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Items: 7


An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.

Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS.

Elife. 2018 Jun 7;7. pii: e36307. doi: 10.7554/eLife.36307.


Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.

Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA.

Cell Death Differ. 2016 Oct;23(10):1717-26. doi: 10.1038/cdd.2016.62. Epub 2016 Jul 1.


CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A.

J Mol Biol. 2016 Feb 22;428(4):709-719. doi: 10.1016/j.jmb.2016.01.029. Epub 2016 Feb 5.


Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.

Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA.

J Med Chem. 2015 Oct 22;58(20):8285-8291. doi: 10.1021/acs.jmedchem.5b01216. Epub 2015 Oct 12.


A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17.


FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.

Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK.

Medchemcomm. 2014 Mar 1;5:370-375.


Hydride as a leaving group in the reaction of pinacolborane with halides under ambient Grignard and Barbier conditions. One-pot synthesis of alkyl, aryl, heteroaryl, vinyl, and allyl pinacolboronic esters.

Clary JW, Rettenmaier TJ, Snelling R, Bryks W, Banwell J, Wipke WT, Singaram B.

J Org Chem. 2011 Dec 2;76(23):9602-10. doi: 10.1021/jo201093u. Epub 2011 Nov 1.


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