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Items: 1 to 50 of 70

1.

Full atomistic model of prion structure and conversion.

Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR.

PLoS Pathog. 2019 Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul.

2.

Ok Google, how could I design therapeutics against prion diseases?

Rigoli M, Spagnolli G, Faccioli P, Requena JR, Biasini E.

Curr Opin Pharmacol. 2019 Feb;44:39-45. doi: 10.1016/j.coph.2019.03.015. Epub 2019 May 3. Review.

PMID:
31059982
3.

The prion 2018 round tables (I): the structure of PrPSc.

Baskakov IV, Caughey B, Requena JR, Sevillano AM, Surewicz WK, Wille H.

Prion. 2019 Jan;13(1):46-52. doi: 10.1080/19336896.2019.1569450.

4.

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function.

Ramos A, Rodríguez-Seoane C, Rosa I, Gorroño-Etxebarria I, Alonso J, Veiga S, Korth C, Kypta RM, García Á, Requena JR.

Int J Mol Sci. 2018 Dec 29;20(1). pii: E119. doi: 10.3390/ijms20010119.

5.

The Structure of PrPSc Prions.

Wille H, Requena JR.

Pathogens. 2018 Feb 7;7(1). pii: E20. doi: 10.3390/pathogens7010020. Review.

6.

Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie.

Silva CJ, Erickson-Beltran ML, Martín-Burriel I, Badiola JJ, Requena JR, Bolea R.

Anal Chem. 2018 Jan 16;90(2):1255-1262. doi: 10.1021/acs.analchem.7b03985. Epub 2018 Jan 2.

PMID:
29240410
7.

Cofactors influence the biological properties of infectious recombinant prions.

Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín M, Pirisinu L, Parra B, Elezgarai SR, Vanni I, López-Moreno R, Vaccari G, Venegas V, Charco JM, Gil D, Harrathi C, D'Agostino C, Agrimi U, Mayoral T, Requena JR, Nonno R, Castilla J.

Acta Neuropathol. 2018 Feb;135(2):179-199. doi: 10.1007/s00401-017-1782-y. Epub 2017 Nov 1.

PMID:
29094186
8.

The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cells.

Akhter S, Chakraborty S, Moutinho D, Álvarez-Coiradas E, Rosa I, Viñuela J, Domínguez E, García A, Requena JR.

PLoS One. 2017 Sep 21;12(9):e0185176. doi: 10.1371/journal.pone.0185176. eCollection 2017.

9.

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.

Elezgarai SR, Fernández-Borges N, Eraña H, Sevillano AM, Charco JM, Harrathi C, Saá P, Gil D, Kong Q, Requena JR, Andréoletti O, Castilla J.

Sci Rep. 2017 Aug 29;7(1):9584. doi: 10.1038/s41598-017-09489-3.

10.

The Structure of the Infectious Prion Protein and Its Propagation.

Requena JR, Wille H.

Prog Mol Biol Transl Sci. 2017;150:341-359. doi: 10.1016/bs.pmbts.2017.06.009. Epub 2017 Jul 31. Review.

PMID:
28838667
11.

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E.

PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017.

12.

Elucidating the structure of an infectious protein.

Zweckstetter M, Requena JR, Wille H.

PLoS Pathog. 2017 Apr 13;13(4):e1006229. doi: 10.1371/journal.ppat.1006229. eCollection 2017 Apr. Review. No abstract available.

13.

The Structure of Mammalian Prions and Their Aggregates.

Vázquez-Fernández E, Young HS, Requena JR, Wille H.

Int Rev Cell Mol Biol. 2017;329:277-301. doi: 10.1016/bs.ircmb.2016.08.013. Epub 2016 Oct 22. Review.

PMID:
28109330
14.

Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep.

Silva CJ, Erickson-Beltran ML, Hui C, Badiola JJ, Nicholson EM, Requena JR, Bolea R.

Anal Chem. 2017 Jan 3;89(1):854-861. doi: 10.1021/acs.analchem.6b03822. Epub 2016 Dec 21.

PMID:
27936597
15.

Reelin Expression in Creutzfeldt-Jakob Disease and Experimental Models of Transmissible Spongiform Encephalopathies.

Mata A, Urrea L, Vilches S, Llorens F, Thüne K, Espinosa JC, Andréoletti O, Sevillano AM, Torres JM, Requena JR, Zerr I, Ferrer I, Gavín R, Del Río JA.

Mol Neurobiol. 2017 Oct;54(8):6412-6425. doi: 10.1007/s12035-016-0177-8. Epub 2016 Oct 10.

PMID:
27726110
16.

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H.

PLoS Pathog. 2016 Sep 8;12(9):e1005835. doi: 10.1371/journal.ppat.1005835. eCollection 2016 Sep.

17.

The Priority position paper: Protecting Europe's food chain from prions.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I.

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.

18.

Larger aggregates of mutant seipin in Celia's Encephalopathy, a new protein misfolding neurodegenerative disease.

Ruiz-Riquelme A, Sánchez-Iglesias S, Rábano A, Guillén-Navarro E, Domingo-Jiménez R, Ramos A, Rosa I, Senra A, Nilsson P, García Á, Araújo-Vilar D, Requena JR.

Neurobiol Dis. 2015 Nov;83:44-53. doi: 10.1016/j.nbd.2015.08.006. Epub 2015 Aug 15.

PMID:
26282322
19.

DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.

Rodríguez-Seoane C, Ramos A, Korth C, Requena JR.

J Neurochem. 2015 Nov;135(3):598-605. doi: 10.1111/jnc.13258. Epub 2015 Aug 12.

20.

Prion-like diseases: Looking for their niche in the realm of infectious diseases.

Castilla J, Requena JR.

Virus Res. 2015 Sep 2;207:1-4. doi: 10.1016/j.virusres.2015.06.001. Epub 2015 Jun 4. No abstract available.

PMID:
26052085
21.

Proteinase K and the structure of PrPSc: The good, the bad and the ugly.

Silva CJ, Vázquez-Fernández E, Onisko B, Requena JR.

Virus Res. 2015 Sep 2;207:120-6. doi: 10.1016/j.virusres.2015.03.008. Epub 2015 Mar 24. Review.

PMID:
25816779
22.

Probing the Conformational Dynamics of the Bioactive Peptide TLQP-21 in Solution: A Molecular Dynamics Study.

Chakraborty S, Akhter S, Requena JR, Basu S.

Chem Biol Drug Des. 2015 Oct;86(4):938-44. doi: 10.1111/cbdd.12541. Epub 2015 Mar 9.

PMID:
25682804
23.

Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.

Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR.

Hum Mol Genet. 2014 Nov 15;23(22):5859-65. doi: 10.1093/hmg/ddu303. Epub 2014 Jun 16.

24.

Loss of prion protein leads to age-dependent behavioral abnormalities and changes in cytoskeletal protein expression.

Schmitz M, Greis C, Ottis P, Silva CJ, Schulz-Schaeffer WJ, Wrede A, Koppe K, Onisko B, Requena JR, Govindarajan N, Korth C, Fischer A, Zerr I.

Mol Neurobiol. 2014 Dec;50(3):923-36. doi: 10.1007/s12035-014-8655-3. Epub 2014 Mar 7.

PMID:
24604355
25.
26.

SAXS structural study of PrP(Sc) reveals ~11 nm diameter of basic double intertwined fibers.

Amenitsch H, Benetti F, Ramos A, Legname G, Requena JR.

Prion. 2013 Nov-Dec;7(6):496-500. Epub 2013 Nov 18.

27.

A new seipin-associated neurodegenerative syndrome.

Guillén-Navarro E, Sánchez-Iglesias S, Domingo-Jiménez R, Victoria B, Ruiz-Riquelme A, Rábano A, Loidi L, Beiras A, González-Méndez B, Ramos A, López-González V, Ballesta-Martínez MJ, Garrido-Pumar M, Aguiar P, Ruibal A, Requena JR, Araújo-Vilar D.

J Med Genet. 2013 Jun;50(6):401-9. doi: 10.1136/jmedgenet-2013-101525. Epub 2013 Apr 6.

PMID:
23564749
28.

Oxidation of methionine 216 in sheep and elk prion protein is highly dependent upon the amino acid at position 218 but is not important for prion propagation.

Silva CJ, Dynin I, Erickson ML, Requena JR, Balachandran A, Hui C, Onisko BC, Carter JM.

Biochemistry. 2013 Mar 26;52(12):2139-47. doi: 10.1021/bi3016795. Epub 2013 Mar 15.

PMID:
23458153
29.

Structural organization of mammalian prions as probed by limited proteolysis.

Vázquez-Fernández E, Alonso J, Pastrana MA, Ramos A, Stitz L, Vidal E, Dynin I, Petsch B, Silva CJ, Requena JR.

PLoS One. 2012;7(11):e50111. doi: 10.1371/journal.pone.0050111. Epub 2012 Nov 20.

30.

Prions, proteinase K and infectivity.

Sajnani G, Requena JR.

Prion. 2012 Nov-Dec;6(5):430-2. doi: 10.4161/pri.22309. Epub 2012 Oct 8.

31.

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.

Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, Lin CY, Ishizuka K, Sawa A, Ramos A, Rosa I, García Á, Requena JR, Hipolito M, Rai N, Nwulia E, Henning U, Ferrea S, Luckhaus C, Ekelund J, Veijola J, Järvelin MR, Hennah W, Korth C.

Hum Mol Genet. 2012 Oct 15;21(20):4406-18. Epub 2012 Jul 13.

32.

Human and rat brain lipofuscin proteome.

Ottis P, Koppe K, Onisko B, Dynin I, Arzberger T, Kretzschmar H, Requena JR, Silva CJ, Huston JP, Korth C.

Proteomics. 2012 Aug;12(15-16):2445-54. doi: 10.1002/pmic.201100668.

PMID:
22707227
33.

PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP.

Sajnani G, Silva CJ, Ramos A, Pastrana MA, Onisko BC, Erickson ML, Antaki EM, Dynin I, Vázquez-Fernández E, Sigurdson CJ, Carter JM, Requena JR.

PLoS Pathog. 2012;8(3):e1002547. doi: 10.1371/journal.ppat.1002547. Epub 2012 Mar 1.

34.

Probing structural differences between PrP(C) and PrP(Sc) by surface nitration and acetylation: evidence of conformational change in the C-terminus.

Gong B, Ramos A, Vázquez-Fernández E, Silva CJ, Alonso J, Liu Z, Requena JR.

Biochemistry. 2011 Jun 7;50(22):4963-72. doi: 10.1021/bi102073j. Epub 2011 May 11.

PMID:
21526750
35.

Utility of mass spectrometry in the diagnosis of prion diseases.

Silva CJ, Onisko BC, Dynin I, Erickson ML, Requena JR, Carter JM.

Anal Chem. 2011 Mar 1;83(5):1609-15. doi: 10.1021/ac102527w. Epub 2011 Feb 2.

PMID:
21288014
36.

Assessing the role of oxidized methionine at position 213 in the formation of prions in hamsters.

Silva CJ, Onisko BC, Dynin I, Erickson ML, Vensel WH, Requena JR, Antaki EM, Carter JM.

Biochemistry. 2010 Mar 9;49(9):1854-61. doi: 10.1021/bi901850n.

PMID:
20121218
37.

Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C.

Leliveld SR, Hendriks P, Michel M, Sajnani G, Bader V, Trossbach S, Prikulis I, Hartmann R, Jonas E, Willbold D, Requena JR, Korth C.

Biochemistry. 2009 Aug 18;48(32):7746-55. doi: 10.1021/bi900901e.

PMID:
19583211
38.

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.

Pamplona R, Naudí A, Gavín R, Pastrana MA, Sajnani G, Ilieva EV, Del Río JA, Portero-Otín M, Ferrer I, Requena JR.

Free Radic Biol Med. 2008 Oct 15;45(8):1159-66. doi: 10.1016/j.freeradbiomed.2008.07.009. Epub 2008 Jul 23.

PMID:
18703134
39.

Scrapie prion protein structural constraints obtained by limited proteolysis and mass spectrometry.

Sajnani G, Pastrana MA, Dynin I, Onisko B, Requena JR.

J Mol Biol. 2008 Sep 26;382(1):88-98. doi: 10.1016/j.jmb.2008.06.070. Epub 2008 Jul 1.

PMID:
18621059
40.

Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.

Leliveld SR, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena JR, Korth C.

J Neurosci. 2008 Apr 9;28(15):3839-45. doi: 10.1523/JNEUROSCI.5389-07.2008.

41.

Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons.

Gavín R, Ureña J, Rangel A, Pastrana MA, Requena JR, Soriano E, Aguzzi A, Del Río JA.

Neurobiol Dis. 2008 May;30(2):243-54. doi: 10.1016/j.nbd.2008.02.001. Epub 2008 Feb 16.

PMID:
18374587
42.

Sensitive, preclinical detection of prions in brain by nanospray liquid chromatography/tandem mass spectrometry.

Onisko BC, Silva CJ, Dynin I, Erickson M, Vensel WH, Hnasko R, Requena JR, Carter JM.

Rapid Commun Mass Spectrom. 2007;21(24):4023-6.

PMID:
18000838
43.

Mass spectrometric detection of attomole amounts of the prion protein by nanoLC/MS/MS.

Onisko B, Dynin I, Requena JR, Silva CJ, Erickson M, Carter JM.

J Am Soc Mass Spectrom. 2007 Jun;18(6):1070-9. Epub 2007 Mar 28.

44.

Isolation and characterization of a proteinase K-sensitive PrPSc fraction.

Pastrana MA, Sajnani G, Onisko B, Castilla J, Morales R, Soto C, Requena JR.

Biochemistry. 2006 Dec 26;45(51):15710-7. Epub 2006 Dec 6.

PMID:
17176093
45.

Probing PrPSc structure using chemical cross-linking and mass spectrometry: evidence of the proximity of Gly90 amino termini in the PrP 27-30 aggregate.

Onisko B, Fernández EG, Freire ML, Schwarz A, Baier M, Camiña F, García JR, Rodríguez-Segade Villamarín S, Requena JR.

Biochemistry. 2005 Aug 2;44(30):10100-9.

PMID:
16042387
46.

Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.

Ruiz MC, Ayala V, Portero-Otín M, Requena JR, Barja G, Pamplona R.

Mech Ageing Dev. 2005 Oct;126(10):1106-14.

PMID:
15955547
47.

Oxidation of methionine residues in the prion protein by hydrogen peroxide.

Requena JR, Dimitrova MN, Legname G, Teijeira S, Prusiner SB, Levine RL.

Arch Biochem Biophys. 2004 Dec 15;432(2):188-95.

PMID:
15542057
48.

Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon.

Portero-Otín M, Requena JR, Bellmunt MJ, Ayala V, Pamplona R.

Exp Gerontol. 2004 Oct;39(10):1527-35.

PMID:
15501023
49.

Recent advances in the analysis of oxidized proteins.

Requena JR, Levine RL, Stadtman ER.

Amino Acids. 2003 Dec;25(3-4):221-6. Epub 2003 Jul 29. Review.

PMID:
14661085
50.

Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids.

Portero-Otin M, Bellmunt MJ, Requena JR, Pamplona R.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1403-5. Review.

PMID:
14641074

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