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Items: 22

1.

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B.

J Clin Invest. 2018 Aug 1;128(8):3535-3545. doi: 10.1172/JCI97065. Epub 2018 Jul 16.

2.

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH.

ACS Cent Sci. 2018 Mar 28;4(3):357-361. doi: 10.1021/acscentsci.7b00504. Epub 2018 Mar 14.

3.

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡ .

Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.

PMID:
29447449
4.

Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia.

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA.

PMID:
29361238
5.

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD.

PLoS One. 2017 Nov 20;12(11):e0188251. doi: 10.1371/journal.pone.0188251. eCollection 2017.

6.

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11063-11068. doi: 10.1073/pnas.1706875114. Epub 2017 Oct 2.

7.

A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease.

Emmadi M, Khan N, Lykke L, Reppe K, G Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH.

J Am Chem Soc. 2017 Oct 18;139(41):14783-14791. doi: 10.1021/jacs.7b07836. Epub 2017 Oct 4.

PMID:
28945368
8.

A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae.

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M.

Angew Chem Int Ed Engl. 2017 Nov 6;56(45):13973-13978. doi: 10.1002/anie.201700964. Epub 2017 Oct 5.

9.

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH.

Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf5347. doi: 10.1126/scitranslmed.aaf5347.

10.

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.

PMID:
28005404
11.

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow ADJ, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH.

Cell Chem Biol. 2016 Nov 17;23(11):1407-1416. doi: 10.1016/j.chembiol.2016.09.016. Epub 2016 Nov 3.

12.

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia.

Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM.

PLoS One. 2016 Apr 21;11(4):e0153847. doi: 10.1371/journal.pone.0153847. eCollection 2016.

13.

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M.

Infect Immun. 2015 Dec;83(12):4617-29. doi: 10.1128/IAI.00948-15. Epub 2015 Sep 14.

14.

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B.

PLoS One. 2015 Feb 6;10(2):e0117022. doi: 10.1371/journal.pone.0117022. eCollection 2015.

15.

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x. Epub 2014 Sep 12.

16.

mCLCA3 modulates IL-17 and CXCL-1 induction and leukocyte recruitment in murine Staphylococcus aureus pneumonia.

Dietert K, Reppe K, Mundhenk L, Witzenrath M, Gruber AD.

PLoS One. 2014 Jul 17;9(7):e102606. doi: 10.1371/journal.pone.0102606. eCollection 2014.

17.

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7. doi: 10.1165/rcmb.2014-0052MA.

PMID:
24960575
18.

NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.

Krljanac B, Weih D, Jacobsen ID, Hu D, Koliesnik I, Reppe K, Witzenrath M, Weih F.

Eur J Immunol. 2014 Mar;44(3):662-72. doi: 10.1002/eji.201343484. Epub 2013 Dec 16.

19.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

PMID:
23633685
20.

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.

Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6.

21.

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

Gutbier B, Kube SM, Reppe K, Santel A, Lange C, Kaufmann J, Suttorp N, Witzenrath M.

Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. doi: 10.1016/j.pupt.2010.03.007. Epub 2010 Apr 1.

PMID:
20362688
22.

Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia.

Reppe K, Tschernig T, Lührmann A, van Laak V, Grote K, Zemlin MV, Gutbier B, Müller HC, Kursar M, Schütte H, Rosseau S, Pabst R, Suttorp N, Witzenrath M.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):474-81. doi: 10.1165/rcmb.2008-0071OC. Epub 2008 Oct 17.

PMID:
18931326

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