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Items: 28


Thrombin signaling promotes pancreatic adenocarcinoma through PAR-1-dependent immune evasion.

Yang Y, Stang A, Schweickert PG, Lanman NA, Paul EN, Monia BP, Revenko AS, Palumbo JS, Mullins ES, Elzey BD, Janssen EM, Konieczny SF, Flick MJ.

Cancer Res. 2019 May 2. pii: canres.3206.2018. doi: 10.1158/0008-5472.CAN-18-3206. [Epub ahead of print]


Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines.

Linnane E, Davey P, Zhang P, Puri S, Edbrooke M, Chiarparin E, Revenko AS, Macleod AR, Norman JC, Ross SJ.

Nucleic Acids Res. 2019 May 21;47(9):4375-4392. doi: 10.1093/nar/gkz214.


Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.

Farfara D, Feierman E, Richards A, Revenko AS, MacLeod RA, Norris EH, Strickland S.

Glia. 2019 Jul;67(7):1359-1373. doi: 10.1002/glia.23611. Epub 2019 Mar 18.


IONIS-PKKRx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.

Ferrone JD, Bhattacharjee G, Revenko AS, Zanardi TA, Warren MS, Derosier FJ, Viney NJ, Pham NC, Kaeser GE, Baker BF, Schneider E, Hughes SG, Monia BP, MacLeod AR.

Nucleic Acid Ther. 2019 Apr;29(2):82-91. doi: 10.1089/nat.2018.0754. Epub 2019 Feb 28.


Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Yang J, van 't Veer C, Roelofs JJTH, van Heijst JWJ, de Vos AF, McCrae KR, Revenko AS, Crosby J, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L187-L196. doi: 10.1152/ajplung.00162.2018. Epub 2018 Oct 25.


Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696. doi: 10.1073/pnas.1811172115. Epub 2018 Sep 25.


Inhibition of the extrinsic or intrinsic coagulation pathway during pneumonia-derived sepsis.

Stroo I, Ding C, Novak A, Yang J, Roelofs JJTH, Meijers JCM, Revenko AS, van 't Veer C, Zeerleder S, Crosby JR, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L799-L809. doi: 10.1152/ajplung.00014.2018. Epub 2018 Aug 23.


Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.

Wang S, Allen N, Vickers TA, Revenko AS, Sun H, Liang XH, Crooke ST.

Nucleic Acids Res. 2018 Apr 20;46(7):3579-3594. doi: 10.1093/nar/gky145.


Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis.

Ding C, van 't Veer C, Roelofs JJTH, Shukla M, McCrae KR, Revenko AS, Crosby J, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L397-L405. doi: 10.1152/ajplung.00288.2017. Epub 2017 Nov 9.


Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.

Ross SJ, Revenko AS, Hanson LL, Ellston R, Staniszewska A, Whalley N, Pandey SK, Revill M, Rooney C, Buckett LK, Klein SK, Hudson K, Monia BP, Zinda M, Blakey DC, Lyne PD, Macleod AR.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaal5253. doi: 10.1126/scitranslmed.aal5253. Erratum in: Sci Transl Med. 2017 Jul 26;9(400):.


Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice.

Chen ZL, Revenko AS, Singh P, MacLeod AR, Norris EH, Strickland S.

Blood. 2017 May 4;129(18):2547-2556. doi: 10.1182/blood-2016-11-753202. Epub 2017 Feb 27.


Plasmin Prevents Dystrophic Calcification After Muscle Injury.

Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AR, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, Flick MJ, Cates JM, Schoenecker JG.

J Bone Miner Res. 2017 Feb;32(2):294-308. doi: 10.1002/jbmr.2973. Epub 2016 Dec 5.


Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.

Duffy AG, Makarova-Rusher OV, Ulahannan SV, Rahma OE, Fioravanti S, Walker M, Abdullah S, Raffeld M, Anderson V, Abi-Jaoudeh N, Levy E, Wood BJ, Lee S, Tomita Y, Trepel JB, Steinberg SM, Revenko AS, MacLeod AR, Peer CJ, Figg WD, Greten TF.

Int J Cancer. 2016 Oct 1;139(7):1648-57. doi: 10.1002/ijc.30199. Epub 2016 Jun 27.


Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen.

Adams GN, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, McElhinney KE, Flick MJ, Monia BP, Revenko AS, Palumbo JS.

Cancer Res. 2015 Oct 1;75(19):4235-43. doi: 10.1158/0008-5472.CAN-15-0964. Epub 2015 Aug 3.


Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.

Yau JW, Liao P, Fredenburgh JC, Stafford AR, Revenko AS, Monia BP, Weitz JI.

Blood. 2014 Mar 27;123(13):2102-7. doi: 10.1182/blood-2013-12-540872. Epub 2014 Feb 5.


Inhibition of vascular permeability by antisense-mediated inhibition of plasma kallikrein and coagulation factor 12.

Bhattacharjee G, Revenko AS, Crosby JR, May C, Gao D, Zhao C, Monia BP, MacLeod AR.

Nucleic Acid Ther. 2013 Jun;23(3):175-87. doi: 10.1089/nat.2013.0417. Epub 2013 Apr 12.


Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.

Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1670-8. doi: 10.1161/ATVBAHA.113.301282. Epub 2013 Apr 4. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):e127. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):e130.


Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR.

Blood. 2011 Nov 10;118(19):5302-11. doi: 10.1182/blood-2011-05-355248. Epub 2011 Aug 5.


ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.

Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW.

Cancer Res. 2010 Nov 15;70(22):9402-12. doi: 10.1158/0008-5472.CAN-10-1199. Epub 2010 Sep 23.


Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.

Revenko AS, Kalashnikova EV, Gemo AT, Zou JX, Chen HW.

Mol Cell Biol. 2010 Nov;30(22):5260-72. doi: 10.1128/MCB.00484-10. Epub 2010 Sep 20.


Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.

Zhang H, Löwenberg EC, Crosby JR, MacLeod AR, Zhao C, Gao D, Black C, Revenko AS, Meijers JC, Stroes ES, Levi M, Monia BP.

Blood. 2010 Nov 25;116(22):4684-92. doi: 10.1182/blood-2010-04-277798. Epub 2010 Aug 31.


Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer.

Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW.

Mol Cancer Res. 2010 Feb;8(2):183-93. doi: 10.1158/1541-7786.MCR-09-0095. Epub 2010 Feb 2.


Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.

Zou JX, Guo L, Revenko AS, Tepper CG, Gemo AT, Kung HJ, Chen HW.

Cancer Res. 2009 Apr 15;69(8):3339-46. doi: 10.1158/0008-5472.CAN-08-3440. Epub 2009 Mar 24.


ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.

Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12.


[Structural and transcriptional variation of mitochondrial DNA in pollen-sterile agamospermous sugar beet (Beta vulgaris L.) progeny].

Ivanov MK, Revenko AS, Maletskaia EI, Maletskiĭ SI, Dymshits GM.

Genetika. 2005 Nov;41(11):1511-21. Russian.


The use of RAPD analysis of sugar-beet mitochondrial DNA in search of CMS genes.

Ivanov MK, Revenko AS, Kabilov MR, Dymshits GM.

Dokl Biol Sci. 2002 Nov-Dec;387:536-8. No abstract available.


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