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Items: 22

1.

A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients with HER2-negative, locally advanced, or metastatic breast cancer.

Abramson VG, Oliveira M, Cervantes A, Wildiers H, Patel MR, Bauer TM, Bedard PL, Becerra C, Richey S, Wei MC, Reyner E, Bond J, Cui N, Wilson TR, Moore HM, Saura C, Krop IE.

Breast Cancer Res Treat. 2019 Jul 31. doi: 10.1007/s10549-019-05360-3. [Epub ahead of print]

PMID:
31368034
2.

Evolution Under Normothermic Machine Perfusion of Type 2 Donation After Cardiac Death Livers Discarded as Nontransplantable.

Pavel MC, Reyner E, Molina V, Garcia R, Ruiz A, Roque R, Diaz A, Fuster J, Garcia-Valdecasas JC.

J Surg Res. 2019 Mar;235:383-394. doi: 10.1016/j.jss.2018.09.066. Epub 2018 Nov 14.

PMID:
30691820
3.

Liver transplantation from type II donation after cardiac death donor with normothermic regional perfusion and normothermic machine perfusion.

Pavel MC, Reyner E, Fuster J, Garcia-Valdecasas JC.

Cir Esp. 2018 Oct;96(8):508-513. doi: 10.1016/j.ciresp.2018.06.016. Epub 2018 Aug 6. English, Spanish.

PMID:
30093100
4.

In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions.

Reyner EL, Sevidal S, West MA, Clouser-Roche A, Freiwald S, Fenner K, Ullah M, Lee CA, Smith BJ.

Drug Metab Dispos. 2013 Aug;41(8):1575-83. doi: 10.1124/dmd.113.051193. Epub 2013 May 31.

PMID:
23729661
5.

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

Bentz J, O'Connor MP, Bednarczyk D, Coleman J, Lee C, Palm J, Pak YA, Perloff ES, Reyner E, Balimane P, Brännström M, Chu X, Funk C, Guo A, Hanna I, Herédi-Szabó K, Hillgren K, Li L, Hollnack-Pusch E, Jamei M, Lin X, Mason AK, Neuhoff S, Patel A, Podila L, Plise E, Rajaraman G, Salphati L, Sands E, Taub ME, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yabut J, Yamagata T, Zhang L, Ellens H.

Drug Metab Dispos. 2013 Jul;41(7):1347-66. doi: 10.1124/dmd.112.050500. Epub 2013 Apr 25.

6.

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

Taub ME, Mease K, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa B, Reyner EL, Jani M, Lee CA.

Drug Metab Dispos. 2011 Nov;39(11):2093-102. doi: 10.1124/dmd.111.040816. Epub 2011 Aug 17.

PMID:
21849517
7.

Development of a new permeability assay using low-efflux MDCKII cells.

Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ 3rd, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, Kempshall S, Fenner K, El-Kattan AF, Liston TE, Troutman MD.

J Pharm Sci. 2011 Nov;100(11):4974-85. doi: 10.1002/jps.22674. Epub 2011 Jul 15.

PMID:
21766308
8.

P-glycoprotein related drug interactions: clinical importance and a consideration of disease states.

Lee CA, Cook JA, Reyner EL, Smith DA.

Expert Opin Drug Metab Toxicol. 2010 May;6(5):603-19. doi: 10.1517/17425251003610640. Review.

PMID:
20397967
9.

Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.

Vernier W, Chong W, Rewolinski D, Greasley S, Pauly T, Shaw M, Dinh D, Ferre RA, Meador JW 3rd, Nukui S, Ornelas M, Paz RL, Reyner E.

Bioorg Med Chem. 2010 May 1;18(9):3307-19. doi: 10.1016/j.bmc.2010.03.014. Epub 2010 Mar 11. Erratum in: Bioorg Med Chem. 2010 Oct 1;18(19):7144. Meador, James W 3rd [added]; Paz, Robert L [added].

PMID:
20363633
10.

Effects of an E-cadherin-derived peptide on the gene expression of Caco-2 cells.

Calcagno AM, Fostel JM, Reyner EL, Sinaga E, Alston JT, Mattes WB, Siahaan TJ, Ware JA.

Pharm Res. 2004 Nov;21(11):2085-94.

PMID:
15587932
11.

The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs.

Sahi J, Reyner EL, Bauman JN, Gueneva-Boucheva K, Burleigh JE, Thomas VH.

Drug Metab Dispos. 2002 Feb;30(2):135-40.

PMID:
11792681
12.

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.

Smaill JB, Rewcastle GW, Loo JA, Greis KD, Chan OH, Reyner EL, Lipka E, Showalter HD, Vincent PW, Elliott WL, Denny WA.

J Med Chem. 2000 Apr 6;43(7):1380-97.

PMID:
10753475
13.

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido

Smaill JB, Rewcastle GW, Loo JA, Greis KD, Chan OH, Reyner EL, Lipka E, Showalter HD, Vincent PW, Elliott WL, Denny WA.

J Med Chem. 2000 Aug 10;43(16):3199. No abstract available.

PMID:
10956451
14.

Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion.

Boyd RA, Stern RH, Stewart BH, Wu X, Reyner EL, Zegarac EA, Randinitis EJ, Whitfield L.

J Clin Pharmacol. 2000 Jan;40(1):91-8.

PMID:
10631627
15.
16.

Nonpeptidic HIV protease inhibitors: 4-hydroxy-pyran-2-one inhibitors with functional tethers to P1 phenyl ring to reach S3 pocket of the enzyme.

Vara Prasad J, Tummino PJ, Ferguson D, Saunders J, Vander Roest S, McQuade TJ, Heldsinger A, Reyner EL, Stewart BH, Guttendorf RJ, Para KS, Lunney EA, Gracheck SJ, Domagala JM.

Biochem Biophys Res Commun. 1996 Apr 25;221(3):815-20.

PMID:
8630044
17.

In vitro assessment of oral delivery for hexapeptide endothelin antagonists.

Stewart BH, Reyner EL, Tse E, Hayes RN, Werness S, He JX, Cody WL, Doherty AM.

Life Sci. 1996;58(12):971-82.

PMID:
8786709
18.

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans.

Stewart BH, Chan OH, Lu RH, Reyner EL, Schmid HL, Hamilton HW, Steinbaugh BA, Taylor MD.

Pharm Res. 1995 May;12(5):693-9.

PMID:
7479555
19.
21.

Human-specific amplification of radiation hybrid DNA fractionated by pulsed-field gel electrophoresis.

Burright EN, Reyner EL, Gorski JL.

Nucleic Acids Res. 1991 Jan 25;19(2):401-2. No abstract available.

22.

Localization of DNA sequences to a region within Xp11.21 between incontinentia pigmenti (IP1) X-chromosomal translocation breakpoints.

Gorski JL, Burright EN, Harnden CE, Stein CK, Glover TW, Reyner EL.

Am J Hum Genet. 1991 Jan;48(1):53-64.

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