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p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.

Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.

J Clin Invest. 2019 Oct 7. pii: 128626. doi: 10.1172/JCI128626. [Epub ahead of print]


Revealing a human p53 universe.

Nguyen TT, Grimm SA, Bushel PR, Li J, Li Y, Bennett BD, Lavender CA, Ward JM, Fargo DC, Anderson CW, Li L, Resnick MA, Menendez D.

Nucleic Acids Res. 2018 Sep 19;46(16):8153-8167. doi: 10.1093/nar/gky720.


ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells.

Alessandrini F, Pezzè L, Menendez D, Resnick MA, Ciribilli Y.

Neoplasia. 2018 Aug;20(8):857-870. doi: 10.1016/j.neo.2018.06.008. Epub 2018 Jul 17.


The global role for Cdc13 and Yku70 in preventing telomere resection across the genome.

Westmoreland JW, Mihalevic MJ, Bernstein KA, Resnick MA.

DNA Repair (Amst). 2018 Feb;62:8-17. doi: 10.1016/j.dnarep.2017.11.010. Epub 2017 Nov 29.


Increased LOH due to Defective Sister Chromatid Cohesion Is due Primarily to Chromosomal Aneuploidy and not Recombination.

Sagi D, Marcos-Hadad E, Bari VK, Resnick MA, Covo S.

G3 (Bethesda). 2017 Oct 5;7(10):3305-3315. doi: 10.1534/g3.117.300091.


The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.

Menendez D, Nguyen TA, Snipe J, Resnick MA.

Mol Cancer Res. 2017 Jun;15(6):735-743. doi: 10.1158/1541-7786.MCR-17-0019. Epub 2017 Feb 23.


The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.

Lowe JM, Nguyen TA, Grimm SA, Gabor KA, Peddada SD, Li L, Anderson CW, Resnick MA, Menendez D, Fessler MB.

Cell Death Differ. 2017 Jan;24(1):181-191. doi: 10.1038/cdd.2016.130. Epub 2016 Nov 11.


Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.

Menendez D, Lowe JM, Snipe J, Resnick MA.

Oncotarget. 2016 Sep 20;7(38):61630-61642. doi: 10.18632/oncotarget.11210.


The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products.

Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA.

Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. Epub 2016 Jun 13.


Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.

Westmoreland JW, Resnick MA.

Nucleic Acids Res. 2016 Jan 29;44(2):695-704. doi: 10.1093/nar/gkv1109. Epub 2015 Oct 25.


Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay.

Sharma V, Jordan JJ, Ciribilli Y, Resnick MA, Bisio A, Inga A.

PLoS One. 2015 Jul 6;10(7):e0130170. doi: 10.1371/journal.pone.0130170. eCollection 2015.


Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.

Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS.

Nat Struct Mol Biol. 2015 Feb;22(2):158-66. doi: 10.1038/nsmb.2945. Epub 2015 Jan 12.


Suppression of allelic recombination and aneuploidy by cohesin is independent of Chk1 in Saccharomyces cerevisiae.

Covo S, Chiou E, Gordenin DA, Resnick MA.

PLoS One. 2014 Dec 31;9(12):e113435. doi: 10.1371/journal.pone.0113435. eCollection 2014.


Break-induced replication is a source of mutation clusters underlying kataegis.

Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A.

Cell Rep. 2014 Jun 12;7(5):1640-1648. doi: 10.1016/j.celrep.2014.04.053. Epub 2014 May 29.


p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.

Lowe JM, Menendez D, Bushel PR, Shatz M, Kirk EL, Troester MA, Garantziotis S, Fessler MB, Resnick MA.

Cancer Res. 2014 Apr 15;74(8):2182-92. doi: 10.1158/0008-5472.CAN-13-1070.


Mutant TP53 posttranslational modifications: challenges and opportunities.

Nguyen TA, Menendez D, Resnick MA, Anderson CW.

Hum Mutat. 2014 Jun;35(6):738-55. doi: 10.1002/humu.22506. Epub 2014 Feb 11. Review.


The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.

Covo S, Puccia CM, Argueso JL, Gordenin DA, Resnick MA.

Genetics. 2014 Feb;196(2):373-84. doi: 10.1534/genetics.113.159202. Epub 2013 Dec 2.


The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis.

Chan K, Resnick MA, Gordenin DA.

DNA Repair (Amst). 2013 Nov;12(11):878-89. doi: 10.1016/j.dnarep.2013.07.008. Epub 2013 Aug 26.


Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines.

Degtyareva NP, Heyburn L, Sterling J, Resnick MA, Gordenin DA, Doetsch PW.

Nucleic Acids Res. 2013 Oct;41(19):8995-9005. doi: 10.1093/nar/gkt671. Epub 2013 Aug 7.


Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.

Ciribilli Y, Monti P, Bisio A, Nguyen HT, Ethayathulla AS, Ramos A, Foggetti G, Menichini P, Menendez D, Resnick MA, Viadiu H, Fronza G, Inga A.

Nucleic Acids Res. 2013 Oct;41(18):8637-53. doi: 10.1093/nar/gkt657. Epub 2013 Jul 26.


Homologous recombination rescues ssDNA gaps generated by nucleotide excision repair and reduced translesion DNA synthesis in yeast G2 cells.

Ma W, Westmoreland JW, Resnick MA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2895-904. doi: 10.1073/pnas.1301676110. Epub 2013 Jul 15.


An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.

Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, Kiezun A, Kryukov GV, Carter SL, Saksena G, Harris S, Shah RR, Resnick MA, Getz G, Gordenin DA.

Nat Genet. 2013 Sep;45(9):970-6. doi: 10.1038/ng.2702. Epub 2013 Jul 14.


Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.

Menendez D, Nguyen TA, Freudenberg JM, Mathew VJ, Anderson CW, Jothi R, Resnick MA.

Nucleic Acids Res. 2013 Aug;41(15):7286-301. doi: 10.1093/nar/gkt504. Epub 2013 Jun 17.


p53 Integrates host defense and cell fate during bacterial pneumonia.

Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB.

J Exp Med. 2013 May 6;210(5):891-904. doi: 10.1084/jem.20121674. Epub 2013 Apr 29.


A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.

McKinney JS, Sethi S, Tripp JD, Nguyen TN, Sanderson BA, Westmoreland JW, Resnick MA, Lewis LK.

BMC Genomics. 2013 Apr 15;14:251. doi: 10.1186/1471-2164-14-251.


Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease.

Westmoreland JW, Resnick MA.

PLoS Genet. 2013 Mar;9(3):e1003420. doi: 10.1371/journal.pgen.1003420. Epub 2013 Mar 28.


Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics.

Lion M, Bisio A, Tebaldi T, De Sanctis V, Menendez D, Resnick MA, Ciribilli Y, Inga A.

Cell Cycle. 2013 Apr 15;12(8):1211-24. doi: 10.4161/cc.24309. Epub 2013 Mar 21.


Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent.

Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA.

PLoS Genet. 2012;8(12):e1003149. doi: 10.1371/journal.pgen.1003149. Epub 2012 Dec 13.


Interactions between the tumor suppressor p53 and immune responses.

Menendez D, Shatz M, Resnick MA.

Curr Opin Oncol. 2013 Jan;25(1):85-92. doi: 10.1097/CCO.0b013e32835b6386. Review.


Transactivation by low and high levels of human p53 reveals new physical rules of engagement and novel super-transactivation sequences.

Menendez D, Resnick MA, Haran T.

Cell Cycle. 2012 Dec 1;11(23):4287-8. doi: 10.4161/cc.22467. Epub 2012 Oct 24. No abstract available.


Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion.

Covo S, Ma W, Westmoreland JW, Gordenin DA, Resnick MA.

Cell Cycle. 2012 Nov 1;11(21):3937-44. doi: 10.4161/cc.21945. Epub 2012 Sep 17.


Low-level p53 expression changes transactivation rules and reveals superactivating sequences.

Jordan JJ, Menendez D, Sharav J, Beno I, Rosenthal K, Resnick MA, Haran TE.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14387-92. doi: 10.1073/pnas.1205971109. Epub 2012 Aug 20.


RAP80 is critical in maintaining genomic stability and suppressing tumor development.

Yin Z, Menendez D, Resnick MA, French JE, Janardhan KS, Jetten AM.

Cancer Res. 2012 Oct 1;72(19):5080-90. doi: 10.1158/0008-5472.CAN-12-1484. Epub 2012 Aug 15.


The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells.

Shatz M, Menendez D, Resnick MA.

Cancer Res. 2012 Aug 15;72(16):3948-57. doi: 10.1158/0008-5472.CAN-11-4134. Epub 2012 Jun 6.


Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA.

Mol Cell. 2012 May 25;46(4):424-35. doi: 10.1016/j.molcel.2012.03.030. Epub 2012 May 17.


Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus.

Ma W, Halweg CJ, Menendez D, Resnick MA.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. doi: 10.1073/pnas.1118078109. Epub 2012 Apr 9.


RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition.

Covo S, Westmoreland JW, Reddy AK, Gordenin DA, Resnick MA.

DNA Repair (Amst). 2012 Mar 1;11(3):317-23. doi: 10.1016/j.dnarep.2011.12.008. Epub 2012 Jan 23.


p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.

Andreotti V, Ciribilli Y, Monti P, Bisio A, Lion M, Jordan J, Fronza G, Menichini P, Resnick MA, Inga A.

PLoS One. 2011;6(6):e20643. doi: 10.1371/journal.pone.0020643. Epub 2011 Jun 2.


Characterizing resection at random and unique chromosome double-strand breaks and telomere ends.

Ma W, Westmoreland J, Nakai W, Malkova A, Resnick MA.

Methods Mol Biol. 2011;745:15-31. doi: 10.1007/978-1-61779-129-1_2.


Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.

Ma W, Westmoreland JW, Gordenin DA, Resnick MA.

PLoS Genet. 2011 Apr;7(4):e1002059. doi: 10.1371/journal.pgen.1002059. Epub 2011 Apr 28.


The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.

Menendez D, Shatz M, Azzam K, Garantziotis S, Fessler MB, Resnick MA.

PLoS Genet. 2011 Mar;7(3):e1001360. doi: 10.1371/journal.pgen.1001360. Epub 2011 Mar 31.


Damage-induced localized hypermutability.

Burch LH, Yang Y, Sterling JF, Roberts SA, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA.

Cell Cycle. 2011 Apr 1;10(7):1073-85. Epub 2011 Apr 1.


Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

Monti P, Perfumo C, Bisio A, Ciribilli Y, Menichini P, Russo D, Umbach DM, Resnick MA, Inga A, Fronza G.

Mol Cancer Res. 2011 Mar;9(3):271-9. doi: 10.1158/1541-7786.MCR-10-0496. Epub 2011 Feb 22.


Chromosome integrity at a double-strand break requires exonuclease 1 and MRX.

Nakai W, Westmoreland J, Yeh E, Bloom K, Resnick MA.

DNA Repair (Amst). 2011 Jan 2;10(1):102-10. doi: 10.1016/j.dnarep.2010.10.004. Epub 2010 Nov 5.


Genome-wide model for the normal eukaryotic DNA replication fork.

Larrea AA, Lujan SA, Nick McElhinny SA, Mieczkowski PA, Resnick MA, Gordenin DA, Kunkel TA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17674-9. doi: 10.1073/pnas.1010178107. Epub 2010 Sep 27.


Potentiating the p53 network.

Menendez D, Inga A, Resnick MA.

Discov Med. 2010 Jul;10(50):94-100. Review.


A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.

Yang Y, Gordenin DA, Resnick MA.

DNA Repair (Amst). 2010 Aug 5;9(8):914-21. doi: 10.1016/j.dnarep.2010.06.005. Epub 2010 Jul 21.


Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes.

Covo S, Westmoreland JW, Gordenin DA, Resnick MA.

PLoS Genet. 2010 Jul 1;6(7):e1001006. doi: 10.1371/journal.pgen.1001006.


The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.

Ciribilli Y, Andreotti V, Menendez D, Langen JS, Schoenfelder G, Resnick MA, Inga A.

PLoS One. 2010 Apr 21;5(4):e10236. doi: 10.1371/journal.pone.0010236.

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