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Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer.

Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP.

Pharmacogenomics J. 2019 Dec 10. doi: 10.1038/s41397-019-0137-6. [Epub ahead of print]


Understanding Payer Perspectives on Value in the Use of Pharmaceuticals in the United States.

Brogan AP, Hogue SL, Vekaria RM, Reynolds I, Coukell A.

J Manag Care Spec Pharm. 2019 Dec;25(12):1319-1327. doi: 10.18553/jmcp.2019.25.12.1319.


Mucinous adenocarcinoma of the colon and rectum: A genomic analysis.

Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP.

J Surg Oncol. 2019 Dec;120(8):1427-1435. doi: 10.1002/jso.25764. Epub 2019 Nov 14.


Mucin Pools Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Marker of Response or Epiphenomenon?

Reynolds IS, O'Connell E, Fichtner M, Kay EW, McNamara DA, Prehn JHM, Burke JP.

Am J Surg Pathol. 2020 Feb;44(2):280-287. doi: 10.1097/PAS.0000000000001373.


Estimated Changes in Manufacturer and Health Care Organization Revenue Following List Price Reductions for Hepatitis C Treatments.

Dickson S, Reynolds I.

JAMA Netw Open. 2019 Jul 3;2(7):e196541. doi: 10.1001/jamanetworkopen.2019.6541.


Meta-analysis of the molecular associations of mucinous colorectal cancer.

Reynolds IS, Furney SJ, Kay EW, McNamara DA, Prehn JHM, Burke JP.

Br J Surg. 2019 May;106(6):682-691. doi: 10.1002/bjs.11142. Epub 2019 Apr 4.


Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers.

Reynolds IS, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Burke JP.

Cancer Metastasis Rev. 2019 Jun;38(1-2):237-257. doi: 10.1007/s10555-019-09781-w.


Thirty-seven-year Population-based Study of Colorectal Cancer Rates in Renal Transplant Recipients in Ireland.

Balhareth A, Reynolds IS, Solon JG, Harte EG, Boland F, O'Sullivan JM, Burke JP, Little D, McNamara DA.

Transplant Proc. 2018 Dec;50(10):3434-3439. doi: 10.1016/j.transproceed.2018.07.031. Epub 2018 Aug 9.


Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.

Johnston TH, Geva M, Steiner L, Orbach A, Papapetropoulos S, Savola JM, Reynolds IJ, Ravenscroft P, Hill M, Fox SH, Brotchie JM, Laufer R, Hayden MR.

Mov Disord. 2019 May;34(5):708-716. doi: 10.1002/mds.27565. Epub 2018 Dec 21.


Characteristics and Patterns of Marijuana Use in Community-Dwelling Older Adults.

Reynolds IR, Fixen DR, Parnes BL, Lum HD, Shanbhag P, Church S, Linnebur SA, Orosz G.

J Am Geriatr Soc. 2018 Nov;66(11):2167-2171. doi: 10.1111/jgs.15507. Epub 2018 Oct 6.


Implementation of day of surgery admission for rectal cancer surgery in Ireland following a national centralisation programme.

Stephens I, Murphy C, Reynolds IS, Sahebally S, Deasy J, Burke JP, McNamara DA.

Ir J Med Sci. 2019 Aug;188(3):765-769. doi: 10.1007/s11845-018-1904-0. Epub 2018 Oct 6.


The significance of mucin pools following neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Reynolds IS, McNamara DA, Kay EW, O'Neill B, Deasy J, Burke JP.

J Surg Oncol. 2018 Dec;118(7):1129-1134. doi: 10.1002/jso.25247. Epub 2018 Sep 27.


Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment–2017, Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D.

Lancet. 2018 Sep 8;392(10150):821-834. doi: 10.1016/S0140-6736(18)31644-1. Review.


Periodontal disease has an impact on patients' quality of life.

Reynolds I, Duane B.

Evid Based Dent. 2018 Mar 23;19(1):14-15. doi: 10.1038/sj.ebd.6401287.


Response to: shift in paradigm of clinical management of anastomotic leak.

Reynolds IS, Deasy J, Burke JP, McNamara DA.

Colorectal Dis. 2017 Oct;19(10):943-944. doi: 10.1111/codi.13825. No abstract available.


Adherence to clinical guidelines and the potential economic benefits of admission avoidance for acute uncomplicated diverticulitis.

Reynolds IS, O'Connell E, Heaney RM, Khan W, Khan IZ, Waldron R, Barry K.

Ir J Med Sci. 2018 Feb;187(1):59-64. doi: 10.1007/s11845-017-1632-x. Epub 2017 May 25.


Drug repurposing from the perspective of pharmaceutical companies.

Cha Y, Erez T, Reynolds IJ, Kumar D, Ross J, Koytiger G, Kusko R, Zeskind B, Risso S, Kagan E, Papapetropoulos S, Grossman I, Laifenfeld D.

Br J Pharmacol. 2018 Jan;175(2):168-180. doi: 10.1111/bph.13798. Epub 2017 May 18. Review.


A bone of contention.

Coughlan JJ, Reynolds IS, Murphy B, Liston R.

Dig Liver Dis. 2017 Jun;49(6):717. doi: 10.1016/j.dld.2017.02.017. Epub 2017 Mar 8. No abstract available.


C-reactive protein as a predictor of anastomotic leak in the first week after anterior resection for rectal cancer.

Reynolds IS, Boland MR, Reilly F, Deasy A, Majeed MH, Deasy J, Burke JP, McNamara DA.

Colorectal Dis. 2017 Sep;19(9):812-818. doi: 10.1111/codi.13649.


Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.

Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN.

J Cell Biol. 2017 Apr 3;216(4):1091-1105. doi: 10.1083/jcb.201612067. Epub 2017 Mar 2.


Precepting Medical Students in the Patient's Presence: An Educational Randomized Trial in Family Medicine Clinic.

Power DV, Rosenbaum ME, Hanson L, Reynolds IR, Brink D, Prasad S, Kreiter CD.

Fam Med. 2017 Feb;49(2):97-105.


The targeted eosinophil-lowering effects of dexpramipexole in clinical studies.

Dworetzky SI, Hebrank GT, Archibald DG, Reynolds IJ, Farwell W, Bozik ME.

Blood Cells Mol Dis. 2017 Mar;63:62-65. doi: 10.1016/j.bcmd.2017.01.008. Epub 2017 Jan 16.


A meta-analysis of the clinicopathological characteristics and survival outcomes of inflammatory bowel disease associated colorectal cancer.

Reynolds IS, O'Toole A, Deasy J, McNamara DA, Burke JP.

Int J Colorectal Dis. 2017 Apr;32(4):443-451. doi: 10.1007/s00384-017-2754-3. Epub 2017 Jan 11. Review.


The Utility of Neutrophil to Lymphocyte Ratio as a Predictor of Intervention in Acute Diverticulitis.

Reynolds IS, Heaney RM, Khan W, Khan IZ, Waldron R, Barry K.

Dig Surg. 2017;34(3):227-232. doi: 10.1159/000450836. Epub 2016 Dec 10.


Liberal perioperative fluid administration is an independent risk factor for morbidity and is associated with longer hospital stay after rectal cancer surgery.

Boland MR, Reynolds I, McCawley N, Galvin E, El-Masry S, Deasy J, McNamara DA.

Ann R Coll Surg Engl. 2017 Feb;99(2):113-116. doi: 10.1308/rcsann.2016.0280. Epub 2016 Sep 23.


An unusual cause of dyspnea and tachycardia.

Reynolds IS, Coyle P, Murray M, Waldron R, Barry K.

Clin Case Rep. 2016 Jul 29;4(9):904-5. doi: 10.1002/ccr3.643. eCollection 2016 Sep.


Endoscopic tattooing to aid tumour localisation in colon cancer: the need for standardisation.

Reynolds IS, Majeed MH, Soric I, Whelan M, Deasy J, McNamara DA.

Ir J Med Sci. 2017 Feb;186(1):75-80. doi: 10.1007/s11845-016-1502-y. Epub 2016 Sep 19. Review.


Magnitude of non-operative surgical emergency admissions; service implications for surgical and radiological practice.

Heaney RM, Reynolds I, Ryan RS, Khan I, Khan W, Waldron R, Barry K.

Ir J Med Sci. 2017 Feb;186(1):219-224. doi: 10.1007/s11845-016-1496-5. Epub 2016 Sep 8.


A Case of Primary Invasive Aspergillus Colitis Masquerading as Clostridium difficile Infection.

Reynolds IS, O'Connell K, Fitzpatrick F, Masania R, Richardson M, McNamara DA.

Surg Infect (Larchmt). 2016 Apr;17(2):262-3. doi: 10.1089/sur.2015.212. Epub 2016 Jan 18. No abstract available.


Aberrant right retroesophageal subclavian artery causing esophageal compression.

Reynolds I, McGarry J, Mullett H.

Clin Case Rep. 2015 Oct;3(10):897-8. doi: 10.1002/ccr3.351. Epub 2015 Aug 27.


Breaking Barriers to Successful Implementation of Day Case Laparoscopic Cholecystectomy.

Reynolds I, Bolger J, Al-Hilli Z, Hill AD.

Ir Med J. 2015 Jul-Aug;108(7):202-4.


Complications of bariatric surgery--What the general surgeon needs to know.

Healy P, Clarke C, Reynolds I, Arumugasamy M, McNamara D.

Surgeon. 2016 Apr;14(2):91-8. doi: 10.1016/j.surge.2015.08.003. Epub 2015 Sep 4. Review.


Assessing the safety and effectiveness of devices after US Food and Drug Administration approval: FDA-mandated postapproval studies.

Reynolds IS, Rising JP, Coukell AJ, Paulson KH, Redberg RF.

JAMA Intern Med. 2014 Nov;174(11):1773-9. doi: 10.1001/jamainternmed.2014.4194.


Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders.

Kalinichev M, Le Poul E, Boléa C, Girard F, Campo B, Fonsi M, Royer-Urios I, Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli S, Celanire S.

J Pharmacol Exp Ther. 2014 Sep;350(3):495-505. doi: 10.1124/jpet.114.214437. Epub 2014 Jun 19.


Malignant tumours of the small intestine.

Reynolds I, Healy P, Mcnamara DA.

Surgeon. 2014 Oct;12(5):263-70. doi: 10.1016/j.surge.2014.02.003. Epub 2014 Mar 14. Review.


Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.

Smith KM, Browne SE, Jayaraman S, Bleickardt CJ, Hodge LM, Lis E, Yao L, Rittle SL, Innocent N, Mullins DE, Boykow G, Reynolds IJ, Hill D, Parker EM, Hodgson RA.

Eur J Pharmacol. 2014 Apr 5;728:31-8. doi: 10.1016/j.ejphar.2014.01.052. Epub 2014 Jan 31.


Health-related quality of life of HIV-infected intravenous drug users.

Surah S, Adams R, Townsend L, Reynolds I, Kinahan JC, Keating S, Mulcahy F, Keenan E, Barry M, Lyons F.

Int J STD AIDS. 2013 Nov;24(11):867-74. doi: 10.1177/0956462413486454. Epub 2013 Jul 23.


A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.

Le Poul E, Boléa C, Girard F, Poli S, Charvin D, Campo B, Bortoli J, Bessif A, Luo B, Koser AJ, Hodge LM, Smith KM, DiLella AG, Liverton N, Hess F, Browne SE, Reynolds IJ.

J Pharmacol Exp Ther. 2012 Oct;343(1):167-77. doi: 10.1124/jpet.112.196063. Epub 2012 Jul 11.


Delays and difficulties in assessing metal-on-metal hip implants.

Rising JP, Reynolds IS, Sedrakyan A.

N Engl J Med. 2012 Jul 5;367(1):e1. doi: 10.1056/NEJMp1206794. Epub 2012 Jun 20. No abstract available.


Tissue and corneal donation and transplantation in the UK.

Gaum L, Reynolds I, Jones MN, Clarkson AJ, Gillan HL, Kaye SB.

Br J Anaesth. 2012 Jan;108 Suppl 1:i43-7. doi: 10.1093/bja/aer398. Review.


Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.

Nikonova EV, Xiong Y, Tanis KQ, Dawson VL, Vogel RL, Finney EM, Stone DJ, Reynolds IJ, Kern JT, Dawson TM.

Hum Mol Genet. 2012 Jan 1;21(1):163-74. doi: 10.1093/hmg/ddr451. Epub 2011 Oct 4.


Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.

Parmentier-Batteur S, Finger EN, Krishnan R, Rajapakse HA, Sanders JM, Kandpal G, Zhu H, Moore KP, Regan CP, Sharma S, Hess JF, Williams TM, Reynolds IJ, Vacca JP, Mark RJ, Nantermet PG.

J Neurochem. 2011 Sep;118(6):1016-31. doi: 10.1111/j.1471-4159.2011.07375.x. Epub 2011 Aug 16.


High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays.

Zhao WQ, Toolan D, Hepler RW, Wolfe AL, Yu Y, Price E, Uebele VN, Schachter JB, Reynolds IJ, Renger JJ, McCampbell A, Ray WJ.

J Alzheimers Dis. 2011;25(4):655-69. doi: 10.3233/JAD-2011-102022.


Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2011 Feb 18;286(7):5215-21. doi: 10.1074/jbc.M110.151084. Epub 2010 Nov 30.


PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.

Lubbers LS, Rowe BA, Hodge LM, Browne SE, Gundersdorf R, Jones P, Hess FJ, Reynolds IJ.

J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):319-28. doi: 10.1016/j.vascn.2010.01.012. Epub 2010 Feb 2.


Mitochondrial trafficking and morphology in neuronal injury.

Rintoul GL, Reynolds IJ.

Biochim Biophys Acta. 2010 Jan;1802(1):143-50. doi: 10.1016/j.bbadis.2009.09.005. Epub 2009 Sep 10. Review.


LRP1 regulates remodeling of the extracellular matrix by fibroblasts.

Gaultier A, Hollister M, Reynolds I, Hsieh EH, Gonias SL.

Matrix Biol. 2010 Jan;29(1):22-30. doi: 10.1016/j.matbio.2009.08.003. Epub 2009 Aug 20.


Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model.

Regan C, Shepherd C, Strack A, Weinberg D, Nargund R, Ye Z, Pollard P, Fong T, Reynolds I, Lynch J.

Pharmacology. 2009;83(1):38-44. doi: 10.1159/000178811. Epub 2008 Dec 4.


Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.

Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, Connolly TM, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB, Woltmann RF, Magee MM, Koblan KS, Renger JJ.

J Med Chem. 2008 Oct 23;51(20):6471-7. doi: 10.1021/jm800830n. Epub 2008 Sep 26.


Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation.

Dineley KE, Devinney MJ 2nd, Zeak JA, Rintoul GL, Reynolds IJ.

J Neurochem. 2008 Sep;106(5):2184-93. doi: 10.1111/j.1471-4159.2008.05536.x. Epub 2008 Jul 4.

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