Jing CB, Nguyen AT, Reyon D, Gans E, Kesarsing M, Peterson J, Pozdnyakova O, Rodig SJ, Mansour MR, Joung K, Look AT.

Dis Model Mech. 2019 May 7;12(5). pii: dmm035790. doi: 10.1242/dmm.035790.

2.

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10.

Maeder ML, Stefanidakis M, Wilson CJ, Baral R, Barrera LA, Bounoutas GS, Bumcrot D, Chao H, Ciulla DM, DaSilva JA, Dass A, Dhanapal V, Fennell TJ, Friedland AE, Giannoukos G, Gloskowski SW, Glucksmann A, Gotta GM, Jayaram H, Haskett SJ, Hopkins B, Horng JE, Joshi S, Marco E, Mepani R, Reyon D, Ta T, Tabbaa DG, Samuelsson SJ, Shen S, Skor MN, Stetkiewicz P, Wang T, Yudkoff C, Myer VE, Albright CF, Jiang H.

Nat Med. 2019 Feb;25(2):229-233. doi: 10.1038/s41591-018-0327-9. Epub 2019 Jan 21.

PMID:
30664785
3.

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.

Dastidar S, Ardui S, Singh K, Majumdar D, Nair N, Fu Y, Reyon D, Samara E, Gerli MFM, Klein AF, De Schrijver W, Tipanee J, Seneca S, Tulalamba W, Wang H, Chai YC, In't Veld P, Furling D, Tedesco FS, Vermeesch JR, Joung JK, Chuah MK, VandenDriessche T.

Nucleic Acids Res. 2018 Sep 19;46(16):8275-8298. doi: 10.1093/nar/gky548.

4.

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Wilson CJ, Fennell T, Bothmer A, Maeder ML, Reyon D, Cotta-Ramusino C, Fernandez CA, Marco E, Barrera LA, Jayaram H, Albright CF, Cox GF, Church GM, Myer VE.

Nat Methods. 2018 Apr;15(4):236-237. doi: 10.1038/nmeth.4552. Epub 2018 Mar 30. No abstract available.

PMID:
29600989
5.

Nodal patterning without Lefty inhibitory feedback is functional but fragile.

Rogers KW, Lord ND, Gagnon JA, Pauli A, Zimmerman S, Aksel DC, Reyon D, Tsai SQ, Joung JK, Schier AF.

Elife. 2017 Dec 7;6. pii: e28785. doi: 10.7554/eLife.28785.

6.

Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.

Johnson BG, Dang LT, Marsh G, Roach AM, Levine ZG, Monti A, Reyon D, Feigenbaum L, Duffield JS.

J Clin Invest. 2017 Nov 1;127(11):3954-3969. doi: 10.1172/JCI93817. Epub 2017 Oct 9.

7.

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.

Hu Z, Liu Y, Huarng MC, Menegatti M, Reyon D, Rost MS, Norris ZG, Richter CE, Stapleton AN, Chi NC, Peyvandi F, Joung JK, Shavit JA.

Blood. 2017 Aug 3;130(5):666-676. doi: 10.1182/blood-2017-02-765206. Epub 2017 Jun 2.

8.

Context influences on TALE-DNA binding revealed by quantitative profiling.

Rogers JM, Barrera LA, Reyon D, Sander JD, Kellis M, Joung JK, Bulyk ML.

Nat Commun. 2015 Jun 11;6:7440. doi: 10.1038/ncomms8440.

9.

Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases.

Hwang WY, Fu Y, Reyon D, Gonzales AP, Joung JK, Yeh JR.

Methods Mol Biol. 2015;1311:317-34. doi: 10.1007/978-1-4939-2687-9_21.

PMID:
25981483
10.

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.

Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, Rinn JL, Gnirke A, Meissner A.

Nat Genet. 2015 May;47(5):469-78. doi: 10.1038/ng.3258. Epub 2015 Mar 30.

11.

Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs.

Fu Y, Reyon D, Joung JK.

Methods Enzymol. 2014;546:21-45. doi: 10.1016/B978-0-12-801185-0.00002-7.

PMID:
25398334
12.

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM.

Genes Dev. 2014 Sep 1;28(17):1957-75. doi: 10.1101/gad.241620.114.

13.

IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.

Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S.

J Biol Chem. 2014 Sep 26;289(39):26960-72. doi: 10.1074/jbc.M114.598763. Epub 2014 Aug 8.

14.

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.

Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK.

Nat Biotechnol. 2014 Jun;32(6):569-76. doi: 10.1038/nbt.2908. Epub 2014 Apr 25.

15.

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.

Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR.

Nat Methods. 2014 Apr;11(4):429-35. doi: 10.1038/nmeth.2845. Epub 2014 Feb 16.

16.

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.

Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK.

Nat Biotechnol. 2014 Mar;32(3):279-284. doi: 10.1038/nbt.2808. Epub 2014 Jan 26.

17.

Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF.

Science. 2014 Feb 14;343(6172):1248636. doi: 10.1126/science.1248636. Epub 2014 Jan 9.

18.

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.

Cell. 2013 Dec 19;155(7):1507-20. doi: 10.1016/j.cell.2013.11.039.

19.

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK.

Nat Biotechnol. 2013 Dec;31(12):1137-42. doi: 10.1038/nbt.2726. Epub 2013 Oct 9.

20.

Locus-specific editing of histone modifications at endogenous enhancers.

Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE.

Nat Biotechnol. 2013 Dec;31(12):1133-6. doi: 10.1038/nbt.2701. Epub 2013 Sep 8.

21.

Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases.

Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF.

G3 (Bethesda). 2013 Oct 3;3(10):1707-15. doi: 10.1534/g3.113.006270.

22.

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.

Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK.

Nucleic Acids Res. 2013 Oct;41(19):e181. doi: 10.1093/nar/gkt716. Epub 2013 Aug 14.

23.

Heritable and precise zebrafish genome editing using a CRISPR-Cas system.

Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR.

PLoS One. 2013 Jul 9;8(7):e68708. doi: 10.1371/journal.pone.0068708. Print 2013.

24.

Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.

Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK.

Curr Protoc Mol Biol. 2013 Jul;Chapter 12:Unit 12.16. doi: 10.1002/0471142727.mb1216s103.

25.

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD.

Nat Biotechnol. 2013 Sep;31(9):822-6. doi: 10.1038/nbt.2623. Epub 2013 Jun 23.

26.

Robust, synergistic regulation of human gene expression using TALE activators.

Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK.

Nat Methods. 2013 Mar;10(3):243-5. doi: 10.1038/nmeth.2366. Epub 2013 Feb 10.

27.

Efficient genome editing in zebrafish using a CRISPR-Cas system.

Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK.

Nat Biotechnol. 2013 Mar;31(3):227-9. doi: 10.1038/nbt.2501. Epub 2013 Jan 29.

28.

Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly.

Reyon D, Khayter C, Regan MR, Joung JK, Sander JD.

Curr Protoc Mol Biol. 2012 Oct;Chapter 12:Unit 12.15. doi: 10.1002/0471142727.mb1215s100.

29.

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.

Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR.

Nucleic Acids Res. 2012 Sep;40(16):8001-10. doi: 10.1093/nar/gks518. Epub 2012 Jun 7.

30.

Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM.

PLoS One. 2012;7(5):e37877. doi: 10.1371/journal.pone.0037877. Epub 2012 May 24.

31.

FLASH assembly of TALENs for high-throughput genome editing.

Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK.

Nat Biotechnol. 2012 May;30(5):460-5. doi: 10.1038/nbt.2170.

32.

Targeted gene disruption in somatic zebrafish cells using engineered TALENs.

Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR.

Nat Biotechnol. 2011 Aug 5;29(8):697-8. doi: 10.1038/nbt.1934. No abstract available.

33.

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.

Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM.

Plant Physiol. 2011 Jun;156(2):466-73. doi: 10.1104/pp.111.172981. Epub 2011 Apr 4.

34.

ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.

Reyon D, Kirkpatrick JR, Sander JD, Zhang F, Voytas DF, Joung JK, Dobbs D, Coffman CR.

BMC Genomics. 2011 Jan 28;12:83. doi: 10.1186/1471-2164-12-83.

35.

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK.

Nat Methods. 2011 Jan;8(1):67-9. doi: 10.1038/nmeth.1542. Epub 2010 Dec 12.

36.

Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences.

Sander JD, Reyon D, Maeder ML, Foley JE, Thibodeau-Beganny S, Li X, Regan MR, Dahlborg EJ, Goodwin MJ, Fu F, Voytas DF, Joung JK, Dobbs D.

BMC Bioinformatics. 2010 Nov 2;11:543. doi: 10.1186/1471-2105-11-543.

37.

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.

Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):12028-33. doi: 10.1073/pnas.0914991107. Epub 2010 May 27.

38.

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.

Sander JD, Maeder ML, Reyon D, Voytas DF, Joung JK, Dobbs D.

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W462-8. doi: 10.1093/nar/gkq319. Epub 2010 Apr 30.

39.

Crystal structure of the membrane fusion protein CusB from Escherichia coli.

Su CC, Yang F, Long F, Reyon D, Routh MD, Kuo DW, Mokhtari AK, Van Ornam JD, Rabe KL, Hoy JA, Lee YJ, Rajashankar KR, Yu EW.

J Mol Biol. 2009 Oct 23;393(2):342-55. doi: 10.1016/j.jmb.2009.08.029. Epub 2009 Aug 18.

40.

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK.

PLoS One. 2009;4(2):e4348. doi: 10.1371/journal.pone.0004348. Epub 2009 Feb 9.

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