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Items: 49


Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants.

Stassen FRM, van Eijck PH, Savelkoul PHM, Wouters EFM, Rohde GGU, Briedé JJ, Reynaert NL, de Kok TM, Benedikter BJ.

Oxid Med Cell Longev. 2019 Aug 14;2019:5204218. doi: 10.1155/2019/5204218. eCollection 2019.


Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease.

Piscaer I, van den Ouweland JMW, Vermeersch K, Reynaert NL, Franssen FME, Keene S, Wouters EFM, Janssens W, Vermeer C, Janssen R.

J Clin Med. 2019 Jul 27;8(8). pii: E1116. doi: 10.3390/jcm8081116.


Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells.

Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL.

Toxicol Appl Pharmacol. 2018 Jun 1;348:43-53. doi: 10.1016/j.taap.2018.04.011. Epub 2018 Apr 17.


Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants.

Benedikter BJ, Volgers C, van Eijck PH, Wouters EFM, Savelkoul PHM, Reynaert NL, Haenen GRMM, Rohde GGU, Weseler AR, Stassen FRM.

Free Radic Biol Med. 2017 Jul;108:334-344. doi: 10.1016/j.freeradbiomed.2017.03.026. Epub 2017 Mar 28.


Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease.

Konings GFJ, Reynaert NL, Delvoux B, Verhamme FM, Bracke KR, Brusselle GG, Romano A, Vernooy JHJ.

Mol Cell Endocrinol. 2017 Mar 5;443:23-31. doi: 10.1016/j.mce.2016.12.001. Epub 2016 Dec 8.


Involvement of c-Jun N-Terminal Kinase in TNF-α-Driven Remodeling.

Eurlings IM, Reynaert NL, van de Wetering C, Aesif SW, Mercken EM, de Cabo R, van der Velden JL, Janssen-Heininger YM, Wouters EF, Dentener MA.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):393-401. doi: 10.1165/rcmb.2015-0195OC.


Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease.

Reynaert NL, Gopal P, Rutten EPA, Wouters EFM, Schalkwijk CG.

Int J Biochem Cell Biol. 2016 Dec;81(Pt B):403-418. doi: 10.1016/j.biocel.2016.06.016. Epub 2016 Jun 29. Review.


Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells.

Perkins TN, Dentener MA, Stassen FR, Rohde GG, Mossman BT, Wouters EF, Reynaert NL.

Toxicol Appl Pharmacol. 2016 Jun 15;301:61-70. doi: 10.1016/j.taap.2016.04.003. Epub 2016 Apr 16.


Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

Hoffman SM, Qian X, Nolin JD, Chapman DG, Chia SB, Lahue KG, Schneider R, Ather JL, Randall MJ, McMillan DH, Jones JT, Taatjes DJ, Aliyeva M, Daphtary N, Abdalla S, Lundblad LK, Ho YS, Anathy V, Irvin CG, Wouters EF, Reynaert NL, Dixon AE, van der Vliet A, Poynter ME, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):377-86. doi: 10.1165/rcmb.2015-0401OC.


Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep.

Nikiforou M, Kemp MW, van Gorp RH, Saito M, Newnham JP, Reynaert NL, Janssen LE, Jobe AH, Kallapur SG, Kramer BW, Wolfs TG.

Lab Invest. 2016 Jan;96(1):69-80. doi: 10.1038/labinvest.2015.127. Epub 2015 Oct 26.


Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed.

Peeters PM, Wouters EF, Reynaert NL.

J Immunol Res. 2015;2015:828264. doi: 10.1155/2015/828264. Epub 2015 Aug 19. Review.


Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.

Vanhove W, Peeters PM, Staelens D, Schraenen A, Van der Goten J, Cleynen I, De Schepper S, Van Lommel L, Reynaert NL, Schuit F, Van Assche G, Ferrante M, De Hertogh G, Wouters EF, Rutgeerts P, Vermeire S, Nys K, Arijs I.

Inflamm Bowel Dis. 2015 Nov;21(11):2673-82. doi: 10.1097/MIB.0000000000000535.


Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD.

Rutten EP, Gopal P, Wouters EF, Franssen FM, Hageman GJ, Vanfleteren LE, Spruit MA, Reynaert NL.

Chest. 2016 Jan;149(1):53-61. doi: 10.1378/chest.15-0645. Epub 2016 Jan 6.


Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice.

Gopal P, Gosker HR, Theije CC, Eurlings IM, Sell DR, Monnier VM, Reynaert NL.

Biochim Biophys Acta. 2015 May;1852(5):992-1000. doi: 10.1016/j.bbadis.2015.02.003. Epub 2015 Feb 19.


The effects of dexamethasone and oxygen in ventilated adult sheep with early phase acute respiratory distress syndrome.

Engel M, Nowacki RM, Boden P, Reiss LK, Uhlig S, Reynaert NL, Gopal P, Wouters EF, Willems CH, Kloosterboer N, Wolfs TG, Zimmermann LJ, Vos GD, Kramer BW.

Lung. 2015 Feb;193(1):97-103. doi: 10.1007/s00408-014-9670-x. Epub 2014 Dec 13.


Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs.

Peeters PM, Eurlings IM, Perkins TN, Wouters EF, Schins RP, Borm PJ, Drommer W, Reynaert NL, Albrecht C.

Part Fibre Toxicol. 2014 Nov 19;11:58. doi: 10.1186/s12989-014-0058-0.


Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells.

Perkins TN, Peeters PM, Shukla A, Arijs I, Dragon J, Wouters EF, Reynaert NL, Mossman BT.

Hum Mol Genet. 2015 Mar 1;24(5):1374-89. doi: 10.1093/hmg/ddu551. Epub 2014 Oct 27.


Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.

Eurlings IM, Reynaert NL, van den Beucken T, Gosker HR, de Theije CC, Verhamme FM, Bracke KR, Wouters EF, Dentener MA.

PLoS One. 2014 Oct 16;9(10):e107757. doi: 10.1371/journal.pone.0107757. eCollection 2014.


A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.

Eurlings IM, Dentener MA, Mercken EM, de Cabo R, Bracke KR, Vernooy JH, Wouters EF, Reynaert NL.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L557-65. doi: 10.1152/ajplung.00116.2014. Epub 2014 Aug 8.


Similar matrix alterations in alveolar and small airway walls of COPD patients.

Eurlings IM, Dentener MA, Cleutjens JP, Peutz CJ, Rohde GG, Wouters EF, Reynaert NL.

BMC Pulm Med. 2014 May 26;14:90. doi: 10.1186/1471-2466-14-90.


Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection.

Gulraiz F, Bellinghausen C, Dentener MA, Reynaert NL, Gaajetaan GR, Beuken EV, Rohde GG, Bruggeman CA, Stassen FR.

PLoS One. 2014 Apr 21;9(4):e95134. doi: 10.1371/journal.pone.0095134. eCollection 2014.


Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD.

Gopal P, Reynaert NL, Scheijen JL, Schalkwijk CG, Franssen FM, Wouters EF, Rutten EP.

Respir Res. 2014 Feb 25;15:24. doi: 10.1186/1465-9921-15-24.


Plasma advanced glycation end-products and skin autofluorescence are increased in COPD.

Gopal P, Reynaert NL, Scheijen JL, Engelen L, Schalkwijk CG, Franssen FM, Wouters EF, Rutten EP.

Eur Respir J. 2014 Feb;43(2):430-8. doi: 10.1183/09031936.00135312. Epub 2013 May 3.


Emerging mechanisms of glutathione-dependent chemistry in biology and disease.

Janssen-Heininger YM, Nolin JD, Hoffman SM, van der Velden JL, Tully JE, Lahue KG, Abdalla ST, Chapman DG, Reynaert NL, van der Vliet A, Anathy V.

J Cell Biochem. 2013 Sep;114(9):1962-8. doi: 10.1002/jcb.24551. Review.


Silica induces NLRP3 inflammasome activation in human lung epithelial cells.

Peeters PM, Perkins TN, Wouters EF, Mossman BT, Reynaert NL.

Part Fibre Toxicol. 2013 Feb 12;10:3. doi: 10.1186/1743-8977-10-3.


Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics.

Kuipers I, Louis R, Manise M, Dentener MA, Irvin CG, Janssen-Heininger YM, Brightling CE, Wouters EF, Reynaert NL.

Eur Respir J. 2013 Feb;41(2):469-72. doi: 10.1183/09031936.00115212. No abstract available.


Interferon-β induces a long-lasting antiviral state in human respiratory epithelial cells.

Gaajetaan GR, Geelen TH, Vernooy JH, Dentener MA, Reynaert NL, Rohde GG, Beuken EV, Grauls GE, Bruggeman CA, Stassen FR.

J Infect. 2013 Feb;66(2):163-9. doi: 10.1016/j.jinf.2012.11.008. Epub 2012 Nov 28.


Altered cigarette smoke-induced lung inflammation due to ablation of Grx1.

Kuipers I, Bracke KR, Brusselle GG, Aesif SW, Krijgsman R, Arts IC, Wouters EF, Reynaert NL.

PLoS One. 2012;7(6):e38984. doi: 10.1371/journal.pone.0038984. Epub 2012 Jun 18.


Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells.

Perkins TN, Shukla A, Peeters PM, Steinbacher JL, Landry CC, Lathrop SA, Steele C, Reynaert NL, Wouters EF, Mossman BT.

Part Fibre Toxicol. 2012 Feb 2;9(1):6. doi: 10.1186/1743-8977-9-6.


Decreased plasma sRAGE levels in COPD: influence of oxygen therapy.

Gopal P, Rutten EP, Dentener MA, Wouters EF, Reynaert NL.

Eur J Clin Invest. 2012 Aug;42(8):807-14. doi: 10.1111/j.1365-2362.2012.02646.x. Epub 2012 Jan 31.


Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice.

Kuipers I, Bracke KR, Brusselle GG, Wouters EF, Reynaert NL.

Free Radic Res. 2012 Feb;46(2):164-73. doi: 10.3109/10715762.2011.647011. Epub 2012 Jan 23.


Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling.

Aesif SW, Kuipers I, van der Velden J, Tully JE, Guala AS, Anathy V, Sheely JI, Reynaert NL, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Free Radic Biol Med. 2011 Sep 15;51(6):1249-57. doi: 10.1016/j.freeradbiomed.2011.06.025. Epub 2011 Jun 27.


Cigarette smoke targets glutaredoxin 1, increasing s-glutathionylation and epithelial cell death.

Kuipers I, Guala AS, Aesif SW, Konings G, Bouwman FG, Mariman EC, Wouters EF, Janssen-Heininger YM, Reynaert NL.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):931-7. doi: 10.1165/rcmb.2010-0249OC. Epub 2011 Mar 31.


Glutathione biochemistry in asthma.

Reynaert NL.

Biochim Biophys Acta. 2011 Nov;1810(11):1045-51. doi: 10.1016/j.bbagen.2011.01.010. Epub 2011 Jan 31. Review.


Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, Budd RC, Reynaert NL, Anathy V.

Ann N Y Acad Sci. 2010 Aug;1203:23-8. doi: 10.1111/j.1749-6632.2010.05553.x. Review.


Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ.

Aesif SW, Janssen-Heininger YM, Reynaert NL.

Methods Enzymol. 2010;474:289-96. doi: 10.1016/S0076-6879(10)74017-9. Epub 2010 Jun 20.


Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

Wouters EF, Reynaert NL, Dentener MA, Vernooy JH.

Proc Am Thorac Soc. 2009 Dec;6(8):638-47. doi: 10.1513/pats.200907-073DP. Review.


Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease.

Yanbaeva DG, Wouters EF, Dentener MA, Spruit MA, Reynaert NL.

Free Radic Res. 2009 Aug;43(8):738-43. doi: 10.1080/10715760903038440.


Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.

Janssen-Heininger YM, Poynter ME, Aesif SW, Pantano C, Ather JL, Reynaert NL, Ckless K, Anathy V, van der Velden J, Irvin CG, van der Vliet A.

Proc Am Thorac Soc. 2009 May 1;6(3):249-55. doi: 10.1513/pats.200806-054RM. Review.


Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.

Anathy V, Aesif SW, Guala AS, Havermans M, Reynaert NL, Ho YS, Budd RC, Janssen-Heininger YM.

J Cell Biol. 2009 Jan 26;184(2):241-52. doi: 10.1083/jcb.200807019.


Catalase overexpression fails to attenuate allergic airways disease in the mouse.

Reynaert NL, Aesif SW, McGovern T, Brown A, Wouters EF, Irvin CG, Janssen-Heininger YM.

J Immunol. 2007 Mar 15;178(6):3814-21.


Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway.

Pantano C, Reynaert NL, van der Vliet A, Janssen-Heininger YM.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1791-806. Review.


Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease.

Reynaert NL, Wouters EF, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2007 Feb;36(2):147-51. Epub 2006 Sep 15.


Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta.

Reynaert NL, van der Vliet A, Guala AS, McGovern T, Hristova M, Pantano C, Heintz NH, Heim J, Ho YS, Matthews DE, Wouters EF, Janssen-Heininger YM.

Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13086-91. Epub 2006 Aug 17.


In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization.

Reynaert NL, Ckless K, Guala AS, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Biochim Biophys Acta. 2006 Mar;1760(3):380-7. Epub 2006 Feb 20.


Nitric oxide and redox signaling in allergic airway inflammation.

Reynaert NL, Ckless K, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Antioxid Redox Signal. 2005 Jan-Feb;7(1-2):129-43. Review.


In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation.

Ckless K, Reynaert NL, Taatjes DJ, Lounsbury KM, van der Vliet A, Janssen-Heininger Y.

Nitric Oxide. 2004 Nov;11(3):216-27.


Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation.

Reynaert NL, Ckless K, Korn SH, Vos N, Guala AS, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8945-50. Epub 2004 Jun 7.


Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium.

Janssen-Heininger YM, Persinger RL, Korn SH, Pantano C, McElhinney B, Reynaert NL, Langen RC, Ckless K, Shrivastava P, Poynter ME.

Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 2):S9-S16. Review.


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