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Items: 1 to 50 of 160

1.

Temperature as a modulator of the gut microbiome: what are the implications and opportunities for thermal medicine?

Hylander BL, Repasky EA.

Int J Hyperthermia. 2019 Nov;36(sup1):83-89. doi: 10.1080/02656736.2019.1647356.

PMID:
31795833
2.

β2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells.

Mohammadpour H, MacDonald CR, Qiao G, Chen M, Dong B, Hylander BL, McCarthy PL, Abrams SI, Repasky EA.

J Clin Invest. 2019 Dec 2;129(12):5537-5552. doi: 10.1172/JCI129502.

3.

Correction: Immune profiling in diffuse large B-cell lymphoma and mantle cell lymphoma patients treated with autologous hematopoietic cell transplant.

Herr MM, Torka P, Zhang Y, Wallace PK, Tario JD Jr, Repasky EA, Chen GL, Ho CM, Balderman SR, Ross M, Paiva B, Hernandez-Ilizaliturri FJ, McCarthy PL, Hahn T.

Bone Marrow Transplant. 2020 Jan;55(1):272. doi: 10.1038/s41409-019-0647-5.

PMID:
31471573
4.

Immune profiling in diffuse large B-cell lymphoma and mantle cell lymphoma patients treated with autologous hematopoietic cell transplant.

Herr MM, Torka P, Zhang Y, Wallace PK, Tario JD Jr, Repasky EA, Chen GL, Ho CM, Balderman SR, Ross M, Paiva B, Hernandez-Ilizaliturri FJ, McCarthy PL, Hahn T.

Bone Marrow Transplant. 2020 Jan;55(1):77-85. doi: 10.1038/s41409-019-0591-4. Epub 2019 Jun 21. Erratum in: Bone Marrow Transplant. 2019 Aug 30;:.

5.

Adrenergic Receptor Signaling Regulates the Response of Tumors to Ionizing Radiation.

MacDonald CR, Bucsek MJ, Qiao G, Chen M, Evans L, Greenberg DJ, Uccello TP, Battaglia NG, Hylander BL, Singh AK, Lord EM, Gerber SA, Repasky EA.

Radiat Res. 2019 Jun;191(6):585-589. doi: 10.1667/RR15193.1. Epub 2019 Apr 25.

PMID:
31021732
6.

Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice.

Hylander BL, Gordon CJ, Repasky EA.

J Immunol. 2019 Feb 1;202(3):631-636. doi: 10.4049/jimmunol.1800621. Review.

7.

Depression Stresses the Immune Response and Promotes Prostate Cancer Growth.

Mohammadpour H, Bucsek MJ, Hylander BL, Repasky EA.

Clin Cancer Res. 2019 Apr 15;25(8):2363-2365. doi: 10.1158/1078-0432.CCR-18-3980. Epub 2019 Jan 22.

PMID:
30670491
8.
9.

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer.

Ling X, Wu W, Fan C, Xu C, Liao J, Rich LJ, Huang RY, Repasky EA, Wang X, Li F.

J Exp Clin Cancer Res. 2018 Oct 3;37(1):240. doi: 10.1186/s13046-018-0899-8.

10.

β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress.

Qiao G, Bucsek MJ, Winder NM, Chen M, Giridharan T, Olejniczak SH, Hylander BL, Repasky EA.

Cancer Immunol Immunother. 2019 Jan;68(1):11-22. doi: 10.1007/s00262-018-2243-8. Epub 2018 Sep 18.

11.

Host-Derived Serine Protease Inhibitor 6 Provides Granzyme B-Independent Protection of Intestinal Epithelial Cells in Murine Graft-versus-Host Disease.

Mohammadpour H, Du W, O'Neill R, Khalili S, Qiu J, Repasky EA, McCarthy PL, Cao X.

Biol Blood Marrow Transplant. 2018 Dec;24(12):2397-2408. doi: 10.1016/j.bbmt.2018.07.003. Epub 2018 Jul 10.

12.

An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity.

Bucsek MJ, Giridharan T, MacDonald CR, Hylander BL, Repasky EA.

Int J Hyperthermia. 2018 Mar;34(2):135-143. doi: 10.1080/02656736.2017.1411621. Review.

13.

Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response.

Qiao G, Chen M, Bucsek MJ, Repasky EA, Hylander BL.

Front Immunol. 2018 Feb 6;9:164. doi: 10.3389/fimmu.2018.00164. eCollection 2018. Review.

14.

Improved Cuff Technique and Intraoperative Detection of Vascular Complications for Hind Limb Transplantation in Mice.

Kim M, Fisher DT, Powers CA, Repasky EA, Skitzki JJ.

Transplant Direct. 2018 Feb 2;4(2):e345. doi: 10.1097/TXD.0000000000000756. eCollection 2018 Feb.

15.

Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs.

Mohammadpour H, O'Neil R, Qiu J, McCarthy PL, Repasky EA, Cao X.

J Immunol. 2018 Apr 1;200(7):2479-2488. doi: 10.4049/jimmunol.1701752. Epub 2018 Feb 14.

16.

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice.

Kokolus KM, Zhang Y, Sivik JM, Schmeck C, Zhu J, Repasky EA, Drabick JJ, Schell TD.

Oncoimmunology. 2017 Dec 21;7(3):e1405205. doi: 10.1080/2162402X.2017.1405205. eCollection 2018.

17.

Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium.

Hong CC, Sucheston-Campbell LE, Liu S, Hu Q, Yao S, Lunetta KL, Haddad SA, Ruiz-Narváez EA, Bensen JT, Cheng TD, Bandera EV, Rosenberg LA, Haiman CA, Lee K, Evans SS, Abrams SI, Repasky EA, Olshan AF, Palmer JR, Ambrosone CB.

Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):321-330. doi: 10.1158/1055-9965.EPI-17-0434. Epub 2018 Jan 16.

18.

The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System.

Hylander BL, Eng JW, Repasky EA.

Adv Exp Med Biol. 2017;1036:173-189. doi: 10.1007/978-3-319-67577-0_12.

PMID:
29275472
19.

Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy.

Maloney E, Khokhlova T, Pillarisetty VG, Schade GR, Repasky EA, Wang YN, Giuliani L, Primavera M, Hwang JH.

Int Rev Immunol. 2017 Nov 2;36(6):338-351. doi: 10.1080/08830185.2017.1363199. Epub 2017 Sep 29. Review.

20.

β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy.

Bucsek MJ, Qiao G, MacDonald CR, Giridharan T, Evans L, Niedzwecki B, Liu H, Kokolus KM, Eng JW, Messmer MN, Attwood K, Abrams SI, Hylander BL, Repasky EA.

Cancer Res. 2017 Oct 15;77(20):5639-5651. doi: 10.1158/0008-5472.CAN-17-0546. Epub 2017 Aug 17.

21.

Highlights of the 31st annual meeting of the Society for Immunotherapy of Cancer (SITC), 2016.

Gulley JL, Repasky EA, Wood LS, Butterfield LH.

J Immunother Cancer. 2017 Jul 18;5(1):55. doi: 10.1186/s40425-017-0262-1. Review.

22.

Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5.

Eng JW, Mace TA, Sharma R, Twum DYF, Peng P, Gibbs JF, Pitoniak R, Reed CB, Abrams SI, Repasky EA, Hylander BL.

J Immunother Cancer. 2016 Jun 21;4:33. doi: 10.1186/s40425-016-0136-y. eCollection 2016.

23.

Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.

Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK.

Int J Hyperthermia. 2016 Aug;32(5):539-42. doi: 10.3109/02656736.2016.1167259. Epub 2016 May 5. No abstract available.

PMID:
27150820
24.

Thermoneutrality, Mice, and Cancer: A Heated Opinion.

Hylander BL, Repasky EA.

Trends Cancer. 2016 Apr;2(4):166-175. doi: 10.1016/j.trecan.2016.03.005. Epub 2016 Apr 22. Review.

PMID:
28741570
25.

Tumor-Priming Smoothened Inhibitor Enhances Deposition and Efficacy of Cytotoxic Nanoparticles in a Pancreatic Cancer Model.

Roy Chaudhuri T, Straubinger NL, Pitoniak RF, Hylander BL, Repasky EA, Ma WW, Straubinger RM.

Mol Cancer Ther. 2016 Jan;15(1):84-93. doi: 10.1158/1535-7163.MCT-15-0602. Epub 2015 Oct 29.

26.

Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling.

Leigh ND, Kokolus KM, O'Neill RE, Du W, Eng JW, Qiu J, Chen GL, McCarthy PL, Farrar JD, Cao X, Repasky EA.

J Immunol. 2015 Nov 15;195(10):5045-54. doi: 10.4049/jimmunol.1500700. Epub 2015 Oct 12.

27.

Tumor priming by Apo2L/TRAIL reduces interstitial fluid pressure and enhances efficacy of liposomal gemcitabine in a patient derived xenograft tumor model.

Hylander BL, Sen A, Beachy SH, Pitoniak R, Ullas S, Gibbs JF, Qiu J, Prey JD, Fetterly GJ, Repasky EA.

J Control Release. 2015 Nov 10;217:160-9. doi: 10.1016/j.jconrel.2015.08.047. Epub 2015 Sep 3.

28.

A role for the thermal environment in defining co-stimulation requirements for CD4(+) T cell activation.

Zynda ER, Grimm MJ, Yuan M, Zhong L, Mace TA, Capitano M, Ostberg JR, Lee KP, Pralle A, Repasky EA.

Cell Cycle. 2015;14(14):2340-54. doi: 10.1080/15384101.2015.1049782.

29.

A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy.

Winslow TB, Eranki A, Ullas S, Singh AK, Repasky EA, Sen A.

Int J Hyperthermia. 2015;31(6):693-701. doi: 10.3109/02656736.2015.1037800. Epub 2015 May 19.

30.

Fever and the thermal regulation of immunity: the immune system feels the heat.

Evans SS, Repasky EA, Fisher DT.

Nat Rev Immunol. 2015 Jun;15(6):335-49. doi: 10.1038/nri3843. Epub 2015 May 15. Review.

31.

Stress, metabolism and cancer: integrated pathways contributing to immune suppression.

Repasky EA, Eng J, Hylander BL.

Cancer J. 2015 Mar-Apr;21(2):97-103. doi: 10.1097/PPO.0000000000000107. Review.

32.

Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.

Lee CT, Kokolus KM, Leigh ND, Capitano M, Hylander BL, Repasky EA.

PLoS One. 2015 Mar 20;10(3):e0120327. doi: 10.1371/journal.pone.0120327. eCollection 2015.

33.

Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.

Povinelli BJ, Kokolus KM, Eng JW, Dougher CW, Curtin L, Capitano ML, Sailsbury-Ruf CT, Repasky EA, Nemeth MJ.

PLoS One. 2015 Mar 20;10(3):e0120078. doi: 10.1371/journal.pone.0120078. eCollection 2015.

34.

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

Eng JW, Reed CB, Kokolus KM, Pitoniak R, Utley A, Bucsek MJ, Ma WW, Repasky EA, Hylander BL.

Nat Commun. 2015 Mar 10;6:6426. doi: 10.1038/ncomms7426.

35.

Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia.

Eng JW, Reed CB, Kokolus KM, Repasky EA.

Int J Hyperthermia. 2014 Dec;30(8):540-6. doi: 10.3109/02656736.2014.981300.

36.

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response.

Eng JW, Kokolus KM, Reed CB, Hylander BL, Ma WW, Repasky EA.

Cancer Immunol Immunother. 2014 Nov;63(11):1115-28. doi: 10.1007/s00262-014-1617-9. Epub 2014 Oct 12. Review.

37.

Behaviorally mediated, warm adaptation: a physiological strategy when mice behaviorally thermoregulate.

Gordon CJ, Aydin C, Repasky EA, Kokolus KM, Dheyongera G, Johnstone AF.

J Therm Biol. 2014 Aug;44:41-6. doi: 10.1016/j.jtherbio.2014.06.006. Epub 2014 Jul 2.

PMID:
25086972
38.

Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.

Messmer MN, Kokolus KM, Eng JW, Abrams SI, Repasky EA.

Bioessays. 2014 Sep;36(9):884-91. doi: 10.1002/bies.201400066. Epub 2014 Jul 25. Review.

39.

Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice.

Kokolus KM, Spangler HM, Povinelli BJ, Farren MR, Lee KP, Repasky EA.

Front Immunol. 2014 Feb 10;5:23. doi: 10.3389/fimmu.2014.00023. eCollection 2014.

40.

Influence of the implantation site on the sensitivity of patient pancreatic tumor xenografts to Apo2L/TRAIL therapy.

Sharma R, Buitrago S, Pitoniak R, Gibbs JF, Curtin L, Seshadri M, Repasky EA, Hylander BL.

Pancreas. 2014 Mar;43(2):298-305. doi: 10.1097/MPA.0000000000000099.

41.

Temperature matters! And why it should matter to tumor immunologists.

Repasky EA, Evans SS, Dewhirst MW.

Cancer Immunol Res. 2013 Oct;1(4):210-6. doi: 10.1158/2326-6066.CIR-13-0118. Review.

42.

Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models.

Zhang H, Hylander BL, LeVea C, Repasky EA, Straubinger RM, Adjei AA, Ma WW.

Br J Cancer. 2014 Jan 21;110(2):320-9. doi: 10.1038/bjc.2013.754. Epub 2013 Dec 10.

43.

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature.

Kokolus KM, Capitano ML, Lee CT, Eng JW, Waight JD, Hylander BL, Sexton S, Hong CC, Gordon CJ, Abrams SI, Repasky EA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20176-81. doi: 10.1073/pnas.1304291110. Epub 2013 Nov 18.

44.

Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA.

Dayanc BE, Bansal S, Gure AO, Gollnick SO, Repasky EA.

Int J Hyperthermia. 2013 Aug;29(5):480-90. doi: 10.3109/02656736.2013.821526.

45.

Progress in development of biomedical applications of heat shock proteins and thermal stress.

Repasky EA.

Int J Hyperthermia. 2013 Aug;29(5):359-61. doi: 10.3109/02656736.2013.825015. No abstract available.

PMID:
23902337
46.

Origin of the vasculature supporting growth of primary patient tumor xenografts.

Hylander BL, Punt N, Tang H, Hillman J, Vaughan M, Bshara W, Pitoniak R, Repasky EA.

J Transl Med. 2013 May 3;11:110. doi: 10.1186/1479-5876-11-110.

47.

Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers.

Hong CC, Yao S, McCann SE, Dolnick RY, Wallace PK, Gong Z, Quan L, Lee KP, Evans SS, Repasky EA, Edge SB, Ambrosone CB.

Breast Cancer Res Treat. 2013 Jun;139(2):477-88. doi: 10.1007/s10549-013-2549-3. Epub 2013 Apr 30.

48.

Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice.

Pawaskar DK, Straubinger RM, Fetterly GJ, Hylander BH, Repasky EA, Ma WW, Jusko WJ.

Cancer Chemother Pharmacol. 2013 May;71(5):1231-40. doi: 10.1007/s00280-013-2117-x. Epub 2013 Mar 3.

49.

Physiologically based pharmacokinetic models for everolimus and sorafenib in mice.

Pawaskar DK, Straubinger RM, Fetterly GJ, Hylander BH, Repasky EA, Ma WW, Jusko WJ.

Cancer Chemother Pharmacol. 2013 May;71(5):1219-29. doi: 10.1007/s00280-013-2116-y. Epub 2013 Mar 3.

50.

Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.

Capitano ML, Nemeth MJ, Mace TA, Salisbury-Ruf C, Segal BH, McCarthy PL, Repasky EA.

Blood. 2012 Sep 27;120(13):2600-9. Epub 2012 Jul 17.

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