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Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells.

Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL.

Sci Rep. 2019 Oct 10;9(1):14547. doi: 10.1038/s41598-019-51020-3.


Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.

Everts-Graber J, Martin KR, Thieblemont N, Mocek J, Roccabianca A, Chafey P, Le Gall M, Tacnet-Delorme P, Reutelingsperger CP, Naccache JM, Bonnotte B, Karras A, Puéchal X, Guillevin L, Terrier B, Frachet P, Perretti M, Mouthon L, Witko-Sarsat V.

Kidney Int. 2019 Aug;96(2):397-408. doi: 10.1016/j.kint.2019.02.017. Epub 2019 Mar 4.


Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.

Gussenhoven R, Klein L, Ophelders DRMG, Habets DHJ, Giebel B, Kramer BW, Schurgers LJ, Reutelingsperger CPM, Wolfs TGAM.

J Clin Med. 2019 Jan 24;8(2). pii: E137. doi: 10.3390/jcm8020137.


AnnexinA5-pHrodo: a new molecular probe for measuring efferocytosis.

Stöhr R, Deckers N, Schurgers L, Marx N, Reutelingsperger CP.

Sci Rep. 2018 Dec 7;8(1):17731. doi: 10.1038/s41598-018-35995-z.


A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.

Eersels K, Diliën H, Lowdon JW, Steen Redeker E, Rogosic R, Heidt B, Peeters M, Cornelis P, Lux P, Reutelingsperger CP, Schurgers LJ, Cleij TJ, van Grinsven B.

Nutrients. 2018 Jun 11;10(6). pii: E751. doi: 10.3390/nu10060751.


C5b9 Formation on Endothelial Cells Reflects Complement Defects among Patients with Renal Thrombotic Microangiopathy and Severe Hypertension.

Timmermans SAMEG, Abdul-Hamid MA, Potjewijd J, Theunissen ROMFIH, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P; Limburg Renal Registry.

J Am Soc Nephrol. 2018 Aug;29(8):2234-2243. doi: 10.1681/ASN.2018020184. Epub 2018 Jun 1.


Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling.

Willems BA, Furmanik M, Caron MMJ, Chatrou MLL, Kusters DHM, Welting TJM, Stock M, Rafael MS, Viegas CSB, Simes DC, Vermeer C, Reutelingsperger CPM, Schurgers LJ.

Sci Rep. 2018 Mar 21;8(1):4961. doi: 10.1038/s41598-018-23353-y.


Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

Ercig B, Wichapong K, Reutelingsperger CPM, Vanhoorelbeke K, Voorberg J, Nicolaes GAF.

Thromb Haemost. 2018 Jan;118(1):28-41. doi: 10.1160/TH17-06-0404. Epub 2018 Jan 5. Review.


Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities.

Timmermans SAMEG, Abdul-Hamid MA, Vanderlocht J, Damoiseaux JGMC, Reutelingsperger CP, van Paassen P; Limburg Renal Registry.

Kidney Int. 2017 Jun;91(6):1420-1425. doi: 10.1016/j.kint.2016.12.009. Epub 2017 Feb 7.


Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys.

van Smaalen TC, Beurskens DM, Hoogland ER, Winkens B, Christiaans MH, Reutelingsperger CP, van Heurn LW, Nicolaes GA.

Transplantation. 2017 Apr;101(4):e93-e101. doi: 10.1097/TP.0000000000001590.


Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking.

Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DH, Reutelingsperger CP, Yaqoob M, Solito E.

Brain Behav Immun. 2016 Jan;51:212-22. doi: 10.1016/j.bbi.2015.08.020. Epub 2015 Aug 29.


Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients.

Wildhagen KC, Wiewel MA, Schultz MJ, Horn J, Schrijver R, Reutelingsperger CP, van der Poll T, Nicolaes GA.

Thromb Res. 2015 Sep;136(3):542-7. doi: 10.1016/j.thromres.2015.06.035. Epub 2015 Jul 23.


Circulating annexin A5 predicts mortality in patients with heart failure.

Schurgers LJ, Burgmaier M, Ueland T, Schutters K, Aakhus S, Hofstra L, Gullestad L, Aukrust P, Hellmich M, Narula J, Reutelingsperger CP.

J Intern Med. 2016 Jan;279(1):89-97. doi: 10.1111/joim.12396. Epub 2015 Jul 30.


Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.

McArthur S, Gobbetti T, Kusters DH, Reutelingsperger CP, Flower RJ, Perretti M.

J Immunol. 2015 Aug 1;195(3):1139-51. doi: 10.4049/jimmunol.1500733. Epub 2015 Jun 22.


Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet.

Kusters DH, Chatrou ML, Willems BA, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EA, Perretti M, Schurgers LJ, Reutelingsperger CP.

PLoS One. 2015 Jun 19;10(6):e0130484. doi: 10.1371/journal.pone.0130484. eCollection 2015.


Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM.

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.


AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice.

Burgmaier M, Schutters K, Willems B, van der Vorst EP, Kusters D, Chatrou M, Norling L, Biessen EA, Cleutjens J, Perretti M, Schurgers LJ, Reutelingsperger CP.

J Cell Mol Med. 2014 Oct;18(10):2117-24. doi: 10.1111/jcmm.12374. Epub 2014 Sep 12.


Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.

Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA.

PLoS One. 2014 Jul 17;9(7):e101446. doi: 10.1371/journal.pone.0101446. eCollection 2014.


A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke.

Zille M, Harhausen D, De Saint-Hubert M, Michel R, Reutelingsperger CP, Dirnagl U, Wunder A.

J Cereb Blood Flow Metab. 2014 Sep;34(9). doi: 10.1038/jcbfm.2014.115. Epub 2014 Jul 2.


Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake.

Ungethüm L, Chatrou M, Kusters D, Schurgers L, Reutelingsperger CP.

PLoS One. 2014 May 6;9(5):e96749. doi: 10.1371/journal.pone.0096749. eCollection 2014.


The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.

Willems BA, Vermeer C, Reutelingsperger CP, Schurgers LJ.

Mol Nutr Food Res. 2014 Aug;58(8):1620-35. doi: 10.1002/mnfr.201300743. Epub 2014 Feb 17. Review.


Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA.

Blood. 2014 Feb 13;123(7):1098-101. doi: 10.1182/blood-2013-07-514984. Epub 2013 Nov 21.


99mTc-HYNIC-Annexin A5 in Oncology: Evaluating Efficacy of Anti-Cancer Therapies.

Schaper FL, Reutelingsperger CP.

Cancers (Basel). 2013 May 15;5(2):550-68. doi: 10.3390/cancers5020550.


In vivo molecular imaging of apoptosis and necrosis in atherosclerotic plaques using microSPECT-CT and microPET-CT imaging.

De Saint-Hubert M, Bauwens M, Deckers N, Drummen M, Douma K, Granton P, Hendrikx G, Kusters D, Bucerius J, Reutelingsperger CP, Mottaghy FM.

Mol Imaging Biol. 2014 Apr;16(2):246-54. doi: 10.1007/s11307-013-0677-0.


Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?

Arends SJ, Damoiseaux JG, Duijvestijn AM, Debrus-Palmans L, Vroomen M, Boomars KA, Brunner-La Rocca HP, Reutelingsperger CP, Cohen Tervaert JW, van Paassen P.

Clin Exp Immunol. 2013 Dec;174(3):433-40. doi: 10.1111/cei.12166.


Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization.

Schurgers LJ, Uitto J, Reutelingsperger CP.

Trends Mol Med. 2013 Apr;19(4):217-26. doi: 10.1016/j.molmed.2012.12.008. Epub 2013 Jan 30. Review.


Mechanisms of arterial remodeling: lessons from genetic diseases.

van Varik BJ, Rennenberg RJ, Reutelingsperger CP, Kroon AA, de Leeuw PW, Schurgers LJ.

Front Genet. 2012 Dec 13;3:290. doi: 10.3389/fgene.2012.00290. eCollection 2012.


Molecular imaging to identify the vulnerable plaque--from basic research to clinical practice.

Kusters DH, Tegtmeier J, Schurgers LJ, Reutelingsperger CP.

Mol Imaging Biol. 2012 Oct;14(5):523-33. doi: 10.1007/s11307-012-0586-7. Review.


Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells.

Schutters K, Kusters DH, Chatrou ML, Montero-Melendez T, Donners M, Deckers NM, Krysko DV, Vandenabeele P, Perretti M, Schurgers LJ, Reutelingsperger CP.

Cell Death Differ. 2013 Jan;20(1):49-56. doi: 10.1038/cdd.2012.107. Epub 2012 Sep 7.


Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype.

Schurgers LJ, Joosen IA, Laufer EM, Chatrou ML, Herfs M, Winkens MH, Westenfeld R, Veulemans V, Krueger T, Shanahan CM, Jahnen-Dechent W, Biessen E, Narula J, Vermeer C, Hofstra L, Reutelingsperger CP.

PLoS One. 2012;7(8):e43229. doi: 10.1371/journal.pone.0043229. Epub 2012 Aug 29.


Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists.

Chatrou ML, Winckers K, Hackeng TM, Reutelingsperger CP, Schurgers LJ.

Blood Rev. 2012 Jul;26(4):155-66. doi: 10.1016/j.blre.2012.03.002. Epub 2012 Apr 18. Review.


(99)mTc-(CO)(3) His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab.

Vangestel C, Van de Wiele C, Van Damme N, Staelens S, Pauwels P, Reutelingsperger CP, Peeters M.

J Nucl Med. 2011 Nov;52(11):1786-94. doi: 10.2967/jnumed.111.092650.


P-selectin imaging in cardiovascular disease: what you see is what you get?

Boersma HH, de Haas HJ, Reutelingsperger CP, Slart RH.

J Nucl Med. 2011 Sep;52(9):1337-8. doi: 10.2967/jnumed.111.090506. Epub 2011 Aug 4. No abstract available.


Role of vitamin K-dependent proteins in the arterial vessel wall.

Chatrou ML, Reutelingsperger CP, Schurgers LJ.

Hamostaseologie. 2011 Nov;31(4):251-7. doi: 10.5482/ha-1157. Epub 2011 Jun 29. Review.


Engineered annexin A5 variants have impaired cell entry for molecular imaging of apoptosis using pretargeting strategies.

Ungethüm L, Kenis H, Nicolaes GA, Autin L, Stoilova-McPhie S, Reutelingsperger CP.

J Biol Chem. 2011 Jan 21;286(3):1903-10. doi: 10.1074/jbc.M110.163527. Epub 2010 Nov 15.


Annexin A5-functionalized bimodal nanoparticles for MRI and fluorescence imaging of atherosclerotic plaques.

van Tilborg GA, Vucic E, Strijkers GJ, Cormode DP, Mani V, Skajaa T, Reutelingsperger CP, Fayad ZA, Mulder WJ, Nicolay K.

Bioconjug Chem. 2010 Oct 20;21(10):1794-803. doi: 10.1021/bc100091q.


Minocycline inhibits apoptotic cell death in a murine model of partial flap loss.

Dumont EA, Lutgens SP, Reutelingsperger CP, Bos GM, Hofstra L.

J Reconstr Microsurg. 2010 Oct;26(8):523-8. doi: 10.1055/s-0030-1262952. Epub 2010 Jul 20.


Current applications of nanotechnology for magnetic resonance imaging of apoptosis.

Strijkers GJ, van Tilborg GA, Geelen T, Reutelingsperger CP, Nicolay K.

Methods Mol Biol. 2010;624:325-42. doi: 10.1007/978-1-60761-609-2_22. Review.


Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging.

Kenis H, Zandbergen HR, Hofstra L, Petrov AD, Dumont EA, Blankenberg FD, Haider N, Bitsch N, Gijbels M, Verjans JW, Narula N, Narula J, Reutelingsperger CP.

J Nucl Med. 2010 Feb;51(2):259-67. doi: 10.2967/jnumed.109.068429.


Site-specific labeling of 'second generation' annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivo.

De Saint-Hubert M, Mottaghy FM, Vunckx K, Nuyts J, Fonge H, Prinsen K, Stroobants S, Mortelmans L, Deckers N, Hofstra L, Reutelingsperger CP, Verbruggen A, Rattat D.

Bioorg Med Chem. 2010 Feb;18(3):1356-63. doi: 10.1016/j.bmc.2009.12.021. Epub 2010 Jan 5.


Transfection efficiency of lipoplexes for site-directed delivery.

Jellema RK, Bomans P, Deckers N, Ungethum L, Reutelingsperger CP, Hofstra L, Frederik PM.

J Liposome Res. 2010 Sep;20(3):258-67. doi: 10.3109/08982100903384137.


Noninvasive imaging of angiotensin receptors after myocardial infarction.

Verjans JW, Lovhaug D, Narula N, Petrov AD, Indrevoll B, Bjurgert E, Krasieva TB, Petersen LB, Kindberg GM, Solbakken M, Cuthbertson A, Vannan MA, Reutelingsperger CP, Tromberg BJ, Hofstra L, Narula J.

JACC Cardiovasc Imaging. 2008 May;1(3):354-62. doi: 10.1016/j.jcmg.2007.11.007.


Nanoparticles for optical molecular imaging of atherosclerosis.

Douma K, Prinzen L, Slaaf DW, Reutelingsperger CP, Biessen EA, Hackeng TM, Post MJ, van Zandvoort MA.

Small. 2009 Mar;5(5):544-57. doi: 10.1002/smll.200801079. Review.


PET and SPECT imaging of apoptosis in vulnerable atherosclerotic plaques with radiolabeled Annexin A5.

Laufer EM, Winkens HM, Corsten MF, Reutelingsperger CP, Narula J, Hofstra L.

Q J Nucl Med Mol Imaging. 2009 Feb;53(1):26-34. Review.


Internalization of annexin A5-functionalized iron oxide particles by apoptotic Jurkat cells.

van Tilborg GA, Geelen T, Duimel H, Bomans PH, Frederik PM, Sanders HM, Deckers NM, Deckers R, Reutelingsperger CP, Strijkers GJ, Nicolay K.

Contrast Media Mol Imaging. 2009 Jan-Feb;4(1):24-32. doi: 10.1002/cmmi.261.


Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes.

van Tilborg GA, Mulder WJ, van der Schaft DW, Reutelingsperger CP, Griffioen AW, Strijkers GJ, Nicolay K.

Neoplasia. 2008 Dec;10(12):1459-69.


Kinetics of avidin-induced clearance of biotinylated bimodal liposomes for improved MR molecular imaging.

van Tilborg GA, Strijkers GJ, Pouget EM, Reutelingsperger CP, Sommerdijk NA, Nicolay K, Mulder WJ.

Magn Reson Med. 2008 Dec;60(6):1444-56. doi: 10.1002/mrm.21780.


Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibition.

Kuijpers MJ, Munnix IC, Cosemans JM, Vlijmen BV, Reutelingsperger CP, Egbrink MO, Heemskerk JW.

Microcirculation. 2008 May;15(4):269-82. doi: 10.1080/10739680701653517.


Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization.

van Genderen HO, Kenis H, Hofstra L, Narula J, Reutelingsperger CP.

Biochim Biophys Acta. 2008 Jun;1783(6):953-63. doi: 10.1016/j.bbamcr.2008.01.030. Epub 2008 Feb 20. Review.


Annexin A5: an imaging biomarker of cardiovascular risk.

Laufer EM, Reutelingsperger CP, Narula J, Hofstra L.

Basic Res Cardiol. 2008 Mar;103(2):95-104. doi: 10.1007/s00395-008-0701-8. Review.


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