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Items: 1 to 50 of 60

1.

KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.

Vieceli Dalla Sega F, Mastrocola R, Aquila G, Fortini F, Fornelli C, Zotta A, Cento AS, Perrelli A, Boda E, Pannuti A, Marchi S, Pinton P, Ferrari R, Rizzo P, Retta SF.

Int J Mol Sci. 2019 Oct 5;20(19). pii: E4930. doi: 10.3390/ijms20194930.

2.

KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins.

Cianfruglia L, Perrelli A, Fornelli C, Magini A, Gorbi S, Salzano AM, Antognelli C, Retta F, Benedetti V, Cassoni P, Emiliani C, Principato G, Scaloni A, Armeni T, Retta SF.

Antioxidants (Basel). 2019 Jan 17;8(1). pii: E27. doi: 10.3390/antiox8010027.

3.

Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation.

De Luca E, Pedone D, Moglianetti M, Pulcini D, Perrelli A, Retta SF, Pompa PP.

ACS Omega. 2018 Nov 30;3(11):15389-15398. doi: 10.1021/acsomega.8b01653. Epub 2018 Nov 13.

4.

Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.

Perrelli A, Goitre L, Salzano AM, Moglia A, Scaloni A, Retta SF.

Oxid Med Cell Longev. 2018 Aug 23;2018:6015351. doi: 10.1155/2018/6015351. eCollection 2018. Review.

5.

Yeast-Derived Recombinant Avenanthramides Inhibit Proliferation, Migration and Epithelial Mesenchymal Transition of Colon Cancer Cells.

Finetti F, Moglia A, Schiavo I, Donnini S, Berta GN, Di Scipio F, Perrelli A, Fornelli C, Trabalzini L, Retta SF.

Nutrients. 2018 Aug 24;10(9). pii: E1159. doi: 10.3390/nu10091159.

6.

Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.

Antognelli C, Trapani E, Delle Monache S, Perrelli A, Fornelli C, Retta F, Cassoni P, Talesa VN, Retta SF.

Data Brief. 2017 Dec 13;16:929-938. doi: 10.1016/j.dib.2017.12.026. eCollection 2018 Feb.

7.

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.

Antognelli C, Trapani E, Delle Monache S, Perrelli A, Daga M, Pizzimenti S, Barrera G, Cassoni P, Angelucci A, Trabalzini L, Talesa VN, Goitre L, Retta SF.

Free Radic Biol Med. 2018 Feb 1;115:202-218. doi: 10.1016/j.freeradbiomed.2017.11.014. Epub 2017 Nov 21.

8.

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.

Goitre L, DiStefano PV, Moglia A, Nobiletti N, Baldini E, Trabalzini L, Keubel J, Trapani E, Shuvaev VV, Muzykantov VR, Sarelius IH, Retta SF, Glading AJ.

Sci Rep. 2017 Aug 15;7(1):8296. doi: 10.1038/s41598-017-08373-4.

9.

Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.

Retta SF, Glading AJ.

Int J Biochem Cell Biol. 2016 Dec;81(Pt B):254-270. doi: 10.1016/j.biocel.2016.09.011. Epub 2016 Sep 14. Review.

10.

Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.

Marchi S, Trapani E, Corricelli M, Goitre L, Pinton P, Retta SF.

Rare Dis. 2016 Jan 25;4(1):e1142640. doi: 10.1080/21675511.2016.1142640. eCollection 2016.

11.

Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view.

Marchi S, Retta SF, Pinton P.

Autophagy. 2016;12(2):424-5. doi: 10.1080/15548627.2015.1125073.

12.

Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.

Moglianetti M, De Luca E, Pedone D, Marotta R, Catelani T, Sartori B, Amenitsch H, Retta SF, Pompa PP.

Nanoscale. 2016 Feb 14;8(6):3739-52. doi: 10.1039/c5nr08358c. Epub 2016 Jan 27.

PMID:
26815950
13.

Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.

Choquet H, Trapani E, Goitre L, Trabalzini L, Akers A, Fontanella M, Hart BL, Morrison LA, Pawlikowska L, Kim H, Retta SF.

Free Radic Biol Med. 2016 Mar;92:100-109. doi: 10.1016/j.freeradbiomed.2016.01.008. Epub 2016 Jan 19.

14.

Defective autophagy is a key feature of cerebral cavernous malformations.

Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF, Pinton P.

EMBO Mol Med. 2015 Nov;7(11):1403-17. doi: 10.15252/emmm.201505316.

15.

Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors.

Trapani E, Retta SF.

J Neurosurg Sci. 2015 Sep;59(3):201-9. Epub 2015 Apr 21. Review.

PMID:
25896717
16.

Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jiménez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E.

Cell Microbiol. 2015 Aug;17(8):1179-204. doi: 10.1111/cmi.12429. Epub 2015 Mar 20.

PMID:
25678064
17.

Evaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.

Moglia A, Goitre L, Gianoglio S, Baldini E, Trapani E, Genre A, Scattina A, Dondo G, Trabalzini L, Beekwilder J, Retta SF.

Biofactors. 2015 Jan-Feb;41(1):15-27. doi: 10.1002/biof.1197. Epub 2015 Jan 30.

18.

Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.

Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY.

Circulation. 2015 Jan 20;131(3):289-99. doi: 10.1161/CIRCULATIONAHA.114.010403. Epub 2014 Dec 8.

19.

Professional athletes and cerebral cavernomas: an obstacle to overcome.

Fontanella MM, Panciani PP, Spena G, Roca E, Migliorati K, Ambrosi C, Sturiale CL, Retta SF.

J Sports Med Phys Fitness. 2015 Sep;55(9):1046-7. Epub 2014 Mar 18. No abstract available.

PMID:
24637509
20.

Fluorescence microscopy study of Rap1 subcellular localization.

Goitre L, Cutano V, Retta SF.

Methods Mol Biol. 2014;1120:197-205. doi: 10.1007/978-1-62703-791-4_13.

PMID:
24470027
21.

Combined pulldown and time-lapse microscopy studies for determining the role of Rap1 in the crosstalk between integrins and cadherins.

Goitre L, Retta SF.

Methods Mol Biol. 2014;1120:177-95. doi: 10.1007/978-1-62703-791-4_12.

PMID:
24470026
22.

Ras GTPases are both regulators and effectors of redox agents.

Ferro E, Goitre L, Baldini E, Retta SF, Trabalzini L.

Methods Mol Biol. 2014;1120:55-74. doi: 10.1007/978-1-62703-791-4_5. Review.

PMID:
24470019
23.

The Ras superfamily of small GTPases: the unlocked secrets.

Goitre L, Trapani E, Trabalzini L, Retta SF.

Methods Mol Biol. 2014;1120:1-18. doi: 10.1007/978-1-62703-791-4_1. Review.

PMID:
24470015
24.

KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.

Goitre L, De Luca E, Braggion S, Trapani E, Guglielmotto M, Biasi F, Forni M, Moglia A, Trabalzini L, Retta SF.

Free Radic Biol Med. 2014 Mar;68:134-47. doi: 10.1016/j.freeradbiomed.2013.11.020. Epub 2013 Nov 28.

25.

miR-21 coordinates tumor growth and modulates KRIT1 levels.

Orso F, Balzac F, Marino M, Lembo A, Retta SF, Taverna D.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):90-6. doi: 10.1016/j.bbrc.2013.07.031. Epub 2013 Jul 18.

26.

A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia.

Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A.

J Med Genet. 2013 Aug;50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7.

27.

EndMT contributes to the onset and progression of cerebral cavernous malformations.

Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E.

Nature. 2013 Jun 27;498(7455):492-6. doi: 10.1038/nature12207. Epub 2013 Jun 9.

PMID:
23748444
28.

Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1.

Guazzi P, Goitre L, Ferro E, Cutano V, Martino C, Trabalzini L, Retta SF.

PLoS One. 2012;7(9):e44705. doi: 10.1371/journal.pone.0044705. Epub 2012 Sep 6.

29.

Reactive oxygen species: friends and foes of signal transduction.

Retta SF, Chiarugi P, Trabalzini L, Pinton P, Belkin AM.

J Signal Transduct. 2012;2012:534029. doi: 10.1155/2012/534029. Epub 2012 Mar 11. No abstract available.

30.

Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.

Bacigaluppi S, Retta SF, Pileggi S, Fontanella M, Goitre L, Tassi L, La Camera A, Citterio A, Patrosso MC, Tredici G, Penco S.

Clin Genet. 2013 Jan;83(1):7-14. doi: 10.1111/j.1399-0004.2012.01892.x. Epub 2012 May 8. Review.

PMID:
22510019
31.

Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

Goitre L, Pergolizzi B, Ferro E, Trabalzini L, Retta SF.

J Signal Transduct. 2012;2012:807682. doi: 10.1155/2012/807682. Epub 2011 Dec 13.

32.

The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications.

Ferro E, Goitre L, Retta SF, Trabalzini L.

J Signal Transduct. 2012;2012:365769. doi: 10.1155/2012/365769. Epub 2011 Nov 30.

33.

Mutation analysis of CCM1, CCM2 and CCM3 genes in a cohort of Italian patients with cerebral cavernous malformation.

D'Angelo R, Marini V, Rinaldi C, Origone P, Dorcaratto A, Avolio M, Goitre L, Forni M, Capra V, Alafaci C, Mareni C, Garrè C, Bramanti P, Sidoti A, Retta SF, Amato A.

Brain Pathol. 2011 Mar;21(2):215-24. doi: 10.1111/j.1750-3639.2010.00441.x. Epub 2010 Oct 4. Erratum in: Brain Pathol. 2011 May;21(3):360.

PMID:
21029238
34.

KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF.

PLoS One. 2010 Jul 26;5(7):e11786. doi: 10.1371/journal.pone.0011786.

35.

A unique interplay between Rap1 and E-cadherin in the endocytic pathway regulates self-renewal of human embryonic stem cells.

Li L, Wang S, Jezierski A, Moalim-Nour L, Mohib K, Parks RJ, Retta SF, Wang L.

Stem Cells. 2010 Feb;28(2):247-57. doi: 10.1002/stem.289.

36.

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.

Jiménez-Soto LF, Kutter S, Sewald X, Ertl C, Weiss E, Kapp U, Rohde M, Pirch T, Jung K, Retta SF, Terradot L, Fischer W, Haas R.

PLoS Pathog. 2009 Dec;5(12):e1000684. doi: 10.1371/journal.ppat.1000684. Epub 2009 Dec 4.

37.

Production of novel antioxidative phenolic amides through heterologous expression of the plant's chlorogenic acid biosynthesis genes in yeast.

Moglia A, Comino C, Lanteri S, de Vos R, de Waard P, van Beek TA, Goitre L, Retta SF, Beekwilder J.

Metab Eng. 2010 May;12(3):223-32. doi: 10.1016/j.ymben.2009.11.003. Epub 2009 Nov 24.

38.

Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis.

Francalanci F, Avolio M, De Luca E, Longo D, Menchise V, Guazzi P, Sgrò F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF.

Exp Cell Res. 2009 Jan 15;315(2):285-303. doi: 10.1016/j.yexcr.2008.10.006. Epub 2008 Oct 21.

PMID:
18992740
39.

Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells.

Vanni C, Visco V, Mancini P, Parodi A, Ottaviano C, Ognibene M, Manazza AD, Retta SF, Varesio L, Torrisi MR, Eva A.

Cell Cycle. 2006 Nov;5(22):2657-65. Epub 2006 Nov 15.

PMID:
17172840
40.

Rap1: a turnabout for the crosstalk between cadherins and integrins.

Retta SF, Balzac F, Avolio M.

Eur J Cell Biol. 2006 Apr;85(3-4):283-93. Epub 2005 Oct 10. Review.

PMID:
16546572
41.

E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function.

Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF.

J Cell Sci. 2005 Oct 15;118(Pt 20):4765-83.

42.

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

Fournier HN, Dupé-Manet S, Bouvard D, Luton F, Degani S, Block MR, Retta SF, Albiges-Rizo C.

Mol Biol Cell. 2005 Apr;16(4):1859-71. Epub 2005 Feb 9.

43.

Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1.

Retta SF, Avolio M, Francalanci F, Procida S, Balzac F, Degani S, Tarone G, Silengo L.

Gene. 2004 Jan 21;325:63-78.

PMID:
14697511
44.

Altered expression of integrins in RSV-transformed chick epiphyseal chondrocytes.

Arcucci A, Alaia V, Montagnani S, Pontarelli G, Retta SF, Tarone G, Gionti E.

Biochimie. 2003 May;85(5):483-92.

45.

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha.

Bouvard D, Vignoud L, Dupé-Manet S, Abed N, Fournier HN, Vincent-Monegat C, Retta SF, Fassler R, Block MR.

J Biol Chem. 2003 Feb 21;278(8):6567-74. Epub 2002 Dec 7.

46.

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

Degani S, Balzac F, Brancaccio M, Guazzone S, Retta SF, Silengo L, Eva A, Tarone G.

J Cell Biol. 2002 Jan 21;156(2):377-87. Epub 2002 Jan 21.

47.

Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.

Moro L, Dolce L, Cabodi S, Bergatto E, Boeri Erba E, Smeriglio M, Turco E, Retta SF, Giuffrida MG, Venturino M, Godovac-Zimmermann J, Conti A, Schaefer E, Beguinot L, Tacchetti C, Gaggini P, Silengo L, Tarone G, Defilippi P.

J Biol Chem. 2002 Mar 15;277(11):9405-14. Epub 2001 Dec 27.

48.

Cross talk between beta(1) and alpha(V) integrins: beta(1) affects beta(3) mRNA stability.

Retta SF, Cassarà G, D'Amato M, Alessandro R, Pellegrino M, Degani S, De Leo G, Silengo L, Tarone G.

Mol Biol Cell. 2001 Oct;12(10):3126-38.

49.

Integrin function and regulation in development.

Tarone G, Hirsch E, Brancaccio M, De Acetis M, Barberis L, Balzac F, Retta SF, Botta C, Altruda F, Silengo L.

Int J Dev Biol. 2000;44(6):725-31. Review. Erratum in: Int J Dev Biol 2001 Sep;45(5-6):following 770. Retta F [corrected to Retta SF].

50.

Adhesion to matrix proteins.

Retta SF, Ternullo M, Tarone G.

Methods Mol Biol. 1999;96:125-30. Review. No abstract available.

PMID:
10098129

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