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Items: 1 to 50 of 136

1.

Mepolizumab effectiveness and identification of super-responders in severe asthma.

Harvey ES, Langton D, Katelaris C, Stevens S, Farah CS, Gillman A, Harrington J, Hew M, Kritikos V, Radhakrishna N, Bardin P, Peters M, Reynolds PN, Upham JW, Baraket M, Bowler S, Bowden J, Chien J, Chung LP, Grainge C, Jenkins C, Katsoulotos GP, Lee J, McDonald VM, Reddel HK, Rimmer J, Wark PAB, Gibson PG.

Eur Respir J. 2020 Mar 5. pii: 1902420. doi: 10.1183/13993003.02420-2019. [Epub ahead of print]

PMID:
32139455
2.

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial.

Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Simpson JL.

ERJ Open Res. 2019 Dec 23;5(4). pii: 00056-2019. doi: 10.1183/23120541.00056-2019. eCollection 2019 Oct.

3.

Twenty-five years of Respirology: From the Editors.

Bardin PG, Reynolds PN.

Respirology. 2020 Jan;25(1):6. doi: 10.1111/resp.13751. No abstract available.

4.

Gastroesophageal reflux and antacid therapy in IPF: analysis from the Australia IPF Registry.

Jo HE, Corte TJ, Glaspole I, Grainge C, Hopkins PMA, Moodley Y, Reynolds PN, Chapman S, Walters EH, Zappala C, Allan H, Keir GJ, Cooper WA, Mahar AM, Ellis S, Macansh S, Goh NS.

BMC Pulm Med. 2019 May 3;19(1):84. doi: 10.1186/s12890-019-0846-2.

5.

BMPR2-expressing bone marrow-derived endothelial-like progenitor cells alleviate pulmonary arterial hypertension in vivo.

Harper RL, Maiolo S, Ward RJ, Seyfang J, Cockshell MP, Bonder CS, Reynolds PN.

Respirology. 2019 Nov;24(11):1095-1103. doi: 10.1111/resp.13552. Epub 2019 Apr 12.

6.

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma.

Taylor SL, Leong LEX, Mobegi FM, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Baraket M, Marks GB, Gibson PG, Rogers GB, Simpson JL.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):309-317. doi: 10.1164/rccm.201809-1739OC.

PMID:
30875247
7.

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma.

Fricker M, Gibson PG, Powell H, Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Baines KJ.

J Allergy Clin Immunol. 2019 Jul;144(1):51-60.e11. doi: 10.1016/j.jaci.2018.12.1020. Epub 2019 Jan 22.

PMID:
30682452
8.

Nurturing Respirology.

Bardin P, Reynolds PN.

Respirology. 2019 Feb;24(2):92. doi: 10.1111/resp.13466. No abstract available.

PMID:
30636382
9.

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD.

Roscioli E, Hamon R, Lester SE, Jersmann HPA, Reynolds PN, Hodge S.

Respir Res. 2018 Nov 28;19(1):234. doi: 10.1186/s12931-018-0945-2.

10.

Pulmonary arterial hypertension: In Asia, as elsewhere, still a lethal disease despite modern treatment.

Reynolds PN.

Respirology. 2019 Feb;24(2):99-100. doi: 10.1111/resp.13438. Epub 2018 Nov 8. No abstract available.

PMID:
30406950
11.

Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.

Jo HE, Glaspole I, Goh N, Hopkins PMA, Moodley Y, Reynolds PN, Chapman S, Walters EH, Zappala C, Allan H, Macansh S, Grainge C, Keir GJ, Hayen A, Henderson D, Klebe S, Heinze SB, Miller A, Rouse HC, Duhig E, Cooper WA, Mahar AM, Ellis S, McCormack SR, Ng B, Godbolt DB, Corte TJ.

Respirology. 2019 Apr;24(4):361-368. doi: 10.1111/resp.13427. Epub 2018 Oct 17.

12.

Treatable traits can be identified in a severe asthma registry and predict future exacerbations.

McDonald VM, Hiles SA, Godbout K, Harvey ES, Marks GB, Hew M, Peters M, Bardin PG, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Respirology. 2019 Jan;24(1):37-47. doi: 10.1111/resp.13389. Epub 2018 Sep 19.

13.

Working while unwell: Workplace impairment in people with severe asthma.

Hiles SA, Harvey ES, McDonald VM, Peters M, Bardin P, Reynolds PN, Upham JW, Baraket M, Bhikoo Z, Bowden J, Brockway B, Chung LP, Cochrane B, Foxley G, Garrett J, Hew M, Jayaram L, Jenkins C, Katelaris C, Katsoulotos G, Koh MS, Kritikos V, Lambert M, Langton D, Lara Rivero A, Marks GB, Middleton PG, Nanguzgambo A, Radhakrishna N, Reddel H, Rimmer J, Southcott AM, Sutherland M, Thien F, Wark PAB, Yang IA, Yap E, Gibson PG.

Clin Exp Allergy. 2018 Jun;48(6):650-662. doi: 10.1111/cea.13153. Epub 2018 May 17.

PMID:
29676834
14.

Diagnosis and management of idiopathic pulmonary fibrosis: Thoracic Society of Australia and New Zealand and Lung Foundation Australia position statements summary.

Jo HE, Prasad JD, Troy LK, Mahar A, Bleasel J, Ellis SJ, Chambers DC, Holland AE, Lake FR, Keir G, Goh NS, Wilsher M, de Boer S, Moodley Y, Grainge C, Whitford HM, Chapman SA, Reynolds PN, Beatson D, Jones LJ, Hopkins P, Allan HM, Glaspole I, Corte TJ.

Med J Aust. 2018 Feb 5;208(2):82-88.

PMID:
29385965
15.

Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8+ T cells.

Hodge G, Hodge S, Nguyen PT, Yeo A, Sarkar P, Badiei A, Holmes-Liew CL, Reynolds PN, Holmes M.

Clin Exp Immunol. 2018 May;192(2):242-250. doi: 10.1111/cei.13103. Epub 2018 Feb 14.

16.

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD.

Tran HB, Jersmann H, Truong TT, Hamon R, Roscioli E, Ween M, Pitman MR, Pitson SM, Hodge G, Reynolds PN, Hodge S.

PLoS One. 2017 Nov 7;12(11):e0179577. doi: 10.1371/journal.pone.0179577. eCollection 2017.

17.

BOS Is Associated With Increased Cytotoxic Proinflammatory CD8 T, NKT-Like, and NK Cells in the Small Airways.

Hodge G, Hodge S, Yeo A, Nguyen P, Hopkins E, Holmes-Liew CL, Reynolds PN, Holmes M.

Transplantation. 2017 Oct;101(10):2469-2476. doi: 10.1097/TP.0000000000001592.

PMID:
28926522
18.

Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages.

Ween MP, Whittall JJ, Hamon R, Reynolds PN, Hodge SJ.

Physiol Rep. 2017 Aug;5(16). pii: e13370. doi: 10.14814/phy2.13370.

19.

Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia.

Jo HE, Troy LK, Keir G, Chambers DC, Holland A, Goh N, Wilsher M, de Boer S, Moodley Y, Grainge C, Whitford H, Chapman S, Reynolds PN, Glaspole I, Beatson D, Jones L, Hopkins P, Corte TJ.

Respirology. 2017 Oct;22(7):1436-1458. doi: 10.1111/resp.13146. Epub 2017 Aug 27. Erratum in: Respirology. 2018 Jan;23 (1):116.

PMID:
28845557
20.

Determinants and outcomes of prolonged anxiety and depression in idiopathic pulmonary fibrosis.

Glaspole IN, Watson AL, Allan H, Chapman S, Cooper WA, Corte TJ, Ellis S, Grainge C, Goh N, Hopkins P, Keir G, Macansh S, Mahar A, Moodley Y, Reynolds PN, Ryerson CJ, Walters EH, Zappala CJ, Holland AE.

Eur Respir J. 2017 Aug 17;50(2). pii: 1700168. doi: 10.1183/13993003.00168-2017. Print 2017 Aug. No abstract available.

21.

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.

Gibson PG, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Powell H, Taylor SL, Leong LEX, Rogers GB, Simpson JL.

Lancet. 2017 Aug 12;390(10095):659-668. doi: 10.1016/S0140-6736(17)31281-3. Epub 2017 Jul 4.

PMID:
28687413
22.

The uncoupling of autophagy and zinc homeostasis in airway epithelial cells as a fundamental contributor to COPD.

Roscioli E, Tran HB, Jersmann H, Nguyen PT, Hopkins E, Lester S, Farrow N, Zalewski P, Reynolds PN, Hodge S.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L453-L465. doi: 10.1152/ajplung.00083.2017. Epub 2017 Jun 8.

23.

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology.

Taylor SL, Leong LEX, Choo JM, Wesselingh S, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Baraket M, Marks GB, Gibson PG, Simpson JL, Rogers GB.

J Allergy Clin Immunol. 2018 Jan;141(1):94-103.e15. doi: 10.1016/j.jaci.2017.03.044. Epub 2017 May 4.

24.

Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases.

Hodge S, Tran HB, Hamon R, Roscioli E, Hodge G, Jersmann H, Ween M, Reynolds PN, Yeung A, Treiberg J, Wilbert S.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L678-L687. doi: 10.1152/ajplung.00518.2016. Epub 2017 Mar 3.

25.

Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.

Jo HE, Glaspole I, Grainge C, Goh N, Hopkins PM, Moodley Y, Reynolds PN, Chapman S, Walters EH, Zappala C, Allan H, Keir GJ, Hayen A, Cooper WA, Mahar AM, Ellis S, Macansh S, Corte TJ.

Eur Respir J. 2017 Feb 23;49(2). pii: 1601592. doi: 10.1183/13993003.01592-2016. Print 2017 Feb. Erratum in: Eur Respir J. 2017 Mar 29;49(3):.

26.

Health-related quality of life in idiopathic pulmonary fibrosis: Data from the Australian IPF Registry.

Glaspole IN, Chapman SA, Cooper WA, Ellis SJ, Goh NS, Hopkins PM, Macansh S, Mahar A, Moodley YP, Paul E, Reynolds PN, Walters EH, Zappala CJ, Corte TJ.

Respirology. 2017 Jul;22(5):950-956. doi: 10.1111/resp.12989. Epub 2017 Feb 6.

27.

Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant.

Hodge G, Hodge S, Holmes-Liew CL, Reynolds PN, Holmes M.

Respirology. 2017 Feb;22(2):394-400. doi: 10.1111/resp.12933. Epub 2016 Nov 6.

PMID:
28102966
28.

Corrigendum to "In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2" [Lung Cancer 53 (3) (September 2006) 273-284].

Finan KM, Hodge G, Reynolds AM, Hodge S, Holmes MD, Baker AH, Reynolds PN.

Lung Cancer. 2016 Nov;101:149. doi: 10.1016/j.lungcan.2016.06.002. Epub 2016 Jun 13. No abstract available.

PMID:
27312600
29.

Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes.

Hodge G, Roscioli E, Jersmann H, Tran HB, Holmes M, Reynolds PN, Hodge S.

Respir Res. 2016 Oct 21;17(1):135.

30.

The Effect of Colonization with Potentially Pathogenic Microorganisms on Efferocytosis in Chronic Obstructive Pulmonary Disease.

Hodge S, Jersmann H, Reynolds PN.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):912-915. No abstract available.

PMID:
27689709
31.

Periostin levels and eosinophilic inflammation in poorly-controlled asthma.

Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Jia G, Holweg CT, Gibson PG.

BMC Pulm Med. 2016 Apr 30;16(1):67. doi: 10.1186/s12890-016-0230-4.

32.

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids.

Simpson JL, Carroll M, Yang IA, Reynolds PN, Hodge S, James AL, Gibson PG, Upham JW.

Chest. 2016 Mar;149(3):704-13. doi: 10.1016/j.chest.2015.12.018. Epub 2015 Dec 24.

PMID:
26836898
33.

BMPR2 gene therapy for PAH acts via Smad and non-Smad signalling.

Harper RL, Reynolds AM, Bonder CS, Reynolds PN.

Respirology. 2016 May;21(4):727-33. doi: 10.1111/resp.12729. Epub 2016 Jan 26.

PMID:
26809239
34.

Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.

Tran HB, Barnawi J, Ween M, Hamon R, Roscioli E, Hodge G, Reynolds PN, Pitson SM, Davies LT, Haberberger R, Hodge S.

J Leukoc Biol. 2016 Jul;100(1):195-202. doi: 10.1189/jlb.3A1015-471R. Epub 2016 Jan 20.

PMID:
26792820
35.

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.

Hodge S, Hodge G, Simpson JL, Yang IA, Upham J, James A, Gibson PG, Reynolds PN; AMAZES Study Research Group.

Clin Exp Allergy. 2016 Jan;46(1):60-70. doi: 10.1111/cea.12634.

PMID:
26767492
36.

BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-β-mediated pulmonary cell signalling.

Feng F, Harper RL, Reynolds PN.

Respirology. 2016 Apr;21(3):526-32. doi: 10.1111/resp.12712. Epub 2015 Dec 21.

37.

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Hugenholtz P, Willner D, Gibson PG.

Eur Respir J. 2016 Mar;47(3):792-800. doi: 10.1183/13993003.00405-2015. Epub 2015 Dec 2.

38.

Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes.

Hodge G, Jersmann H, Tran HB, Roscioli E, Holmes M, Reynolds PN, Hodge S.

Respir Res. 2015 Oct 24;16:130. doi: 10.1186/s12931-015-0287-2.

39.

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Zhang J, Simpson JL.

Respir Res. 2015 Jan 24;16:5. doi: 10.1186/s12931-014-0163-5.

40.

Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes.

Hodge G, Jersmann H, Tran HB, Holmes M, Reynolds PN, Hodge S.

Respir Res. 2015 Jan 9;16:2. doi: 10.1186/s12931-014-0161-7.

41.

Increased CD8 T-cell granzyme B in COPD is suppressed by treatment with low-dose azithromycin.

Hodge S, Hodge G, Holmes M, Jersmann H, Reynolds PN.

Respirology. 2015 Jan;20(1):95-100. doi: 10.1111/resp.12415. Epub 2014 Oct 12.

42.

Australian Idiopathic Pulmonary Fibrosis Registry: vital lessons from a national prospective collaborative project.

Moodley Y, Goh N, Glaspole I, Macansh S, Walters EH, Chapman S, Hopkins P, Reynolds PN, Zappala C, Cooper W, Mahar A, Ellis S, McCormack S, Darbishire W, Wood-Baker R, Corte TJ; Australian IPF Registry Steering Committee.

Respirology. 2014 Oct;19(7):1088-91. doi: 10.1111/resp.12358. Epub 2014 Aug 14.

43.

Loss of glucocorticoid receptor from pro-inflammatory T cells after lung transplant.

Hodge G, Hodge S, Holmes-Liew CL, Reynolds PN, Holmes M.

J Heart Lung Transplant. 2014 Sep;33(9):957-62. doi: 10.1016/j.healun.2014.05.004. Epub 2014 Jun 2.

PMID:
25016921
44.

Oxidative stress decreases functional airway mannose binding lectin in COPD.

Tran HB, Ahern J, Hodge G, Holt P, Dean MM, Reynolds PN, Hodge S.

PLoS One. 2014 Jun 5;9(6):e98571. doi: 10.1371/journal.pone.0098571. eCollection 2014.

45.

Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells, natural killer (NK) T-like and NK cells.

Hodge G, Barnawi J, Jurisevic C, Moffat D, Holmes M, Reynolds PN, Jersmann H, Hodge S.

Clin Exp Immunol. 2014 Oct;178(1):79-85. doi: 10.1111/cei.12392.

46.

Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD.

Hodge G, Holmes M, Jersmann H, Reynolds PN, Hodge S.

BMC Pulm Med. 2014 May 15;14:85. doi: 10.1186/1471-2466-14-85.

47.

Full blood count parameters for the detection of asthma inflammatory phenotypes.

Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Lin JT, Gibson PG.

Clin Exp Allergy. 2014 Sep;44(9):1137-45. doi: 10.1111/cea.12345.

48.

Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma.

Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S; AMAZES Study Research Group.

Respirology. 2014 Feb;19(2):280-287. doi: 10.1111/resp.12213. Epub 2013 Dec 23.

49.

Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: possible relevance to treatment of bronchiolitis obliterans syndrome.

Hodge G, Hodge S, Reynolds PN, Holmes M.

J Heart Lung Transplant. 2013 Nov;32(11):1081-9. doi: 10.1016/j.healun.2013.07.017. Epub 2013 Sep 7.

PMID:
24021943

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