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Items: 1 to 50 of 55

1.

Stem cells in cancer initiation and progression.

Bajaj J, Diaz E, Reya T.

J Cell Biol. 2020 Jan 6;219(1). pii: e201911053. doi: 10.1083/jcb.201911053.

PMID:
31874116
2.

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring.

Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T.

Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. Epub 2019 Apr 17.

3.

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.

Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T.

Cell. 2019 Apr 18;177(3):572-586.e22. doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4.

PMID:
30955884
4.

Stem cell fate in cancer growth, progression and therapy resistance.

Lytle NK, Barber AG, Reya T.

Nat Rev Cancer. 2018 Nov;18(11):669-680. doi: 10.1038/s41568-018-0056-x. Review.

PMID:
30228301
5.

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM.

Cancer Cell. 2018 Sep 10;34(3):466-482.e6. doi: 10.1016/j.ccell.2018.08.001. Epub 2018 Aug 30.

6.

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.

Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.

Cancer Cell. 2017 Dec 11;32(6):824-839.e8. doi: 10.1016/j.ccell.2017.10.011. Epub 2017 Nov 16.

7.

Glucose feeds the TCA cycle via circulating lactate.

Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD.

Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. Epub 2017 Oct 18.

8.

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.

Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.

Cancer Cell. 2016 Nov 14;30(5):792-805. doi: 10.1016/j.ccell.2016.10.003. Epub 2016 Oct 27.

9.

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.

Koechlein CS, Harris JR, Lee TK, Weeks J, Fox RG, Zimdahl B, Ito T, Blevins A, Jung SH, Chute JP, Chourasia A, Covert MW, Reya T.

Nat Commun. 2016 Jul 18;7:12169. doi: 10.1038/ncomms12169.

10.

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T.

Nature. 2016 Jun 16;534(7607):407-411. doi: 10.1038/nature17988. Epub 2016 Jun 6.

11.

Delayed Onset of Symptoms Through Feedback Interference in Chronic Cancers.

Haney S, Reya T, Bazhenov M.

Converg Sci Phys Oncol. 2016;2(4). pii: 045002. doi: 10.1088/2057-1739/2/4/045002. Epub 2016 Oct 21.

12.

Musashi signaling in stem cells and cancer.

Fox RG, Park FD, Koechlein CS, Kritzik M, Reya T.

Annu Rev Cell Dev Biol. 2015;31:249-67. doi: 10.1146/annurev-cellbio-100814-125446. Review.

PMID:
26566113
13.

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.

Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.

Cell Stem Cell. 2015 Aug 6;17(2):152-164. doi: 10.1016/j.stem.2015.06.006. Epub 2015 Jul 23.

14.

GLI2 inhibition abrogates human leukemia stem cell dormancy.

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH.

J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.

15.

Fearful symmetry: subversion of asymmetric division in cancer development and progression.

Bajaj J, Zimdahl B, Reya T.

Cancer Res. 2015 Mar 1;75(5):792-7. doi: 10.1158/0008-5472.CAN-14-2750. Epub 2015 Feb 13. Review. Erratum in: Cancer Res. 2015 Apr 15;75(8):1770.

16.

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. Epub 2014 Sep 4.

17.

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration.

Lento W, Ito T, Zhao C, Harris JR, Huang W, Jiang C, Owzar K, Piryani S, Racioppi L, Chao N, Reya T.

Genes Dev. 2014 May 1;28(9):995-1004. doi: 10.1101/gad.231944.113.

18.

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.

Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T.

Nat Genet. 2014 Mar;46(3):245-52. doi: 10.1038/ng.2889. Epub 2014 Feb 2.

19.

Wnt signaling in normal and malignant hematopoiesis.

Lento W, Congdon K, Voermans C, Kritzik M, Reya T.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a008011. doi: 10.1101/cshperspect.a008011. Review.

20.

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2300-5. doi: 10.1073/pnas.1206551110. Epub 2013 Jan 16.

21.

Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.

Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP.

Cell Rep. 2012 Oct 25;2(4):964-75. doi: 10.1016/j.celrep.2012.09.002. Epub 2012 Oct 19. Erratum in: Cell Rep. 2012 Dec 27;2(6):1774.

22.

Tannishtha Reya: classic pathways, new views on cancer. Interview by Caitlin Sedwick.

Reya T.

J Cell Biol. 2012 Sep 3;198(5):766-7. doi: 10.1083/jcb.1985pi. No abstract available.

23.

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12532-7. doi: 10.1073/pnas.1209815109. Epub 2012 Jul 5.

24.

aSIRTing control over cancer stem cells.

Ito T, Zimdahl B, Reya T.

Cancer Cell. 2012 Feb 14;21(2):140-2. doi: 10.1016/j.ccr.2012.01.014.

25.

Illuminating immune privilege--a role for regulatory T cells in preventing rejection.

Reya T.

N Engl J Med. 2011 Sep 8;365(10):956-7. doi: 10.1056/NEJMcibr1107781. No abstract available.

PMID:
21899457
26.

Regulation of myeloid leukaemia by the cell-fate determinant Musashi.

Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T.

Nature. 2010 Aug 5;466(7307):765-8. doi: 10.1038/nature09171. Epub 2010 Jul 18.

27.

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.

Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA.

Cancer Cell. 2010 Apr 13;17(4):388-99. doi: 10.1016/j.ccr.2010.02.027.

28.

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells.

Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP.

Nat Med. 2010 Apr;16(4):475-82. doi: 10.1038/nm.2119. Epub 2010 Mar 21.

29.

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T.

Nature. 2009 Apr 9;458(7239):776-9. doi: 10.1038/nature07737. Erratum in: Nature. 2009 Jul 30;460(7255):652.

30.

Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias.

Kurokawa M, Zhao C, Reya T, Kornbluth S.

Mol Cell Biol. 2008 Sep;28(17):5494-506. doi: 10.1128/MCB.00265-08. Epub 2008 Jun 30.

31.

Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system.

Congdon KL, Reya T.

Curr Opin Immunol. 2008 Jun;20(3):302-7. doi: 10.1016/j.coi.2008.05.003. Epub 2008 Jun 12. Review.

32.

Imaging hematopoietic precursor division in real time.

Wu M, Kwon HY, Rattis F, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T, Reya T.

Cell Stem Cell. 2007 Nov;1(5):541-54. doi: 10.1016/j.stem.2007.08.009.

33.

Activation of Wnt signaling in hematopoietic regeneration.

Congdon KL, Voermans C, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C, Reya T.

Stem Cells. 2008 May;26(5):1202-10. doi: 10.1634/stemcells.2007-0768. Epub 2008 Feb 28.

34.

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.

Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T.

Cancer Cell. 2007 Dec;12(6):528-41.

35.

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC.

Mol Cell Biol. 2007 Jun;27(12):4328-39. Epub 2007 Mar 19.

36.

Identification of adiponectin as a novel hemopoietic stem cell growth factor.

DiMascio L, Voermans C, Uqoezwa M, Duncan A, Lu D, Wu J, Sankar U, Reya T.

J Immunol. 2007 Mar 15;178(6):3511-20.

37.

Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.

Kitsos CM, Sankar U, Illario M, Colomer-Font JM, Duncan AW, Ribar TJ, Reya T, Means AR.

J Biol Chem. 2005 Sep 30;280(39):33101-8. Epub 2005 Jul 14.

38.

Wnt signalling in stem cells and cancer.

Reya T, Clevers H.

Nature. 2005 Apr 14;434(7035):843-50. Review.

PMID:
15829953
39.

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.

Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T.

Nat Immunol. 2005 Mar;6(3):314-22. Epub 2005 Jan 23.

40.

Frizzled 9 knock-out mice have abnormal B-cell development.

Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U.

Blood. 2005 Mar 15;105(6):2487-94. Epub 2004 Nov 30.

PMID:
15572594
41.

Wnt signaling in the stem cell niche.

Rattis FM, Voermans C, Reya T.

Curr Opin Hematol. 2004 Mar;11(2):88-94. Review. Erratum in: Curr Opin Hematol. 2004 Jul;11(4):284.

PMID:
15257024
42.

The elements of stem cell self-renewal: a genetic perspective.

Pazianos G, Uqoezwa M, Reya T.

Biotechniques. 2003 Dec;35(6):1240-7. Review.

43.

Regulation of hematopoietic stem cell self-renewal.

Reya T.

Recent Prog Horm Res. 2003;58:283-95. Review.

PMID:
12795424
44.

Wnt proteins are lipid-modified and can act as stem cell growth factors.

Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, Nusse R.

Nature. 2003 May 22;423(6938):448-52. Epub 2003 Apr 27.

PMID:
12717451
45.

A role for Wnt signalling in self-renewal of haematopoietic stem cells.

Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL.

Nature. 2003 May 22;423(6938):409-14. Epub 2003 Apr 27.

PMID:
12717450
46.

Stem cells, cancer, and cancer stem cells.

Reya T, Morrison SJ, Clarke MF, Weissman IL.

Nature. 2001 Nov 1;414(6859):105-11. Review.

47.

Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors.

Reya T, Okamura R, Grosschedl R.

Cold Spring Harb Symp Quant Biol. 1999;64:133-40. No abstract available.

PMID:
11232278
48.

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.

Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, Grosschedl R.

Immunity. 2000 Jul;13(1):15-24.

49.

Lymphoid precursors.

Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL.

Curr Opin Immunol. 2000 Apr;12(2):144-50. Review.

PMID:
10712944
50.

Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.

Reya T, Bassiri H, Biancaniello R, Carding SR.

Dev Immunol. 1998;5(4):287-302.

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