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Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients.

Jensen SB, Vissink A, Limesand KH, Reyland ME.

J Natl Cancer Inst Monogr. 2019 Aug 1;2019(53). pii: lgz016. doi: 10.1093/jncimonographs/lgz016.


Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination.

Washino S, Rider LC, Romero L, Jillson LK, Affandi T, Ohm AM, Lam ET, Reyland ME, Costello JC, Cramer SD.

Mol Cancer Res. 2019 Oct;17(10):1985-1998. doi: 10.1158/1541-7786.MCR-18-1335. Epub 2019 Jul 12.


EGF receptor and PKCδ kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases.

Ohm AM, Affandi T, Reyland ME.

J Biol Chem. 2019 Mar 22;294(12):4488-4497. doi: 10.1074/jbc.RA118.006944. Epub 2019 Jan 24.


Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.

Keysar SB, Eagles JR, Miller B, Jackson BC, Chowdhury FN, Reisinger J, Chimed TS, Le PN, Morton JJ, Somerset HL, Varella-Garcia M, Tan AC, Song JI, Bowles DW, Reyland ME, Jimeno A.

Clin Cancer Res. 2018 Jun 15;24(12):2935-2943. doi: 10.1158/1078-0432.CCR-17-3871. Epub 2018 Mar 19.


RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1.

Moua P, Checketts M, Xu LG, Shu HB, Reyland ME, Cusick JK.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):25-32. doi: 10.1016/j.bbrc.2017.07.022. Epub 2017 Jul 5.


Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-δ.

Wie SM, Wellberg E, Karam SD, Reyland ME.

Mol Cancer Ther. 2017 Sep;16(9):1989-1998. doi: 10.1158/1535-7163.MCT-17-0267. Epub 2017 Jun 21.


Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.

Ohm AM, Tan AC, Heasley LE, Reyland ME.

Oncogene. 2017 Jul 27;36(30):4370-4378. doi: 10.1038/onc.2017.27. Epub 2017 Apr 3.


Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.

Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ.

Oncogenesis. 2017 Jan 16;6(1):e287. doi: 10.1038/oncsis.2016.89.


Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease.

Reyland ME, Jones DN.

Pharmacol Ther. 2016 Sep;165:1-13. doi: 10.1016/j.pharmthera.2016.05.001. Epub 2016 May 11. Review.


PKCδ regulates integrin αVβ3 expression and transformed growth of K-ras dependent lung cancer cells.

Symonds JM, Ohm AM, Tan AC, Reyland ME.

Oncotarget. 2016 Apr 5;7(14):17905-19. doi: 10.18632/oncotarget.7560.


Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage.

Wie SM, Adwan TS, DeGregori J, Anderson SM, Reyland ME.

J Biol Chem. 2014 Apr 11;289(15):10900-8. doi: 10.1074/jbc.M114.551366. Epub 2014 Feb 25.


Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.

Allen-Petersen BL, Carter CJ, Ohm AM, Reyland ME.

Oncogene. 2014 Mar 6;33(10):1306-15. doi: 10.1038/onc.2013.59. Epub 2013 Mar 11.


Role of protein kinase C δ in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells.

Larroque-Cardoso P, Swiader A, Ingueneau C, Nègre-Salvayre A, Elbaz M, Reyland ME, Salvayre R, Vindis C.

Cell Death Dis. 2013 Feb 28;4:e520. doi: 10.1038/cddis.2013.47.


Mechanisms of taste bud cell loss after head and neck irradiation.

Nguyen HM, Reyland ME, Barlow LA.

J Neurosci. 2012 Mar 7;32(10):3474-84. doi: 10.1523/JNEUROSCI.4167-11.2012.


Identification of PLSCR1 as a protein that interacts with RELT family members.

Cusick JK, Mustian A, Jacobs AT, Reyland ME.

Mol Cell Biochem. 2012 Mar;362(1-2):55-63. doi: 10.1007/s11010-011-1127-4. Epub 2011 Nov 4.


Regulated binding of importin-α to protein kinase Cδ in response to apoptotic signals facilitates nuclear import.

Adwan TS, Ohm AM, Jones DN, Humphries MJ, Reyland ME.

J Biol Chem. 2011 Oct 14;286(41):35716-24. doi: 10.1074/jbc.M111.255950. Epub 2011 Aug 24.


Loss of PKCδ results in characteristics of Sjögren's syndrome including salivary gland dysfunction.

Banninger GP, Cha S, Said MS, Pauley KM, Carter CJ, Onate M, Pauley BA, Anderson SM, Reyland ME.

Oral Dis. 2011 Sep;17(6):601-9. doi: 10.1111/j.1601-0825.2011.01819.x. Epub 2011 Jun 27.


Acute ethanol exposure prevents PMA-mediated augmentation of N-methyl-D-aspartate receptor function in primary cultured cerebellar granule cells.

Reneau J, Reyland ME, Popp RL.

Alcohol. 2011 Sep;45(6):595-605. doi: 10.1016/j.alcohol.2011.03.002. Epub 2011 May 31.


Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME.

Cancer Res. 2011 Mar 15;71(6):2087-97. doi: 10.1158/0008-5472.CAN-10-1511. Epub 2011 Feb 18.


Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.

Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, Elting LS, Langendijk JA, Coppes RP, Reyland ME.

Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):983-91. doi: 10.1016/j.ijrobp.2010.06.052. Review.


Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus.

Irani BG, Donato J Jr, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ.

Neuroscience. 2010 Nov 10;170(4):1065-79. doi: 10.1016/j.neuroscience.2010.07.064. Epub 2010 Aug 5.


Loss of protein kinase C delta alters mammary gland development and apoptosis.

Allen-Petersen BL, Miller MR, Neville MC, Anderson SM, Nakayama KI, Reyland ME.

Cell Death Dis. 2010;1:e17. doi: 10.1038/cddis.2009.20.


RELT induces cellular death in HEK 293 epithelial cells.

Cusick JK, Mustian A, Goldberg K, Reyland ME.

Cell Immunol. 2010;261(1):1-8. doi: 10.1016/j.cellimm.2009.10.013. Epub 2009 Nov 4.


PKC{alpha}{beta}{gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells.

Perry C, Baker OJ, Reyland ME, Grichtchenko II.

Am J Physiol Cell Physiol. 2009 Dec;297(6):C1409-23. doi: 10.1152/ajpcell.00028.2009. Epub 2009 Sep 25.


Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha.

Reneau JC, Reyland ME, Phillips J, Kindy C, Popp RL.

J Pharmacol Exp Ther. 2009 Aug;330(2):641-9. doi: 10.1124/jpet.109.153163. Epub 2009 May 8.


Protein kinase C isoforms: Multi-functional regulators of cell life and death.

Reyland ME.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2386-99. Review.


Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.

Perry C, Quissell DO, Reyland ME, Grichtchenko II.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1385-98. doi: 10.1152/ajpcell.00153.2008. Epub 2008 Sep 24.


Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II.

Nakashima H, Frank GD, Shirai H, Hinoki A, Higuchi S, Ohtsu H, Eguchi K, Sanjay A, Reyland ME, Dempsey PJ, Inagami T, Eguchi S.

Hypertension. 2008 Feb;51(2):232-8. doi: 10.1161/HYPERTENSIONAHA.107.101253. Epub 2008 Jan 7.


Tyrosine phosphorylation regulates nuclear translocation of PKCdelta.

Humphries MJ, Ohm AM, Schaack J, Adwan TS, Reyland ME.

Oncogene. 2008 May 8;27(21):3045-53. Epub 2007 Dec 3.


Protein kinase Cdelta and apoptosis.

Reyland ME.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1001-4. Review.


Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent.

Clavijo C, Chen JL, Kim KJ, Reyland ME, Ann DK.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2150-60.


Induction of apoptosis is driven by nuclear retention of protein kinase C delta.

DeVries-Seimon TA, Ohm AM, Humphries MJ, Reyland ME.

J Biol Chem. 2007 Aug 3;282(31):22307-14. Epub 2007 Jun 11.


Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.

McManaman JL, Reyland ME, Thrower EC.

J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):249-68. Review.


Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo.

Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME.

J Biol Chem. 2006 Apr 7;281(14):9728-37. Epub 2006 Feb 1.


PKCdelta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells.

Mingo-Sion AM, Ferguson HA, Koller E, Reyland ME, Van Den Berg CL.

Breast Cancer Res Treat. 2005 Jun;91(3):259-69.


Suppression of cell migration by protein kinase Cdelta.

Jackson D, Zheng Y, Lyo D, Shen Y, Nakayama K, Nakayama KI, Humphries MJ, Reyland ME, Foster DA.

Oncogene. 2005 Apr 21;24(18):3067-72.


Protein kinase Cdelta regulates apoptosis via activation of STAT1.

DeVries TA, Kalkofen RL, Matassa AA, Reyland ME.

J Biol Chem. 2004 Oct 29;279(44):45603-12. Epub 2004 Aug 20.


Oxysterols regulate expression of the steroidogenic acute regulatory protein.

King SR, Matassa AA, White EK, Walsh LP, Jo Y, Rao RM, Stocco DM, Reyland ME.

J Mol Endocrinol. 2004 Apr;32(2):507-17.


Characterization of rat parotid and submandibular acinar cell apoptosis in primary culture.

Limesand KH, Barzen KA, Sanders LA, Sclafani RA, Raynolds MV, Reyland ME, Anderson SM, Quissell DO.

In Vitro Cell Dev Biol Anim. 2003 Mar-Apr;39(3-4):170-7.


Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells.

Matassa AA, Kalkofen RL, Carpenter L, Biden TJ, Reyland ME.

Cell Death Differ. 2003 Mar;10(3):269-77.


Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes.

Shizukuda Y, Reyland ME, Buttrick PM.

Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1625-34.


Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail.

Helt CE, Hoernig GR, Albeck DS, Gerhardt GA, Ickes B, Reyland ME, Quissell DO, Strömberg I, Granholm AC.

Exp Neurol. 2001 Aug;170(2):258-69.


PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.

Matassa AA, Carpenter L, Biden TJ, Humphries MJ, Reyland ME.

J Biol Chem. 2001 Aug 10;276(32):29719-28. Epub 2001 May 21.


Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells.

Reyland ME, Barzen KA, Anderson SM, Quissell DO, Matassa AA.

Cell Death Differ. 2000 Dec;7(12):1200-9.


Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.

Smith L, Chen L, Reyland ME, DeVries TA, Talanian RV, Omura S, Smith JB.

J Biol Chem. 2000 Dec 22;275(51):40620-7.


Protein kinase C isozymes and the regulation of diverse cell responses.

Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO.

Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L429-38. Review.


Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes.

Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR.

Am J Respir Cell Mol Biol. 2000 Jan;22(1):15-25.


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