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Items: 1 to 50 of 224

1.

A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex.

Gottwick C, He X, Hofmann A, Vesper N, Reth M, Yang J.

Proc Natl Acad Sci U S A. 2019 Jun 17. pii: 201907481. doi: 10.1073/pnas.1907481116. [Epub ahead of print]

PMID:
31209055
2.

Antigen Receptor Function in the Context of the Nanoscale Organization of the B Cell Membrane.

Gold MR, Reth MG.

Annu Rev Immunol. 2019 Apr 26;37:97-123. doi: 10.1146/annurev-immunol-042718-041704.

PMID:
31026412
3.

Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.

Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M, Jumaa H.

EMBO J. 2019 Jun 3;38(11). pii: e100249. doi: 10.15252/embj.2018100249. Epub 2019 Apr 23.

4.

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.

Łyszkiewicz M, Kotlarz D, Ziȩtara N, Brandes G, Diestelhorst J, Glage S, Hobeika E, Reth M, Huber LA, Krueger A, Klein C.

Front Immunol. 2019 Mar 18;10:497. doi: 10.3389/fimmu.2019.00497. eCollection 2019.

5.

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins.

Wilhelm I, Levit-Zerdoun E, Jakob J, Villringer S, Frensch M, Übelhart R, Landi A, Müller P, Imberty A, Thuenauer R, Claudinon J, Jumaa H, Reth M, Eibel H, Hobeika E, Römer W.

Sci Signal. 2019 Mar 5;12(571). pii: eaao7194. doi: 10.1126/scisignal.aao7194.

PMID:
30837305
6.

Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach.

Kulathu Y, Zuern C, Yang J, Reth M.

Biol Chem. 2019 Mar 26;400(4):555-563. doi: 10.1515/hsz-2018-0308.

PMID:
30465710
7.

Conditional Selection of B Cells in Mice With an Inducible B Cell Development.

Hobeika E, Dautzenberg M, Levit-Zerdoun E, Pelanda R, Reth M.

Front Immunol. 2018 Aug 6;9:1806. doi: 10.3389/fimmu.2018.01806. eCollection 2018.

8.

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.

Weber F, Breustedt D, Schlicht S, Meyer CA, Niewoehner J, Ebeling M, Freskgard PO, Bruenker P, Singer T, Reth M, Iglesias A.

Pharm Res. 2018 Jun 27;35(9):169. doi: 10.1007/s11095-018-2448-8.

9.

Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.

He X, Kläsener K, Iype JM, Becker M, Maity PC, Cavallari M, Nielsen PJ, Yang J, Reth M.

EMBO J. 2018 Jun 1;37(11). pii: e97980. doi: 10.15252/embj.201797980. Epub 2018 Apr 18.

10.

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.

Patzelt T, Keppler SJ, Gorka O, Thoene S, Wartewig T, Reth M, Förster I, Lang R, Buchner M, Ruland J.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3120-3125. doi: 10.1073/pnas.1711335115. Epub 2018 Mar 5.

11.

Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay.

Kläsener K, Yang J, Reth M.

Methods Mol Biol. 2018;1707:171-181. doi: 10.1007/978-1-4939-7474-0_12. Review.

PMID:
29388107
12.

Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.

Minguet S, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA.

Nat Immunol. 2017 Oct;18(10):1150-1159. doi: 10.1038/ni.3813. Epub 2017 Aug 14.

13.

The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.

Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M.

Nat Immunol. 2017 Aug;18(8):911-920. doi: 10.1038/ni.3774. Epub 2017 Jun 19.

PMID:
28628091
14.

CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.

Becker M, Hobeika E, Jumaa H, Reth M, Maity PC.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):5231-5236. doi: 10.1073/pnas.1621512114. Epub 2017 May 1.

15.

The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR.

Nguyen TT, Kläsener K, Zürn C, Castillo PA, Brust-Mascher I, Imai DM, Bevins CL, Reardon C, Reth M, Baumgarth N.

Nat Immunol. 2017 Mar;18(3):321-333. doi: 10.1038/ni.3677. Epub 2017 Jan 30.

16.

LED Thermo Flow - Combining Optogenetics with Flow Cytometry.

Brenker K, Osthof K, Yang J, Reth M.

J Vis Exp. 2016 Dec 30;(118). doi: 10.3791/54707.

17.

Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia.

Benkisser-Petersen M, Buchner M, Dörffel A, Dühren-von-Minden M, Claus R, Kläsener K, Leberecht K, Burger M, Dierks C, Jumaa H, Malavasi F, Reth M, Veelken H, Duyster J, Zirlik K.

PLoS One. 2016 Dec 30;11(12):e0169159. doi: 10.1371/journal.pone.0169159. eCollection 2016.

18.

What goes up must come down: A tripartite Dok-3/Grb2/SHIP1 inhibitory module limits BCR signaling.

Reth M, Gold MR.

Eur J Immunol. 2016 Nov;46(11):2507-2511. doi: 10.1002/eji.201646705.

19.

Molecular requirements of the B-cell antigen receptor for sensing monovalent antigens.

Volkmann C, Brings N, Becker M, Hobeika E, Yang J, Reth M.

EMBO J. 2016 Nov 2;35(21):2371-2381. Epub 2016 Sep 15.

20.

Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M.

Nature. 2016 Jun 2;534(7605):138. doi: 10.1038/nature16997. Epub 2016 Mar 9. No abstract available.

PMID:
26958840
21.

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.

Levit-Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity PC, Rajewsky K, Reth M, Hobeika E.

J Immunol. 2016 Mar 1;196(5):2348-60. doi: 10.4049/jimmunol.1501707. Epub 2016 Feb 3.

22.

Receptor Dissociation and B-Cell Activation.

Yang J, Reth M.

Curr Top Microbiol Immunol. 2016;393:27-43. doi: 10.1007/82_2015_482. Review.

PMID:
26428245
23.

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation.

Maity PC, Blount A, Jumaa H, Ronneberger O, Lillemeier BF, Reth M.

Sci Signal. 2015 Sep 15;8(394):ra93. doi: 10.1126/scisignal.2005887.

PMID:
26373673
24.

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.

Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.

J Exp Med. 2015 Sep 21;212(10):1693-708. doi: 10.1084/jem.20141271. Epub 2015 Aug 31.

25.

Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.

Hüttl S, Kläsener K, Schweizer M, Schneppenheim J, Oberg HH, Kabelitz D, Reth M, Saftig P, Schröder B.

J Immunol. 2015 Aug 15;195(4):1548-63. doi: 10.4049/jimmunol.1403171. Epub 2015 Jul 8.

26.

Erratum: Responsiveness of B cells is regulated by the hinge region of IgD.

Übelhart R, Hug E, Bach MP, Wossning T, Minden MD, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H.

Nat Immunol. 2015 Jul;16(7):785. doi: 10.1038/ni0715-785d. No abstract available.

PMID:
26086144
27.

Responsiveness of B cells is regulated by the hinge region of IgD.

Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H.

Nat Immunol. 2015 May;16(5):534-43. doi: 10.1038/ni.3141. Epub 2015 Apr 6. Erratum in: Nat Immunol. 2015 Jul;16(7):785.

PMID:
25848865
28.

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M.

Nature. 2015 May 21;521(7552):357-61. doi: 10.1038/nature14231. Epub 2015 Mar 23. Erratum in: Nature. 2016 Jun 2;534(7605):138.

29.

TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.

Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K.

Dev Cell. 2015 Mar 9;32(5):617-30. doi: 10.1016/j.devcel.2015.01.026. Epub 2015 Feb 26. Erratum in: Dev Cell. 2015 May 4;33(3):366.

30.

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T, Rodewald HR.

Nature. 2015 Feb 26;518(7540):542-6. doi: 10.1038/nature14242. Epub 2015 Feb 11.

PMID:
25686605
31.

Preface to special issue on nanoscale membrane organisations.

Alarcón B, Reth M, Schamel W.

Biochim Biophys Acta. 2015 Apr;1853(4):765-6. doi: 10.1016/j.bbamcr.2015.02.003. Epub 2015 Feb 10. No abstract available.

32.

CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.

Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M.

EMBO J. 2015 Apr 1;34(7):925-39. doi: 10.15252/embj.201489732. Epub 2015 Jan 28.

33.

The nanoscale organization of the B lymphocyte membrane.

Maity PC, Yang J, Klaesener K, Reth M.

Biochim Biophys Acta. 2015 Apr;1853(4):830-40. doi: 10.1016/j.bbamcr.2014.11.010. Epub 2014 Nov 15. Review.

34.

Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.

Königsberger S, Weis V, Prodöhl J, Stehling M, Hobeika E, Reth M, Kiefer F.

Eur J Immunol. 2015 Feb;45(2):603-11. doi: 10.1002/eji.201444538. Epub 2014 Dec 2.

35.

The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells.

Grötsch B, Brachs S, Lang C, Luther J, Derer A, Schlötzer-Schrehardt U, Bozec A, Fillatreau S, Berberich I, Hobeika E, Reth M, Wagner EF, Schett G, Mielenz D, David JP.

J Exp Med. 2014 Oct 20;211(11):2199-212. doi: 10.1084/jem.20130795. Epub 2014 Oct 6. Erratum in: J Exp Med. 2014 Oct 20;211(11):223.

36.

Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE.

Umiker BR, McDonald G, Larbi A, Medina CO, Hobeika E, Reth M, Imanishi-Kari T.

Eur J Immunol. 2014 Oct;44(10):3093-108. doi: 10.1002/eji.201344282. Epub 2014 Aug 19.

37.

PDK1 regulates B cell differentiation and homeostasis.

Baracho GV, Cato MH, Zhu Z, Jaren OR, Hobeika E, Reth M, Rickert RC.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9573-8. doi: 10.1073/pnas.1314562111. Epub 2014 Jun 16.

38.

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.

Kläsener K, Maity PC, Hobeika E, Yang J, Reth M.

Elife. 2014 Jun 24;3:e02069. doi: 10.7554/eLife.02069.

39.

The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.

Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M.

J Immunol. 2014 Jul 1;193(1):268-76. doi: 10.4049/jimmunol.1203040. Epub 2014 Jun 4.

40.

The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.

Hutzler S, Özgör L, Naito-Matsui Y, Kläsener K, Winkler TH, Reth M, Nitschke L.

J Immunol. 2014 Jun 1;192(11):5406-14. doi: 10.4049/jimmunol.1302875. Epub 2014 Apr 30.

41.

MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.

Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O.

J Immunol. 2014 Jun 1;192(11):5273-84. doi: 10.4049/jimmunol.1302209. Epub 2014 Apr 23.

42.

Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.

Reth M.

J Immunol. 2014 May 1;192(9):4015-6. No abstract available.

43.

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.

Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll RE, Hiepe F, Reth M.

J Exp Med. 2014 Mar 10;211(3):427-40. doi: 10.1084/jem.20131196. Epub 2014 Mar 3.

44.

Signaling circuits in early B-cell development.

Reth M, Nielsen P.

Adv Immunol. 2014;122:129-75. doi: 10.1016/B978-0-12-800267-4.00004-3. Review.

PMID:
24507157
45.

Michael Neuberger (1953-2013).

Alt F, Reth M.

Immunity. 2013 Dec 12;39(6):987-8. No abstract available.

46.

Pre-clustering of the B cell antigen receptor demonstrated by mathematically extended electron microscopy.

Fiala GJ, Kaschek D, Blumenthal B, Reth M, Timmer J, Schamel WW.

Front Immunol. 2013 Dec 6;4:427. doi: 10.3389/fimmu.2013.00427. eCollection 2013.

47.

Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip.

Blazek M, Betz C, Hall MN, Reth M, Zengerle R, Meier M.

Mol Cell Proteomics. 2013 Dec;12(12):3898-907. doi: 10.1074/mcp.M113.032821. Epub 2013 Sep 26.

48.

Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation.

Hug E, Hobeika E, Reth M, Jumaa H.

Oncogene. 2014 Jul 10;33(28):3730-41. doi: 10.1038/onc.2013.326. Epub 2013 Aug 19.

PMID:
23955076
49.

Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.

Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R.

Cell. 2013 Aug 15;154(4):859-74. doi: 10.1016/j.cell.2013.07.031. Erratum in: Cell. 2013 Nov 7;155(4):964-6.

50.

The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination.

Su YW, Chen YP, Chen MY, Reth M, Tan TH.

PLoS One. 2013 Jul 16;8(7):e68804. doi: 10.1371/journal.pone.0068804. Print 2013.

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