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Items: 1 to 50 of 89

1.

Transcriptome Analysis of Human Reninomas as an Approach to Understanding Juxtaglomerular Cell Biology.

Martini AG, Xa LK, Lacombe MJ, Blanchet-Cohen A, Mercure C, Haibe-Kains B, Friesema ECH, van den Meiracker AH, Gross KW, Azizi M, Corvol P, Nguyen G, Reudelhuber TL, Danser AHJ.

Hypertension. 2017 Jun;69(6):1145-1155. doi: 10.1161/HYPERTENSIONAHA.117.09179. Epub 2017 Apr 10.

2.

A novel mouse model of advanced diabetic kidney disease.

Thibodeau JF, Holterman CE, Burger D, Read NC, Reudelhuber TL, Kennedy CR.

PLoS One. 2014 Dec 16;9(12):e113459. doi: 10.1371/journal.pone.0113459. eCollection 2014.

3.

Differences in cell-type-specific responses to angiotensin II explain cardiac remodeling differences in C57BL/6 mouse substrains.

Cardin S, Scott-Boyer MP, Praktiknjo S, Jeidane S, Picard S, Reudelhuber TL, Deschepper CF.

Hypertension. 2014 Nov;64(5):1040-6. doi: 10.1161/HYPERTENSIONAHA.114.04067. Epub 2014 Jul 28.

PMID:
25069667
4.

General lysosomal hydrolysis can process prorenin accurately.

Xa LK, Lacombe MJ, Mercure C, Lazure C, Reudelhuber TL.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R505-13. doi: 10.1152/ajpregu.00467.2013. Epub 2014 Jun 25.

5.

Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.

Burger D, Reudelhuber TL, Mahajan A, Chibale K, Sturrock ED, Touyz RM.

Clin Sci (Lond). 2014 Jul;127(1):57-63. doi: 10.1042/CS20130808.

PMID:
24506807
6.

Where hypertension happens.

Reudelhuber TL.

J Clin Invest. 2013 May;123(5):1934-6. doi: 10.1172/JCI69296. Epub 2013 Apr 24.

7.

The interaction between prorenin, renin and the (pro)renin receptor: time to rethink the role in hypertension.

Reudelhuber TL.

Curr Opin Nephrol Hypertens. 2012 Mar;21(2):137-41. doi: 10.1097/MNH.0b013e3283500927. Review.

PMID:
22240442
8.

Deciphering the roles of tissue renin-angiotensin systems in whole animals.

Reudelhuber TL.

Hypertension. 2011 Mar;57(3):532-7. doi: 10.1161/HYPERTENSIONAHA.110.167114. Epub 2010 Dec 28. No abstract available.

PMID:
21189400
9.

Local angiotensin II aggravates cardiac remodeling in hypertension.

Xu J, Carretero OA, Liao TD, Peng H, Shesely EG, Xu J, Liu TS, Yang JJ, Reudelhuber TL, Yang XP.

Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1328-38. doi: 10.1152/ajpheart.00538.2010. Epub 2010 Sep 10.

10.

Deleterious combined effects of salt-loading and endothelial cell restricted endothelin-1 overexpression on blood pressure and vascular function in mice.

Amiri F, Ko EA, Javeshghani D, Reudelhuber TL, Schiffrin EL.

J Hypertens. 2010 Jun;28(6):1243-51. doi: 10.1097/HJH.0b013e328338bb8b.

PMID:
20308920
11.

Prorenin, Renin, and their receptor: moving targets.

Reudelhuber TL.

Hypertension. 2010 May;55(5):1071-4. doi: 10.1161/HYPERTENSIONAHA.108.120279. Epub 2010 Mar 8. No abstract available.

PMID:
20212275
12.

Cathepsin B is not the processing enzyme for mouse prorenin.

Mercure C, Lacombe MJ, Khazaie K, Reudelhuber TL.

Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1212-6. doi: 10.1152/ajpregu.00830.2009. Epub 2010 Feb 17.

13.

Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection after myocardial infarction.

Wang Y, Qian C, Roks AJ, Westermann D, Schumacher SM, Escher F, Schoemaker RG, Reudelhuber TL, van Gilst WH, Schultheiss HP, Tschöpe C, Walther T.

Circ Heart Fail. 2010 Mar;3(2):286-93. doi: 10.1161/CIRCHEARTFAILURE.109.905968. Epub 2010 Jan 26.

PMID:
20103774
14.

Physiological Genomics Identifies Estrogen-Related Receptor α as a Regulator of Renal Sodium and Potassium Homeostasis and the Renin-Angiotensin Pathway.

Tremblay AM, Dufour CR, Ghahremani M, Reudelhuber TL, Gigue Re V.

Endocr Rev. 2009 Dec 1;30(7):930-931. doi: 10.1210/edrv.30.7.9989. No abstract available.

PMID:
28199518
15.

Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.

Tremblay AM, Dufour CR, Ghahremani M, Reudelhuber TL, Giguère V.

Mol Endocrinol. 2010 Jan;24(1):22-32. doi: 10.1210/me.2009-0254. Epub 2009 Nov 9.

16.

Truncated prorenin comes up ... short.

Reudelhuber TL.

Hypertension. 2009 Dec;54(6):1216-7. doi: 10.1161/HYPERTENSIONAHA.109.140392. Epub 2009 Oct 12. No abstract available.

PMID:
19822794
17.

Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.

Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7408-13. doi: 10.1073/pnas.0809576106. Epub 2009 Apr 17.

18.

Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies.

Mercure C, Prescott G, Lacombe MJ, Silversides DW, Reudelhuber TL.

Hypertension. 2009 Jun;53(6):1062-9. doi: 10.1161/HYPERTENSIONAHA.108.115444. Epub 2009 Apr 13.

PMID:
19364992
19.

Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart.

Mercure C, Yogi A, Callera GE, Aranha AB, Bader M, Ferreira AJ, Santos RA, Walther T, Touyz RM, Reudelhuber TL.

Circ Res. 2008 Nov 21;103(11):1319-26. doi: 10.1161/CIRCRESAHA.108.184911. Epub 2008 Oct 9.

PMID:
18845809
20.

Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats.

Nadu AP, Ferreira AJ, Reudelhuber TL, Bader M, Santos RA.

J Am Soc Hypertens. 2008 Sep-Oct;2(5):341-8. doi: 10.1016/j.jash.2008.04.012. Epub 2008 Jul 2.

PMID:
20409916
21.

Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cells.

Amiri F, Paradis P, Reudelhuber TL, Schiffrin EL.

J Hypertens. 2008 Jun;26(6):1102-9. doi: 10.1097/HJH.0b013e3282fc2184.

PMID:
18475147
22.

Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis.

Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A.

J Neurosci. 2007 Aug 22;27(34):9032-42.

23.

PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.

Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL.

FEBS J. 2007 Aug;274(16):4094-102. Epub 2007 Jul 20.

24.

Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction.

Xu J, Carretero OA, Lin CX, Cavasin MA, Shesely EG, Yang JJ, Reudelhuber TL, Yang XP.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1900-7. Epub 2007 Jun 22.

25.

The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.

Rabah N, Gauthier D, Dikeakos JD, Reudelhuber TL, Lazure C.

FEBS J. 2007 Jul;274(13):3482-91. Epub 2007 Jun 12.

26.

Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look.

Reudelhuber TL, Bernstein KE, Delafontaine P.

Hypertension. 2007 Jun;49(6):1196-201. Epub 2007 Apr 23. Review. No abstract available.

27.

Sending proteins to dense core secretory granules: still a lot to sort out.

Dikeakos JD, Reudelhuber TL.

J Cell Biol. 2007 Apr 23;177(2):191-6. Epub 2007 Apr 16. Review.

28.

Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance.

Botelho-Santos GA, Sampaio WO, Reudelhuber TL, Bader M, Campagnole-Santos MJ, Souza dos Santos RA.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2485-90. Epub 2007 Jan 5.

29.

A hydrophobic patch in a charged alpha-helix is sufficient to target proteins to dense core secretory granules.

Dikeakos JD, Lacombe MJ, Mercure C, Mireuta M, Reudelhuber TL.

J Biol Chem. 2007 Jan 12;282(2):1136-43. Epub 2006 Nov 8.

30.

Renal function in transgenic rats expressing an angiotensin-(1-7)-producing fusion protein.

Ferreira AJ, Pinheiro SV, Castro CH, Silva GA, Silva AC, Almeida AP, Bader M, Rentzsch B, Reudelhuber TL, Santos RA.

Regul Pept. 2006 Dec 10;137(3):128-33. Epub 2006 Aug 28.

PMID:
16934886
31.

A place in our hearts for the lowly angiotensin 1-7 peptide?

Reudelhuber TL.

Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6. Review. No abstract available.

PMID:
16520407
32.

The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous.

Reudelhuber TL.

Hypertension. 2005 Dec;46(6):1261-2. Epub 2005 Nov 14. Review. No abstract available.

PMID:
16286568
33.

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG.

FEBS Lett. 2005 Oct 24;579(25):5621-5. Epub 2005 Sep 28.

34.

Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis.

Bouzeghrane F, Reinhardt DP, Reudelhuber TL, Thibault G.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H982-91. Epub 2005 Apr 22.

35.

Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.

Touyz RM, Mercure C, He Y, Javeshghani D, Yao G, Callera GE, Yogi A, Lochard N, Reudelhuber TL.

Hypertension. 2005 Apr;45(4):530-7. Epub 2005 Mar 7.

PMID:
15753233
36.

The renin-angiotensin system: peptides and enzymes beyond angiotensin II.

Reudelhuber TL.

Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9. Review.

PMID:
15687842
37.

Modulation of secretory granule-targeting efficiency by cis and trans compounding of sorting signals.

Lacombe MJ, Mercure C, Dikeakos JD, Reudelhuber TL.

J Biol Chem. 2005 Feb 11;280(6):4803-7. Epub 2004 Nov 29.

38.

Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.

Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL.

Circulation. 2004 Oct 12;110(15):2233-40. Epub 2004 Oct 4.

PMID:
15466627
39.

Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist.

Lochard N, Thibault G, Silversides DW, Touyz RM, Reudelhuber TL.

Circ Res. 2004 Jun 11;94(11):1451-7. Epub 2004 Apr 29.

PMID:
15117826
40.

Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats.

Santos RA, Ferreira AJ, Nadu AP, Braga AN, de Almeida AP, Campagnole-Santos MJ, Baltatu O, Iliescu R, Reudelhuber TL, Bader M.

Physiol Genomics. 2004 May 19;17(3):292-9.

PMID:
15039487
41.

Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium.

Bouzeghrane F, Mercure C, Reudelhuber TL, Thibault G.

J Mol Cell Cardiol. 2004 Mar;36(3):343-53.

PMID:
15010273
42.

Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts.

Zahabi A, Picard S, Fortin N, Reudelhuber TL, Deschepper CF.

J Biol Chem. 2003 Nov 28;278(48):47694-9. Epub 2003 Sep 18.

43.

Salt-sensitive hypertension: if only it were as simple as rocket science.

Reudelhuber TL.

J Clin Invest. 2003 Apr;111(8):1115-6. No abstract available.

44.

Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice.

Lochard N, Silversides DW, van Kats JP, Mercure C, Reudelhuber TL.

J Biol Chem. 2003 Jan 24;278(4):2184-9. Epub 2002 Oct 23.

45.

Transendothelial transport of renin-angiotensin system components.

van den Eijnden MM, de Bruin RJ, de Wit E, Sluiter W, Deinum J, Reudelhuber TL, Danser AH.

J Hypertens. 2002 Oct;20(10):2029-37.

PMID:
12359982
46.

A genetically clamped renin transgene for the induction of hypertension.

Caron KM, James LR, Kim HS, Morham SG, Sequeira Lopez ML, Gomez RA, Reudelhuber TL, Smithies O.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8248-52. Epub 2002 May 28.

47.

Tissue activity of circulating prorenin.

Prescott G, Silversides DW, Reudelhuber TL.

Am J Hypertens. 2002 Mar;15(3):280-5.

PMID:
11939621
48.

Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart.

van Kats JP, Methot D, Paradis P, Silversides DW, Reudelhuber TL.

J Biol Chem. 2001 Nov 23;276(47):44012-7. Epub 2001 Sep 10.

49.

Development and application of a biological peptide pump for the study of the in vivo actions of angiotensin peptides.

Methot D, vanKats JP, Lochard N, Tremblay F, Silversides DW, Reudelhuber TL.

Am J Hypertens. 2001 Jun;14(6 Pt 2):38S-43S. Review.

PMID:
11411764
50.

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors.

van den Eijnden MM, Saris JJ, de Bruin RJ, de Wit E, Sluiter W, Reudelhuber TL, Schalekamp MA, Derkx FH, Danser AH.

Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):911-6.

PMID:
11397696

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