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Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells.

Siegrist KJ, Reynolds SH, Porter DW, Mercer RR, Bauer AK, Lowry D, Cena L, Stueckle TA, Kashon ML, Wiley J, Salisbury JL, Mastovich J, Bunker K, Sparrow M, Lupoi JS, Stefaniak AB, Keane MJ, Tsuruoka S, Terrones M, McCawley M, Sargent LM.

Part Fibre Toxicol. 2019 Oct 7;16(1):36. doi: 10.1186/s12989-019-0318-0.


Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.

Hubbs AF, Fluharty KL, Edwards RJ, Barnabei JL, Grantham JT, Palmer SM, Kelly F, Sargent LM, Reynolds SH, Mercer RR, Goravanahally MP, Kashon ML, Honaker JC, Jackson MC, Cumpston AM, Goldsmith WT, McKinney W, Fedan JS, Battelli LA, Munro T, Bucklew-Moyers W, McKinstry K, Schwegler-Berry D, Friend S, Knepp AK, Smith SL, Sriram K.

Am J Pathol. 2016 Nov;186(11):2887-2908. doi: 10.1016/j.ajpath.2016.07.018.


mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.

Snyder-Talkington BN, Dong C, Sargent LM, Porter DW, Staska LM, Hubbs AF, Raese R, McKinney W, Chen BT, Battelli L, Lowry DT, Reynolds SH, Castranova V, Qian Y, Guo NL.

J Appl Toxicol. 2016 Jan;36(1):161-74. doi: 10.1002/jat.3157. Epub 2015 Apr 29.


Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses.

Siegrist KJ, Reynolds SH, Kashon ML, Lowry DT, Dong C, Hubbs AF, Young SH, Salisbury JL, Porter DW, Benkovic SA, McCawley M, Keane MJ, Mastovich JT, Bunker KL, Cena LG, Sparrow MC, Sturgeon JL, Dinu CZ, Sargent LM.

Part Fibre Toxicol. 2014 Jan 30;11:6. doi: 10.1186/1743-8977-11-6.


Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes.

Sargent LM, Porter DW, Staska LM, Hubbs AF, Lowry DT, Battelli L, Siegrist KJ, Kashon ML, Mercer RR, Bauer AK, Chen BT, Salisbury JL, Frazer D, McKinney W, Andrew M, Tsuruoka S, Endo M, Fluharty KL, Castranova V, Reynolds SH.

Part Fibre Toxicol. 2014 Jan 9;11:3. doi: 10.1186/1743-8977-11-3.


TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages.

Yuan BZ, Chapman J, Ding M, Wang J, Jiang B, Rojanasakul Y, Reynolds SH.

BMC Cancer. 2013 Mar 22;13:140. doi: 10.1186/1471-2407-13-140.


Nanotechnology: toxicologic pathology.

Hubbs AF, Sargent LM, Porter DW, Sager TM, Chen BT, Frazer DG, Castranova V, Sriram K, Nurkiewicz TR, Reynolds SH, Battelli LA, Schwegler-Berry D, McKinney W, Fluharty KL, Mercer RR.

Toxicol Pathol. 2013 Feb;41(2):395-409. doi: 10.1177/0192623312467403. Epub 2013 Feb 6. Review.


Exposure to carbon nanotubes leads to changes in the cellular biomechanics.

Dong C, Kashon ML, Lowry D, Dordick JS, Reynolds SH, Rojanasakul Y, Sargent LM, Dinu CZ.

Adv Healthc Mater. 2013 Jul;2(7):945-51. doi: 10.1002/adhm.201200430. Epub 2013 Jan 18. No abstract available.


Single-walled carbon nanotube-induced mitotic disruption.

Sargent LM, Hubbs AF, Young SH, Kashon ML, Dinu CZ, Salisbury JL, Benkovic SA, Lowry DT, Murray AR, Kisin ER, Siegrist KJ, Battelli L, Mastovich J, Sturgeon JL, Bunker KL, Shvedova AA, Reynolds SH.

Mutat Res. 2012 Jun 14;745(1-2):28-37. doi: 10.1016/j.mrgentox.2011.11.017. Epub 2011 Dec 8.


Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects.

Sargent LM, Reynolds SH, Castranova V.

Nanotoxicology. 2010 Dec;4:396-408. doi: 10.3109/17435390.2010.500444. Review.


Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes.

Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, Hayashi Y, Krajnak KM, Soukup JM, Ghio AJ, Reynolds SH, Castranova V, Munson AE, Antonini JM.

FASEB J. 2010 Dec;24(12):4989-5002. doi: 10.1096/fj.10-163964. Epub 2010 Aug 26.


The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis.

Gwinn MR, Leonard SS, Sargent LM, Lowry DT, McKinstry K, Meighan T, Reynolds SH, Kashon M, Castranova V, Vallyathan V.

J Toxicol Environ Health A. 2009;72(23):1509-19. doi: 10.1080/15287390903129291.


Induction of aneuploidy by single-walled carbon nanotubes.

Sargent LM, Shvedova AA, Hubbs AF, Salisbury JL, Benkovic SA, Kashon ML, Lowry DT, Murray AR, Kisin ER, Friend S, McKinstry KT, Battelli L, Reynolds SH.

Environ Mol Mutagen. 2009 Oct;50(8):708-17. doi: 10.1002/em.20529.


Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage.

Yuan BZ, Chapman J, Reynolds SH.

Oncogene. 2009 Oct 29;28(43):3775-86. doi: 10.1038/onc.2009.240. Epub 2009 Aug 17.


PIWI goes solo in the soma.

Reynolds SH, Ruohola-Baker H.

Dev Cell. 2009 May;16(5):627-8. doi: 10.1016/j.devcel.2009.05.004.


Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.

Yu JY, Reynolds SH, Hatfield SD, Shcherbata HR, Fischer KA, Ward EJ, Long D, Ding Y, Ruohola-Baker H.

Development. 2009 May;136(9):1497-507. doi: 10.1242/dev.025999. Epub 2009 Mar 31.


Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume.

Zeidler-Erdely PC, Kashon ML, Battelli LA, Young SH, Erdely A, Roberts JR, Reynolds SH, Antonini JM.

Part Fibre Toxicol. 2008 Sep 8;5:12. doi: 10.1186/1743-8977-5-12.


Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains.

Sargent LM, Ensell MX, Ostvold AC, Baldwin KT, Kashon ML, Lowry DT, Senft JR, Jefferson AM, Johnson RC, Li Z, Tyson FL, Reynolds SH.

Toxicol Appl Pharmacol. 2008 Nov 15;233(1):81-91. doi: 10.1016/j.taap.2008.01.031. Epub 2008 Feb 8.


Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary.

Shcherbata HR, Ward EJ, Fischer KA, Yu JY, Reynolds SH, Chen CH, Xu P, Hay BA, Ruohola-Baker H.

Cell Stem Cell. 2007 Dec 13;1(6):698-709. doi: 10.1016/j.stem.2007.11.007.


Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.

Yuan BZ, Jefferson AM, Millecchia L, Popescu NC, Reynolds SH.

Exp Cell Res. 2007 Nov 1;313(18):3868-80. Epub 2007 Aug 21.


Stem cells signal to the niche through the Notch pathway in the Drosophila ovary.

Ward EJ, Shcherbata HR, Reynolds SH, Fischer KA, Hatfield SD, Ruohola-Baker H.

Curr Biol. 2006 Dec 5;16(23):2352-8. Epub 2006 Nov 2.


Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice.

Solano-Lopez C, Zeidler-Erdely PC, Hubbs AF, Reynolds SH, Roberts JR, Taylor MD, Young SH, Castranova V, Antonini JM.

Toxicol Pathol. 2006;34(4):364-72.


High-throughput TILLING for Arabidopsis.

Till BJ, Colbert T, Codomo C, Enns L, Johnson J, Reynolds SH, Henikoff JG, Greene EA, Steine MN, Comai L, Henikoff S.

Methods Mol Biol. 2006;323:127-35.


Increased gene copy number of the transcription factor E2F1 in malignant melanoma.

Nelson MA, Reynolds SH, Rao UN, Goulet AC, Feng Y, Beas A, Honchak B, Averill J, Lowry DT, Senft JR, Jefferson AM, Johnson RC, Sargent LM.

Cancer Biol Ther. 2006 Apr;5(4):407-12. Epub 2006 Apr 17.


Mutational activation of the MAP3K8 protooncogene in lung cancer.

Clark AM, Reynolds SH, Anderson M, Wiest JS.

Genes Chromosomes Cancer. 2004 Oct;41(2):99-108.


Discovery of induced point mutations in maize genes by TILLING.

Till BJ, Reynolds SH, Weil C, Springer N, Burtner C, Young K, Bowers E, Codomo CA, Enns LC, Odden AR, Greene EA, Comai L, Henikoff S.

BMC Plant Biol. 2004 Jul 28;4:12.


Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.

Clark LS, Harrington-Brock K, Wang J, Sargent L, Lowry D, Reynolds SH, Moore MM.

Mutagenesis. 2004 Jul;19(4):263-8.


Efficient discovery of DNA polymorphisms in natural populations by Ecotilling.

Comai L, Young K, Till BJ, Reynolds SH, Greene EA, Codomo CA, Enns LC, Johnson JE, Burtner C, Odden AR, Henikoff S.

Plant J. 2004 Mar;37(5):778-86.


DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.

Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, Reynolds SH.

Oncogene. 2004 Feb 19;23(7):1405-11.


High-throughput TILLING for functional genomics.

Till BJ, Colbert T, Tompa R, Enns LC, Codomo CA, Johnson JE, Reynolds SH, Henikoff JG, Greene EA, Steine MN, Comai L, Henikoff S.

Methods Mol Biol. 2003;236:205-20.


Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis.

Greene EA, Codomo CA, Taylor NE, Henikoff JG, Till BJ, Reynolds SH, Enns LC, Burtner C, Johnson JE, Odden AR, Comai L, Henikoff S.

Genetics. 2003 Jun;164(2):731-40.


Large-scale discovery of induced point mutations with high-throughput TILLING.

Till BJ, Reynolds SH, Greene EA, Codomo CA, Enns LC, Johnson JE, Burtner C, Odden AR, Young K, Taylor NE, Henikoff JG, Comai L, Henikoff S.

Genome Res. 2003 Mar;13(3):524-30.


Remodeling of DNA methylation and phenotypic and transcriptional changes in synthetic Arabidopsis allotetraploids.

Madlung A, Masuelli RW, Watson B, Reynolds SH, Davison J, Comai L.

Plant Physiol. 2002 Jun;129(2):733-46.


Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma.

Sargent LM, Senft JR, Lowry DT, Jefferson AM, Tyson FL, Malkinson AM, Coleman AE, Reynolds SH.

Cancer Res. 2002 Feb 15;62(4):1152-7.


Detection of three novel translocations and specific common chromosomal break sites in malignant melanoma by spectral karyotyping.

Sargent LM, Nelson MA, Lowry DT, Senft JR, Jefferson AM, Ariza ME, Reynolds SH.

Genes Chromosomes Cancer. 2001 Sep;32(1):18-25.


Phenotypic instability and rapid gene silencing in newly formed arabidopsis allotetraploids.

Comai L, Tyagi AP, Winter K, Holmes-Davis R, Reynolds SH, Stevens Y, Byers B.

Plant Cell. 2000 Sep;12(9):1551-68.


Proliferating cell nuclear antigen staining of Fischer-344/N rat spleens affected by large granular lymphocyte leukemia.

Stefanski SA, Greenwell A, Merrick BA, Brown TT, Reynolds SH.

Toxicol Pathol. 1995 Jan-Feb;23(1):1-6.


A novel mechanism of in vivo ras gene activation involving tandem duplication of coding sequences.

Wiest JS, Burnett VL, Anderson MW, Reynolds SH.

Oncogene. 1994 Sep;9(9):2449-54.


Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.

Mills KJ, Reynolds SH, Smart RC.

Carcinogenesis. 1993 Dec;14(12):2645-8.


Role of proto-oncogene activation in carcinogenesis.

Anderson MW, Reynolds SH, You M, Maronpot RM.

Environ Health Perspect. 1992 Nov;98:13-24. Review.


Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH, Anderson M.

Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5804-8.


Protooncogene activation in spontaneously occurring and chemically induced rodent and human lung tumors.

Reynolds SH, Wiest JS, Devereux TR, Anderson MW, You M.

Prog Clin Biol Res. 1992;376:303-20. Review. No abstract available.


Development of a highly efficient expression cDNA cloning system: application to oncogene isolation.

Miki T, Fleming TP, Crescenzi M, Molloy CJ, Blam SB, Reynolds SH, Aaronson SA.

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5167-71.


Activation of proto-oncogenes in human and mouse lung tumors.

Reynolds SH, Anderson MW.

Environ Health Perspect. 1991 Jun;93:145-8. Review.


Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.

Candrian U, You M, Goodrow T, Maronpot RR, Reynolds SH, Anderson MW.

Cancer Res. 1991 Feb 15;51(4):1148-53.


Activated protooncogenes in human lung tumors from smokers.

Reynolds SH, Anna CK, Brown KC, Wiest JS, Beattie EJ, Pero RW, Iglehart JD, Anderson MW.

Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1085-9.


Proto-oncogene activation in rodent and human tumors.

Anderson MW, You M, Reynolds SH.

Adv Exp Med Biol. 1991;283:235-43. Review.


Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.

Wang Y, You M, Reynolds SH, Stoner GD, Anderson MW.

Cancer Res. 1990 Mar 1;50(5):1591-5.

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