Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40

1.

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP.

Shepherd C, Reese AE, Reynard LN, Loughlin J.

Arthritis Res Ther. 2019 Jun 18;21(1):149. doi: 10.1186/s13075-019-1934-7.

2.

Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals.

Rice SJ, Cheung K, Reynard LN, Loughlin J.

Osteoarthritis Cartilage. 2019 Oct;27(10):1545-1556. doi: 10.1016/j.joca.2019.05.017. Epub 2019 Jun 5.

3.

Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci.

Rice SJ, Tselepi M, Sorial AK, Aubourg G, Shepherd C, Almarza D, Skelton AJ, Pangou I, Deehan D, Reynard LN, Loughlin J.

Arthritis Rheumatol. 2019 Aug;71(8):1285-1296. doi: 10.1002/art.40849. Epub 2019 Jun 27.

PMID:
30730609
4.

Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk.

Rice SJ, Aubourg G, Sorial AK, Almarza D, Tselepi M, Deehan DJ, Reynard LN, Loughlin J.

Hum Mol Genet. 2018 Oct 1;27(19):3464-3474. doi: 10.1093/hmg/ddy257.

5.

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Shepherd C, Zhu D, Skelton AJ, Combe J, Threadgold H, Zhu L, Vincent TL, Stuart P, Reynard LN, Loughlin J.

Arthritis Rheumatol. 2018 Oct;70(10):1577-1587. doi: 10.1002/art.40545. Epub 2018 Aug 23.

6.

CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.

Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG.

Arthritis Rheumatol. 2018 Mar;70(3):361-370. doi: 10.1002/art.40393. Epub 2018 Jan 30.

7.

Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F, Azizi F, Koh JM, Tang NLS, Danesphour M, Mayordomo JI, Welt C, Braund PS, Samani NJ, Kiemeney LA, Lohmander LS, Christiansen C, Andreassen OA, Consortium A, Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K.

Nat Genet. 2017 Jul 27;49(8):1286. doi: 10.1038/ng0817-1286b. No abstract available.

PMID:
28747754
8.

A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5.

Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard LN, Loughlin J.

PLoS One. 2017 May 8;12(5):e0176523. doi: 10.1371/journal.pone.0176523. eCollection 2017.

9.

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl GL, Agustsdottir AB, Reynard LN, Villalvilla A, Halldorsson GH, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir HS, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl IS, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F, Azizi F, Koh JM, Tang NLS, Daneshpour MS, Mayordomo JI, Welt C, Braund PS, Samani NJ, Kiemeney LA, Lohmander LS, Christiansen C, Andreassen OA; arcOGEN consortium, Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K.

Nat Genet. 2017 May;49(5):801-805. doi: 10.1038/ng.3816. Epub 2017 Mar 20. Erratum in: Nat Genet. 2017 Jul 27;49(8):1286.

PMID:
28319091
10.

Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study.

Reynard LN, Ratnayake M, Santibanez-Koref M, Loughlin J.

PLoS One. 2016 Jul 8;11(7):e0159024. doi: 10.1371/journal.pone.0159024. eCollection 2016.

11.

Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?

Reynard LN.

Semin Cell Dev Biol. 2017 Feb;62:57-66. doi: 10.1016/j.semcdb.2016.04.017. Epub 2016 Apr 26. Review.

12.

The first international workshop on the epigenetics of osteoarthritis.

Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J.

Connect Tissue Res. 2017 Jan;58(1):37-48. doi: 10.3109/03008207.2016.1168409. Epub 2016 Mar 30.

PMID:
27028588
13.

Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency.

Dang TS, Willet JD, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Koref MS, Reynard LN, Ali S, Hambleton S.

J Clin Immunol. 2016 Apr;36(3):336-7. doi: 10.1007/s10875-016-0248-7. No abstract available.

14.

Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency.

Dang TS, Willet JD, Griffin HR, Morgan NV, O'Boyle G, Arkwright PD, Hughes SM, Abinun M, Tee LJ, Barge D, Engelhardt KR, Jackson M, Cant AJ, Maher ER, Koref MS, Reynard LN, Ali S, Hambleton S.

J Clin Immunol. 2016 Feb;36(2):117-22. doi: 10.1007/s10875-016-0232-2. Epub 2016 Jan 22. Erratum in: J Clin Immunol. 2016 Apr;36(3):336-7.

15.

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.

Shepherd C, Skelton AJ, Rushton MD, Reynard LN, Loughlin J.

BMC Med Genet. 2015 Nov 19;16:108. doi: 10.1186/s12881-015-0254-2.

16.

The role of inflammation-related genes in osteoarthritis.

Rogers EL, Reynard LN, Loughlin J.

Osteoarthritis Cartilage. 2015 Nov;23(11):1933-8. doi: 10.1016/j.joca.2015.01.003. Review.

17.

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk.

Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J.

Hum Mol Genet. 2015 Dec 20;24(25):7432-44. doi: 10.1093/hmg/ddv433. Epub 2015 Oct 13.

18.

Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.

Johnson K, Reynard LN, Loughlin J.

BMC Med Genet. 2015 Sep 7;16:81. doi: 10.1186/s12881-015-0215-9.

20.

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients.

Rushton MD, Young DA, Loughlin J, Reynard LN.

Ann Rheum Dis. 2015 Sep;74(9):1778-82. doi: 10.1136/annrheumdis-2014-206752. Epub 2015 Apr 8.

21.

Dual proteolytic pathways govern glycolysis and immune competence.

Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MF, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC.

Cell. 2014 Dec 18;159(7):1578-90. doi: 10.1016/j.cell.2014.12.001.

22.

Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA.

Loughlin J, Reynard LN.

Nat Rev Rheumatol. 2015 Jan;11(1):6-7. doi: 10.1038/nrrheum.2014.189. Epub 2014 Nov 4. No abstract available.

PMID:
25366188
23.

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1.

Gee F, Clubbs CF, Raine EV, Reynard LN, Loughlin J.

BMC Med Genet. 2014 May 4;15:53. doi: 10.1186/1471-2350-15-53.

24.

CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383.

Reynard LN, Bui C, Syddall CM, Loughlin J.

Hum Genet. 2014 Aug;133(8):1059-73. doi: 10.1007/s00439-014-1447-z. Epub 2014 May 27.

25.

Characterization of the cartilage DNA methylome in knee and hip osteoarthritis.

Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J.

Arthritis Rheumatol. 2014 Sep;66(9):2450-60. doi: 10.1002/art.38713.

26.

Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome.

Raine EV, Reynard LN, van de Laar IM, Bertoli-Avella AM, Loughlin J.

Osteoarthritis Cartilage. 2014 May;22(5):698-705. doi: 10.1016/j.joca.2014.02.931. Epub 2014 Feb 28.

27.

Insights from human genetic studies into the pathways involved in osteoarthritis.

Reynard LN, Loughlin J.

Nat Rev Rheumatol. 2013 Oct;9(10):573-83. doi: 10.1038/nrrheum.2013.121. Epub 2013 Aug 20. Review.

PMID:
23958796
28.

The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.

Syddall CM, Reynard LN, Young DA, Loughlin J.

PLoS Genet. 2013 Jun;9(6):e1003557. doi: 10.1371/journal.pgen.1003557. Epub 2013 Jun 27.

29.

Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues.

Raine EV, Dodd AW, Reynard LN, Loughlin J.

BMC Musculoskelet Disord. 2013 Mar 8;14:85. doi: 10.1186/1471-2474-14-85.

30.

The genetics and functional analysis of primary osteoarthritis susceptibility.

Reynard LN, Loughlin J.

Expert Rev Mol Med. 2013 Feb 18;15:e2. doi: 10.1017/erm.2013.4. Review.

31.

Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22.

Raine EV, Wreglesworth N, Dodd AW, Reynard LN, Loughlin J.

Ann Rheum Dis. 2012 Dec;71(12):2020-7. doi: 10.1136/annrheumdis-2012-201304. Epub 2012 May 14.

PMID:
22586168
32.

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.

Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA.

FASEB J. 2012 Jul;26(7):3000-11. doi: 10.1096/fj.12-206367. Epub 2012 Apr 13.

PMID:
22505473
33.

Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3.

Ratnayake M, Reynard LN, Raine EV, Santibanez-Koref M, Loughlin J.

BMC Med Genet. 2012 Mar 2;13:12. doi: 10.1186/1471-2350-13-12.

34.

Genetics and epigenetics of osteoarthritis.

Reynard LN, Loughlin J.

Maturitas. 2012 Mar;71(3):200-4. doi: 10.1016/j.maturitas.2011.12.001. Epub 2011 Dec 29. Review.

PMID:
22209350
35.

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.

Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M.

Blood. 2011 Sep 8;118(10):2656-8. doi: 10.1182/blood-2011-06-360313. Epub 2011 Jul 15.

36.

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.

Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J.

Hum Mol Genet. 2011 Sep 1;20(17):3450-60. doi: 10.1093/hmg/ddr253. Epub 2011 Jun 3.

PMID:
21642387
37.

Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus.

Dodd AW, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino JJ, Tsezou A, Reynard LN, Gonzalez A, Loughlin J.

Osteoarthritis Cartilage. 2011 Apr;19(4):430-4. doi: 10.1016/j.joca.2011.01.014. Epub 2011 Jan 31.

38.

Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.

Reynard LN, Turner JM.

J Cell Sci. 2009 Nov 15;122(Pt 22):4239-48. doi: 10.1242/jcs.049916. Epub 2009 Oct 27.

39.

The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.

Reynard LN, Cocquet J, Burgoyne PS.

Biol Reprod. 2009 Aug;81(2):250-7. doi: 10.1095/biolreprod.108.075382. Epub 2009 Jan 28.

40.

Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR.

Reynard LN, Turner JM, Cocquet J, Mahadevaiah SK, Touré A, Höög C, Burgoyne PS.

Biol Reprod. 2007 Aug;77(2):329-35. Epub 2007 May 2.

PMID:
17475928

Supplemental Content

Loading ...
Support Center