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Items: 1 to 50 of 115

1.

In Vitro Analysis of Hedgehog Acyltransferase and Porcupine Fatty Acyltransferase Activities.

Asciolla JJ, Rajanala K, Resh MD.

Methods Mol Biol. 2019;2009:243-255. doi: 10.1007/978-1-4939-9532-5_19.

PMID:
31152409
2.

Specification of positional identity in forebrain organoids.

Cederquist GY, Asciolla JJ, Tchieu J, Walsh RM, Cornacchia D, Resh MD, Studer L.

Nat Biotechnol. 2019 Apr;37(4):436-444. doi: 10.1038/s41587-019-0085-3. Epub 2019 Apr 1.

3.

An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine.

Asciolla JJ, Miele MM, Hendrickson RC, Resh MD.

J Biol Chem. 2017 Aug 18;292(33):13507-13513. doi: 10.1074/jbc.C117.800136. Epub 2017 Jun 27.

4.

Palmitoylation of proteins in cancer.

Resh MD.

Biochem Soc Trans. 2017 Apr 15;45(2):409-416. doi: 10.1042/BST20160233. Review.

PMID:
28408481
5.

HO-2 Pockets Myristoylated Gag.

Resh MD.

Cell Host Microbe. 2017 Feb 8;21(2):131-133. doi: 10.1016/j.chom.2017.01.011.

6.

Fatty acylation of proteins: The long and the short of it.

Resh MD.

Prog Lipid Res. 2016 Jul;63:120-31. doi: 10.1016/j.plipres.2016.05.002. Epub 2016 May 24. Review.

7.
8.

Membrane topology of hedgehog acyltransferase.

Matevossian A, Resh MD.

J Biol Chem. 2015 Jan 23;290(4):2235-43. doi: 10.1074/jbc.M114.625764. Epub 2014 Dec 8.

9.

Identification of key residues and regions important for porcupine-mediated Wnt acylation.

Rios-Esteves J, Haugen B, Resh MD.

J Biol Chem. 2014 Jun 13;289(24):17009-19. doi: 10.1074/jbc.M114.561209. Epub 2014 May 5.

10.

Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stévant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jégou B, Trainor PA, Resh MD, Antonarakis SE, Nef S.

PLoS Genet. 2014 May 1;10(5):e1004340. doi: 10.1371/journal.pgen.1004340. eCollection 2014 May.

11.

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.

Petrova E, Matevossian A, Resh MD.

Oncogene. 2015 Jan 8;34(2):263-8. doi: 10.1038/onc.2013.575. Epub 2014 Jan 27.

12.

Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.

Rios-Esteves J, Resh MD.

Cell Rep. 2013 Sep 26;4(6):1072-81. doi: 10.1016/j.celrep.2013.08.027. Epub 2013 Sep 19.

13.

Covalent lipid modifications of proteins.

Resh MD.

Curr Biol. 2013 May 20;23(10):R431-5. doi: 10.1016/j.cub.2013.04.024. No abstract available.

14.

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD.

Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.

15.

Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.

Hardy RY, Resh MD.

J Biol Chem. 2012 Dec 14;287(51):42881-9. doi: 10.1074/jbc.M112.426833. Epub 2012 Oct 30.

16.

Palmitoylation of Hedgehog proteins.

Buglino JA, Resh MD.

Vitam Horm. 2012;88:229-52. doi: 10.1016/B978-0-12-394622-5.00010-9. Review.

17.

Targeting protein lipidation in disease.

Resh MD.

Trends Mol Med. 2012 Apr;18(4):206-14. doi: 10.1016/j.molmed.2012.01.007. Epub 2012 Feb 17. Review.

18.
19.
20.

Myristoylation and membrane binding regulate c-Src stability and kinase activity.

Patwardhan P, Resh MD.

Mol Cell Biol. 2010 Sep;30(17):4094-107. doi: 10.1128/MCB.00246-10. Epub 2010 Jun 28.

21.

p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo.

See WL, Heinberg AR, Holland EC, Resh MD.

Cell Cycle. 2010 Apr 15;9(8):1562-7. Epub 2010 Apr 15.

PMID:
20404478
22.

Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas.

See WL, Miller JP, Squatrito M, Holland E, Resh MD, Koff A.

Oncogene. 2010 Mar 25;29(12):1720-31. doi: 10.1038/onc.2009.465. Epub 2010 Jan 11.

23.

Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.

Martinez NW, Xue X, Berro RG, Kreitzer G, Resh MD.

J Virol. 2008 Oct;82(20):9937-50. doi: 10.1128/JVI.00819-08. Epub 2008 Aug 6.

24.

The ups and downs of SRC regulation: tumor suppression by Cbp.

Resh MD.

Cancer Cell. 2008 Jun;13(6):469-71. doi: 10.1016/j.ccr.2008.05.011.

25.

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.

Buglino JA, Resh MD.

J Biol Chem. 2008 Aug 8;283(32):22076-88. doi: 10.1074/jbc.M803901200. Epub 2008 Jun 4.

26.

c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.

Donepudi M, Resh MD.

Cell Signal. 2008 Jul;20(7):1359-67. doi: 10.1016/j.cellsig.2008.03.007. Epub 2008 Mar 21.

27.

Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag.

Valiathan RR, Resh MD.

Virol J. 2008 Feb 11;5:23. doi: 10.1186/1743-422X-5-23.

28.

Palmitoylation of ligands, receptors, and intracellular signaling molecules.

Resh MD.

Sci STKE. 2006 Oct 31;2006(359):re14. Review.

PMID:
17077383
29.

Trafficking and signaling by fatty-acylated and prenylated proteins.

Resh MD.

Nat Chem Biol. 2006 Nov;2(11):584-90. Review.

PMID:
17051234
30.
31.

Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells.

Liang X, Hajivandi M, Veach D, Wisniewski D, Clarkson B, Resh MD, Pope RM.

Proteomics. 2006 Aug;6(16):4554-64.

PMID:
16858728
32.
33.

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.

Miura GI, Buglino J, Alvarado D, Lemmon MA, Resh MD, Treisman JE.

Dev Cell. 2006 Feb;10(2):167-76.

34.
35.
36.

Membrane targeting of lipid modified signal transduction proteins.

Resh MD.

Subcell Biochem. 2004;37:217-32. Review.

PMID:
15376622
37.
39.

A myristoyl switch regulates membrane binding of HIV-1 Gag.

Resh MD.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):417-8. Epub 2004 Jan 5. No abstract available.

40.
41.

Compartmentalization of integrin alpha6beta4 signaling in lipid rafts.

Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, Resh MD, Giancotti FG.

J Cell Biol. 2003 Sep 29;162(7):1189-96.

42.

Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma.

Van Laethem F, Liang X, Andris F, Urbain J, Vandenbranden M, Ruysschaert JM, Resh MD, Stulnig TM, Leo O.

J Immunol. 2003 Mar 15;170(6):2932-9.

43.

p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Wolf RM, Draghi N, Liang X, Dai C, Uhrbom L, Eklöf C, Westermark B, Holland EC, Resh MD.

Genes Dev. 2003 Feb 15;17(4):476-87.

44.
45.
46.

Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral budding.

Lindwasser OW, Resh MD.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13037-42. Epub 2002 Sep 20.

47.

Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species.

Liang X, Lu Y, Neubert TA, Resh MD.

J Biol Chem. 2002 Sep 6;277(36):33032-40. Epub 2002 Jun 24.

48.

Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.

Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD.

J Biol Chem. 2002 Apr 19;277(16):13732-8. Epub 2002 Feb 1.

49.

Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.

Wolf RM, Wilkes JJ, Chao MV, Resh MD.

J Neurobiol. 2001 Oct;49(1):62-78.

PMID:
11536198

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